Click here to switch to the map view.

The map label for this gene is yegE [H]

Identifier: 45659150

GI number: 45659150

Start: 4086571

End: 4088130

Strand: Reverse

Name: yegE [H]

Synonym: LIC13331

Alternate gene names: 45659150

Gene position: 4088130-4086571 (Counterclockwise)

Preceding gene: 45659151

Following gene: 45659149

Centisome position: 95.58

GC content: 33.65

Gene sequence:

>1560_bases
TTGAGGAAATCAACGGTACACAAATTGAGTGAATTTAAGATTCAGTCGGCTGATTTTTATAAATTTCTAATTGAAAGAAG
TCCGGAGCTAATTTGTTTTCATGATCCGAACGGAATTTTTCTTTATGTCAGCCCTTCCGTAACTTCTATGTTAGGTTATC
AACCAGAAGAATTGATCGGTAAAAATCCATATGATTACTTTAATCCTTTAGATAGAGAAAGGATATTTACAAATTCTCAT
AAACCGATTTTAGAAGGAAGAGAACGGGAACGTGTAGAGTATCAGTTTCTGAGAAAGGATGGAAAATACGTTTGGTTACA
GACGATTACCCAACCGATTTTTGACGACCAAGGAAATGTGATCGCGCTTTTAGCAACTACAAGAGAATATCTAGAGCAAA
ATACAATTTTAGATACTACAAATAGTAAACAGGTTCTGGATGAGATTCGTCTTTCCGAAGAAAAGTTTTTTAATGCGTTT
TATTATTCTGGCATTGGAATGGCTCTTGTTTCTTTAGAAGGAAAATGGCTGGAAGTGAATTCGAGCCTTTTGGATATAAT
CGGTTATTCTAGAGATGAAATTTTAAAACTTACATTTCAAGATATAACACACCCAGATGATCTTACCGCCGATTTAAATC
TTTTGCAGGAAACACTAGAGAATAAGCGAGATAGCTATAGAATGGAGAAGAGGTACTTTCATAAAAACGGAAGTATCATT
TGGGTTTTATTGATGGTATCTATTGTAAGAGATTCTCAAAAGAACCCGTTGTTTTTCATTTCTCAGATCCAAGATATTAC
TGATCGCAAGAATATGCTTTCTGCTTTGATAGAAAAGAATGAAACGCTTCAAGTTTTGAGTAATCACTTGGCGGAAAGAA
ATTCTCAATTGGAAGAATTCAACCAGATCGTTTCTCACAATCTGCGTTCTCCTATTGGAAATATATTTACTCTTACTACT
ATGCTTTGCGAGAAATATGGCACAGACAAAGACCAGCTTTTTCAATCTTTAGAAACGAGCGTAGAAGATTTAATGACCAC
CTTAAATGATATTGTAGAAGTAATCAAAATTCGAAAGAATCGAAATGTAGATAAACAGACGATTCTGTTTAAAGATGCAT
TTAATAAGGTTCAAAATCTTCTTTCTGCTCAGATTCAGGAAATGAATGTAGATATTCGAACTGATTTTAATGCGTCTCCT
GAAATTTTTTATTCGAAAGTATATCTGGAAAGTATATTGTTGAATTTATTGAGTAATGCCTTAAAATATTCCGATCCGAA
CAAAAAACCGGAAATTTCTTTCGTCTCATTTATTGAGGATAAAAAGATCTTTTTAGCTGTACGGGATAACGGTCTAGGAA
TCGATCTTAAAAAATACGGTCATCAAATCTTTAAAATGAACAAAACGTTCCATCGAGAAAAAGAGGGTCAAGGTATCGGG
TTATTTATGACGAAAAATCAAATAGAATCTCTTGGGGGTGAAATAACGGTTGAAAGTTCTCCCGGTAAAGGTACATCTTT
CCTCATTAATTTCAATAAATACAATGATTTCGAACAATAG

Upstream 100 bases:

