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The map label for this gene is neuA

Identifier: 45658026

GI number: 45658026

Start: 2630324

End: 2631010

Strand: Reverse

Name: neuA

Synonym: LIC12177

Alternate gene names: 45658026

Gene position: 2631010-2630324 (Counterclockwise)

Preceding gene: 45658027

Following gene: 45658025

Centisome position: 61.51

GC content: 40.61

Gene sequence:

>687_bases
GTGACTGATCAAAAAATACTCGGTTTGATTCCAGCACGGGGGGGATCCAAAGGAATTCCGAGAAAAAATATAAAACTCAT
CGCGGGGAAACCTTTGATTGTTTGGACGATCGAAGCCGCCTTGAAGTCGAAGCATTTGACTTCAATTGTCGTTTCCACAG
ACGATCCTGAAATTGCAGAAATAGCAGAGCAATCGGGTGCATCTGTTCCGTTTCTCAGGCCTGCTGAATTGGCGACTGAT
TATTCTTCCGGAATTGATCCCGTTTTACACGCGCTTGACAATTTACCGGGATTCGATTATGTGATGCTCTTACAACCTAC
CTCCCCGCTTCGAACAAGTGCTGATATAGACGATTGTATCGAATTTACTATGCGTAAAAAGACGAATAGCGTTGTTTCGG
TTTGCGAAGCGCAGGAAAATCCGTTTTGGATGTTTCGTTTGGACGACGACTCATTCAAGATGACTAAATTGTTGAATGGG
GAAGATGTGGCGCGTAGACAAGATAGTCCTAAAGTATTTACACTGAACGGATCAATTTATTTATCAGAAGTAAATTATTT
TCGTGAAAAGAAAAAATTCATCACCGATGATACTCTCGCTTATTTGATGAGCAAGGAGAATTCAATCGATATTGACGATA
TGATAGATTGGAAATTGGCAGAGATTTTACTTTTGGATAAAGTATAA

Upstream 100 bases:

>100_bases
ATATGCAAGAAGAGGTCTAAAATTTTTCCGAACTCATACAAAAGCCGAACGGTTATTTCGCATCTATGTTTGAAATGCAG
ACAGGAACCAGCGTTAGAAA

Downstream 100 bases:

>100_bases
ATATGATTCTAATTACCGGTGCAGACGGGTTTATAGGTTCTCATTTGACGGAAACTCTTGTTCGGCAAGGTCACGAAGTA
AGAGCATTCGTACTTTATAA

Product: CMP-N-acetlyneuraminic acid synthetase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTDQKILGLIPARGGSKGIPRKNIKLIAGKPLIVWTIEAALKSKHLTSIVVSTDDPEIAEIAEQSGASVPFLRPAELATD
YSSGIDPVLHALDNLPGFDYVMLLQPTSPLRTSADIDDCIEFTMRKKTNSVVSVCEAQENPFWMFRLDDDSFKMTKLLNG
EDVARRQDSPKVFTLNGSIYLSEVNYFREKKKFITDDTLAYLMSKENSIDIDDMIDWKLAEILLLDKV

Sequences:

>Translated_228_residues
MTDQKILGLIPARGGSKGIPRKNIKLIAGKPLIVWTIEAALKSKHLTSIVVSTDDPEIAEIAEQSGASVPFLRPAELATD
YSSGIDPVLHALDNLPGFDYVMLLQPTSPLRTSADIDDCIEFTMRKKTNSVVSVCEAQENPFWMFRLDDDSFKMTKLLNG
EDVARRQDSPKVFTLNGSIYLSEVNYFREKKKFITDDTLAYLMSKENSIDIDDMIDWKLAEILLLDKV
>Mature_227_residues
TDQKILGLIPARGGSKGIPRKNIKLIAGKPLIVWTIEAALKSKHLTSIVVSTDDPEIAEIAEQSGASVPFLRPAELATDY
SSGIDPVLHALDNLPGFDYVMLLQPTSPLRTSADIDDCIEFTMRKKTNSVVSVCEAQENPFWMFRLDDDSFKMTKLLNGE
DVARRQDSPKVFTLNGSIYLSEVNYFREKKKFITDDTLAYLMSKENSIDIDDMIDWKLAEILLLDKV

Specific function: Unknown

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=223, Percent_Identity=36.322869955157, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 25545; Mature: 25413

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQKILGLIPARGGSKGIPRKNIKLIAGKPLIVWTIEAALKSKHLTSIVVSTDDPEIAE
CCCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEEEEHHHHCCCCEEEEEEECCCCHHHH
IAEQSGASVPFLRPAELATDYSSGIDPVLHALDNLPGFDYVMLLQPTSPLRTSADIDDCI
HHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHH
EFTMRKKTNSVVSVCEAQENPFWMFRLDDDSFKMTKLLNGEDVARRQDSPKVFTLNGSIY
HHHHHHCCHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHCCCCCEEEEECCEEE
LSEVNYFREKKKFITDDTLAYLMSKENSIDIDDMIDWKLAEILLLDKV
EEHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCC
>Mature Secondary Structure 
TDQKILGLIPARGGSKGIPRKNIKLIAGKPLIVWTIEAALKSKHLTSIVVSTDDPEIAE
CCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEEEEHHHHCCCCEEEEEEECCCCHHHH
IAEQSGASVPFLRPAELATDYSSGIDPVLHALDNLPGFDYVMLLQPTSPLRTSADIDDCI
HHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHH
EFTMRKKTNSVVSVCEAQENPFWMFRLDDDSFKMTKLLNGEDVARRQDSPKVFTLNGSIY
HHHHHHCCHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCHHHHCCCCCEEEEECCEEE
LSEVNYFREKKKFITDDTLAYLMSKENSIDIDDMIDWKLAEILLLDKV
EEHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]