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The map label for this gene is uvrC

Identifier: 33862996

GI number: 33862996

Start: 782299

End: 784302

Strand: Direct

Name: uvrC

Synonym: PMT0724

Alternate gene names: 33862996

Gene position: 782299-784302 (Clockwise)

Preceding gene: 33862995

Following gene: 33862997

Centisome position: 32.45

GC content: 45.56

Gene sequence:

>2004_bases
ATGCGCTTAACCTCGCTTCAACGGGTTGGTCATACGGCGGTTGAAAATAATTTGAGCAACGCTTCTCAGCGCACCATCCT
TCTAAAGGATGAAAATAGACTTGAGCAAAGGCTTAAGGAGATTCCAGCTGAACCTGGTTGTTATCTCATGCGTGATGTAG
AAGACAGGTTGTTATATGTTGGAAAATCAAAATGTTTGCGAAATCGAGTCAGAAGCTATTTCCGAAGTAGCAGTGATCAT
GGGCCGCGTATTCGATTGATGGTGCGACAAATTGCTGAGATTGAATTTATCGTTACTGATAGCGAGGCTGAATCCTTAGT
CCTGGAATCTAATCTGATCAAAAATCAACAACCACATTTCAATGTGTTGTTAAAAGATGACAAGAAATATCCATATCTTT
GCATAACATGGAGCGAGGAATATCCACGTATCTTTATCACAAGAAGGCGACGTTTCCGAAATAAGAATGATCGCTTCTAT
GGTCCATATGTAGATGTAGGACTATTACGTAGAACCTTATTACTAGTCAAACGTTCGTTCCCGCTGAGACAACGACCACG
GCCACTGCATCAGGATCGCACCTGCCTTAACTATTCAATTGGACGTTGCCCTGGCGTATGCCAGCAGAAGATCACACCAC
AGGATTATCATCAAGTTCTTCGCAAAGTTGCGATGGTCTTTCAGGGCAGGAATCAAGAGCTTAAGGTTTTGCTTGAGAAG
CAAATGGAACGCTATTCAGATCGAATGGACTATGAGTCAGCCGCTAATATAAGGGATCAGATTAAAGGGTTAGAACAACT
GACAGAAGGACAGAAGATGAGCTTGCCAGATTCAAGCGTAAGCCGAGATGTACTAGCCATTGCAAGTGATCATAGGGTTG
CTGCAGTTCAGCTTTTTCAGATGCGTGCAGGTAAACTTGTTAATCGTCTTGGCTTTACTGCTGATGCAGTCGATCAAACT
CTTGGAAGTGTACTCCAGCGAGTTATCGAAGAACATTACAGTCAAGTAGATGCTGTAGAGGTGCCGCCAGAAGTTCTTGT
TCAATACTCATTACCTCAGCAAGAATTGCTAGTTGATTGGCTCAGTGAGCACCGAGGTCGGCGTGTTCAAATCAGTTGTC
CTCAACGCCAAGCGAAAGCAGAGTTGATAGAACTTGTTGAACGCAATGCAGTATTTGAACTATCGCGTGCGAAGAGTGGG
CAGCAGCAACAGGAATTGGCAACAGAGGATCTAGCCCAGTTGCTTGAACTCACGACACAACCAAGAAGAATCGAAGGATA
TGATATTAGTCATATCCAAGGAAGTGATGCTGTTGCATCACAGGTTGTATTTATCGATGGGCTTCCCGCTAAACAGCATT
ACCGAAAGTATAAAATTAAAAGTAGCAGTATCAAATCTGGCCATAGCGATGACTTCATGGCGATGGCTGAGATTATGCGC
CGTCGCTTTCGTCGTTGGGCAAGGGTGAAGCAAGAAGGATCCAATTTTGAAAACCTGCAGCGTTGCAGTGGCAGTGCCTT
GCAGACAGATGGTCTCAATGATTGGCCTGATGTGGTGATGATTGATGGCGGTAAGGGGCAGCTTTCATCAGCCATGGAAG
CTTTACGAGAGCTTGACCTTCATGAGGATCTCGTCGTTTGTTCATTGGCTAAGAAGCATGAACAGATCTTTGTACCTGGA
CAAAGCAAACCATTGGATTCTGATCCTGATCAGTTGGGTGTAGTCCTTTTAAGGCGGCTTCGCGATGAAGCACATCGCTT
TGCAGTGAGTTATCACCGCCAACAAAGAGGGGTAAGAATGAACCGATCGCGGCTTACAGACATCCCTGGACTTGGGCCTA
GGCGTGTCCGTGACCTTCTTGCCCACTTTCAATCCATTGATGCTATTCAGTTGGCTAGCGTCCAGCAAATTAGTCAGGCA
CCAGGGCTTGGACCAGCACTTGCCTTACAGGTTTGGACCTATTTCCACCCTGAAGCCGATATTGCGTTGGAGGAGGTTGC
CTGA

Upstream 100 bases:

>100_bases
ATTGGAGGGGTTGAGTGTGAACTTGTGGGCCAGGTCGTCCATGGTGATCACACTGTGTTCGTCGGAGAAGTGAAATCAGC
CCATCTAAATCAGGATGGGG

Downstream 100 bases:

>100_bases
TCAAGACGGATCACTTTTTTTAACTCTCACTACTTGTTCATCTCAGCAGATTGCTAATTGTTATCCATGACTTTTCCGCC
CGAGGCATACCTGTGGTTTA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MRLTSLQRVGHTAVENNLSNASQRTILLKDENRLEQRLKEIPAEPGCYLMRDVEDRLLYVGKSKCLRNRVRSYFRSSSDH
GPRIRLMVRQIAEIEFIVTDSEAESLVLESNLIKNQQPHFNVLLKDDKKYPYLCITWSEEYPRIFITRRRRFRNKNDRFY
GPYVDVGLLRRTLLLVKRSFPLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPQDYHQVLRKVAMVFQGRNQELKVLLEK
QMERYSDRMDYESAANIRDQIKGLEQLTEGQKMSLPDSSVSRDVLAIASDHRVAAVQLFQMRAGKLVNRLGFTADAVDQT
LGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLVDWLSEHRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSG
QQQQELATEDLAQLLELTTQPRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
RRFRRWARVKQEGSNFENLQRCSGSALQTDGLNDWPDVVMIDGGKGQLSSAMEALRELDLHEDLVVCSLAKKHEQIFVPG
QSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRMNRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQA
PGLGPALALQVWTYFHPEADIALEEVA

Sequences:

>Translated_667_residues
MRLTSLQRVGHTAVENNLSNASQRTILLKDENRLEQRLKEIPAEPGCYLMRDVEDRLLYVGKSKCLRNRVRSYFRSSSDH
GPRIRLMVRQIAEIEFIVTDSEAESLVLESNLIKNQQPHFNVLLKDDKKYPYLCITWSEEYPRIFITRRRRFRNKNDRFY
GPYVDVGLLRRTLLLVKRSFPLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPQDYHQVLRKVAMVFQGRNQELKVLLEK
QMERYSDRMDYESAANIRDQIKGLEQLTEGQKMSLPDSSVSRDVLAIASDHRVAAVQLFQMRAGKLVNRLGFTADAVDQT
LGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLVDWLSEHRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSG
QQQQELATEDLAQLLELTTQPRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
RRFRRWARVKQEGSNFENLQRCSGSALQTDGLNDWPDVVMIDGGKGQLSSAMEALRELDLHEDLVVCSLAKKHEQIFVPG
QSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRMNRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQA
PGLGPALALQVWTYFHPEADIALEEVA
>Mature_667_residues
MRLTSLQRVGHTAVENNLSNASQRTILLKDENRLEQRLKEIPAEPGCYLMRDVEDRLLYVGKSKCLRNRVRSYFRSSSDH
GPRIRLMVRQIAEIEFIVTDSEAESLVLESNLIKNQQPHFNVLLKDDKKYPYLCITWSEEYPRIFITRRRRFRNKNDRFY
GPYVDVGLLRRTLLLVKRSFPLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPQDYHQVLRKVAMVFQGRNQELKVLLEK
QMERYSDRMDYESAANIRDQIKGLEQLTEGQKMSLPDSSVSRDVLAIASDHRVAAVQLFQMRAGKLVNRLGFTADAVDQT
LGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLVDWLSEHRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSG
QQQQELATEDLAQLLELTTQPRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
RRFRRWARVKQEGSNFENLQRCSGSALQTDGLNDWPDVVMIDGGKGQLSSAMEALRELDLHEDLVVCSLAKKHEQIFVPG
QSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRMNRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQA
PGLGPALALQVWTYFHPEADIALEEVA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=644, Percent_Identity=31.9875776397516, Blast_Score=317, Evalue=2e-87,
Organism=Escherichia coli, GI1788037, Length=194, Percent_Identity=28.8659793814433, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_PROMM (Q7V7L7)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_894556.1
- HSSP:   Q9WYA3
- ProteinModelPortal:   Q7V7L7
- STRING:   Q7V7L7
- GeneID:   1729047
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT0724
- NMPDR:   fig|74547.1.peg.723
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   PMAR74547:PMT0724-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 76662; Mature: 76662

