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The map label for this gene is guaA [H]

Identifier: 45359008

GI number: 45359008

Start: 1416060

End: 1416629

Strand: Direct

Name: guaA [H]

Synonym: MMP1445

Alternate gene names: 45359008

Gene position: 1416060-1416629 (Clockwise)

Preceding gene: 45359007

Following gene: 45359010

Centisome position: 85.25

GC content: 36.32

Gene sequence:

>570_bases
ATGATCGTCATTTTAAACAACGGTGGACAGTACGTGCACAGGATACAAAGAAGCTTAAAGTACCTTGACGTACCTGCAAA
AATAGTTCCAAATTCAACCACTCTTGAAGAAATTGCTGCAAATCCGGAAATAAAAGGAGTAATATTGAGCGGTGGCCCAG
ATATTACAAAAGCTACAAACTGCGAAAATATTGCATTAAATTCAGAACTTCCAGTTCTTGGAATTTGCCTTGGACACCAG
TTAATTTCAAAAGCTTACGGTGGAGAAGTTTCAAGAGCAGATTCAGAAGAATATGCAAGCATTAAAATTTACGTAAAACA
GGAAAATGACCTTTTCAAAGGAGTTCCAAGCGAATTTACTGCATGGGCTTCCCACATGGACGAAGTAAAAGTAACTCCTG
ACTGCTTTGAAGTTTTAGCATACTCTGACATTTGCGGAGTAGAATCAATAAAACACAAAGAAAAATCAATTTACGGTGTT
CAATTCCACCCTGAAGTGTCACATACTGAATATGGAGACATTATTTTGAAAAACTTCTGTAAAAAATGTGGATTTGGATT
TGAAGAATAA

Upstream 100 bases:

>100_bases
GAAAGAGAACATGGAATGGTTTCCCAGTGTGAACATACAGTCTTAGTCACCGAAAATGGTGTTGAAATCACTACAAAATA
ATTGAATAAAAGGTGGAGTT

Downstream 100 bases:

>100_bases
ATTAGTTAATTAAATAAAAAAAGTTTTATTTTTTTAAAATTATTTATCCACAATTATAGTATTGTCGCTTAAAAGTGCTA
TTTCGTCTTCTGTTAAAAGC

Product: GMP synthase subunit A

Products: NA

Alternate protein names: Glutamine amidotransferase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MIVILNNGGQYVHRIQRSLKYLDVPAKIVPNSTTLEEIAANPEIKGVILSGGPDITKATNCENIALNSELPVLGICLGHQ
LISKAYGGEVSRADSEEYASIKIYVKQENDLFKGVPSEFTAWASHMDEVKVTPDCFEVLAYSDICGVESIKHKEKSIYGV
QFHPEVSHTEYGDIILKNFCKKCGFGFEE

Sequences:

>Translated_189_residues
MIVILNNGGQYVHRIQRSLKYLDVPAKIVPNSTTLEEIAANPEIKGVILSGGPDITKATNCENIALNSELPVLGICLGHQ
LISKAYGGEVSRADSEEYASIKIYVKQENDLFKGVPSEFTAWASHMDEVKVTPDCFEVLAYSDICGVESIKHKEKSIYGV
QFHPEVSHTEYGDIILKNFCKKCGFGFEE
>Mature_189_residues
MIVILNNGGQYVHRIQRSLKYLDVPAKIVPNSTTLEEIAANPEIKGVILSGGPDITKATNCENIALNSELPVLGICLGHQ
LISKAYGGEVSRADSEEYASIKIYVKQENDLFKGVPSEFTAWASHMDEVKVTPDCFEVLAYSDICGVESIKHKEKSIYGV
QFHPEVSHTEYGDIILKNFCKKCGFGFEE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=181, Percent_Identity=36.4640883977901, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1788854, Length=192, Percent_Identity=32.2916666666667, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789760, Length=116, Percent_Identity=35.3448275862069, Blast_Score=82, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133901714, Length=193, Percent_Identity=36.7875647668394, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71992717, Length=193, Percent_Identity=36.7875647668394, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71992710, Length=193, Percent_Identity=36.7875647668394, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323873, Length=184, Percent_Identity=38.0434782608696, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322638, Length=167, Percent_Identity=29.940119760479, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281365319, Length=181, Percent_Identity=34.2541436464088, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR004739 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 20884; Mature: 20884

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVILNNGGQYVHRIQRSLKYLDVPAKIVPNSTTLEEIAANPEIKGVILSGGPDITKATN
CEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCC
CENIALNSELPVLGICLGHQLISKAYGGEVSRADSEEYASIKIYVKQENDLFKGVPSEFT
CCEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCHHCCCCHHHH
AWASHMDEVKVTPDCFEVLAYSDICGVESIKHKEKSIYGVQFHPEVSHTEYGDIILKNFC
HHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHH
KKCGFGFEE
HHCCCCCCC
>Mature Secondary Structure
MIVILNNGGQYVHRIQRSLKYLDVPAKIVPNSTTLEEIAANPEIKGVILSGGPDITKATN
CEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCC
CENIALNSELPVLGICLGHQLISKAYGGEVSRADSEEYASIKIYVKQENDLFKGVPSEFT
CCEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCHHCCCCHHHH
AWASHMDEVKVTPDCFEVLAYSDICGVESIKHKEKSIYGVQFHPEVSHTEYGDIILKNFC
HHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHH
KKCGFGFEE
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA