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The map label for this gene is prlC

Identifier: 45657239

GI number: 45657239

Start: 1677240

End: 1679195

Strand: Direct

Name: prlC

Synonym: LIC11361

Alternate gene names: 45657239

Gene position: 1677240-1679195 (Clockwise)

Preceding gene: 45657236

Following gene: 45657242

Centisome position: 39.21

GC content: 36.4

Gene sequence:

>1956_bases
ATGTTTCCTGAATTTGAAGCAGATAAAGTAATACTCACTAAGAACGAAATTTTAGAAAAAATCAAAAAGATCCGAAATGA
AATTCCGGTTTTACTTTCTCAAAAAGAAAGGTCTTACGAGAACGTTATTCGTCCTTTAGACGATCTCGTGCAAGAAATGC
AGGTAGAGTTTACCGTTCTTGCCCATCTAAATAGCGTAAAAAATTCTAAGGAGATCCAAACGTATTATACGGAAGTGCTT
CCAGAAATTACCGCTTTTTATTCTGACTTAGGACAAAACGAAGAATTAAACTCTGTATATCAGGAAATTCTAAAGAATGA
AGAGAATATCTTGAGTATTCCCCGAAATAAAAGTCTTCAAGATTCTATTCTACAATTTCGGTTGAGTGGTATTGGTTTAA
AACCAGAGATTAAAAAAAGGATCCAGGAAATTCAAATTCGACTTTCCGATTTAAATAATCAATATTCTCAAAATCTTCTG
GATGCTACAAACACATTTGAATTGATTTTGGATCGCCCAGAAGACGTAGAAGGTATTCCAGAATCCGATCTAAACGCTGC
TAAAACAGAAGACGGTAAATATTGTTTTACACTTCAGATGCCTAGTTATACCGCTTATATGACTCATGGTCCAAATCGGA
ATATTCGAGAATCATTATATAAGGCTTATACTACACGTGCTCCTCAAAATGGAAAACTGATCCAAGAAATACTTTCTTTG
AGAAGTGAACTTGCAAGACTTTTAGACTATTTCAGCTACGCGGAACTTTCTTTGGCCACTAAAGTAGCCAATTCCGTTCC
TACGGTTTTAAAATTTTTAAGAGACCTCGCCAAACAAGTTAAACCGATTGCAGAAAAAGAATTTAAAGATCTTTCTGATT
TTGCAAAAACTTTGGGAATTGATTCTATTCAGGCTTATGATACTGCGTTTGTAAGTGAAAAGATGATGAAGTCCCAATTC
AATTTTGATGAAGAGGAAACTCGTCCATATTTTGAAAAGGACAGTGTCATTTCCGGAACATTCCAATTTTTGAATATGCT
TTTTGGAATTGAATTTCGCAAAACTTCCGCTAAAGTCTGGGAAGAAAAGGTTCAAGTTTATGATCTTTATAAGGAAGGAA
AACTTCTCTCTCGTTTATATTTGGACTTGGAAACTCGTAAGGACAAACAGGGCGGAGCTTGGATGCACAACTGGCATTCC
AGAAATAGAATGAATGGACGCGAAGTTCTTCCAACTGCGTTTGTGGTCTGTAATTTTCCTGTTTCTACAAAAGATTCTCC
ATCTCTTTTAAAACATAGGGACGTGGTAACTTTCTTTCACGAAATGGGACACGCTTTACATCATCTTTGTACAAAAATAG
AAGAGCCCCCCGTAAGTGGTATTAATGGAGTAGAGTGGGACGCGGTAGAATTTCCGTCACAGTTTTTGGAAAATTTTGCG
ACCGAAGCGGACGTTCTAAAGATATTCGGAAAACATTATAAAACCGGAGAAACGATTCCGGATTCTATGATCGTAAAACT
CAAGGAGACTAAAAACTTTCTTTCCGCAATGGGAATCGTAAGACAACTTGAGTTCTCACTTTTTGATATTTTCATTCATT
TAAAAAGTCATACAGAAGAAGAGGTACATTCTATTCTTCAAGACGTTCGTAAAGAAGTAGCGGTTGTGATTCCTCCGGAA
TATAATCGTTTCCAAAACGGATTCTCTCATATTTTTTCGGGAGGTTATGCTGCGGGATATTATAGTTATAAGTGGGCGGA
AGTCATGAGTGCCGACGCATTTTTCGCTTTTGTGGAAAGAGGGATTTTTGATTCTGAACTGAGTGAAGTATACTTTAGAG
AGATTTTAGAAAAAGGCGGAAGTGAAAACGCGATGATACTTTTTAAAAGATTTTTAGGAAGAGAACCAGAGGTAAAATCT
CTATTGAAACTATACGGGCTTAAGGAAGCGGCTTAA

Upstream 100 bases:

>100_bases
AAATATTTAGAGTTTTTAAAAGAGGACTCAATCATGATTCTAATTTTACATAAGTCAAAAAAATGGATGAAGTTTCGAAG
GTGGGAAAGATATTGGAAGT

Downstream 100 bases:

>100_bases
AAGTTGATTAAGAAAGACTTTTCCTAAAATTTTGCAGTAAGGATTCTTTTCCCGCTAAAAGTACTTCTACCTGATCCTGA
TCTATGTTATAGACAACGTT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MFPEFEADKVILTKNEILEKIKKIRNEIPVLLSQKERSYENVIRPLDDLVQEMQVEFTVLAHLNSVKNSKEIQTYYTEVL
PEITAFYSDLGQNEELNSVYQEILKNEENILSIPRNKSLQDSILQFRLSGIGLKPEIKKRIQEIQIRLSDLNNQYSQNLL
DATNTFELILDRPEDVEGIPESDLNAAKTEDGKYCFTLQMPSYTAYMTHGPNRNIRESLYKAYTTRAPQNGKLIQEILSL
RSELARLLDYFSYAELSLATKVANSVPTVLKFLRDLAKQVKPIAEKEFKDLSDFAKTLGIDSIQAYDTAFVSEKMMKSQF
NFDEEETRPYFEKDSVISGTFQFLNMLFGIEFRKTSAKVWEEKVQVYDLYKEGKLLSRLYLDLETRKDKQGGAWMHNWHS
RNRMNGREVLPTAFVVCNFPVSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
TEADVLKIFGKHYKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDIFIHLKSHTEEEVHSILQDVRKEVAVVIPPE
YNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVERGIFDSELSEVYFREILEKGGSENAMILFKRFLGREPEVKS
LLKLYGLKEAA

Sequences:

>Translated_651_residues
MFPEFEADKVILTKNEILEKIKKIRNEIPVLLSQKERSYENVIRPLDDLVQEMQVEFTVLAHLNSVKNSKEIQTYYTEVL
PEITAFYSDLGQNEELNSVYQEILKNEENILSIPRNKSLQDSILQFRLSGIGLKPEIKKRIQEIQIRLSDLNNQYSQNLL
DATNTFELILDRPEDVEGIPESDLNAAKTEDGKYCFTLQMPSYTAYMTHGPNRNIRESLYKAYTTRAPQNGKLIQEILSL
RSELARLLDYFSYAELSLATKVANSVPTVLKFLRDLAKQVKPIAEKEFKDLSDFAKTLGIDSIQAYDTAFVSEKMMKSQF
NFDEEETRPYFEKDSVISGTFQFLNMLFGIEFRKTSAKVWEEKVQVYDLYKEGKLLSRLYLDLETRKDKQGGAWMHNWHS
RNRMNGREVLPTAFVVCNFPVSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
TEADVLKIFGKHYKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDIFIHLKSHTEEEVHSILQDVRKEVAVVIPPE
YNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVERGIFDSELSEVYFREILEKGGSENAMILFKRFLGREPEVKS
LLKLYGLKEAA
>Mature_651_residues
MFPEFEADKVILTKNEILEKIKKIRNEIPVLLSQKERSYENVIRPLDDLVQEMQVEFTVLAHLNSVKNSKEIQTYYTEVL
PEITAFYSDLGQNEELNSVYQEILKNEENILSIPRNKSLQDSILQFRLSGIGLKPEIKKRIQEIQIRLSDLNNQYSQNLL
DATNTFELILDRPEDVEGIPESDLNAAKTEDGKYCFTLQMPSYTAYMTHGPNRNIRESLYKAYTTRAPQNGKLIQEILSL
RSELARLLDYFSYAELSLATKVANSVPTVLKFLRDLAKQVKPIAEKEFKDLSDFAKTLGIDSIQAYDTAFVSEKMMKSQF
NFDEEETRPYFEKDSVISGTFQFLNMLFGIEFRKTSAKVWEEKVQVYDLYKEGKLLSRLYLDLETRKDKQGGAWMHNWHS
RNRMNGREVLPTAFVVCNFPVSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
TEADVLKIFGKHYKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDIFIHLKSHTEEEVHSILQDVRKEVAVVIPPE
YNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVERGIFDSELSEVYFREILEKGGSENAMILFKRFLGREPEVKS
LLKLYGLKEAA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=665, Percent_Identity=29.7744360902256, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI14149738, Length=650, Percent_Identity=29.0769230769231, Blast_Score=238, Evalue=2e-62,
Organism=Homo sapiens, GI156105687, Length=576, Percent_Identity=25, Blast_Score=175, Evalue=1e-43,
Organism=Escherichia coli, GI1789913, Length=669, Percent_Identity=40.2092675635277, Blast_Score=497, Evalue=1e-141,
Organism=Escherichia coli, GI1787819, Length=657, Percent_Identity=29.2237442922374, Blast_Score=235, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71999758, Length=662, Percent_Identity=22.9607250755287, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32565901, Length=546, Percent_Identity=21.6117216117216, Blast_Score=90, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319793, Length=508, Percent_Identity=32.2834645669291, Blast_Score=244, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6322715, Length=596, Percent_Identity=23.489932885906, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21356111, Length=671, Percent_Identity=23.6959761549926, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI20129717, Length=608, Percent_Identity=24.6710526315789, Blast_Score=149, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 75159; Mature: 75159

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPEFEADKVILTKNEILEKIKKIRNEIPVLLSQKERSYENVIRPLDDLVQEMQVEFTVL
CCCCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLNSVKNSKEIQTYYTEVLPEITAFYSDLGQNEELNSVYQEILKNEENILSIPRNKSLQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECCCCCCHH
DSILQFRLSGIGLKPEIKKRIQEIQIRLSDLNNQYSQNLLDATNTFELILDRPEDVEGIP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHEECCCCCCCCCC
ESDLNAAKTEDGKYCFTLQMPSYTAYMTHGPNRNIRESLYKAYTTRAPQNGKLIQEILSL
CCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
RSELARLLDYFSYAELSLATKVANSVPTVLKFLRDLAKQVKPIAEKEFKDLSDFAKTLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSIQAYDTAFVSEKMMKSQFNFDEEETRPYFEKDSVISGTFQFLNMLFGIEFRKTSAKVW
CHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
EEKVQVYDLYKEGKLLSRLYLDLETRKDKQGGAWMHNWHSRNRMNGREVLPTAFVVCNFP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHCCCEEEEEECC
VSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
TEADVLKIFGKHYKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDIFIHLKSHTEE
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EVHSILQDVRKEVAVVIPPEYNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVER
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GIFDSELSEVYFREILEKGGSENAMILFKRFLGREPEVKSLLKLYGLKEAA
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MFPEFEADKVILTKNEILEKIKKIRNEIPVLLSQKERSYENVIRPLDDLVQEMQVEFTVL
CCCCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLNSVKNSKEIQTYYTEVLPEITAFYSDLGQNEELNSVYQEILKNEENILSIPRNKSLQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECCCCCCHH
DSILQFRLSGIGLKPEIKKRIQEIQIRLSDLNNQYSQNLLDATNTFELILDRPEDVEGIP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHEECCCCCCCCCC
ESDLNAAKTEDGKYCFTLQMPSYTAYMTHGPNRNIRESLYKAYTTRAPQNGKLIQEILSL
CCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
RSELARLLDYFSYAELSLATKVANSVPTVLKFLRDLAKQVKPIAEKEFKDLSDFAKTLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DSIQAYDTAFVSEKMMKSQFNFDEEETRPYFEKDSVISGTFQFLNMLFGIEFRKTSAKVW
CHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
EEKVQVYDLYKEGKLLSRLYLDLETRKDKQGGAWMHNWHSRNRMNGREVLPTAFVVCNFP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHCCCEEEEEECC
VSTKDSPSLLKHRDVVTFFHEMGHALHHLCTKIEEPPVSGINGVEWDAVEFPSQFLENFA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHC
TEADVLKIFGKHYKTGETIPDSMIVKLKETKNFLSAMGIVRQLEFSLFDIFIHLKSHTEE
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EVHSILQDVRKEVAVVIPPEYNRFQNGFSHIFSGGYAAGYYSYKWAEVMSADAFFAFVER
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GIFDSELSEVYFREILEKGGSENAMILFKRFLGREPEVKSLLKLYGLKEAA
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]