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The map label for this gene is cyp18 [H]

Identifier: 34498639

GI number: 34498639

Start: 3465397

End: 3465954

Strand: Direct

Name: cyp18 [H]

Synonym: CV_3184

Alternate gene names: 34498639

Gene position: 3465397-3465954 (Clockwise)

Preceding gene: 34498637

Following gene: 34498640

Centisome position: 72.94

GC content: 62.54

Gene sequence:

>558_bases
ATGAAGAAACTGATCAGCAGCCTGGCCCTCGCCGCCCTGCCCGCACTCGCCTTCGCCGCCCCGGTGGCGGAGATGGTCAC
CAACAAGGGCAATATCGAAATCGCGCTGGATTCGGCCAAGGCGCCCAAGTCCGTCGCCAATTTCGTCGCCTACGCCAAGG
CCGGCCACTACAACGGCACCGTGTTCCACCGCGTGATAGACGGTTTCATGATCCAGGGCGGCGGCTTCGACGCCAAGCTC
AACCAGAAGCCGACTCGCGCGCCGATCGCCAACGAGGCGAGCAACGGCCTGAAGAACGATGTCGGCACCATCGCGATGGC
CCGCACCTCGGATCCGAACTCCGCCACCGCGCAGTTCTTCATCAACGTCGCCGCCAACGACTTCCTCAATTACAGTTCGC
CGACCCCGCAGGGCGCCGGCTACGCCGTATTCGGCAAAGTCACCAAGGGCATGGATGTGGTCAACCGCATCGCCAAAGTC
CGCACCGGCAGCATGAACGGCATGCAGGACGTGCCGTTCGAGCCGGTGATCATCCAGAAAGTCACCATCAAACCGTAA

Upstream 100 bases:

>100_bases
CGATTGCGAACCCGGCCGCGCGCCGACGCGCCCCTATCCGCCGCAGTCGGCTGTGCTAGAATCAGCGCCCTGTCCCACAC
GTCCGCAAAGCCCATCCACG

Downstream 100 bases:

>100_bases
GGCCGTCCCGCGGCTGCATCGCAAAGGAAAACGCAATGATCAAACTGACGACCAATTTCGGTGAAATCACCCTGGAACTG
GATCACGAGAAGGCGCCGAA

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKKLISSLALAALPALAFAAPVAEMVTNKGNIEIALDSAKAPKSVANFVAYAKAGHYNGTVFHRVIDGFMIQGGGFDAKL
NQKPTRAPIANEASNGLKNDVGTIAMARTSDPNSATAQFFINVAANDFLNYSSPTPQGAGYAVFGKVTKGMDVVNRIAKV
RTGSMNGMQDVPFEPVIIQKVTIKP

Sequences:

>Translated_185_residues
MKKLISSLALAALPALAFAAPVAEMVTNKGNIEIALDSAKAPKSVANFVAYAKAGHYNGTVFHRVIDGFMIQGGGFDAKL
NQKPTRAPIANEASNGLKNDVGTIAMARTSDPNSATAQFFINVAANDFLNYSSPTPQGAGYAVFGKVTKGMDVVNRIAKV
RTGSMNGMQDVPFEPVIIQKVTIKP
>Mature_185_residues
MKKLISSLALAALPALAFAAPVAEMVTNKGNIEIALDSAKAPKSVANFVAYAKAGHYNGTVFHRVIDGFMIQGGGFDAKL
NQKPTRAPIANEASNGLKNDVGTIAMARTSDPNSATAQFFINVAANDFLNYSSPTPQGAGYAVFGKVTKGMDVVNRIAKV
RTGSMNGMQDVPFEPVIIQKVTIKP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=169, Percent_Identity=35.5029585798817, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI7706339, Length=176, Percent_Identity=32.9545454545455, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI19557636, Length=167, Percent_Identity=31.1377245508982, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=30.2469135802469, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=30.2469135802469, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=30.2469135802469, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310110104, Length=144, Percent_Identity=34.7222222222222, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI64276486, Length=149, Percent_Identity=32.8859060402685, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=157, Percent_Identity=59.2356687898089, Blast_Score=190, Evalue=4e-50,
Organism=Escherichia coli, GI1789763, Length=181, Percent_Identity=54.1436464088398, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71980594, Length=160, Percent_Identity=31.875, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=159, Percent_Identity=32.0754716981132, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=161, Percent_Identity=34.1614906832298, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=29.3413173652695, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=154, Percent_Identity=32.4675324675325, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=189, Percent_Identity=32.2751322751323, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=148, Percent_Identity=35.8108108108108, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17986117, Length=179, Percent_Identity=30.7262569832402, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922912, Length=176, Percent_Identity=34.0909090909091, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19473; Mature: 19473

Theoretical pI: Translated: 10.32; Mature: 10.32

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLISSLALAALPALAFAAPVAEMVTNKGNIEIALDSAKAPKSVANFVAYAKAGHYNGT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCH
VFHRVIDGFMIQGGGFDAKLNQKPTRAPIANEASNGLKNDVGTIAMARTSDPNSATAQFF
HHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEE
INVAANDFLNYSSPTPQGAGYAVFGKVTKGMDVVNRIAKVRTGSMNGMQDVPFEPVIIQK
EEEHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
VTIKP
EEECC
>Mature Secondary Structure
MKKLISSLALAALPALAFAAPVAEMVTNKGNIEIALDSAKAPKSVANFVAYAKAGHYNGT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCH
VFHRVIDGFMIQGGGFDAKLNQKPTRAPIANEASNGLKNDVGTIAMARTSDPNSATAQFF
HHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEE
INVAANDFLNYSSPTPQGAGYAVFGKVTKGMDVVNRIAKVRTGSMNGMQDVPFEPVIIQK
EEEHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
VTIKP
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]