The gene/protein map for NC_005823 is currently unavailable.
Definition Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession NC_005823
Length 4,277,185

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The map label for this gene is dltE

Identifier: 45657242

GI number: 45657242

Start: 1680356

End: 1681141

Strand: Direct

Name: dltE

Synonym: LIC11364

Alternate gene names: 45657242

Gene position: 1680356-1681141 (Clockwise)

Preceding gene: 45657239

Following gene: 45657243

Centisome position: 39.29

GC content: 39.57

Gene sequence:

>786_bases
ATGACAAAAACGGCAATCATTACGGGTGGTACGGTGGGGATCGGCTACGAATTGAGTAAACTTATCGCGGCGGACGGTTA
CGATTTGATTTTAGTCGCTAGAAACGAAAAAACCTTAAAGAAGGTAAAAAAAGAAATTGAATCGTCAAACAAAGTAAAGG
TGGACATTCTTTCCCTGGATCTGGCTGATCCTAAATCTCCTAAAAAGATTTTCGACTTCGCAAAAAAAACAAAAGCGGTT
GTGGAAGTTTTAGTAAATAATGCAGGTTTTGGAACAAACGGAAAATTCGATCGAATGGATCTCAAAGAAGAACTTCAGAT
GGTTCAGGTAAACGTGGCTTCTTTAGTAGAGTTGACTCATCTTTTTTTACAAGGTATGGTGGAACGTAAGAATGGAAAAA
TTTTGAACGTGGCTTCCATCGCAGGGTTTCAACCTGGACCGAATATGGCGAATTATTATGCGACAAAAGCTTATGTATTA
TCCTTTTCAGAAGCGGTTTACGAAGACGTAAAAAAAGACGGAGTGACCGTAACCGCTCTTTGCCCAGGGCCTACCAAGAC
CGAATTTTTTGAAAGGGCGGAGATCACAAAGTCAAAACTTTTGGACAATCCGATGGCGCCGATTATGGAAGCAAAAGAAG
TAGCGGAAATAGGATACGACGCTTTAAAAAAAGGAAAATCAGTCGTAATCGCCGGGGCTTTGAATAAAATATTAGCTCAG
AGTGTAAGGATTACTCCTAGATTTGTCACACGTAAGATTACAAAATTTTTCAATCAAAACGGTTAA

Upstream 100 bases:

>100_bases
GATTTCATCTAAAATGAAAACGTAATGTTCAATTTCTCTTCAAAAAAAGTCTTTCTCTCTTTTTTTATAGAATTAATTTC
GACCGCAAAGGAAATTAAAA

Downstream 100 bases:

>100_bases
AACAAAATGCAAGGATCCGTTCTAGATTTAGCGGTACCATTTTTTCTGATTTTAATCGGGTTCGAGGTTTTGTATTCTAA
GATCGTTGGAAAAAAAGTTT

Product: short-chain dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTKTAIITGGTVGIGYELSKLIAADGYDLILVARNEKTLKKVKKEIESSNKVKVDILSLDLADPKSPKKIFDFAKKTKAV
VEVLVNNAGFGTNGKFDRMDLKEELQMVQVNVASLVELTHLFLQGMVERKNGKILNVASIAGFQPGPNMANYYATKAYVL
SFSEAVYEDVKKDGVTVTALCPGPTKTEFFERAEITKSKLLDNPMAPIMEAKEVAEIGYDALKKGKSVVIAGALNKILAQ
SVRITPRFVTRKITKFFNQNG

Sequences:

>Translated_261_residues
MTKTAIITGGTVGIGYELSKLIAADGYDLILVARNEKTLKKVKKEIESSNKVKVDILSLDLADPKSPKKIFDFAKKTKAV
VEVLVNNAGFGTNGKFDRMDLKEELQMVQVNVASLVELTHLFLQGMVERKNGKILNVASIAGFQPGPNMANYYATKAYVL
SFSEAVYEDVKKDGVTVTALCPGPTKTEFFERAEITKSKLLDNPMAPIMEAKEVAEIGYDALKKGKSVVIAGALNKILAQ
SVRITPRFVTRKITKFFNQNG
>Mature_260_residues
TKTAIITGGTVGIGYELSKLIAADGYDLILVARNEKTLKKVKKEIESSNKVKVDILSLDLADPKSPKKIFDFAKKTKAVV
EVLVNNAGFGTNGKFDRMDLKEELQMVQVNVASLVELTHLFLQGMVERKNGKILNVASIAGFQPGPNMANYYATKAYVLS
FSEAVYEDVKKDGVTVTALCPGPTKTEFFERAEITKSKLLDNPMAPIMEAKEVAEIGYDALKKGKSVVIAGALNKILAQS
VRITPRFVTRKITKFFNQNG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG0300

COG function: function code R; Short-chain dehydrogenases of various substrate specificities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705855, Length=266, Percent_Identity=29.3233082706767, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI226371731, Length=182, Percent_Identity=32.967032967033, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557649, Length=193, Percent_Identity=32.1243523316062, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI7706318, Length=199, Percent_Identity=31.1557788944724, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI20149619, Length=241, Percent_Identity=26.5560165975104, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=25.9259259259259, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40807363, Length=216, Percent_Identity=28.2407407407407, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4503817, Length=206, Percent_Identity=31.5533980582524, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4504503, Length=190, Percent_Identity=28.9473684210526, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI31542939, Length=198, Percent_Identity=26.7676767676768, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI32483357, Length=203, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI223718074, Length=209, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI7657478, Length=188, Percent_Identity=27.1276595744681, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI157739938, Length=188, Percent_Identity=24.468085106383, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787335, Length=219, Percent_Identity=27.3972602739726, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI87082100, Length=190, Percent_Identity=28.4210526315789, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787820, Length=186, Percent_Identity=29.5698924731183, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=28.6458333333333, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1786701, Length=206, Percent_Identity=26.2135922330097, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788459, Length=191, Percent_Identity=28.7958115183246, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789378, Length=220, Percent_Identity=28.1818181818182, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=225, Percent_Identity=32, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994600, Length=182, Percent_Identity=31.8681318681319, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=199, Percent_Identity=32.1608040201005, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=196, Percent_Identity=30.1020408163265, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=258, Percent_Identity=25.1937984496124, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193203115, Length=227, Percent_Identity=29.9559471365639, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=231, Percent_Identity=28.1385281385281, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=227, Percent_Identity=29.9559471365639, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=196, Percent_Identity=28.0612244897959, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=196, Percent_Identity=28.0612244897959, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=196, Percent_Identity=29.5918367346939, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI212646214, Length=220, Percent_Identity=29.5454545454545, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=195, Percent_Identity=31.2820512820513, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=207, Percent_Identity=24.6376811594203, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=221, Percent_Identity=27.1493212669683, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=221, Percent_Identity=28.5067873303167, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=263, Percent_Identity=23.9543726235741, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557668, Length=206, Percent_Identity=26.6990291262136, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25152911, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559552, Length=193, Percent_Identity=26.4248704663212, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=198, Percent_Identity=28.2828282828283, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=206, Percent_Identity=26.6990291262136, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=197, Percent_Identity=28.9340101522843, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319635, Length=188, Percent_Identity=28.7234042553192, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323882, Length=243, Percent_Identity=29.2181069958848, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320089, Length=211, Percent_Identity=27.4881516587678, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24584744, Length=185, Percent_Identity=34.0540540540541, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574402, Length=185, Percent_Identity=34.0540540540541, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640442, Length=190, Percent_Identity=34.2105263157895, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24584752, Length=203, Percent_Identity=33.4975369458128, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI161076933, Length=186, Percent_Identity=32.258064516129, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24584748, Length=186, Percent_Identity=32.258064516129, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI116007236, Length=221, Percent_Identity=27.1493212669683, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28571526, Length=204, Percent_Identity=30.3921568627451, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24639444, Length=220, Percent_Identity=27.7272727272727, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=27.734375, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357041, Length=227, Percent_Identity=29.9559471365639, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=29.5918367346939, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24580925, Length=202, Percent_Identity=28.2178217821782, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355319, Length=222, Percent_Identity=27.027027027027, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116007238, Length=177, Percent_Identity=27.1186440677966, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24644339, Length=190, Percent_Identity=29.4736842105263, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641232, Length=213, Percent_Identity=25.3521126760563, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571387, Length=223, Percent_Identity=23.7668161434978, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221331216, Length=193, Percent_Identity=26.9430051813472, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24665247, Length=193, Percent_Identity=26.9430051813472, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641388, Length=229, Percent_Identity=24.8908296943231, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24665243, Length=193, Percent_Identity=26.9430051813472, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648693, Length=225, Percent_Identity=21.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355889, Length=225, Percent_Identity=21.7777777777778, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221331218, Length=193, Percent_Identity=26.9430051813472, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355631, Length=169, Percent_Identity=26.6272189349112, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 28598; Mature: 28467

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MTKTAIITGGTVGIGYELSKLIAADGYDLILVARNEKTLKKVKKEIESSNKVKVDILSLD
CCCEEEEECCCEECCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEEEE
LADPKSPKKIFDFAKKTKAVVEVLVNNAGFGTNGKFDRMDLKEELQMVQVNVASLVELTH
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LFLQGMVERKNGKILNVASIAGFQPGPNMANYYATKAYVLSFSEAVYEDVKKDGVTVTAL
HHHHHHHHHCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
CPGPTKTEFFERAEITKSKLLDNPMAPIMEAKEVAEIGYDALKKGKSVVIAGALNKILAQ
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHCCCEEEEHHHHHHHHHH
SVRITPRFVTRKITKFFNQNG
HHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKTAIITGGTVGIGYELSKLIAADGYDLILVARNEKTLKKVKKEIESSNKVKVDILSLD
CCEEEEECCCEECCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEEEE
LADPKSPKKIFDFAKKTKAVVEVLVNNAGFGTNGKFDRMDLKEELQMVQVNVASLVELTH
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LFLQGMVERKNGKILNVASIAGFQPGPNMANYYATKAYVLSFSEAVYEDVKKDGVTVTAL
HHHHHHHHHCCCCEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
CPGPTKTEFFERAEITKSKLLDNPMAPIMEAKEVAEIGYDALKKGKSVVIAGALNKILAQ
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHCCCEEEEHHHHHHHHHH
SVRITPRFVTRKITKFFNQNG
HHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]