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The map label for this gene is msrA2 [H]

Identifier: 37521388

GI number: 37521388

Start: 1939127

End: 1939840

Strand: Reverse

Name: msrA2 [H]

Synonym: gll1819

Alternate gene names: 37521388

Gene position: 1939840-1939127 (Counterclockwise)

Preceding gene: 37521390

Following gene: 37521385

Centisome position: 41.64

GC content: 60.22

Gene sequence:

>714_bases
ATGATTTTTAAAGGATTTTGCCACACCATGCCACTACGCCGTTTAGCCTTCGTCCGCTTCCTGGGCCGCGCTTTGCCGAT
TGTGGCATTGAGCGCCGGAACGCTCGCTTGCAGCGCTTCCTCCGCGACCACTCCCGATCCGGCCACGGATGCGGCCTTGA
CCAGTGCCGTCGGCCCCCAGACTGCGGTGTTTGCCGGGGGATGCTTTTGGGGGGTCGAGGCGGTCTTCGAGCACCTCAAA
GGCGTCGAAGATGCGGTCTCCGGCTACGCCGGAGGTGACGCCTCCACCGCCAAATACGCAGCGGTGGGCTCCGGCCGGTC
GGGCCACGCCGAAGCGGTGCGCATCACCTACGACCCGTCCAAAATCACCTACGGTCAATTGTTGAAGGTGTTCTTTCAGG
TGGCCCACGACCCGACCCAGCTCAACCGACAGGGACCGGACCAGGGTACCCAGTACCGCTCGGCCATCTTTTTTACCGAT
GGCGAACAGCAGCGCATTGCTCAAACGTACATCGAACAGCTCGACAAAGCGCGCGTTTTCCCGCAACCGATTGTCACCCA
ACTGGCGCCCCTGCAGAAGTTCTATCTAGCCGAGCCCTATCACCAGGACTTCGTCAAGCTCAACCCTGCCCATCCCTACG
TGGTCTTCCACGATCTGCCCAAGCTCGCCCAACTGCGCAAACAATTTTCCAATCTGTACCAAGACCAAAGCTGA

Upstream 100 bases:

>100_bases
AGGCACGCAAATCACCAGCCGGGTAGGCGCCGCGCAAAAAGGTGACAATCGTAGCGGGGCGATCCAATCTGATAGAGGGG
CGGCTTCGTATCCCAGTCAG

Downstream 100 bases:

>100_bases
AGCCCAGGGCTCAATCGAGATGGCGCAGCACCCGGCACGGATTGCCGGCGGCGATGACGTTGGCGGGGATACTTTTGACT
ACGACGCTGCCCGCGCCGAT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIFKGFCHTMPLRRLAFVRFLGRALPIVALSAGTLACSASSATTPDPATDAALTSAVGPQTAVFAGGCFWGVEAVFEHLK
GVEDAVSGYAGGDASTAKYAAVGSGRSGHAEAVRITYDPSKITYGQLLKVFFQVAHDPTQLNRQGPDQGTQYRSAIFFTD
GEQQRIAQTYIEQLDKARVFPQPIVTQLAPLQKFYLAEPYHQDFVKLNPAHPYVVFHDLPKLAQLRKQFSNLYQDQS

Sequences:

>Translated_237_residues
MIFKGFCHTMPLRRLAFVRFLGRALPIVALSAGTLACSASSATTPDPATDAALTSAVGPQTAVFAGGCFWGVEAVFEHLK
GVEDAVSGYAGGDASTAKYAAVGSGRSGHAEAVRITYDPSKITYGQLLKVFFQVAHDPTQLNRQGPDQGTQYRSAIFFTD
GEQQRIAQTYIEQLDKARVFPQPIVTQLAPLQKFYLAEPYHQDFVKLNPAHPYVVFHDLPKLAQLRKQFSNLYQDQS
>Mature_237_residues
MIFKGFCHTMPLRRLAFVRFLGRALPIVALSAGTLACSASSATTPDPATDAALTSAVGPQTAVFAGGCFWGVEAVFEHLK
GVEDAVSGYAGGDASTAKYAAVGSGRSGHAEAVRITYDPSKITYGQLLKVFFQVAHDPTQLNRQGPDQGTQYRSAIFFTD
GEQQRIAQTYIEQLDKARVFPQPIVTQLAPLQKFYLAEPYHQDFVKLNPAHPYVVFHDLPKLAQLRKQFSNLYQDQS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=46.7948717948718, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=46.7948717948718, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=45.3703703703704, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1790665, Length=155, Percent_Identity=47.741935483871, Blast_Score=134, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=205, Percent_Identity=31.7073170731707, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=173, Percent_Identity=35.8381502890173, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664627, Length=162, Percent_Identity=34.5679012345679, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664631, Length=162, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45553131, Length=142, Percent_Identity=34.5070422535211, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25903; Mature: 25903

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFKGFCHTMPLRRLAFVRFLGRALPIVALSAGTLACSASSATTPDPATDAALTSAVGPQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHCCCC
TAVFAGGCFWGVEAVFEHLKGVEDAVSGYAGGDASTAKYAAVGSGRSGHAEAVRITYDPS
HHEEECHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCHHEEECCCCCCCCCEEEEEEECCC
KITYGQLLKVFFQVAHDPTQLNRQGPDQGTQYRSAIFFTDGEQQRIAQTYIEQLDKARVF
CCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHCCC
PQPIVTQLAPLQKFYLAEPYHQDFVKLNPAHPYVVFHDLPKLAQLRKQFSNLYQDQS
CHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIFKGFCHTMPLRRLAFVRFLGRALPIVALSAGTLACSASSATTPDPATDAALTSAVGPQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHCCCC
TAVFAGGCFWGVEAVFEHLKGVEDAVSGYAGGDASTAKYAAVGSGRSGHAEAVRITYDPS
HHEEECHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCHHEEECCCCCCCCCEEEEEEECCC
KITYGQLLKVFFQVAHDPTQLNRQGPDQGTQYRSAIFFTDGEQQRIAQTYIEQLDKARVF
CCCHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHCCC
PQPIVTQLAPLQKFYLAEPYHQDFVKLNPAHPYVVFHDLPKLAQLRKQFSNLYQDQS
CHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]