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The map label for this gene is dprE1 [H]

Identifier: 45657788

GI number: 45657788

Start: 2331150

End: 2332652

Strand: Reverse

Name: dprE1 [H]

Synonym: LIC11928

Alternate gene names: 45657788

Gene position: 2332652-2331150 (Counterclockwise)

Preceding gene: 45657789

Following gene: 45657787

Centisome position: 54.54

GC content: 36.13

Gene sequence:

>1503_bases
ATGGCAATTTCATCCAAGGCCAAAACTTCTCCTAAAAAGAAAACTTCTGCAAAGACTTTGAAAGTTAAGAATATAAAAAA
AGTTCCGATTGAAATTCAACTTCCGGAACCTACCAAAGTAGAAGCTTGGGGAATGAATCATCATTCTATTTCGCCGGTTC
TTTTTCCAGAAAAGGAAGAAGATTTTAAAAATATATTTTCTTATGCGGATCAAAAAGGGCTTAAATTGACTTTTCGGGGA
GGAGGCTGTAGTTACGGGGACGCAGCCACCAATACGAAAGGTACGGTGATTGATATTTCTAAGTATAATCGAATTTTGGA
ATTCGATTCTAAAAACGGAATTATCAAAGCGGAATCCGGAGTTACGATCAAACAACTTTGGGAATTTGGAATCGAAAAAG
GTTATTGGCCCCCTGTCGTAAGCGGAACCATGTTTCCTACATTAGGCGGAGCCTTATCTATGAACATTCACGGAAAGAAC
AATTTTGCCGTGGGTCCGATTGGTGATCACGTTCTAGAATTTACGTTTATGACTCCGGACGGTAAGGTTCATATTTGTTC
TCGTAAAAAAAATCAGGAACTGTTTTTTGCTGCTATTTCCAGCTTCGGAATGTTAGGTGTTTTTTTAACGGTCACTATAC
AATTAAAACGTATCTATGCAGGAAAGATGAAAGTTTGGCCCGTTGTAAGCACAAATCTTCAAGATATGTTTGATTATTTT
GAAAGGGAATATAAAAATTCAGATTATCTCGTGGGTTGGGTGGACGCTTTTGCATCTGGAAATTCTCTCGGAAGAGGTTT
AGTTCATAAAGCAATTCATTTAAAAAAAGGAGAAGACCCAGACTTTCCTGAAAATTGTAAATTAGAAAAACAGAATTTAC
CTAGTACTTTTTTAGGAGTGGTTCCAAAAGCTTGGATGTGGATATTTATGCTTCCATTTGCCAACAATTTAGGAATGAGG
TTTGTCAATTTTGCAAAGTTTATCTCCGGTTATTTAACAAATAATAAACCATATCTACAGGGCCACGCGGAGTATGCGTT
TTTATTGGATTACGTCCCGAATTGGAAATTTATGTATAAACCAGGTTCTATGATTCAATACCAGAGTTTTATTCCTAAGG
AAAATGCAGTGGATGCATTTTCGGAAATTTTACGAATCTGTCAAAAAAGAGGAATTATAACTTGGCTTGCAGTATTCAAA
AAACATAAACCAGATTCGTTTCTTTTGACACATGCATTAGACGGTTATTCAATGGCGATGGATTTTCCAGTAACTTCTAT
AAATCGAAAAAAACTCTGGGAGCTTGCGGGAGAGTTAGACGAAACCGTTTTGAAATTCGGTGGTAAGTTCTATTTTGCAA
AGGATAGTACTCTGAGACCAGAGACTGTTCAAAGAGCGTTTCCAAAAAAGAATTTGGAAACGTTTCATTCTTTAAAAAAG
AAATTAGATCCAAAAGGAATTTTGGAAACAGATCTCTATAGAAGAATTATGGGAATTTGGTAA

Upstream 100 bases:

>100_bases
TTATGTTCCGGCACGTTGGGGCCTTGTAGGTTTAATTATCCGTTGTATTCCTTCTTTTATTTTTAGACGTCTTTCCATTT
GATTATTAAAGGGTAATACT

Downstream 100 bases:

>100_bases
TTGGTGTTCGGTTTGAGTTCGTTTTTGACGGAAATTAAAAAAAATAAAGATCTCAAGATTTTTCTTTTTGTATTTACGTT
AGGCGCTTTTTTTAGACTTT

Product: FAD-binding oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MAISSKAKTSPKKKTSAKTLKVKNIKKVPIEIQLPEPTKVEAWGMNHHSISPVLFPEKEEDFKNIFSYADQKGLKLTFRG
GGCSYGDAATNTKGTVIDISKYNRILEFDSKNGIIKAESGVTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKN
NFAVGPIGDHVLEFTFMTPDGKVHICSRKKNQELFFAAISSFGMLGVFLTVTIQLKRIYAGKMKVWPVVSTNLQDMFDYF
EREYKNSDYLVGWVDAFASGNSLGRGLVHKAIHLKKGEDPDFPENCKLEKQNLPSTFLGVVPKAWMWIFMLPFANNLGMR
FVNFAKFISGYLTNNKPYLQGHAEYAFLLDYVPNWKFMYKPGSMIQYQSFIPKENAVDAFSEILRICQKRGIITWLAVFK
KHKPDSFLLTHALDGYSMAMDFPVTSINRKKLWELAGELDETVLKFGGKFYFAKDSTLRPETVQRAFPKKNLETFHSLKK
KLDPKGILETDLYRRIMGIW

Sequences:

>Translated_500_residues
MAISSKAKTSPKKKTSAKTLKVKNIKKVPIEIQLPEPTKVEAWGMNHHSISPVLFPEKEEDFKNIFSYADQKGLKLTFRG
GGCSYGDAATNTKGTVIDISKYNRILEFDSKNGIIKAESGVTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKN
NFAVGPIGDHVLEFTFMTPDGKVHICSRKKNQELFFAAISSFGMLGVFLTVTIQLKRIYAGKMKVWPVVSTNLQDMFDYF
EREYKNSDYLVGWVDAFASGNSLGRGLVHKAIHLKKGEDPDFPENCKLEKQNLPSTFLGVVPKAWMWIFMLPFANNLGMR
FVNFAKFISGYLTNNKPYLQGHAEYAFLLDYVPNWKFMYKPGSMIQYQSFIPKENAVDAFSEILRICQKRGIITWLAVFK
KHKPDSFLLTHALDGYSMAMDFPVTSINRKKLWELAGELDETVLKFGGKFYFAKDSTLRPETVQRAFPKKNLETFHSLKK
KLDPKGILETDLYRRIMGIW
>Mature_499_residues
AISSKAKTSPKKKTSAKTLKVKNIKKVPIEIQLPEPTKVEAWGMNHHSISPVLFPEKEEDFKNIFSYADQKGLKLTFRGG
GCSYGDAATNTKGTVIDISKYNRILEFDSKNGIIKAESGVTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNN
FAVGPIGDHVLEFTFMTPDGKVHICSRKKNQELFFAAISSFGMLGVFLTVTIQLKRIYAGKMKVWPVVSTNLQDMFDYFE
REYKNSDYLVGWVDAFASGNSLGRGLVHKAIHLKKGEDPDFPENCKLEKQNLPSTFLGVVPKAWMWIFMLPFANNLGMRF
VNFAKFISGYLTNNKPYLQGHAEYAFLLDYVPNWKFMYKPGSMIQYQSFIPKENAVDAFSEILRICQKRGIITWLAVFKK
HKPDSFLLTHALDGYSMAMDFPVTSINRKKLWELAGELDETVLKFGGKFYFAKDSTLRPETVQRAFPKKNLETFHSLKKK
LDPKGILETDLYRRIMGIW

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 56819; Mature: 56688

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISSKAKTSPKKKTSAKTLKVKNIKKVPIEIQLPEPTKVEAWGMNHHSISPVLFPEKEE
CCCCCCCCCCCCHHCCCCEEEECCEEECCEEEECCCCCEEEEECCCCCCCCCEECCCCHH
DFKNIFSYADQKGLKLTFRGGGCSYGDAATNTKGTVIDISKYNRILEFDSKNGIIKAESG
HHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEHHHCCEEEEECCCCCEEEECCC
VTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNFAVGPIGDHVLEFTFMTPD
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCCCEEEEEEECCC
GKVHICSRKKNQELFFAAISSFGMLGVFLTVTIQLKRIYAGKMKVWPVVSTNLQDMFDYF
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCEEEEEEECCCHHHHHHHH
EREYKNSDYLVGWVDAFASGNSLGRGLVHKAIHLKKGEDPDFPENCKLEKQNLPSTFLGV
HHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
VPKAWMWIFMLPFANNLGMRFVNFAKFISGYLTNNKPYLQGHAEYAFLLDYVPNWKFMYK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCEEEEC
PGSMIQYQSFIPKENAVDAFSEILRICQKRGIITWLAVFKKHKPDSFLLTHALDGYSMAM
CCCCEEHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCEEEE
DFPVTSINRKKLWELAGELDETVLKFGGKFYFAKDSTLRPETVQRAFPKKNLETFHSLKK
ECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHH
KLDPKGILETDLYRRIMGIW
HCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AISSKAKTSPKKKTSAKTLKVKNIKKVPIEIQLPEPTKVEAWGMNHHSISPVLFPEKEE
CCCCCCCCCCCHHCCCCEEEECCEEECCEEEECCCCCEEEEECCCCCCCCCEECCCCHH
DFKNIFSYADQKGLKLTFRGGGCSYGDAATNTKGTVIDISKYNRILEFDSKNGIIKAESG
HHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEEEHHHCCEEEEECCCCCEEEECCC
VTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNFAVGPIGDHVLEFTFMTPD
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCCCEEEEEEECCC
GKVHICSRKKNQELFFAAISSFGMLGVFLTVTIQLKRIYAGKMKVWPVVSTNLQDMFDYF
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEHHCCCEEEEEEECCCHHHHHHHH
EREYKNSDYLVGWVDAFASGNSLGRGLVHKAIHLKKGEDPDFPENCKLEKQNLPSTFLGV
HHHHCCCCEEEEEHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
VPKAWMWIFMLPFANNLGMRFVNFAKFISGYLTNNKPYLQGHAEYAFLLDYVPNWKFMYK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCEEEEC
PGSMIQYQSFIPKENAVDAFSEILRICQKRGIITWLAVFKKHKPDSFLLTHALDGYSMAM
CCCCEEHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCEEEE
DFPVTSINRKKLWELAGELDETVLKFGGKFYFAKDSTLRPETVQRAFPKKNLETFHSLKK
ECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHH
KLDPKGILETDLYRRIMGIW
HCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]