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The map label for this gene is cyp18 [H]

Identifier: 34498640

GI number: 34498640

Start: 3465990

End: 3466481

Strand: Direct

Name: cyp18 [H]

Synonym: CV_3185

Alternate gene names: 34498640

Gene position: 3465990-3466481 (Clockwise)

Preceding gene: 34498639

Following gene: 34498641

Centisome position: 72.95

GC content: 60.16

Gene sequence:

>492_bases
ATGATCAAACTGACGACCAATTTCGGTGAAATCACCCTGGAACTGGATCACGAGAAGGCGCCGAAAACCGCCGCCAACTT
CGAGCAATACGTGAAAAGCGGCCACTACGACGGCACCATCTTCCACCGCGTGATCAACGGCTTCATGATCCAGGGCGGCG
GCTTCGACGCCGACATGAACCAGAAGCCGACCCAGGAGCCGATCCAGAACGAGGCCAACAACGGCCTGTCCAACAAGACC
TACACCGTCGCCATGGCCCGCACCATGGATCCGCACTCGGCGTCGGCGCAGTTCTTCATCAACGTCTCCGACAACGATTT
CCTGGACTTCAAATCGGAAAGCACCCAGGGCTGGGGTTACGCGGTGTTCGGCCAGGTCGTCGCCGGCCAGGACATCGTGG
ACCGCATCAAGACCGTACGCACCGGCCGCACTGGCATGCATCAGGACGTGCCGGTGGAGCCGGTGGTGATCCAGAAGGCC
GAGATCGTCTAA

Upstream 100 bases:

>100_bases
TGAACGGCATGCAGGACGTGCCGTTCGAGCCGGTGATCATCCAGAAAGTCACCATCAAACCGTAAGGCCGTCCCGCGGCT
GCATCGCAAAGGAAAACGCA

Downstream 100 bases:

>100_bases
ACCCGTCTCGCCGAAAAACCAGCCGGGGCCCCGCCCCGGCTTTGTCTTGCCCCGGATAAGGCAGCAGCCATGGCCATTCA
CTTCATTTCCGACCTGCATC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MIKLTTNFGEITLELDHEKAPKTAANFEQYVKSGHYDGTIFHRVINGFMIQGGGFDADMNQKPTQEPIQNEANNGLSNKT
YTVAMARTMDPHSASAQFFINVSDNDFLDFKSESTQGWGYAVFGQVVAGQDIVDRIKTVRTGRTGMHQDVPVEPVVIQKA
EIV

Sequences:

>Translated_163_residues
MIKLTTNFGEITLELDHEKAPKTAANFEQYVKSGHYDGTIFHRVINGFMIQGGGFDADMNQKPTQEPIQNEANNGLSNKT
YTVAMARTMDPHSASAQFFINVSDNDFLDFKSESTQGWGYAVFGQVVAGQDIVDRIKTVRTGRTGMHQDVPVEPVVIQKA
EIV
>Mature_163_residues
MIKLTTNFGEITLELDHEKAPKTAANFEQYVKSGHYDGTIFHRVINGFMIQGGGFDADMNQKPTQEPIQNEANNGLSNKT
YTVAMARTMDPHSASAQFFINVSDNDFLDFKSESTQGWGYAVFGQVVAGQDIVDRIKTVRTGRTGMHQDVPVEPVVIQKA
EIV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=32.2981366459627, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI22547212, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI7657473, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI22547215, Length=142, Percent_Identity=33.0985915492958, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI19557636, Length=145, Percent_Identity=30.3448275862069, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=31.9018404907975, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=61.7283950617284, Blast_Score=213, Evalue=4e-57,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=54.9382716049383, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=32.3170731707317, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=37.0629370629371, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=161, Percent_Identity=31.055900621118, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980590, Length=162, Percent_Identity=30.8641975308642, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=166, Percent_Identity=30.7228915662651, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=31.2883435582822, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922912, Length=138, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18071; Mature: 18071

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLTTNFGEITLELDHEKAPKTAANFEQYVKSGHYDGTIFHRVINGFMIQGGGFDADMN
CEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCCCCCCC
QKPTQEPIQNEANNGLSNKTYTVAMARTMDPHSASAQFFINVSDNDFLDFKSESTQGWGY
CCCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCC
AVFGQVVAGQDIVDRIKTVRTGRTGMHQDVPVEPVVIQKAEIV
CEEHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MIKLTTNFGEITLELDHEKAPKTAANFEQYVKSGHYDGTIFHRVINGFMIQGGGFDADMN
CEEEECCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCEEEECCCCCCCCC
QKPTQEPIQNEANNGLSNKTYTVAMARTMDPHSASAQFFINVSDNDFLDFKSESTQGWGY
CCCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCC
AVFGQVVAGQDIVDRIKTVRTGRTGMHQDVPVEPVVIQKAEIV
CEEHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]