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The map label for this gene is hemH

Identifier: 46447191

GI number: 46447191

Start: 1865025

End: 1866068

Strand: Reverse

Name: hemH

Synonym: pc1557

Alternate gene names: 46447191

Gene position: 1866068-1865025 (Counterclockwise)

Preceding gene: 46447192

Following gene: 46447190

Centisome position: 77.29

GC content: 36.49

Gene sequence:

>1044_bases
ATGAATCAAAGAACAGGAATTTTACTTGTTAACCTTGGAACACCTAAAACTCCTCGACCTAAAGATGTCTATCGTTATTT
GAATGAATTTTTAACCGATGGGAGAGTAATTGATTTGCCCTGGCTAAAAAGACAGCTCTTAGTAAGATGCATTATTGTTC
CTTTTAGATATAAACAATCAAGCATGCTCTACCAAAAACTATGGACAGCTGAAGGATCTCCTCTTCTTGTTCATGGAATA
GCTGTTCAAACTAAACTGCAAATGATTTTAGGTGAATCATTTCAAGTTGAGTTGGCGATGCGTTATCAAAATCCCTCAAT
TGAAGAAGGTTTAGAGCGCTTAAAATTAGCAAATGTAAAAGAAATTGTGATTTTTCCTTTATTTCCTCAATATGCGTCTG
CCACAACAGGCTCTGTACATCAAGAAGTTATGAAACATTTACAGCAGTGGCAAAATATCCCAACACTGACATTTATCAAT
AGTTACCCAGACCATCCTGGTTTAGTAGGAGCTTTCTGTGAAAGGGCAAAGCAATACGATTTAAGTATTTATGATTATTT
TTTATTTAGCTTTCACGGATTACCGGAAAGGCAGATTCGAAAAGGAGATTCAACAGGTAAATGTTTAACAGAAAACTGTT
GTCAAGTGATTTGCTCGGACAATGCATTTTGTTACAAAGCCCAGTGCTATAGAACAGCAAAAGCCATTGCTTCAAAACTT
AGGATTAAACTCGAGCAATATACCGTTTGTTTTCAGTCTAGACTCGGAAAAGAGACATGGATTCAGCCTTATACAAGTGA
TTTATTAAAAGATTGTCTCGCAAAAAATAGAAAAAAAATCCTTGTTTTTTGCCCTGCTTTTGTTTGTGATTGTCTTGAAA
CCACGTGTGAAGTTTCTATCGAATATGCTGAAGAATTTAAACATTTGGGAGGGGATACTCTGCATCTAGTGGAGGGTCTA
AACAGCCATCCCGTTTGGATAGAGGCTATAAAGACGATCATTCAAGAACATCTTCCTCACCCTCACAGTCAATTTTCTCG
GTAA

Upstream 100 bases:

>100_bases
ACATCCAAGTAGATGCTTCACTGATTCAACAAGTTTTTAATGAATCAGTAGCACTGTTGCCCGACACGCCTATTTTATAA
ACTTGATAAATGAGAAAAAA

Downstream 100 bases:

>100_bases
GATTTTGCCAAAATAGATTCAAATAAAAAAAGCTATTTATTGTAAGTTAAAATTTAATTGACCTCGAATGGAAAACGGGT
TAAGGTCCGAAAGTGGACTA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNQRTGILLVNLGTPKTPRPKDVYRYLNEFLTDGRVIDLPWLKRQLLVRCIIVPFRYKQSSMLYQKLWTAEGSPLLVHGI
AVQTKLQMILGESFQVELAMRYQNPSIEEGLERLKLANVKEIVIFPLFPQYASATTGSVHQEVMKHLQQWQNIPTLTFIN
SYPDHPGLVGAFCERAKQYDLSIYDYFLFSFHGLPERQIRKGDSTGKCLTENCCQVICSDNAFCYKAQCYRTAKAIASKL
RIKLEQYTVCFQSRLGKETWIQPYTSDLLKDCLAKNRKKILVFCPAFVCDCLETTCEVSIEYAEEFKHLGGDTLHLVEGL
NSHPVWIEAIKTIIQEHLPHPHSQFSR

Sequences:

