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The map label for this gene is pth

Identifier: 45657470

GI number: 45657470

Start: 1957813

End: 1958385

Strand: Direct

Name: pth

Synonym: LIC11598

Alternate gene names: 45657470

Gene position: 1957813-1958385 (Clockwise)

Preceding gene: 45657469

Following gene: 45657471

Centisome position: 45.77

GC content: 35.6

Gene sequence:

>573_bases
ATGGCAAATCTAAAACTATTATTGGTAGGGATTGGAAATCCAGGCCAAAAATATGTTCACAACCGGCATAACATCGGTTT
TGTGATCTTGGATTCTCTCTTGGATTCTTCTTCCGTAAGTTATCAAACCAATTCTAAATATTCTTTAGCTAGAACCGATG
AAGATGGGGTTACGATTTTTTATCTAAAACCCTTAGAATTTATGAATCTTTCTGGAAAGTCTGTTGCGGAAATCGCTAAA
AAAAACGGAATTTCTCCTGAAAACATTTTAATTATTCACGATGAAATTGATTTCGAGTTCGGTAAGTTGAAATTGAAAGG
CGGAGGTGGACACGCTGGTCATAACGGACTTAGAAACATAGTAGAAAAATTAGGTACCAATACATTCTTTCGACTTAGGT
TTGGGGTCGGAAAACCTTCCATTACTTCAGAAGTGCCGGATTATGTGCTTTCCAATTTTCTTCCGAACGAAAAAGAAAAA
ATTCCAGAACTTGTAAAAGTTTCTTTGCAAAAAATCTCGGATTGGATTCGAGAAAGAAAAAACGGATTTCAAAAACTCTC
CGATAATCAATAG

Upstream 100 bases:

>100_bases
TAGAAGAGGACCAGACTTTCAAAACGATGGGAGTTCATCCGGATCAAACGGTTGCAGCGGTTCATGCAACTGAAAAGATG
CTCAATCAAATTCTACAACC

Downstream 100 bases:

>100_bases
GAAGGAATCGTTTTCACTTTTGTAAAACTGGGTATAAGACTATAGATTTTGCTTCTATAAAATGAATTTTTAATATAATG
ACCACAAAACGGCGATTTCA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MANLKLLLVGIGNPGQKYVHNRHNIGFVILDSLLDSSSVSYQTNSKYSLARTDEDGVTIFYLKPLEFMNLSGKSVAEIAK
KNGISPENILIIHDEIDFEFGKLKLKGGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSITSEVPDYVLSNFLPNEKEK
IPELVKVSLQKISDWIRERKNGFQKLSDNQ

Sequences:

>Translated_190_residues
MANLKLLLVGIGNPGQKYVHNRHNIGFVILDSLLDSSSVSYQTNSKYSLARTDEDGVTIFYLKPLEFMNLSGKSVAEIAK
KNGISPENILIIHDEIDFEFGKLKLKGGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSITSEVPDYVLSNFLPNEKEK
IPELVKVSLQKISDWIRERKNGFQKLSDNQ
>Mature_189_residues
ANLKLLLVGIGNPGQKYVHNRHNIGFVILDSLLDSSSVSYQTNSKYSLARTDEDGVTIFYLKPLEFMNLSGKSVAEIAKK
NGISPENILIIHDEIDFEFGKLKLKGGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSITSEVPDYVLSNFLPNEKEKI
PELVKVSLQKISDWIRERKNGFQKLSDNQ

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=182, Percent_Identity=34.6153846153846, Blast_Score=118, Evalue=4e-27,
Organism=Escherichia coli, GI1787455, Length=175, Percent_Identity=38.2857142857143, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321983, Length=169, Percent_Identity=29.585798816568, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_LEPIC (Q72RZ0)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001556.1
- ProteinModelPortal:   Q72RZ0
- SMR:   Q72RZ0
- GeneID:   2769927
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11598
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- ProtClustDB:   PRK05426
- BioCyc:   LINT267671:LIC_11598-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21217; Mature: 21085

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLKLLLVGIGNPGQKYVHNRHNIGFVILDSLLDSSSVSYQTNSKYSLARTDEDGVTIF
CCCEEEEEEECCCCCHHHHCCCCCCHHEEEEHHHCCCCCCEECCCCEEEEECCCCCEEEE
YLKPLEFMNLSGKSVAEIAKKNGISPENILIIHDEIDFEFGKLKLKGGGGHAGHNGLRNI
EECCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHHHH
VEKLGTNTFFRLRFGVGKPSITSEVPDYVLSNFLPNEKEKIPELVKVSLQKISDWIRERK
HHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NGFQKLSDNQ
HHHHHCCCCC
>Mature Secondary Structure 
ANLKLLLVGIGNPGQKYVHNRHNIGFVILDSLLDSSSVSYQTNSKYSLARTDEDGVTIF
CCEEEEEEECCCCCHHHHCCCCCCHHEEEEHHHCCCCCCEECCCCEEEEECCCCCEEEE
YLKPLEFMNLSGKSVAEIAKKNGISPENILIIHDEIDFEFGKLKLKGGGGHAGHNGLRNI
EECCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHHHH
VEKLGTNTFFRLRFGVGKPSITSEVPDYVLSNFLPNEKEKIPELVKVSLQKISDWIRERK
HHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NGFQKLSDNQ
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA