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The map label for this gene is galE [C]

Identifier: 45658025

GI number: 45658025

Start: 2629329

End: 2630321

Strand: Reverse

Name: galE [C]

Synonym: LIC12176

Alternate gene names: 45658025

Gene position: 2630321-2629329 (Counterclockwise)

Preceding gene: 45658026

Following gene: 45658024

Centisome position: 61.5

GC content: 40.79

Gene sequence:

>993_bases
ATGATTCTAATTACCGGTGCAGACGGGTTTATAGGTTCTCATTTGACGGAAACTCTTGTTCGGCAAGGTCACGAAGTAAG
AGCATTCGTACTTTATAATTCTTTTAATTCTTGGGGATGGTTGGATCAGTGTCCGGACGATATCAAGGGTAAATTTGAAG
TTTTTTCAGGGGATATTCGTGATCCGAACGGGGTGCGGGCGGCAATGAAAGGTTGCGATGCGGTTCTGCATTTAGCTGCT
TTGATCGCGATACCTTACTCTTACCACTCACCGGATACATATATCGATACGAATGTTAAAGGGACTTTAAACGTAGTTCA
AGCGGCTCGAGATCTGAATGTATCCAAAGTGATTCATACATCCACGAGTGAGGTCTATGGAACTGCTAGATTTGTTCCGA
TTACGGAAGAACATCCTTTACAAGGCCAATCCCCTTATTCCGCCAGTAAGATTGGTGCAGATCAGATCGCTATGTCCTTT
TATAATTCCTTTGGGACGCCGGTTAGTATCATTCGTCCTTTCAATACGTATGGTCCGAGGCAATCCGCTAGGGCGGTGAT
TCCTACTATTATTACACAAATTGCTAAAGGGAATAGGAAGATAAAGTTAGGCGCCGTTCATCCTACTAGAGACTTTAATT
TTGTAAAAGACACAGTTGCGGGTTTTATTGCGGCTTTGAATTCGGATGTTTGTGTGGGAGAAGTGATTAATCTTGGAAGT
AACTATGAAATTTCCGTGGGAGATACGGTTCGATTGATCGCCGAAGTTATGAAAGTGAACGTTGAAATTGAATCCGATGA
TCAAAGACTTAGACCGGAAAAAAGCGAAGTCGAAAGGTTATGGGCTTCCAATCAAAAAGCAAAAGATTTAATCAATTGGT
CTCCTGAATACGGAGGGAGAGATGGTTTTAAAAGAGGCCTCTCTGAAACGATTGATTGGTTTTCTGATATAGATAATCTT
TCCTTTTATAAAACAGATATTTATAATATATAA

Upstream 100 bases:

>100_bases
ATACTCTCGCTTATTTGATGAGCAAGGAGAATTCAATCGATATTGACGATATGATAGATTGGAAATTGGCAGAGATTTTA
CTTTTGGATAAAGTATAAAT

Downstream 100 bases:

>100_bases
TGTTAAGTGAACAAATTGTATCCGTTTTAAGATCGGTGATCACTGATAAAAATGATGTCGTTCCATTGCATGAGCCGATT
TTCCAAGGGAACGAGTGGGC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MILITGADGFIGSHLTETLVRQGHEVRAFVLYNSFNSWGWLDQCPDDIKGKFEVFSGDIRDPNGVRAAMKGCDAVLHLAA
LIAIPYSYHSPDTYIDTNVKGTLNVVQAARDLNVSKVIHTSTSEVYGTARFVPITEEHPLQGQSPYSASKIGADQIAMSF
YNSFGTPVSIIRPFNTYGPRQSARAVIPTIITQIAKGNRKIKLGAVHPTRDFNFVKDTVAGFIAALNSDVCVGEVINLGS
NYEISVGDTVRLIAEVMKVNVEIESDDQRLRPEKSEVERLWASNQKAKDLINWSPEYGGRDGFKRGLSETIDWFSDIDNL
SFYKTDIYNI

Sequences:

