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The map label for this gene is panE [C]

Identifier: 29140818

GI number: 29140818

Start: 321370

End: 322287

Strand: Direct

Name: panE [C]

Synonym: t0284

Alternate gene names: 29140818

Gene position: 321370-322287 (Clockwise)

Preceding gene: 29140817

Following gene: 29140820

Centisome position: 6.71

GC content: 48.91

Gene sequence:

>918_bases
ATGAAAATTGCAATCGCAGGTGCAGGCGCTATGGGATGTCGTTTTGGCTATATGCTGCTGGAGGCCGGGCACGACGTGAC
GCTTATTGATGGCTGGCAGGAGCATGTCGACGCTATTCGTAGCAAGGGGTTGTTTGTCGAAACGGAAACGACTCAGAAGT
ATTACCCCATCCCTGCTATGTTGGCTGATGAATCCCAGGGGGAGTTTGAGCTGGTTATTCTGTTTACCAAAGCCATGCAG
TTGGATAGCATGTTACAGCGTATTAAGCCGCTGCTGCCAGCCGCGAAGGTCGTGATGATTTTATCTAACGGCCTGGGAAA
TATCGAAACCCTGGAGAAATATGTCGATCGGCAGAAAATCTATGCGGGTGTGACGTTATGGTCCAGCGAACTGGAGGGGG
CTGGGCATATTATGGCCACCGGTACCGGAACGATTGAACTGCAGCCGATAGCCAGCCAAGATTCGGCTCAAGAGGCTAAG
GTCATTGCCACCCTTAATAGTGCTGGATTGAATGCTGAAATAAGCCCTGACGTATTATTATCGATCTGGAAGAAAGCAGC
CTTTAATAGCGTAATGAACACCTATTGCGCGTTACTGGATTGTAATGTCGGCGGATTTGGTCAGCGGCCTGGTGCTTTAG
ATTTAGCGCAAGCGGTAGTTGATGAGTTTGTGTTAGTTGCTGCCAGCCAGAATATTCCGTTGACTGAGCAAATGGTGATG
AATACGGTGAAGAAAGTGTTCGATCCGCGTGAGAGCGGCCACCACTATCCTTCTATGCATCAGGATTTACATAAAGGCCG
ACTGACCGAAATCGACTATTTAAATGGTGCGATTGCGCGAATCGGCGCTCAGAACAATATTGCCGTACCGGTTAACACAC
TCCTGACGCAATTGATTCACGCTAAAGAAGCGCAATAA

Upstream 100 bases:

>100_bases
GGTGCTATTGCTTATTGGAGTCGTGTTGACCCTGATAACGAAAAAATATGTCGCAACGGTTTTAGCCAAAATTCATTAAT
CAGATAATAAGGAAATAAAA

Downstream 100 bases:

>100_bases
ACTTGATAGCTCTTCTGCATGAGGCGGAAGAGCCATTTTCAAACCAGTTTTTTTACCAGCGCCTCGCTATGGCGAATACG
CTCCGGCGCCCGCTCTAAAT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNTLLTQLIHAKEAQ

Sequences:

>Translated_305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNTLLTQLIHAKEAQ
>Mature_305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNTLLTQLIHAKEAQ

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=312, Percent_Identity=25.6410256410256, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320057, Length=201, Percent_Identity=29.3532338308458, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33124; Mature: 33124

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAM
CEEEEECCCHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHCCCEEEECCCCEECCCCCE
LADESQGEFELVILFTKAMQLDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKI
ECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAKVIATLNSAGLNAEISPDVLL
HHEEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCHHCEEEEEECCCCCCCCCCHHHHH
SIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHH
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNTLLTQLIH
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEHHHCCHHHHHCCCCCCEEEHHHHHHHHHH
AKEAQ
HCCCC
>Mature Secondary Structure
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDGWQEHVDAIRSKGLFVETETTQKYYPIPAM
CEEEEECCCHHHHHHHHHHEECCCCEEEECCHHHHHHHHHHCCCEEEECCCCEECCCCCE
LADESQGEFELVILFTKAMQLDSMLQRIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKI
ECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YAGVTLWSSELEGAGHIMATGTGTIELQPIASQDSAQEAKVIATLNSAGLNAEISPDVLL
HHEEEEECCCCCCCCEEEEECCCEEEEEECCCCCCCHHCEEEEEECCCCCCCCCCHHHHH
SIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHH
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNTLLTQLIH
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEHHHCCHHHHHCCCCCCEEEHHHHHHHHHH
AKEAQ
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]