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The map label for this gene is lpxD

Identifier: 29349615

GI number: 29349615

Start: 5543651

End: 5544691

Strand: Reverse

Name: lpxD

Synonym: BT_4207

Alternate gene names: 29349615

Gene position: 5544691-5543651 (Counterclockwise)

Preceding gene: 29349616

Following gene: 29349614

Centisome position: 88.57

GC content: 43.8

Gene sequence:

>1041_bases
ATGGAGTTCTCGGCTAAGCAAATTGCAGCATTTATCCAAGGGGAAATCATTGGAGATGAAAACGCAACGGTACACACATT
CGCTAAAATAGAAGAGGGAATGCCCGGAGCTATTTCTTTCCTGTCGAACCCTAAATATACGCCTTATATCTACGAGACAC
AATCAAGCATTGTATTAGTTAATAAAGATTTTGTCCCTGAACATGAGATTCGGGCTACTCTGATCAAAGTAGACAATGCT
TATGAAAGCCTGGCGAAGCTGCTTAACCTCTATGAAATGAGTAAACCAAAGAAGCAAGGTATCGATTCACTGGCTTATAT
TGCCCCCAGCGCCAAAATTGGCGAGAACGTATACATCGGTGCCTTTGCCTATATCGGCGAAAACGCCGTTATCGGAGATA
ATACTCAAATTTACCCGCATACTTTCGTTGGAGACGGTGTGAAGATAGGCAATGGTTGTCTTCTTTACTCAAATGTAAAT
GTTTATCATGACTGCCGTATCGGTAATGAATGTATCCTTCACTCAGGTGCAGTGATCGGAGCCGATGGATTCGGTTTCGC
TCCCACCCCGAACGGATACGATAAGATTCCACAAATCGGAATTGTGATCCTGGAAGACAAAGTAGATATAGGTGCCAATA
CCTGTGTAGACCGTGCTACAATGGGAGCTACCATCATACATAGTGGCGCTAAAATTGATAATCTTGTGCAGATTGCGCAC
AACGATGAAATTGGCTCACACACAGTTATGGCGGCTCAAGTTGGCATAGCAGGCTCTGCCAAAATCGGAGAATGGTGTAT
GTTTGGCGGTCAGGTAGGTATTGCCGGACATATCACAATCGGCGACCGGGTAAATCTGGGAGCACAATCAGGTATACCAA
GCAGCATCAAAGCAGACAGCGTACTGATCGGGACTCCTCCTATGGAACCGAAAGCTTACTTCAAGGCTGCCGTTGTGACT
AAGAATTTGCCGGATATGCAAAAAGAAATACGCAATCTGCGTAAAGAAGTAGAAGAATTAAAACAACTATTAAATAAGTA
A

Upstream 100 bases:

>100_bases
CCAGCGATTGCATAGATAAGTATAAAATATTCATTCAATAACACGGAAATCTGAAAAAAAAATCCGTTATTTGTGAACTA
ATTTAATTTAAAATAAAGAC

Downstream 100 bases:

>100_bases
ATAAGTAACCAATGCTGAAACAAAAAACGCTGAAAGATAGCTTTTCACTGAGCGGGAAAGGTCTTCACACTGGACTTGAT
CTCACTGTAACTTTTAATCC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEFSAKQIAAFIQGEIIGDENATVHTFAKIEEGMPGAISFLSNPKYTPYIYETQSSIVLVNKDFVPEHEIRATLIKVDNA
YESLAKLLNLYEMSKPKKQGIDSLAYIAPSAKIGENVYIGAFAYIGENAVIGDNTQIYPHTFVGDGVKIGNGCLLYSNVN
VYHDCRIGNECILHSGAVIGADGFGFAPTPNGYDKIPQIGIVILEDKVDIGANTCVDRATMGATIIHSGAKIDNLVQIAH
NDEIGSHTVMAAQVGIAGSAKIGEWCMFGGQVGIAGHITIGDRVNLGAQSGIPSSIKADSVLIGTPPMEPKAYFKAAVVT
KNLPDMQKEIRNLRKEVEELKQLLNK

Sequences:

>Translated_346_residues
MEFSAKQIAAFIQGEIIGDENATVHTFAKIEEGMPGAISFLSNPKYTPYIYETQSSIVLVNKDFVPEHEIRATLIKVDNA
YESLAKLLNLYEMSKPKKQGIDSLAYIAPSAKIGENVYIGAFAYIGENAVIGDNTQIYPHTFVGDGVKIGNGCLLYSNVN
VYHDCRIGNECILHSGAVIGADGFGFAPTPNGYDKIPQIGIVILEDKVDIGANTCVDRATMGATIIHSGAKIDNLVQIAH
NDEIGSHTVMAAQVGIAGSAKIGEWCMFGGQVGIAGHITIGDRVNLGAQSGIPSSIKADSVLIGTPPMEPKAYFKAAVVT
KNLPDMQKEIRNLRKEVEELKQLLNK
>Mature_346_residues
MEFSAKQIAAFIQGEIIGDENATVHTFAKIEEGMPGAISFLSNPKYTPYIYETQSSIVLVNKDFVPEHEIRATLIKVDNA
YESLAKLLNLYEMSKPKKQGIDSLAYIAPSAKIGENVYIGAFAYIGENAVIGDNTQIYPHTFVGDGVKIGNGCLLYSNVN
VYHDCRIGNECILHSGAVIGADGFGFAPTPNGYDKIPQIGIVILEDKVDIGANTCVDRATMGATIIHSGAKIDNLVQIAH
NDEIGSHTVMAAQVGIAGSAKIGEWCMFGGQVGIAGHITIGDRVNLGAQSGIPSSIKADSVLIGTPPMEPKAYFKAAVVT
KNLPDMQKEIRNLRKEVEELKQLLNK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=333, Percent_Identity=38.1381381381381, Blast_Score=223, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_BACTN (Q8A014)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_813118.1
- ProteinModelPortal:   Q8A014
- SMR:   Q8A014
- GeneID:   1074215
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_4207
- NMPDR:   fig|226186.1.peg.4205
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- PhylomeDB:   Q8A014
- ProtClustDB:   PRK00892
- BioCyc:   BTHE226186:BT_4207-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37169; Mature: 37169

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSAKQIAAFIQGEIIGDENATVHTFAKIEEGMPGAISFLSNPKYTPYIYETQSSIVLV
CCCCHHHHHHHHHCEEECCCCCEEEEEEHHHCCCCHHHHHHCCCCCCCEEEECCCCEEEE
NKDFVPEHEIRATLIKVDNAYESLAKLLNLYEMSKPKKQGIDSLAYIAPSAKIGENVYIG
ECCCCCCHHHEEEEEEECHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCCCCEEEEE
AFAYIGENAVIGDNTQIYPHTFVGDGVKIGNGCLLYSNVNVYHDCRIGNECILHSGAVIG
EEEEECCCEEECCCCEECCEEECCCCEEECCCEEEEECCCEEEECCCCCEEEEECCCEEE
ADGFGFAPTPNGYDKIPQIGIVILEDKVDIGANTCVDRATMGATIIHSGAKIDNLVQIAH
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCEEEEEC
NDEIGSHTVMAAQVGIAGSAKIGEWCMFGGQVGIAGHITIGDRVNLGAQSGIPSSIKADS
CCCCCCEEEEEEEECCCCCCCCCCCEEECCEECEEEEEEECCCCCCCCCCCCCCCCCCCE
VLIGTPPMEPKAYFKAAVVTKNLPDMQKEIRNLRKEVEELKQLLNK
EEEECCCCCHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFSAKQIAAFIQGEIIGDENATVHTFAKIEEGMPGAISFLSNPKYTPYIYETQSSIVLV
CCCCHHHHHHHHHCEEECCCCCEEEEEEHHHCCCCHHHHHHCCCCCCCEEEECCCCEEEE
NKDFVPEHEIRATLIKVDNAYESLAKLLNLYEMSKPKKQGIDSLAYIAPSAKIGENVYIG
ECCCCCCHHHEEEEEEECHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCCCCCCEEEEE
AFAYIGENAVIGDNTQIYPHTFVGDGVKIGNGCLLYSNVNVYHDCRIGNECILHSGAVIG
EEEEECCCEEECCCCEECCEEECCCCEEECCCEEEEECCCEEEECCCCCEEEEECCCEEE
ADGFGFAPTPNGYDKIPQIGIVILEDKVDIGANTCVDRATMGATIIHSGAKIDNLVQIAH
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCEEEEEC
NDEIGSHTVMAAQVGIAGSAKIGEWCMFGGQVGIAGHITIGDRVNLGAQSGIPSSIKADS
CCCCCCEEEEEEEECCCCCCCCCCCEEECCEECEEEEEEECCCCCCCCCCCCCCCCCCCE
VLIGTPPMEPKAYFKAAVVTKNLPDMQKEIRNLRKEVEELKQLLNK
EEEECCCCCHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928