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTSLQRVGHTAVENNLSNASQRTILLKDENRLEQRLKEIPAEPGCYLMRDVEDRLLYV
CCCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GKSKCLRNRVRSYFRSSSDHGPRIRLMVRQIAEIEFIVTDSEAESLVLESNLIKNQQPHF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCCCE
NVLLKDDKKYPYLCITWSEEYPRIFITRRRRFRNKNDRFYGPYVDVGLLRRTLLLVKRSF
EEEEECCCCCCEEEEEECCCCCEEHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHCC
PLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPQDYHQVLRKVAMVFQGRNQELKVLLEK
CCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QMERYSDRMDYESAANIRDQIKGLEQLTEGQKMSLPDSSVSRDVLAIASDHRVAAVQLFQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHCCCCHHHHHHHHH
MRAGKLVNRLGFTADAVDQTLGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLVDW
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCHHHHHHHH
LSEHRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSGQQQQELATEDLAQLLELTTQ
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
PRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
CCCCCCCCCCCCCCCHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RRFRRWARVKQEGSNFENLQRCSGSALQTDGLNDWPDVVMIDGGKGQLSSAMEALRELDL
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
HEDLVVCSLAKKHEQIFVPGQSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRM
HHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQAPGLGPALALQVWTYFHPEAD
CHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
IALEEVA
CHHHHCC
>Mature Secondary Structure
MRLTSLQRVGHTAVENNLSNASQRTILLKDENRLEQRLKEIPAEPGCYLMRDVEDRLLYV
CCCCHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GKSKCLRNRVRSYFRSSSDHGPRIRLMVRQIAEIEFIVTDSEAESLVLESNLIKNQQPHF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCCCE
NVLLKDDKKYPYLCITWSEEYPRIFITRRRRFRNKNDRFYGPYVDVGLLRRTLLLVKRSF
EEEEECCCCCCEEEEEECCCCCEEHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHCC
PLRQRPRPLHQDRTCLNYSIGRCPGVCQQKITPQDYHQVLRKVAMVFQGRNQELKVLLEK
CCCCCCCCCCCCCHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QMERYSDRMDYESAANIRDQIKGLEQLTEGQKMSLPDSSVSRDVLAIASDHRVAAVQLFQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHCCCCHHHHHHHHH
MRAGKLVNRLGFTADAVDQTLGSVLQRVIEEHYSQVDAVEVPPEVLVQYSLPQQELLVDW
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCHHHHHHHH
LSEHRGRRVQISCPQRQAKAELIELVERNAVFELSRAKSGQQQQELATEDLAQLLELTTQ
HHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
PRRIEGYDISHIQGSDAVASQVVFIDGLPAKQHYRKYKIKSSSIKSGHSDDFMAMAEIMR
CCCCCCCCCCCCCCCHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
RRFRRWARVKQEGSNFENLQRCSGSALQTDGLNDWPDVVMIDGGKGQLSSAMEALRELDL
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCC
HEDLVVCSLAKKHEQIFVPGQSKPLDSDPDQLGVVLLRRLRDEAHRFAVSYHRQQRGVRM
HHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NRSRLTDIPGLGPRRVRDLLAHFQSIDAIQLASVQQISQAPGLGPALALQVWTYFHPEAD
CHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
IALEEVA
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642