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The map label for this gene is nox2 [H]

Identifier: 28377624

GI number: 28377624

Start: 700545

End: 701903

Strand: Direct

Name: nox2 [H]

Synonym: lp_0766

Alternate gene names: 28377624

Gene position: 700545-701903 (Clockwise)

Preceding gene: 28377622

Following gene: 28377626

Centisome position: 21.18

GC content: 44.44

Gene sequence:

>1359_bases
ATGAAAGTTGCCATTATTGGCTGTACACATGCGGGGATTGCCGCCATGAAACAAATCTTGAAATATTATCCGGGCACTGA
AATTACCGTCTATGAACGGCACGCGGATATTTCATATATGTCTTGTGGGACTTATCTACACTTAGGGGGTACCATCCATA
ATTTGGATCAAGCGTTGTACGCTAATCCTAGTGAATTTAGTGAACAAGGTGTGCAGATGCGGATGCAGTATGATGTGATC
AATGTGAATGCTGATAAGCATACAATTTTGGCTCAAAATTTACAGACAAAAGAATTACAAACGGATCACTATGATAAGTT
AGTCATGGCGACGGGTTCAATCACTGCAATCCCGGCTATTCCGGGCGTAGAGAATCCTAAGGTCATGCTTTGCAAAACAT
GTGAACAGGCCCAGCAACTCTACGAAGCAGCTAAACATGCACACCATATTGCAATCGTTGGTGGTGGCTATTCGGGGGTG
GAACTTGCTGAGGGGTACGTGAAGTCTGGACACACTGTGACGTTGTTTCAACGGGGCCCCCACTTAATTAATGAGTATCT
TGATCCACAAATTTCTGAGAAGATCGAAGACTTGTTAACGACGAAAGGCATCCAAGTTAGAACCAATGCACAAGTGACGG
CTTTTAGTGATACGGCTGATAATCGACTACGAGTTGCAACCGCTGATAGTGAAGAAATATTTGATATGGCTGTTATTTGT
CCGGGGGTGATTCCACAATCAGAGTTATTGGCGGGACAGGTCAACCGAACGAAGCAGGGGGCCATTGTAACGGACCGTTA
TATGGGAACCTCCAACCCGGATATATTTGCGGCTGGCGATGTGACGGAAGTTAACTTTAATCCTACGAAGGAACACGCCT
ATATGCCATTAGTCTCACATGCAATTCGGCAAGGTGCACTGGCAGGAATTAATATCTTTGATAAACGCTTAGGTGCAATT
GGTACGCAAGCGACGACTGGGATGTTGATTTTTGATCAGACCGTGGCTTGTGCAGGTCTGACCTTAACGGCGGCCAAAGC
AGCTAACTTCGATGCCCAAGCAGCTTTTTATGAAGGCAATTATCGGCCGGACTTTATGCCTACCACGGCGAAAGTCATGA
TTGAGTTGGTTTATGATCAACAAACGCGGAAGGTTTTGGGTGGTCAACTAATGAGTGCTCATGAAGTTTCACAATCAGCA
AATACGTTGTCCGTAGTGATTCATAATGGTAATACGATTGATGAATTAGCCTTCATGGATATGCTATTCTCACCCAACTT
TGATGAACCGTTTAATTACTTGAATTTAGTGGCGCAGGCTGCAGTAGATCAGGAACATGGCTATCGTCGGAATAATTAA

Upstream 100 bases:

>100_bases
AACCGAATCGCTGTATACTCTAAGTATACGTCAACTTAAATAAATGTTTAACTTAATCCAAGTTAAATTTTAACTTTTAA
TGAAAGCTGTGGTCGAAACA

Downstream 100 bases:

>100_bases
GTTTTTGCACTAATTATGTTCAGAAGGTGCTGGTTGTTAAAATCAAGAACAGCCAGCTTAGACCCGCTGGAATAAGTTCA
GATTAGCGTAAACTTGTTTG

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKVAIIGCTHAGIAAMKQILKYYPGTEITVYERHADISYMSCGTYLHLGGTIHNLDQALYANPSEFSEQGVQMRMQYDVI
NVNADKHTILAQNLQTKELQTDHYDKLVMATGSITAIPAIPGVENPKVMLCKTCEQAQQLYEAAKHAHHIAIVGGGYSGV
ELAEGYVKSGHTVTLFQRGPHLINEYLDPQISEKIEDLLTTKGIQVRTNAQVTAFSDTADNRLRVATADSEEIFDMAVIC
PGVIPQSELLAGQVNRTKQGAIVTDRYMGTSNPDIFAAGDVTEVNFNPTKEHAYMPLVSHAIRQGALAGINIFDKRLGAI
GTQATTGMLIFDQTVACAGLTLTAAKAANFDAQAAFYEGNYRPDFMPTTAKVMIELVYDQQTRKVLGGQLMSAHEVSQSA
NTLSVVIHNGNTIDELAFMDMLFSPNFDEPFNYLNLVAQAAVDQEHGYRRNN

Sequences:

>Translated_452_residues
MKVAIIGCTHAGIAAMKQILKYYPGTEITVYERHADISYMSCGTYLHLGGTIHNLDQALYANPSEFSEQGVQMRMQYDVI
NVNADKHTILAQNLQTKELQTDHYDKLVMATGSITAIPAIPGVENPKVMLCKTCEQAQQLYEAAKHAHHIAIVGGGYSGV
ELAEGYVKSGHTVTLFQRGPHLINEYLDPQISEKIEDLLTTKGIQVRTNAQVTAFSDTADNRLRVATADSEEIFDMAVIC
PGVIPQSELLAGQVNRTKQGAIVTDRYMGTSNPDIFAAGDVTEVNFNPTKEHAYMPLVSHAIRQGALAGINIFDKRLGAI
GTQATTGMLIFDQTVACAGLTLTAAKAANFDAQAAFYEGNYRPDFMPTTAKVMIELVYDQQTRKVLGGQLMSAHEVSQSA
NTLSVVIHNGNTIDELAFMDMLFSPNFDEPFNYLNLVAQAAVDQEHGYRRNN
>Mature_452_residues
MKVAIIGCTHAGIAAMKQILKYYPGTEITVYERHADISYMSCGTYLHLGGTIHNLDQALYANPSEFSEQGVQMRMQYDVI
NVNADKHTILAQNLQTKELQTDHYDKLVMATGSITAIPAIPGVENPKVMLCKTCEQAQQLYEAAKHAHHIAIVGGGYSGV
ELAEGYVKSGHTVTLFQRGPHLINEYLDPQISEKIEDLLTTKGIQVRTNAQVTAFSDTADNRLRVATADSEEIFDMAVIC
PGVIPQSELLAGQVNRTKQGAIVTDRYMGTSNPDIFAAGDVTEVNFNPTKEHAYMPLVSHAIRQGALAGINIFDKRLGAI
GTQATTGMLIFDQTVACAGLTLTAAKAANFDAQAAFYEGNYRPDFMPTTAKVMIELVYDQQTRKVLGGQLMSAHEVSQSA
NTLSVVIHNGNTIDELAFMDMLFSPNFDEPFNYLNLVAQAAVDQEHGYRRNN

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1789065, Length=225, Percent_Identity=30.6666666666667, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789915, Length=182, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789765, Length=293, Percent_Identity=25.5972696245734, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49445; Mature: 49445

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAIIGCTHAGIAAMKQILKYYPGTEITVYERHADISYMSCGTYLHLGGTIHNLDQALY
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCEEEECCCHHHHHHHHC
ANPSEFSEQGVQMRMQYDVINVNADKHTILAQNLQTKELQTDHYDKLVMATGSITAIPAI
CCHHHHHHCCCEEEEEEEEEEECCCCCEEEECCCCHHHCCCCCCCEEEEECCCEEEECCC
PGVENPKVMLCKTCEQAQQLYEAAKHAHHIAIVGGGYSGVELAEGYVKSGHTVTLFQRGP
CCCCCCCEEEEHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCC
HLINEYLDPQISEKIEDLLTTKGIQVRTNAQVTAFSDTADNRLRVATADSEEIFDMAVIC
HHHHHHCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCEEEEEECCCHHHHHHHHHC
PGVIPQSELLAGQVNRTKQGAIVTDRYMGTSNPDIFAAGDVTEVNFNPTKEHAYMPLVSH
CCCCCHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEECCCEEEECCCCCCCHHHHHHHHH
AIRQGALAGINIFDKRLGAIGTQATTGMLIFDQTVACAGLTLTAAKAANFDAQAAFYEGN
HHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEECHHHHCCEEEEEHHHCCCCCCEEEECCC
YRPDFMPTTAKVMIELVYDQQTRKVLGGQLMSAHEVSQSANTLSVVIHNGNTIDELAFMD
CCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
MLFSPNFDEPFNYLNLVAQAAVDQEHGYRRNN
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKVAIIGCTHAGIAAMKQILKYYPGTEITVYERHADISYMSCGTYLHLGGTIHNLDQALY
CEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCEEEECCCHHHHHHHHC
ANPSEFSEQGVQMRMQYDVINVNADKHTILAQNLQTKELQTDHYDKLVMATGSITAIPAI
CCHHHHHHCCCEEEEEEEEEEECCCCCEEEECCCCHHHCCCCCCCEEEEECCCEEEECCC
PGVENPKVMLCKTCEQAQQLYEAAKHAHHIAIVGGGYSGVELAEGYVKSGHTVTLFQRGP
CCCCCCCEEEEHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCC
HLINEYLDPQISEKIEDLLTTKGIQVRTNAQVTAFSDTADNRLRVATADSEEIFDMAVIC
HHHHHHCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCEEEEEECCCHHHHHHHHHC
PGVIPQSELLAGQVNRTKQGAIVTDRYMGTSNPDIFAAGDVTEVNFNPTKEHAYMPLVSH
CCCCCHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEECCCEEEECCCCCCCHHHHHHHHH
AIRQGALAGINIFDKRLGAIGTQATTGMLIFDQTVACAGLTLTAAKAANFDAQAAFYEGN
HHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEECHHHHCCEEEEEHHHCCCCCCEEEECCC
YRPDFMPTTAKVMIELVYDQQTRKVLGGQLMSAHEVSQSANTLSVVIHNGNTIDELAFMD
CCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHH
MLFSPNFDEPFNYLNLVAQAAVDQEHGYRRNN
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]