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The map label for this gene is luxQ [H]

Identifier: 37521385

GI number: 37521385

Start: 1936112

End: 1937458

Strand: Reverse

Name: luxQ [H]

Synonym: gll1816

Alternate gene names: 37521385

Gene position: 1937458-1936112 (Counterclockwise)

Preceding gene: 37521388

Following gene: 37521382

Centisome position: 41.59

GC content: 63.85

Gene sequence:

>1347_bases
GTGAATAGCCAAGATCAACAGCGCGAACCGCAAAACGGCCGTCAAATCCCCGCTAGTCGGGCAGAGGCAAGTTCCTGCCC
AGGCGAGGGGGGGGTGGGTTTTCCCGCGAACGAGGACGAACGCCTGGCGGCTTTGCGGCGCTACAAGGTCCTCGATACTC
CCCCCGAGCCCGGCTTTGAGCGGATAACGGCCCTCGCGGTTCGGCTTTTCGCGGTGCCAGTCTGTGTCATCTCGTTGGTG
GACGAATGCCGTGTCTGGTTTAAGTCCAAGGTCGGCTGGAGCGGCGAACAAGTTCAGCGCGACGAGTCATTGTGCAGCTG
GGCGATCTTGCAGAAAGAACTGATGGTGATCCACGACGCCCGGTTCGACGGGCGGTTGGCGTGCAACCCGTGGGTCCAGG
CTGAACCCGGCATTCGCTTCTACGCGGGGGCACCACTGACCAGCCCGGACGGTTTCAACCTGGGTACCCTTTGTCTGATC
GACACCCAACCGCACGCGACCTTCGACGAACCGCAGCGCCGGACACTCGCAGACCTGGCGGCCATTGTCGTCGACGAACT
GGAATTGCGGCTGTCACTGGAGAGTGCCGAGCAGTCGCGATTGGCGGCCGAAGCCGCCAATCGCGCCAAGGACGAGTTTT
TGGCCCTGCTCAGTCACGAGTTGCGCACACCGCTCAACCCGATCATCGGCTGGACCCAGATGCTCAAGCGCGGCTCGGTG
GCCGCCGACAAGCAGGTGGAGGTGCTCGAGATCATCGAGCGCAACGCCAAGCTGCAAAACCAGCTCATCCAGGACCTGCT
CGATGTCGCGCGCATCGAGCAGGGAAAGTTCAGCCACCGGCCCCAGCCGGTGATTCTGAGCGGGGTGGTGCAGGCGGCGG
TGGAGGCGGTGCGCACCCTGGCCAAGGACGCCGGGGTGGCCTTGGAAGTCGAAGTGGCCGAGCGGTTGCCGGAGGTGATG
GTCGATCCCACCCGCATGCAACAGGTGGTCTGGAACTTGCTTACCAATGCCATCAAGTTCACCCCGTCCGGCGGCTGGGT
GCAGCTGCACTTGGTGGAGGCGGCCGACTGCCTGTGCCTGGTGGTATCTGACAGCGGGACAGGCATCTCGCCTGCGTTTA
TCCCGCATCTGTTCGAGCGCTTTCGCCAGGCGGGAGACGCGGGCACGCGCAGGCAAGGGGGCCTGGGATTGGGCCTGTTT
ATCGTGCGCTACATCGTCGAACTGCACGGCGGTCGGGTTTGGGCCAAGAGCGATGGGCAAGGCAAGGGGGCAGTTTTTAC
CGTCGAACTGCCCCTGTGCGAGTGCCGTGCGAATGCTTCCGACTCCGTCTTGGCGGCGGAACCCTGA

Upstream 100 bases:

>100_bases
ATGGCAAAAAGTTCCCTGGTATTCTTGCGTTACGGGGTGACGAACACTCGTATCTGTCGCCCAATCGGGCACCGTTGGCG
GTGGGAGGCACAACTGGACC

Downstream 100 bases:

>100_bases
AGGTGAGCACAGCGAGTCAGTAGCGTGAAACCCGCCTACTGCAACGAGAAAGTGATCGGTACCCGTACCCAGGCGGAGAC
CACTTCTTCGCCGCGGCGGG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNSQDQQREPQNGRQIPASRAEASSCPGEGGVGFPANEDERLAALRRYKVLDTPPEPGFERITALAVRLFAVPVCVISLV
DECRVWFKSKVGWSGEQVQRDESLCSWAILQKELMVIHDARFDGRLACNPWVQAEPGIRFYAGAPLTSPDGFNLGTLCLI
DTQPHATFDEPQRRTLADLAAIVVDELELRLSLESAEQSRLAAEAANRAKDEFLALLSHELRTPLNPIIGWTQMLKRGSV
AADKQVEVLEIIERNAKLQNQLIQDLLDVARIEQGKFSHRPQPVILSGVVQAAVEAVRTLAKDAGVALEVEVAERLPEVM
VDPTRMQQVVWNLLTNAIKFTPSGGWVQLHLVEAADCLCLVVSDSGTGISPAFIPHLFERFRQAGDAGTRRQGGLGLGLF
IVRYIVELHGGRVWAKSDGQGKGAVFTVELPLCECRANASDSVLAAEP

Sequences:

