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The map label for this gene is fabG [C]

Identifier: 45657789

GI number: 45657789

Start: 2332671

End: 2333447

Strand: Reverse

Name: fabG [C]

Synonym: LIC11929

Alternate gene names: 45657789

Gene position: 2333447-2332671 (Counterclockwise)

Preceding gene: 45657790

Following gene: 45657788

Centisome position: 54.56

GC content: 38.48

Gene sequence:

>777_bases
TTGTCAGTTCCGTTTATTCCCGTAGAACGGACTGATATGGCAAAAAAAATCATCGTCGTAGGTGCGTCTAGCGGGATCGG
AAAAGAATTAGCTACTTTACTTTTAGAACAGGGACACACAGTCACTCTTGTGGCTCGCAGAGATAAGGAGTTAAAGTCTA
TCTTGGCTTCTTTCAATTCATCTGGAAAAATGAATGCATTTGTAATTAAACACGATGTCACAAACTTTGATCAGGTAGAA
ACTGTGTTTCAAAAAGCGATCAAATCCATGAAAGGTTTAGACGAAATCTACTACGCTTCTGGTGTTATGCATAATATTAA
ACCGGACGAGTTCGACGTAGAAAAAGATATTTCTATGTTGAATACCAATCTTTTAGGATGTGTAGCGTGGCTCAATCCAG
CAGCAAATCTTTTTCAAAAACAAAAAAGTGGAAAGATCATAGGAATTTCTTCAATCGCGGGAGATCGTGGTAGGAGAGGA
AATCCGGTTTACAATACTTCTAAAGCGGGAATGAACACGTATTTAGAAGCTCTTAGAAATCGTCTTTCGGTGTTAGGTGT
TCAAGTACTTACCGTAAAACCAGGTTTTATAGATACTGCCATGACAAAAGGTATGAAGGGGCTTTTTTGGTTGATTTCTG
CAAAAGAAGCCGCAGAGATCATTTTGAAAGCGGCAGATTCTGGAAAAGAAAATATTTATGTTCCGGCACGTTGGGGCCTT
GTAGGTTTAATTATCCGTTGTATTCCTTCTTTTATTTTTAGACGTCTTTCCATTTGA

Upstream 100 bases:

>100_bases
GGAACCGGTTTCTAATGAAAATCGTTGGATTGAAACAGACGATTTTCAAAAAAGATACTCTGACTTTTCTTGGTAAGAAT
TTTCTACCTTTAAATCATAC

Downstream 100 bases:

>100_bases
TTATTAAAGGGTAATACTATGGCAATTTCATCCAAGGCCAAAACTTCTCCTAAAAAGAAAACTTCTGCAAAGACTTTGAA
AGTTAAGAATATAAAAAAAG

Product: short-chain dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MSVPFIPVERTDMAKKIIVVGASSGIGKELATLLLEQGHTVTLVARRDKELKSILASFNSSGKMNAFVIKHDVTNFDQVE
TVFQKAIKSMKGLDEIYYASGVMHNIKPDEFDVEKDISMLNTNLLGCVAWLNPAANLFQKQKSGKIIGISSIAGDRGRRG
NPVYNTSKAGMNTYLEALRNRLSVLGVQVLTVKPGFIDTAMTKGMKGLFWLISAKEAAEIILKAADSGKENIYVPARWGL
VGLIIRCIPSFIFRRLSI

Sequences:

>Translated_258_residues
MSVPFIPVERTDMAKKIIVVGASSGIGKELATLLLEQGHTVTLVARRDKELKSILASFNSSGKMNAFVIKHDVTNFDQVE
TVFQKAIKSMKGLDEIYYASGVMHNIKPDEFDVEKDISMLNTNLLGCVAWLNPAANLFQKQKSGKIIGISSIAGDRGRRG
NPVYNTSKAGMNTYLEALRNRLSVLGVQVLTVKPGFIDTAMTKGMKGLFWLISAKEAAEIILKAADSGKENIYVPARWGL
VGLIIRCIPSFIFRRLSI
>Mature_257_residues
SVPFIPVERTDMAKKIIVVGASSGIGKELATLLLEQGHTVTLVARRDKELKSILASFNSSGKMNAFVIKHDVTNFDQVET
VFQKAIKSMKGLDEIYYASGVMHNIKPDEFDVEKDISMLNTNLLGCVAWLNPAANLFQKQKSGKIIGISSIAGDRGRRGN
PVYNTSKAGMNTYLEALRNRLSVLGVQVLTVKPGFIDTAMTKGMKGLFWLISAKEAAEIILKAADSGKENIYVPARWGLV
GLIIRCIPSFIFRRLSI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=194, Percent_Identity=30.4123711340206, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4503817, Length=200, Percent_Identity=28, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI32455239, Length=240, Percent_Identity=30, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031765, Length=240, Percent_Identity=30, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20149619, Length=191, Percent_Identity=21.9895287958115, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=196, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367175, Length=189, Percent_Identity=26.4550264550265, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787820, Length=182, Percent_Identity=25.2747252747253, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507613, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI23397609, Length=185, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28571387, Length=225, Percent_Identity=27.1111111111111, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=189, Percent_Identity=28.042328042328, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357041, Length=189, Percent_Identity=26.984126984127, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 28322; Mature: 28190

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPFIPVERTDMAKKIIVVGASSGIGKELATLLLEQGHTVTLVARRDKELKSILASFNS
CCCCCCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCC
SGKMNAFVIKHDVTNFDQVETVFQKAIKSMKGLDEIYYASGVMHNIKPDEFDVEKDISML
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCHHHHHHHH
NTNLLGCVAWLNPAANLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMNTYLEALRN
HHHHHHHHHHHCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RLSVLGVQVLTVKPGFIDTAMTKGMKGLFWLISAKEAAEIILKAADSGKENIYVPARWGL
HHHHHCEEEEEECCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCCCCEEEECHHHH
VGLIIRCIPSFIFRRLSI
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVPFIPVERTDMAKKIIVVGASSGIGKELATLLLEQGHTVTLVARRDKELKSILASFNS
CCCCCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCC
SGKMNAFVIKHDVTNFDQVETVFQKAIKSMKGLDEIYYASGVMHNIKPDEFDVEKDISML
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCHHHHHHHH
NTNLLGCVAWLNPAANLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMNTYLEALRN
HHHHHHHHHHHCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RLSVLGVQVLTVKPGFIDTAMTKGMKGLFWLISAKEAAEIILKAADSGKENIYVPARWGL
HHHHHCEEEEEECCCCHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCCCCEEEECHHHH
VGLIIRCIPSFIFRRLSI
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]