>Translated_347_residues
MNQRTGILLVNLGTPKTPRPKDVYRYLNEFLTDGRVIDLPWLKRQLLVRCIIVPFRYKQSSMLYQKLWTAEGSPLLVHGI
AVQTKLQMILGESFQVELAMRYQNPSIEEGLERLKLANVKEIVIFPLFPQYASATTGSVHQEVMKHLQQWQNIPTLTFIN
SYPDHPGLVGAFCERAKQYDLSIYDYFLFSFHGLPERQIRKGDSTGKCLTENCCQVICSDNAFCYKAQCYRTAKAIASKL
RIKLEQYTVCFQSRLGKETWIQPYTSDLLKDCLAKNRKKILVFCPAFVCDCLETTCEVSIEYAEEFKHLGGDTLHLVEGL
NSHPVWIEAIKTIIQEHLPHPHSQFSR
>Mature_347_residues
MNQRTGILLVNLGTPKTPRPKDVYRYLNEFLTDGRVIDLPWLKRQLLVRCIIVPFRYKQSSMLYQKLWTAEGSPLLVHGI
AVQTKLQMILGESFQVELAMRYQNPSIEEGLERLKLANVKEIVIFPLFPQYASATTGSVHQEVMKHLQQWQNIPTLTFIN
SYPDHPGLVGAFCERAKQYDLSIYDYFLFSFHGLPERQIRKGDSTGKCLTENCCQVICSDNAFCYKAQCYRTAKAIASKL
RIKLEQYTVCFQSRLGKETWIQPYTSDLLKDCLAKNRKKILVFCPAFVCDCLETTCEVSIEYAEEFKHLGGDTLHLVEGL
NSHPVWIEAIKTIIQEHLPHPHSQFSR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=356, Percent_Identity=24.7191011235955, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI60499021, Length=356, Percent_Identity=24.7191011235955, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1786681, Length=336, Percent_Identity=35.1190476190476, Blast_Score=204, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6324750, Length=355, Percent_Identity=24.5070422535211, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17864156, Length=357, Percent_Identity=25.4901960784314, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24651774, Length=288, Percent_Identity=24.6527777777778, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45552018, Length=203, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_PARUW (Q6MAW8)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_008556.1
- ProteinModelPortal:   Q6MAW8
- SMR:   Q6MAW8
- STRING:   Q6MAW8
- GeneID:   2781264
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc1557
- NMPDR:   fig|264201.1.peg.1557
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   GLPERHL
- PhylomeDB:   Q6MAW8
- ProtClustDB:   PRK00035
- BioCyc:   CPRO264201:PC1557-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 39974; Mature: 39974

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQRTGILLVNLGTPKTPRPKDVYRYLNEFLTDGRVIDLPWLKRQLLVRCIIVPFRYKQS
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCCHH
SMLYQKLWTAEGSPLLVHGIAVQTKLQMILGESFQVELAMRYQNPSIEEGLERLKLANVK
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
EIVIFPLFPQYASATTGSVHQEVMKHLQQWQNIPTLTFINSYPDHPGLVGAFCERAKQYD
EEEEEECCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCC
LSIYDYFLFSFHGLPERQIRKGDSTGKCLTENCCQVICSDNAFCYKAQCYRTAKAIASKL
CHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHH
RIKLEQYTVCFQSRLGKETWIQPYTSDLLKDCLAKNRKKILVFCPAFVCDCLETTCEVSI
HHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
EYAEEFKHLGGDTLHLVEGLNSHPVWIEAIKTIIQEHLPHPHSQFSR
HHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure
MNQRTGILLVNLGTPKTPRPKDVYRYLNEFLTDGRVIDLPWLKRQLLVRCIIVPFRYKQS
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCCHH
SMLYQKLWTAEGSPLLVHGIAVQTKLQMILGESFQVELAMRYQNPSIEEGLERLKLANVK
HHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
EIVIFPLFPQYASATTGSVHQEVMKHLQQWQNIPTLTFINSYPDHPGLVGAFCERAKQYD
EEEEEECCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCC
LSIYDYFLFSFHGLPERQIRKGDSTGKCLTENCCQVICSDNAFCYKAQCYRTAKAIASKL
CHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHH
RIKLEQYTVCFQSRLGKETWIQPYTSDLLKDCLAKNRKKILVFCPAFVCDCLETTCEVSI
HHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
EYAEEFKHLGGDTLHLVEGLNSHPVWIEAIKTIIQEHLPHPHSQFSR
HHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA