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The map label for this gene is lpxC/fabZ

Identifier: 29349614

GI number: 29349614

Start: 5542254

End: 5543639

Strand: Reverse

Name: lpxC/fabZ

Synonym: BT_4206

Alternate gene names: 29349614

Gene position: 5543639-5542254 (Counterclockwise)

Preceding gene: 29349615

Following gene: 29349613

Centisome position: 88.55

GC content: 44.81

Gene sequence:

>1386_bases
ATGCTGAAACAAAAAACGCTGAAAGATAGCTTTTCACTGAGCGGGAAAGGTCTTCACACTGGACTTGATCTCACTGTAAC
TTTTAATCCTGCCCCGGACAATCATGGATATAAAATCCAGCGTATTGACCTGGAAGGACAACCAACTATCGATGCAGTAG
CCGACAATGTGACGGAAACAACCCGTGGCACAGTATTGTCAAAGAATGGAGTCAAAGTAAGTACCGTAGAGCATGGTATG
GCAGCCCTTTATGCATTGGGCATTGATAACTGCCTTATCCAGGTTAATGGTCCGGAATTTCCGATTTTGGACGGTAGTGC
ACAATATTATGTACAAGAAATAGAACGTGTAGGAACAGAAGAACAAAGTGCTGTCAAGGATTTTTATATCATCAAATCTA
AAATTGAATTCCGGGACGAATCAACCGGCTCTTCTATCATCGTGCTACCGGACGAGAATTTTAGTCTGAATGTACTCGTT
TCCTACGATTCAACCATTATCCCGAATCAGTTTGCAACACTTGAGGATATGCACAATTTCAAAGACGAAGTGGCTGCCAG
CCGTACTTTCGTCTTTGTTCGTGAAATAGAGCCGCTTCTCTCCGCCGGCCTCATTAAAGGTGGTGACCTCGACAACGCAA
TCGTTATTTACGAACGCAAAATGTCACAGGAAAGCTATGACAAACTGGCTGATGTAATGGGTGTTCCTCACATGGATGCG
GATCAGTTGGGGTACATCAATCACAAACCACTGGTTTGGCCGAACGAGTGTGCCCGTCACAAACTGCTGGATGTTATCGG
TGATCTTGCATTGATTGGTAAACCGATTAAAGGTCGCATCATTGCTACCCGCCCCGGTCACACCATCAACAATAAGTTTG
CGCGTCAGATGCGGAAGGAAATTCGCCTGCATGAAATACAGGCACCGACATACGACTGTAACCGCGAACCGGTGATGGAC
GTAAATCGTATCCGTGAGCTATTACCCCACCGTTATCCTTTCCAATTGGTAGACAAGGTAATTGAGATGGGTGCCAGCTA
TATCGTAGGTATCAAAAATATCACAGCAAACGAACCTTTCTTCCAGGGACATTTCCCACAGGAACCAGTGATGCCGGGCG
TACTTCAAATAGAAGCAATGGCTCAGGTAGGCGGTTTGCTCGTTCTTAATTCTGTTGACGAACCGGAACGTTATTCTACC
TATTTCATGAAGATAGATGGCGTAAAGTTCCGCCAGAAAGTAGTACCGGGAGATACACTGCTTTTCCGTGTAGAATTATT
AGCCCCGATCCGTCGTGGCATCTCCACAATGAAAGGTTATGCATTCGTTGGCGAAAAAGTCGTTTGCGAAGCAGAATTCA
TGGCACAAATAGTAAAAAATAAATAA

Upstream 100 bases:

>100_bases
TTGTGACTAAGAATTTGCCGGATATGCAAAAAGAAATACGCAATCTGCGTAAAGAAGTAGAAGAATTAAAACAACTATTA
AATAAGTAAATAAGTAACCA

Downstream 100 bases:

>100_bases
AACCAAAAACATGGTAAGTCCTCTAGCGTATATTCATCCCGAAGCTAAAATCGGAGAAAATGTAGAAATTGCGCCTTTTG
TATTTATTGATAAAAACGTA

Product: bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Products: NA

Alternate protein names: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MLKQKTLKDSFSLSGKGLHTGLDLTVTFNPAPDNHGYKIQRIDLEGQPTIDAVADNVTETTRGTVLSKNGVKVSTVEHGM
AALYALGIDNCLIQVNGPEFPILDGSAQYYVQEIERVGTEEQSAVKDFYIIKSKIEFRDESTGSSIIVLPDENFSLNVLV
SYDSTIIPNQFATLEDMHNFKDEVAASRTFVFVREIEPLLSAGLIKGGDLDNAIVIYERKMSQESYDKLADVMGVPHMDA
DQLGYINHKPLVWPNECARHKLLDVIGDLALIGKPIKGRIIATRPGHTINNKFARQMRKEIRLHEIQAPTYDCNREPVMD
VNRIRELLPHRYPFQLVDKVIEMGASYIVGIKNITANEPFFQGHFPQEPVMPGVLQIEAMAQVGGLLVLNSVDEPERYST
YFMKIDGVKFRQKVVPGDTLLFRVELLAPIRRGISTMKGYAFVGEKVVCEAEFMAQIVKNK

Sequences:

>Translated_461_residues
MLKQKTLKDSFSLSGKGLHTGLDLTVTFNPAPDNHGYKIQRIDLEGQPTIDAVADNVTETTRGTVLSKNGVKVSTVEHGM
AALYALGIDNCLIQVNGPEFPILDGSAQYYVQEIERVGTEEQSAVKDFYIIKSKIEFRDESTGSSIIVLPDENFSLNVLV
SYDSTIIPNQFATLEDMHNFKDEVAASRTFVFVREIEPLLSAGLIKGGDLDNAIVIYERKMSQESYDKLADVMGVPHMDA
DQLGYINHKPLVWPNECARHKLLDVIGDLALIGKPIKGRIIATRPGHTINNKFARQMRKEIRLHEIQAPTYDCNREPVMD
VNRIRELLPHRYPFQLVDKVIEMGASYIVGIKNITANEPFFQGHFPQEPVMPGVLQIEAMAQVGGLLVLNSVDEPERYST
YFMKIDGVKFRQKVVPGDTLLFRVELLAPIRRGISTMKGYAFVGEKVVCEAEFMAQIVKNK
>Mature_461_residues
MLKQKTLKDSFSLSGKGLHTGLDLTVTFNPAPDNHGYKIQRIDLEGQPTIDAVADNVTETTRGTVLSKNGVKVSTVEHGM
AALYALGIDNCLIQVNGPEFPILDGSAQYYVQEIERVGTEEQSAVKDFYIIKSKIEFRDESTGSSIIVLPDENFSLNVLV
SYDSTIIPNQFATLEDMHNFKDEVAASRTFVFVREIEPLLSAGLIKGGDLDNAIVIYERKMSQESYDKLADVMGVPHMDA
DQLGYINHKPLVWPNECARHKLLDVIGDLALIGKPIKGRIIATRPGHTINNKFARQMRKEIRLHEIQAPTYDCNREPVMD
VNRIRELLPHRYPFQLVDKVIEMGASYIVGIKNITANEPFFQGHFPQEPVMPGVLQIEAMAQVGGLLVLNSVDEPERYST
YFMKIDGVKFRQKVVPGDTLLFRVELLAPIRRGISTMKGYAFVGEKVVCEAEFMAQIVKNK

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thioester dehydratase family

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=36.026936026936, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1786377, Length=141, Percent_Identity=48.2269503546099, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXZ_BACTN (Q8A015)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_813117.1
- ProteinModelPortal:   Q8A015
- GeneID:   1073681
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_4206
- NMPDR:   fig|226186.1.peg.4204
- HOGENOM:   HBG302394
- OMA:   PGHASNV
- PhylomeDB:   Q8A015
- ProtClustDB:   PRK13188
- BioCyc:   BTHE226186:BT_4206-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00388
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR01750
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF07977 FabA; PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-; 4.2.1.-

Molecular weight: Translated: 51601; Mature: 51601

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: ACT_SITE 364-364

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKQKTLKDSFSLSGKGLHTGLDLTVTFNPAPDNHGYKIQRIDLEGQPTIDAVADNVTET
CCCCHHCCHHCCCCCCCEECCEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHCCHHHH
TRGTVLSKNGVKVSTVEHGMAALYALGIDNCLIQVNGPEFPILDGSAQYYVQEIERVGTE
CCCEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHCCC
EQSAVKDFYIIKSKIEFRDESTGSSIIVLPDENFSLNVLVSYDSTIIPNQFATLEDMHNF
HHHHHHHEEEEEEEEEECCCCCCCEEEEECCCCCEEEEEEECCCEECCCCHHHHHHHHHH
KDEVAASRTFVFVREIEPLLSAGLIKGGDLDNAIVIYERKMSQESYDKLADVMGVPHMDA
HHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCH
DQLGYINHKPLVWPNECARHKLLDVIGDLALIGKPIKGRIIATRPGHTINNKFARQMRKE
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
IRLHEIQAPTYDCNREPVMDVNRIRELLPHRYPFQLVDKVIEMGASYIVGIKNITANEPF
HHHHEECCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
FQGHFPQEPVMPGVLQIEAMAQVGGLLVLNSVDEPERYSTYFMKIDGVKFRQKVVPGDTL
CCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHEEEEEEECCCHHHHHCCCCCCE
LFRVELLAPIRRGISTMKGYAFVGEKVVCEAEFMAQIVKNK
EEHHHHHHHHHHHHHHHCCCEEECCCEEECHHHHHHHHHCC
>Mature Secondary Structure
MLKQKTLKDSFSLSGKGLHTGLDLTVTFNPAPDNHGYKIQRIDLEGQPTIDAVADNVTET
CCCCHHCCHHCCCCCCCEECCEEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHCCHHHH
TRGTVLSKNGVKVSTVEHGMAALYALGIDNCLIQVNGPEFPILDGSAQYYVQEIERVGTE
CCCEEEECCCCEEEEHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHCCC
EQSAVKDFYIIKSKIEFRDESTGSSIIVLPDENFSLNVLVSYDSTIIPNQFATLEDMHNF
HHHHHHHEEEEEEEEEECCCCCCCEEEEECCCCCEEEEEEECCCEECCCCHHHHHHHHHH
KDEVAASRTFVFVREIEPLLSAGLIKGGDLDNAIVIYERKMSQESYDKLADVMGVPHMDA
HHHHHHCCEEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCH
DQLGYINHKPLVWPNECARHKLLDVIGDLALIGKPIKGRIIATRPGHTINNKFARQMRKE
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
IRLHEIQAPTYDCNREPVMDVNRIRELLPHRYPFQLVDKVIEMGASYIVGIKNITANEPF
HHHHEECCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
FQGHFPQEPVMPGVLQIEAMAQVGGLLVLNSVDEPERYSTYFMKIDGVKFRQKVVPGDTL
CCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHEEEEEEECCCHHHHHCCCCCCE
LFRVELLAPIRRGISTMKGYAFVGEKVVCEAEFMAQIVKNK
EEHHHHHHHHHHHHHHHCCCEEECCCEEECHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928