>Translated_330_residues
MILITGADGFIGSHLTETLVRQGHEVRAFVLYNSFNSWGWLDQCPDDIKGKFEVFSGDIRDPNGVRAAMKGCDAVLHLAA
LIAIPYSYHSPDTYIDTNVKGTLNVVQAARDLNVSKVIHTSTSEVYGTARFVPITEEHPLQGQSPYSASKIGADQIAMSF
YNSFGTPVSIIRPFNTYGPRQSARAVIPTIITQIAKGNRKIKLGAVHPTRDFNFVKDTVAGFIAALNSDVCVGEVINLGS
NYEISVGDTVRLIAEVMKVNVEIESDDQRLRPEKSEVERLWASNQKAKDLINWSPEYGGRDGFKRGLSETIDWFSDIDNL
SFYKTDIYNI
>Mature_330_residues
MILITGADGFIGSHLTETLVRQGHEVRAFVLYNSFNSWGWLDQCPDDIKGKFEVFSGDIRDPNGVRAAMKGCDAVLHLAA
LIAIPYSYHSPDTYIDTNVKGTLNVVQAARDLNVSKVIHTSTSEVYGTARFVPITEEHPLQGQSPYSASKIGADQIAMSF
YNSFGTPVSIIRPFNTYGPRQSARAVIPTIITQIAKGNRKIKLGAVHPTRDFNFVKDTVAGFIAALNSDVCVGEVINLGS
NYEISVGDTVRLIAEVMKVNVEIESDDQRLRPEKSEVERLWASNQKAKDLINWSPEYGGRDGFKRGLSETIDWFSDIDNL
SFYKTDIYNI

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=327, Percent_Identity=29.3577981651376, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI42516563, Length=323, Percent_Identity=29.1021671826625, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI4504031, Length=328, Percent_Identity=28.3536585365854, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI56237023, Length=326, Percent_Identity=25.1533742331288, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI56118217, Length=326, Percent_Identity=25.1533742331288, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI189083684, Length=326, Percent_Identity=25.1533742331288, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI193211614, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI8393516, Length=243, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786974, Length=317, Percent_Identity=29.3375394321767, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788353, Length=342, Percent_Identity=27.7777777777778, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788366, Length=340, Percent_Identity=27.9411764705882, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI48994969, Length=359, Percent_Identity=26.7409470752089, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788589, Length=354, Percent_Identity=25.9887005649718, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=335, Percent_Identity=29.2537313432836, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17568069, Length=326, Percent_Identity=23.6196319018405, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71982038, Length=338, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=324, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI115532424, Length=328, Percent_Identity=24.390243902439, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17539424, Length=324, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133901790, Length=324, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71987463, Length=190, Percent_Identity=32.1052631578947, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17539422, Length=324, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=324, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=324, Percent_Identity=23.7654320987654, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71982035, Length=335, Percent_Identity=26.5671641791045, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=27.9883381924198, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21356223, Length=333, Percent_Identity=30.3303303303303, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19923002, Length=328, Percent_Identity=28.6585365853659, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24158427, Length=324, Percent_Identity=24.3827160493827, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36562; Mature: 36562

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILITGADGFIGSHLTETLVRQGHEVRAFVLYNSFNSWGWLDQCPDDIKGKFEVFSGDIR
CEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCC
DPNGVRAAMKGCDAVLHLAALIAIPYSYHSPDTYIDTNVKGTLNVVQAARDLNVSKVIHT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHCCCHHHEEEC
STSEVYGTARFVPITEEHPLQGQSPYSASKIGADQIAMSFYNSFGTPVSIIRPFNTYGPR
CCHHHCCCEEEEECCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCCC
QSARAVIPTIITQIAKGNRKIKLGAVHPTRDFNFVKDTVAGFIAALNSDVCVGEVINLGS
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCC
NYEISVGDTVRLIAEVMKVNVEIESDDQRLRPEKSEVERLWASNQKAKDLINWSPEYGGR
CEEEECCHHHHHHHHHHHHEEEEECCHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCCCH
DGFKRGLSETIDWFSDIDNLSFYKTDIYNI
HHHHHHHHHHHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MILITGADGFIGSHLTETLVRQGHEVRAFVLYNSFNSWGWLDQCPDDIKGKFEVFSGDIR
CEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHCCCEEEEECCCC
DPNGVRAAMKGCDAVLHLAALIAIPYSYHSPDTYIDTNVKGTLNVVQAARDLNVSKVIHT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHCCCHHHEEEC
STSEVYGTARFVPITEEHPLQGQSPYSASKIGADQIAMSFYNSFGTPVSIIRPFNTYGPR
CCHHHCCCEEEEECCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCCC
QSARAVIPTIITQIAKGNRKIKLGAVHPTRDFNFVKDTVAGFIAALNSDVCVGEVINLGS
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCC
NYEISVGDTVRLIAEVMKVNVEIESDDQRLRPEKSEVERLWASNQKAKDLINWSPEYGGR
CEEEECCHHHHHHHHHHHHEEEEECCHHHHCCCHHHHHHHHHCCHHHHHHHCCCCCCCCH
DGFKRGLSETIDWFSDIDNLSFYKTDIYNI
HHHHHHHHHHHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]