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The map label for this gene is map [H]

Identifier: 45359007

GI number: 45359007

Start: 1415153

End: 1416040

Strand: Direct

Name: map [H]

Synonym: MMP1444

Alternate gene names: 45359007

Gene position: 1415153-1416040 (Clockwise)

Preceding gene: 45359006

Following gene: 45359008

Centisome position: 85.19

GC content: 36.71

Gene sequence:

>888_bases
ATGAATGAAGAAGAATACAGTAAAATTATTGAAGCTGGAAAAATTGCATCCCAAGTTAAAGAAGAAGCAGTAAAATTAGT
AAAACCTGGCGCAAAACTCTACGATGTTGCAGAATTTGTAGAAAACAGGACAAGAGAACTCGGTGCAGGTGTAGGATTTC
CATGCAATATTTCATTAAACGACATTGCAGCACACTACAGCCCTTCATATGGTGATAATTCGATTTTTTCAGAAGAAGAC
GTTGTAAAATTAGACCTTGGATCACACGTTGATGGATTTATTGCTGATACTGCAGTAACTATCGATTTATCTGGAAAATA
TTCTGACTTAAAAAAAGCTTCAGAAGATGCGTTAAATACAGTAATTAAAGAAATCATGCCCGAAATGAATATTGGGGAAA
TGGGAAAAATAATTCAGGAAGTAATTGAAAGTTACGGCTACAGGCCAGTTTCAAATCTTTCAGGGCACGTAATGCACCAA
TATTCACTCCACTCAGGAGTAAGTATTCCAAATGTTTCCGAAAATACAAAAGATACCATCGATGTTGGCGACCTCGTTGC
AATTGAACCGTTTGCAACAGATGGTTTTGGGCAGGTTGTAGATGGAAAAGACGTATATATCTTTAAATATCTAAGATCGA
GACCAACAAGACTCCCAGCTGCAAGAAACTTATTAAGAGATATCGAACAAAACCATGCATATCTACCATTTTCAGAAAGA
GACATGGCAAAAATCGATAAACATTATAAAACCGGCTTAAAAGGCTTGATGATGGCAGGAGTTCTTTATGGATACCCAAC
ACTGGTTGAAAGAGAACATGGAATGGTTTCCCAGTGTGAACATACAGTCTTAGTCACCGAAAATGGTGTTGAAATCACTA
CAAAATAA

Upstream 100 bases:

>100_bases
TCTGCAAAACACCCAGGTCAAAGAGTAGGATTAGACCACGTGCTAAAAGATGGAGATATATTGACGATCGTTGTTAGAAG
ATCACTTTAAGGTAGATAAA

Downstream 100 bases:

>100_bases
TTGAATAAAAGGTGGAGTTATGATCGTCATTTTAAACAACGGTGGACAGTACGTGCACAGGATACAAAGAAGCTTAAAGT
ACCTTGACGTACCTGCAAAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNEEEYSKIIEAGKIASQVKEEAVKLVKPGAKLYDVAEFVENRTRELGAGVGFPCNISLNDIAAHYSPSYGDNSIFSEED
VVKLDLGSHVDGFIADTAVTIDLSGKYSDLKKASEDALNTVIKEIMPEMNIGEMGKIIQEVIESYGYRPVSNLSGHVMHQ
YSLHSGVSIPNVSENTKDTIDVGDLVAIEPFATDGFGQVVDGKDVYIFKYLRSRPTRLPAARNLLRDIEQNHAYLPFSER
DMAKIDKHYKTGLKGLMMAGVLYGYPTLVEREHGMVSQCEHTVLVTENGVEITTK

Sequences:

>Translated_295_residues
MNEEEYSKIIEAGKIASQVKEEAVKLVKPGAKLYDVAEFVENRTRELGAGVGFPCNISLNDIAAHYSPSYGDNSIFSEED
VVKLDLGSHVDGFIADTAVTIDLSGKYSDLKKASEDALNTVIKEIMPEMNIGEMGKIIQEVIESYGYRPVSNLSGHVMHQ
YSLHSGVSIPNVSENTKDTIDVGDLVAIEPFATDGFGQVVDGKDVYIFKYLRSRPTRLPAARNLLRDIEQNHAYLPFSER
DMAKIDKHYKTGLKGLMMAGVLYGYPTLVEREHGMVSQCEHTVLVTENGVEITTK
>Mature_295_residues
MNEEEYSKIIEAGKIASQVKEEAVKLVKPGAKLYDVAEFVENRTRELGAGVGFPCNISLNDIAAHYSPSYGDNSIFSEED
VVKLDLGSHVDGFIADTAVTIDLSGKYSDLKKASEDALNTVIKEIMPEMNIGEMGKIIQEVIESYGYRPVSNLSGHVMHQ
YSLHSGVSIPNVSENTKDTIDVGDLVAIEPFATDGFGQVVDGKDVYIFKYLRSRPTRLPAARNLLRDIEQNHAYLPFSER
DMAKIDKHYKTGLKGLMMAGVLYGYPTLVEREHGMVSQCEHTVLVTENGVEITTK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=315, Percent_Identity=32.6984126984127, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI124494254, Length=265, Percent_Identity=25.2830188679245, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17544396, Length=316, Percent_Identity=30.379746835443, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17542840, Length=318, Percent_Identity=26.4150943396226, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319380, Length=321, Percent_Identity=33.6448598130841, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17137568, Length=315, Percent_Identity=31.7460317460317, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24658585, Length=273, Percent_Identity=27.1062271062271, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32597; Mature: 32597

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS01202 MAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEEEYSKIIEAGKIASQVKEEAVKLVKPGAKLYDVAEFVENRTRELGAGVGFPCNISLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
DIAAHYSPSYGDNSIFSEEDVVKLDLGSHVDGFIADTAVTIDLSGKYSDLKKASEDALNT
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCEEECEEEEEEECCCHHHHHHHHHHHHHH
VIKEIMPEMNIGEMGKIIQEVIESYGYRPVSNLSGHVMHQYSLHSGVSIPNVSENTKDTI
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEEHHHCCCCCCCCCCCCCCCC
DVGDLVAIEPFATDGFGQVVDGKDVYIFKYLRSRPTRLPAARNLLRDIEQNHAYLPFSER
CCCCEEEECCCCCCCCCCEECCCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DMAKIDKHYKTGLKGLMMAGVLYGYPTLVEREHGMVSQCEHTVLVTENGVEITTK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCEEEEECCCEEEECC
>Mature Secondary Structure
MNEEEYSKIIEAGKIASQVKEEAVKLVKPGAKLYDVAEFVENRTRELGAGVGFPCNISLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
DIAAHYSPSYGDNSIFSEEDVVKLDLGSHVDGFIADTAVTIDLSGKYSDLKKASEDALNT
HHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCEEECEEEEEEECCCHHHHHHHHHHHHHH
VIKEIMPEMNIGEMGKIIQEVIESYGYRPVSNLSGHVMHQYSLHSGVSIPNVSENTKDTI
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEEHHHCCCCCCCCCCCCCCCC
DVGDLVAIEPFATDGFGQVVDGKDVYIFKYLRSRPTRLPAARNLLRDIEQNHAYLPFSER
CCCCEEEECCCCCCCCCCEECCCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCC
DMAKIDKHYKTGLKGLMMAGVLYGYPTLVEREHGMVSQCEHTVLVTENGVEITTK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]