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The map label for this gene is erg3

Identifier: 45657243

GI number: 45657243

Start: 1681148

End: 1682344

Strand: Direct

Name: erg3

Synonym: LIC11365

Alternate gene names: 45657243

Gene position: 1681148-1682344 (Clockwise)

Preceding gene: 45657242

Following gene: 45657245

Centisome position: 39.31

GC content: 33.83

Gene sequence:

>1197_bases
ATGCAAGGATCCGTTCTAGATTTAGCGGTACCATTTTTTCTGATTTTAATCGGGTTCGAGGTTTTGTATTCTAAGATCGT
TGGAAAAAAAGTTTATCGATGGAACGATACGGTAGCGGATTTAAGTACTGGAATTTTGTTTTCTCTGACTGGGGTTTGTG
TAACTATCTTTTCTCTTTGGATATATGAGAAATTTAGAATATTCTGTTCTTTGCAAACTCTATTTGGAGTTCCTGAAATT
CCACTTGGAATTCCTATCTGGCCGGATCCTGTAGGTTGGCATTTCGATTTTAAAAGTTTAGTCGGATGGATCTTTGTATT
TTTGGCTGTAGATTTTGTATATTACTGGTTTCATAGGGCTACACATGAAATCAATTTTCTTTGGGCCTGTCACGTGACTC
ATCATTCTAGCGAAGAATTTAATCTTTCTGTAGCTCTAAGACAGTCTAGTTTTCAAAGAATTTTCGAATATATGTTTAAT
CTTTCGATCGCGTTTTGTGGAGTTCCTTGGCAGGCGTTTTTGTTAGCTCATGGGATTTTAAAAATCTATCAGTTTTGGGT
ACATACTCGGTTGGTCGGAAAGTTGGGGTTTTTAGAAGAAATTCTAATTACACCTTCGCATCATCGTGTGCATCATGGAA
GAGATCCAAAATATATAGATAAGAATCACGGAGGAATTTTAGTATTTTGGGATAGAATTTTTGGTTCCTTTGCAAGAGAA
GAAGAGGAACCGATTTATGGACTTACAAAACCAGTAACTACGTTTGATCCGGTTTACACGAACGTTCATGTTTATGAAGA
AATTTTTTCATTGGTGCAAAAGACAAATAATTGGAAAGAAAGAATTCTACTATTCTTAAAACCTCCTGGATGGAGGCCTG
AAAGTTTAGGGTCATCGGTTTATGCCGAAGAGGTGGATCGAAATAGATATATAAAATACGATCCGATTGTATCTAAACAA
AGAATGGTTTTAGGTTTTTTGGAATTTTTAGTATTAACTGTTTTTTCTCTATTATTATTAAAATATTTTAAATCTGGGAT
TTTTGAATTATGGAAAATTTTTCCTGTGATTGTATTTTTCTTTTATGGGTTTAGACTTACTGGATTTGTTTTGGATGGAT
ATACAATTGGAAAGGCTCGTATCATCTTATTTCTTTTAGTAGGAATGATACTTTACTGGATTTTATTTTTTGTCTAA

Upstream 100 bases:

>100_bases
CGGGGCTTTGAATAAAATATTAGCTCAGAGTGTAAGGATTACTCCTAGATTTGTCACACGTAAGATTACAAAATTTTTCA
ATCAAAACGGTTAAAACAAA

Downstream 100 bases:

>100_bases
AGAATAGAGTTGTTGAAAAATGAATTCTTCATTTGTTTTCGTTGTATAGAAACGGTAGATTGAAGCAGTTTTATTAAGCT
CCACTATGGAATTTTTTAAT

Product: C-5 sterol desaturase

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQGSVLDLAVPFFLILIGFEVLYSKIVGKKVYRWNDTVADLSTGILFSLTGVCVTIFSLWIYEKFRIFCSLQTLFGVPEI
PLGIPIWPDPVGWHFDFKSLVGWIFVFLAVDFVYYWFHRATHEINFLWACHVTHHSSEEFNLSVALRQSSFQRIFEYMFN
LSIAFCGVPWQAFLLAHGILKIYQFWVHTRLVGKLGFLEEILITPSHHRVHHGRDPKYIDKNHGGILVFWDRIFGSFARE
EEEPIYGLTKPVTTFDPVYTNVHVYEEIFSLVQKTNNWKERILLFLKPPGWRPESLGSSVYAEEVDRNRYIKYDPIVSKQ
RMVLGFLEFLVLTVFSLLLLKYFKSGIFELWKIFPVIVFFFYGFRLTGFVLDGYTIGKARIILFLLVGMILYWILFFV

Sequences:

>Translated_398_residues
MQGSVLDLAVPFFLILIGFEVLYSKIVGKKVYRWNDTVADLSTGILFSLTGVCVTIFSLWIYEKFRIFCSLQTLFGVPEI
PLGIPIWPDPVGWHFDFKSLVGWIFVFLAVDFVYYWFHRATHEINFLWACHVTHHSSEEFNLSVALRQSSFQRIFEYMFN
LSIAFCGVPWQAFLLAHGILKIYQFWVHTRLVGKLGFLEEILITPSHHRVHHGRDPKYIDKNHGGILVFWDRIFGSFARE
EEEPIYGLTKPVTTFDPVYTNVHVYEEIFSLVQKTNNWKERILLFLKPPGWRPESLGSSVYAEEVDRNRYIKYDPIVSKQ
RMVLGFLEFLVLTVFSLLLLKYFKSGIFELWKIFPVIVFFFYGFRLTGFVLDGYTIGKARIILFLLVGMILYWILFFV
>Mature_398_residues
MQGSVLDLAVPFFLILIGFEVLYSKIVGKKVYRWNDTVADLSTGILFSLTGVCVTIFSLWIYEKFRIFCSLQTLFGVPEI
PLGIPIWPDPVGWHFDFKSLVGWIFVFLAVDFVYYWFHRATHEINFLWACHVTHHSSEEFNLSVALRQSSFQRIFEYMFN
LSIAFCGVPWQAFLLAHGILKIYQFWVHTRLVGKLGFLEEILITPSHHRVHHGRDPKYIDKNHGGILVFWDRIFGSFARE
EEEPIYGLTKPVTTFDPVYTNVHVYEEIFSLVQKTNNWKERILLFLKPPGWRPESLGSSVYAEEVDRNRYIKYDPIVSKQ
RMVLGFLEFLVLTVFSLLLLKYFKSGIFELWKIFPVIVFFFYGFRLTGFVLDGYTIGKARIILFLLVGMILYWILFFV

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=334, Percent_Identity=36.5269461077844, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI25144659, Length=274, Percent_Identity=35.4014598540146, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 46724; Mature: 46724

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGSVLDLAVPFFLILIGFEVLYSKIVGKKVYRWNDTVADLSTGILFSLTGVCVTIFSLW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYEKFRIFCSLQTLFGVPEIPLGIPIWPDPVGWHFDFKSLVGWIFVFLAVDFVYYWFHRA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THEINFLWACHVTHHSSEEFNLSVALRQSSFQRIFEYMFNLSIAFCGVPWQAFLLAHGIL
HCCEEEEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHH
KIYQFWVHTRLVGKLGFLEEILITPSHHRVHHGRDPKYIDKNHGGILVFWDRIFGSFARE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEHHHHHHHHHCC
EEEPIYGLTKPVTTFDPVYTNVHVYEEIFSLVQKTNNWKERILLFLKPPGWRPESLGSSV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCHHHHCCHH
YAEEVDRNRYIKYDPIVSKQRMVLGFLEFLVLTVFSLLLLKYFKSGIFELWKIFPVIVFF
HHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGFRLTGFVLDGYTIGKARIILFLLVGMILYWILFFV
HHHHHHHHEEECCEEEHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MQGSVLDLAVPFFLILIGFEVLYSKIVGKKVYRWNDTVADLSTGILFSLTGVCVTIFSLW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IYEKFRIFCSLQTLFGVPEIPLGIPIWPDPVGWHFDFKSLVGWIFVFLAVDFVYYWFHRA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THEINFLWACHVTHHSSEEFNLSVALRQSSFQRIFEYMFNLSIAFCGVPWQAFLLAHGIL
HCCEEEEEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHH
KIYQFWVHTRLVGKLGFLEEILITPSHHRVHHGRDPKYIDKNHGGILVFWDRIFGSFARE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEHHHHHHHHHCC
EEEPIYGLTKPVTTFDPVYTNVHVYEEIFSLVQKTNNWKERILLFLKPPGWRPESLGSSV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCHHHHCCHH
YAEEVDRNRYIKYDPIVSKQRMVLGFLEFLVLTVFSLLLLKYFKSGIFELWKIFPVIVFF
HHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGFRLTGFVLDGYTIGKARIILFLLVGMILYWILFFV
HHHHHHHHEEECCEEEHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]