>100_bases
ACCGTTTCAGGTTAAAAATTTATGAATTCGACAAAATAAAAACGTAAAAATCTACGTTTCATTTCCGTAATGAATTGTCT
TTTATAAAATAGTACCCAAT

Downstream 100 bases:

>100_bases
TAATATGAATTTTTGGTTGGTGGATGATGATTCCATCTATATTATGATCGCTAGGCGTTTTTTGGAAAAAGACGGTAGGG
TTACAAAACTACGCGATTTC

Product: histidine kinase sensor protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MRKSTVHKLSEFKIQSADFYKFLIERSPELICFHDPNGIFLYVSPSVTSMLGYQPEELIGKNPYDYFNPLDRERIFTNSH
KPILEGRERERVEYQFLRKDGKYVWLQTITQPIFDDQGNVIALLATTREYLEQNTILDTTNSKQVLDEIRLSEEKFFNAF
YYSGIGMALVSLEGKWLEVNSSLLDIIGYSRDEILKLTFQDITHPDDLTADLNLLQETLENKRDSYRMEKRYFHKNGSII
WVLLMVSIVRDSQKNPLFFISQIQDITDRKNMLSALIEKNETLQVLSNHLAERNSQLEEFNQIVSHNLRSPIGNIFTLTT
MLCEKYGTDKDQLFQSLETSVEDLMTTLNDIVEVIKIRKNRNVDKQTILFKDAFNKVQNLLSAQIQEMNVDIRTDFNASP
EIFYSKVYLESILLNLLSNALKYSDPNKKPEISFVSFIEDKKIFLAVRDNGLGIDLKKYGHQIFKMNKTFHREKEGQGIG
LFMTKNQIESLGGEITVESSPGKGTSFLINFNKYNDFEQ

Sequences:

>Translated_519_residues
MRKSTVHKLSEFKIQSADFYKFLIERSPELICFHDPNGIFLYVSPSVTSMLGYQPEELIGKNPYDYFNPLDRERIFTNSH
KPILEGRERERVEYQFLRKDGKYVWLQTITQPIFDDQGNVIALLATTREYLEQNTILDTTNSKQVLDEIRLSEEKFFNAF
YYSGIGMALVSLEGKWLEVNSSLLDIIGYSRDEILKLTFQDITHPDDLTADLNLLQETLENKRDSYRMEKRYFHKNGSII
WVLLMVSIVRDSQKNPLFFISQIQDITDRKNMLSALIEKNETLQVLSNHLAERNSQLEEFNQIVSHNLRSPIGNIFTLTT
MLCEKYGTDKDQLFQSLETSVEDLMTTLNDIVEVIKIRKNRNVDKQTILFKDAFNKVQNLLSAQIQEMNVDIRTDFNASP
EIFYSKVYLESILLNLLSNALKYSDPNKKPEISFVSFIEDKKIFLAVRDNGLGIDLKKYGHQIFKMNKTFHREKEGQGIG
LFMTKNQIESLGGEITVESSPGKGTSFLINFNKYNDFEQ
>Mature_519_residues
MRKSTVHKLSEFKIQSADFYKFLIERSPELICFHDPNGIFLYVSPSVTSMLGYQPEELIGKNPYDYFNPLDRERIFTNSH
KPILEGRERERVEYQFLRKDGKYVWLQTITQPIFDDQGNVIALLATTREYLEQNTILDTTNSKQVLDEIRLSEEKFFNAF
YYSGIGMALVSLEGKWLEVNSSLLDIIGYSRDEILKLTFQDITHPDDLTADLNLLQETLENKRDSYRMEKRYFHKNGSII
WVLLMVSIVRDSQKNPLFFISQIQDITDRKNMLSALIEKNETLQVLSNHLAERNSQLEEFNQIVSHNLRSPIGNIFTLTT
MLCEKYGTDKDQLFQSLETSVEDLMTTLNDIVEVIKIRKNRNVDKQTILFKDAFNKVQNLLSAQIQEMNVDIRTDFNASP
EIFYSKVYLESILLNLLSNALKYSDPNKKPEISFVSFIEDKKIFLAVRDNGLGIDLKKYGHQIFKMNKTFHREKEGQGIG
LFMTKNQIESLGGEITVESSPGKGTSFLINFNKYNDFEQ

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2202

COG function: function code T; FOG: PAS/PAC domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=164, Percent_Identity=41.4634146341463, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI48994928, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788713, Length=268, Percent_Identity=26.4925373134328, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=288, Percent_Identity=25.3472222222222, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790346, Length=215, Percent_Identity=25.1162790697674, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=25.7510729613734, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=25.3275109170306, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790436, Length=207, Percent_Identity=27.0531400966184, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=242, Percent_Identity=25.6198347107438, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1786783, Length=295, Percent_Identity=24.406779661017, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 60334; Mature: 60334

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSTVHKLSEFKIQSADFYKFLIERSPELICFHDPNGIFLYVSPSVTSMLGYQPEELIG
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHCCCCHHHHC
KNPYDYFNPLDRERIFTNSHKPILEGRERERVEYQFLRKDGKYVWLQTITQPIFDDQGNV
CCCCHHCCCCCHHHHHCCCCCCHHCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCE
IALLATTREYLEQNTILDTTNSKQVLDEIRLSEEKFFNAFYYSGIGMALVSLEGKWLEVN
EEEEEHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECC
SSLLDIIGYSRDEILKLTFQDITHPDDLTADLNLLQETLENKRDSYRMEKRYFHKNGSII
HHHHHHHCCCHHHHEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
WVLLMVSIVRDSQKNPLFFISQIQDITDRKNMLSALIEKNETLQVLSNHLAERNSQLEEF
HHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
NQIVSHNLRSPIGNIFTLTTMLCEKYGTDKDQLFQSLETSVEDLMTTLNDIVEVIKIRKN
HHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNVDKQTILFKDAFNKVQNLLSAQIQEMNVDIRTDFNASPEIFYSKVYLESILLNLLSNA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LKYSDPNKKPEISFVSFIEDKKIFLAVRDNGLGIDLKKYGHQIFKMNKTFHREKEGQGIG
HHCCCCCCCCCCHHHHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEE
LFMTKNQIESLGGEITVESSPGKGTSFLINFNKYNDFEQ
EEEEHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRKSTVHKLSEFKIQSADFYKFLIERSPELICFHDPNGIFLYVSPSVTSMLGYQPEELIG
CCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHCCCCHHHHC
KNPYDYFNPLDRERIFTNSHKPILEGRERERVEYQFLRKDGKYVWLQTITQPIFDDQGNV
CCCCHHCCCCCHHHHHCCCCCCHHCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCE
IALLATTREYLEQNTILDTTNSKQVLDEIRLSEEKFFNAFYYSGIGMALVSLEGKWLEVN
EEEEEHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECC
SSLLDIIGYSRDEILKLTFQDITHPDDLTADLNLLQETLENKRDSYRMEKRYFHKNGSII
HHHHHHHCCCHHHHEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
WVLLMVSIVRDSQKNPLFFISQIQDITDRKNMLSALIEKNETLQVLSNHLAERNSQLEEF
HHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
NQIVSHNLRSPIGNIFTLTTMLCEKYGTDKDQLFQSLETSVEDLMTTLNDIVEVIKIRKN
HHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNVDKQTILFKDAFNKVQNLLSAQIQEMNVDIRTDFNASPEIFYSKVYLESILLNLLSNA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
LKYSDPNKKPEISFVSFIEDKKIFLAVRDNGLGIDLKKYGHQIFKMNKTFHREKEGQGIG
HHCCCCCCCCCCHHHHEECCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEE
LFMTKNQIESLGGEITVESSPGKGTSFLINFNKYNDFEQ
EEEEHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]