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The map label for this gene is mgrA [H]

Identifier: 28378489

GI number: 28378489

Start: 1648048

End: 1648485

Strand: Direct

Name: mgrA [H]

Synonym: lp_1821

Alternate gene names: 28378489

Gene position: 1648048-1648485 (Clockwise)

Preceding gene: 28378488

Following gene: 28378490

Centisome position: 49.82

GC content: 46.8

Gene sequence:

>438_bases
ATGACACCAGAAATTGACCTTGCTAATCAACTTTGTTTTAGCATATACAATGCCAATCGGTTATTTAACAAATTTTATGT
CGAAGCGTTAACACCATTCAAACTGACTTACGCACAGTATCTCGTACTAATGGCATTGTGGGAACACGACGACCAGTCAT
TACACGAGTTAGGTCAGGTTCTGCGCTTAAGCAGCAACACCTTGACACCGCTTTTGCGACGCATGGAAGACGCAGGGTGG
TTGCAGCGCGAGCGACCGGCAACAGATCGGCGCCAGTTACTCATTCATCTCACGACGCAGGGTAAGCAACAACAAGCACC
AATCGAAGCCGCGATTGCAACTTGTATCAGTCGCTACCACCTGACTGTCGATGAATATCAACAAGCACTGGCCCTGAACC
AGAAGATTATTACCGCATTATCACAGGATTTGGCCTAA

Upstream 100 bases:

>100_bases
TGTGGCGACCAGCAGATTACAAATTTATTTACCCCTTGTTTTTTACGGGCAAGGGGCTTATACTGATAATCAATCGCACG
CGATTGAAAGGAGCATCCGC

Downstream 100 bases:

>100_bases
ACGGGCCTTTTTATTGACCGTTTCAATCGCGTGCGACTGAAATATAATTTTAGGAGGAATCTCTAATGGCAGATTATGAC
ACAATTTTTATCGGTAGCGG

Product: transcription regulator

Products: NA

Alternate protein names: Regulator of autolytic activity [H]

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MTPEIDLANQLCFSIYNANRLFNKFYVEALTPFKLTYAQYLVLMALWEHDDQSLHELGQVLRLSSNTLTPLLRRMEDAGW
LQRERPATDRRQLLIHLTTQGKQQQAPIEAAIATCISRYHLTVDEYQQALALNQKIITALSQDLA

Sequences:

>Translated_145_residues
MTPEIDLANQLCFSIYNANRLFNKFYVEALTPFKLTYAQYLVLMALWEHDDQSLHELGQVLRLSSNTLTPLLRRMEDAGW
LQRERPATDRRQLLIHLTTQGKQQQAPIEAAIATCISRYHLTVDEYQQALALNQKIITALSQDLA
>Mature_144_residues
TPEIDLANQLCFSIYNANRLFNKFYVEALTPFKLTYAQYLVLMALWEHDDQSLHELGQVLRLSSNTLTPLLRRMEDAGWL
QRERPATDRRQLLIHLTTQGKQQQAPIEAAIATCISRYHLTVDEYQQALALNQKIITALSQDLA

Specific function: Regulatory protein involved in autolytic activity, multidrug resistance and virulence. Controls autolysis by inactivating lytM, lytN (autolysins) and sarV (autolysis activator) and activating arlRS, lrgAB and lytSR (autolysis inhibitors). Acts as a dual r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR [H]

EC number: NA

Molecular weight: Translated: 16717; Mature: 16586

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEIDLANQLCFSIYNANRLFNKFYVEALTPFKLTYAQYLVLMALWEHDDQSLHELGQV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LRLSSNTLTPLLRRMEDAGWLQRERPATDRRQLLIHLTTQGKQQQAPIEAAIATCISRYH
HHHCCCHHHHHHHHHHHHCHHHCCCCCCCHHHEEEEECCCCCCHHCHHHHHHHHHHHHHC
LTVDEYQQALALNQKIITALSQDLA
CCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPEIDLANQLCFSIYNANRLFNKFYVEALTPFKLTYAQYLVLMALWEHDDQSLHELGQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LRLSSNTLTPLLRRMEDAGWLQRERPATDRRQLLIHLTTQGKQQQAPIEAAIATCISRYH
HHHCCCHHHHHHHHHHHHCHHHCCCCCCCHHHEEEEECCCCCCHHCHHHHHHHHHHHHHC
LTVDEYQQALALNQKIITALSQDLA
CCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12791130 [H]