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The map label for this gene is hycC [H]

Identifier: 29143112

GI number: 29143112

Start: 2835294

End: 2837120

Strand: Reverse

Name: hycC [H]

Synonym: t2753

Alternate gene names: 29143112

Gene position: 2837120-2835294 (Counterclockwise)

Preceding gene: 29143113

Following gene: 29143111

Centisome position: 59.21

GC content: 61.3

Gene sequence:

>1827_bases
ATGAGTTCACTTTCACTGATTACTAGCGGCGTCGCGTGGTTTGCCGCCGCCGCCGTTCTGGCGTTTCTGTTTTCGTTTCA
TAAAGCGCTGAGCGGCTGGATTGCCGGTATCGGCGGCGCGGTCGGCAGCCTGTGTACGGCAGGCGCGGGGTTCACCGCGC
TGACCAGCGCCGTTACGGTTAGCGGCGTGATGCCGTTTACCGGTCACATGCTGCAAATTACGCCGCTGAATGCTATCTGG
CTGATTACGCTGGGGCTGTGCGGTCTGTTCGTCAGCCTGTTCAATATCGACTGGCATCGCCATCCACAGGTAAAAGCCAA
CGGACTGTTGATCAACCTGCTGATGGCGGCAGCCGTCTGCGCTGTGGTCGCCAGTAATCTGGGGACGATGGTGGTGATGG
CTGAAATCATGGCGCTCTGCGCCGTGTTCCTTACCGGCGGTAGCAAAGAGGGCAAACTGTGGTTTGCGCTGGGCCGTCTC
GGTACGCTGCTGCTGGCAATCGCCTGCTGGCTGGTGTGGCAGCGCTACGGCACGCTGGATCTGGGGCTGCTGGATCAACG
CGCTCAGCAACTGCCGCTGGGCTCCGATATCTGGCTGCTCGGCGTTATCGGTTTTGGTCTGCTGGCCGGGATTATCCCGC
TACACGGTTGGGTGCCGCAGGCGCACGCCAACGCCAGCGCTCCCGCCGCCGCGCTGTTCTCGACCGTGGTGATGAAAATC
GGGCTGCTGGGCATTCTCTCGCTATCTCTGCTTGGCGGCAATGCGCCACTGTGGTGGGGCGTGGCGCTGTTGGTGCTTGG
GATGATCACCGCCTTTGTCGGCGGTCTGTACGCGCTGATGGAGCATAACATTCAGCGCCTGCTGGCCTATCACACGCTGG
AAAATATCGGCATCATTTTGCTCGGTCTGGGCGCAGGCGTTACCGGGATTGCTCTCAATCAGCCGGTACTGATCGCGCTG
GGTCTGACCGGCGGGCTCTATCATCTGCTGAACCATAGCCTGTTCAAAAGCGTGCTGTTACTGGGCGCGGGCAGCATCTG
GTTCCGTACCGGTCATCGCGACATCGAAAAACTGGGCGGTATTGGTAAACGGATGCCGGTTATTTCTATCGCCATGCTGG
TCGGTCTGATGGCGATGGCGGCGCTGCCGCCGCTGAACGGCTTTGCCGGCGAGTGGGTGATTTACCAGTCCTTCTTCAAA
CTGGGCAACAGCGGCGCGTTTGTTGGTCGTCTGTTAGGACCGCTGCTGGCGGTTGGCCTGGCGATTACCGGCGCGCTGGC
GGTGATGTGTATGGCGAAAGTTTACGGCGTGACGTTCCTTGGCGCGCCGCGCACGAAGGAAGCTGAAAATGCCAGCTGCG
CGCCGATCCTGATGGGCGTCAGCGTGGTGGCATTGGCGGTTTGCTGCGTACTGGGCGGGGTTGCCGCGCCGTGGCTGCTG
CCGATGATTTCCACTGCGGTACCGTTGCCGCTGGAAACCGCGCACACCACCGTATCGCAGCCGATGATCACGCTGCTGTT
GGTCGCCTGTCCGCTACTGCCATTCATCATTATGGCGATGTTCAAAGGCAACCGTCTGCCGTCGCGTTCTCGCGGCGCGG
CCTGGGTGTGCGGCTACGACCATGAGCAGTCGATGGTGATTACCGCGCACGGTTTCGCCATGCCGGTGAAAGAGGCCTTT
GCCCCGGTACTCAAACTGCGTAAATGGCTGAACCCGGTATCGCTGGTGCCGGGCTGGCAGAACGCGGCGGCCGCGGGGCT
GTTCCGTCGTCTGGCGCTGATTGAGCTGGCGGTGCTGGTGGTGATTGTGGTTTCACGAGGAGCCTGA

Upstream 100 bases:

>100_bases
CGGATATCGCCCGCGCCAGCAAACGTAAACGTGAGCTGACGTTTAATACCGATTTTGGCGATCTCACCTTGTTTCAGCAG
GCTCAGAGTGGGGATGCATA

Downstream 100 bases:

>100_bases
AAATGAGTGTGTTTTATCCGTTAATTCAGGCGCTGGTGCTATTTGCCGTTGCGCCATTGCTGTCCGGTATTACTCGCGTG
GCGCGCGCCCGTCTACACAA

Product: formate hydrogenlyase subunit 3

Products: NA

Alternate protein names: FHL subunit 3; Hydrogenase-3 component C [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTVSGVMPFTGHMLQITPLNAIW
LITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVCAVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRL
GTLLLAIACWLVWQRYGTLDLGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
GLLGILSLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGAGVTGIALNQPVLIAL
GLTGGLYHLLNHSLFKSVLLLGAGSIWFRTGHRDIEKLGGIGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFK
LGNSGAFVGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAVCCVLGGVAAPWLL
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYDHEQSMVITAHGFAMPVKEAF
APVLKLRKWLNPVSLVPGWQNAAAAGLFRRLALIELAVLVVIVVSRGA

Sequences:

>Translated_608_residues
MSSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTVSGVMPFTGHMLQITPLNAIW
LITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVCAVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRL
GTLLLAIACWLVWQRYGTLDLGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
GLLGILSLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGAGVTGIALNQPVLIAL
GLTGGLYHLLNHSLFKSVLLLGAGSIWFRTGHRDIEKLGGIGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFK
LGNSGAFVGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAVCCVLGGVAAPWLL
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYDHEQSMVITAHGFAMPVKEAF
APVLKLRKWLNPVSLVPGWQNAAAAGLFRRLALIELAVLVVIVVSRGA
>Mature_607_residues
SSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTVSGVMPFTGHMLQITPLNAIWL
ITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVCAVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRLG
TLLLAIACWLVWQRYGTLDLGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKIG
LLGILSLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIILLGLGAGVTGIALNQPVLIALG
LTGGLYHLLNHSLFKSVLLLGAGSIWFRTGHRDIEKLGGIGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKL
GNSGAFVGRLLGPLLAVGLAITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAVCCVLGGVAAPWLLP
MISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYDHEQSMVITAHGFAMPVKEAFA
PVLKLRKWLNPVSLVPGWQNAAAAGLFRRLALIELAVLVVIVVSRGA

Specific function: Hydrogen metabolism; FHL pathway. [C]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=179, Percent_Identity=30.1675977653631, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI2367154, Length=608, Percent_Identity=88.8157894736842, Blast_Score=1016, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=534, Percent_Identity=38.9513108614232, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1788831, Length=356, Percent_Identity=28.6516853932584, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788829, Length=190, Percent_Identity=26.8421052631579, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788614, Length=289, Percent_Identity=28.719723183391, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788613, Length=193, Percent_Identity=26.9430051813472, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: NA

Molecular weight: Translated: 63642; Mature: 63511

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SGVMPFTGHMLQITPLNAIWLITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVC
HCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRLGTLLLAIACWLVWQRYGTLD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
LGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GLLGILSLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LGLGAGVTGIALNQPVLIALGLTGGLYHLLNHSLFKSVLLLGAGSIWFRTGHRDIEKLGG
EECCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHCC
IGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLGNSGAFVGRLLGPLLAVGL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAVCCVLGGVAAPWLL
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
HEQSMVITAHGFAMPVKEAFAPVLKLRKWLNPVSLVPGWQNAAAAGLFRRLALIELAVLV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VIVVSRGA
HHHHCCCC
>Mature Secondary Structure 
SSLSLITSGVAWFAAAAVLAFLFSFHKALSGWIAGIGGAVGSLCTAGAGFTALTSAVTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
SGVMPFTGHMLQITPLNAIWLITLGLCGLFVSLFNIDWHRHPQVKANGLLINLLMAAAVC
HCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
AVVASNLGTMVVMAEIMALCAVFLTGGSKEGKLWFALGRLGTLLLAIACWLVWQRYGTLD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
LGLLDQRAQQLPLGSDIWLLGVIGFGLLAGIIPLHGWVPQAHANASAPAAALFSTVVMKI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GLLGILSLSLLGGNAPLWWGVALLVLGMITAFVGGLYALMEHNIQRLLAYHTLENIGIIL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LGLGAGVTGIALNQPVLIALGLTGGLYHLLNHSLFKSVLLLGAGSIWFRTGHRDIEKLGG
EECCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHEEECCCHHHHHHCC
IGKRMPVISIAMLVGLMAMAALPPLNGFAGEWVIYQSFFKLGNSGAFVGRLLGPLLAVGL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AITGALAVMCMAKVYGVTFLGAPRTKEAENASCAPILMGVSVVALAVCCVLGGVAAPWLL
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMISTAVPLPLETAHTTVSQPMITLLLVACPLLPFIIMAMFKGNRLPSRSRGAAWVCGYD
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
HEQSMVITAHGFAMPVKEAFAPVLKLRKWLNPVSLVPGWQNAAAAGLFRRLALIELAVLV
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VIVVSRGA
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2187144; 9278503 [H]