>Translated_448_residues
MNSQDQQREPQNGRQIPASRAEASSCPGEGGVGFPANEDERLAALRRYKVLDTPPEPGFERITALAVRLFAVPVCVISLV
DECRVWFKSKVGWSGEQVQRDESLCSWAILQKELMVIHDARFDGRLACNPWVQAEPGIRFYAGAPLTSPDGFNLGTLCLI
DTQPHATFDEPQRRTLADLAAIVVDELELRLSLESAEQSRLAAEAANRAKDEFLALLSHELRTPLNPIIGWTQMLKRGSV
AADKQVEVLEIIERNAKLQNQLIQDLLDVARIEQGKFSHRPQPVILSGVVQAAVEAVRTLAKDAGVALEVEVAERLPEVM
VDPTRMQQVVWNLLTNAIKFTPSGGWVQLHLVEAADCLCLVVSDSGTGISPAFIPHLFERFRQAGDAGTRRQGGLGLGLF
IVRYIVELHGGRVWAKSDGQGKGAVFTVELPLCECRANASDSVLAAEP
>Mature_448_residues
MNSQDQQREPQNGRQIPASRAEASSCPGEGGVGFPANEDERLAALRRYKVLDTPPEPGFERITALAVRLFAVPVCVISLV
DECRVWFKSKVGWSGEQVQRDESLCSWAILQKELMVIHDARFDGRLACNPWVQAEPGIRFYAGAPLTSPDGFNLGTLCLI
DTQPHATFDEPQRRTLADLAAIVVDELELRLSLESAEQSRLAAEAANRAKDEFLALLSHELRTPLNPIIGWTQMLKRGSV
AADKQVEVLEIIERNAKLQNQLIQDLLDVARIEQGKFSHRPQPVILSGVVQAAVEAVRTLAKDAGVALEVEVAERLPEVM
VDPTRMQQVVWNLLTNAIKFTPSGGWVQLHLVEAADCLCLVVSDSGTGISPAFIPHLFERFRQAGDAGTRRQGGLGLGLF
IVRYIVELHGGRVWAKSDGQGKGAVFTVELPLCECRANASDSVLAAEP

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=35.8078602620087, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=32.03125, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=33.1896551724138, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI145693157, Length=276, Percent_Identity=32.2463768115942, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081816, Length=238, Percent_Identity=34.0336134453782, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786912, Length=266, Percent_Identity=32.3308270676692, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=31.4410480349345, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790436, Length=283, Percent_Identity=27.9151943462898, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786783, Length=226, Percent_Identity=29.646017699115, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=28.125, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=30.0411522633745, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=27.1604938271605, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=224, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=26.5560165975104, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=31.140350877193, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=247, Percent_Identity=27.5303643724696, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=27.2321428571429, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790551, Length=281, Percent_Identity=26.3345195729537, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49075; Mature: 49075

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSQDQQREPQNGRQIPASRAEASSCPGEGGVGFPANEDERLAALRRYKVLDTPPEPGFE
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHH
RITALAVRLFAVPVCVISLVDECRVWFKSKVGWSGEQVQRDESLCSWAILQKELMVIHDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
RFDGRLACNPWVQAEPGIRFYAGAPLTSPDGFNLGTLCLIDTQPHATFDEPQRRTLADLA
CCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHH
AIVVDELELRLSLESAEQSRLAAEAANRAKDEFLALLSHELRTPLNPIIGWTQMLKRGSV
HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
AADKQVEVLEIIERNAKLQNQLIQDLLDVARIEQGKFSHRPQPVILSGVVQAAVEAVRTL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AKDAGVALEVEVAERLPEVMVDPTRMQQVVWNLLTNAIKFTPSGGWVQLHLVEAADCLCL
HHHCCCEEEEHHHHHCHHHHCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCEEEE
VVSDSGTGISPAFIPHLFERFRQAGDAGTRRQGGLGLGLFIVRYIVELHGGRVWAKSDGQ
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCC
GKGAVFTVELPLCECRANASDSVLAAEP
CCCEEEEEECCHHHHCCCCCCCEEECCC
>Mature Secondary Structure
MNSQDQQREPQNGRQIPASRAEASSCPGEGGVGFPANEDERLAALRRYKVLDTPPEPGFE
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHH
RITALAVRLFAVPVCVISLVDECRVWFKSKVGWSGEQVQRDESLCSWAILQKELMVIHDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
RFDGRLACNPWVQAEPGIRFYAGAPLTSPDGFNLGTLCLIDTQPHATFDEPQRRTLADLA
CCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHH
AIVVDELELRLSLESAEQSRLAAEAANRAKDEFLALLSHELRTPLNPIIGWTQMLKRGSV
HHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
AADKQVEVLEIIERNAKLQNQLIQDLLDVARIEQGKFSHRPQPVILSGVVQAAVEAVRTL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AKDAGVALEVEVAERLPEVMVDPTRMQQVVWNLLTNAIKFTPSGGWVQLHLVEAADCLCL
HHHCCCEEEEHHHHHCHHHHCCHHHHHHHHHHHHHHHEEECCCCCEEEEEEEECCCEEEE
VVSDSGTGISPAFIPHLFERFRQAGDAGTRRQGGLGLGLFIVRYIVELHGGRVWAKSDGQ
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCC
GKGAVFTVELPLCECRANASDSVLAAEP
CCCEEEEEECCHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]