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The map label for this gene is norA [H]

Identifier: 28377626

GI number: 28377626

Start: 703076

End: 704272

Strand: Direct

Name: norA [H]

Synonym: lp_0770

Alternate gene names: 28377626

Gene position: 703076-704272 (Clockwise)

Preceding gene: 28377624

Following gene: 28377627

Centisome position: 21.25

GC content: 45.28

Gene sequence:

>1197_bases
ATGGATCGACAAACACGACGCGCAATTTTAATTTTAGTTTTTAGTGAGTTTTTAGTTTGTTTAGGGATTAGTTTAGTTAT
TCCAGTCATGCCGTTTATTAAAAATGAACTGCATTTAACGGCTACCGATATGGGAATAATGAATGCGCTATTCGCATTGG
CACAATTTGTGGCCTCACCCATTATTGGCCGGGTTTCAGACAAAGTTGGTCGCAAGCCCGTATTAACGGTAGGGCTAGTC
TTATATATGGTCTCGGAAGTACTATTTGCGCTAACCAACCAGCTGTGGGTCTTTAATATTTCCCGGATTGTTGGTGGCTT
ATCAGCAGCGATGGTCGTTCCGACGGCGATGGCGTTAGCATCCGATATTACGACCAAACGACAGCGAGCTAAAGTAATTG
GCTGGTTATCGGCGGCCTTTAGTGGTGGCTTGATTTTAGGACCCGGTATCGGTGGGGTATTGGCTGGCATTAGTTATAAG
ACGCCGTTCTGGGTTGCTGGTGCATTGGGATTACTCAGTGCCATTGTGCTCGTCATTCTGTTGCCTGCGGATCGTCAGAT
TGATCCTGATCGCGAAGCAATTACGGCCACGACAACGACGACCAATCATCCGATGACGCGGGCATTTTGGACCGTCCCGA
TTATTATATTATTTACGATGATTTTAGTGTCTTCCTTTGGCTTACAGGGGTTTGAGAGCATTTATAGTATTTACGTGAAT
GAAGTCTTTCATTTTAGTCTGAGCAACATTGCGTTGGTCTTGACTTTAAATGGTTTGATTTCGCTCTTCCTACAGGTGGC
ACTATTTGATACCTTTGTCCAGCGTTGGGGCGAACGGCGGGTCATTCGGGTGTGCTTTGCAGCTGCGGCGCTCTGCACTA
TCTGGATTACGCAGGCTCATTCGAAAGTTGCTGTCATGGTTGCAACGCTCGTTATTTTTTCGGCATTCGATCTTTTGCGG
CCCGCTATTACGACCCTATTAACGAAAGCAAGTGAGGCCAACCAGGGGCTAATCAATGGGCTTAACATGTCCTTAACGAG
TGTTGGCAATATCGTTGGCCCAATCATGTCGGGGATGTTACTAGATATGAATTATCACTATCCATATCTAGTGGTGGCCG
GATTCTTGATTGTCTCTTATTTAATGGCGTTTATGTTACGATTACCGAACCAGGTTCATTCACATCAGCAAGTTTAA

Upstream 100 bases:

>100_bases
GTTGCAAATGGTGTCAAACTTTCTGCTAGCTTTCAATCCGGGTCCCTGATATGATGGAAAGCGGTGTAAATTTAACAATT
GATTGAAGAGGTGAGGTCGC

Downstream 100 bases:

>100_bases
CATTGCATAACAGTTAAGCTAATCAGCGAAAGCGCTCCGGGTTTGCGTCCCCGGGGCGCTTTTGTTACACTTAGGCCAAA
TTAGATTGAAGGATGGTGGG

Product: multidrug transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MDRQTRRAILILVFSEFLVCLGISLVIPVMPFIKNELHLTATDMGIMNALFALAQFVASPIIGRVSDKVGRKPVLTVGLV
LYMVSEVLFALTNQLWVFNISRIVGGLSAAMVVPTAMALASDITTKRQRAKVIGWLSAAFSGGLILGPGIGGVLAGISYK
TPFWVAGALGLLSAIVLVILLPADRQIDPDREAITATTTTTNHPMTRAFWTVPIIILFTMILVSSFGLQGFESIYSIYVN
EVFHFSLSNIALVLTLNGLISLFLQVALFDTFVQRWGERRVIRVCFAAAALCTIWITQAHSKVAVMVATLVIFSAFDLLR
PAITTLLTKASEANQGLINGLNMSLTSVGNIVGPIMSGMLLDMNYHYPYLVVAGFLIVSYLMAFMLRLPNQVHSHQQV

Sequences:

>Translated_398_residues
MDRQTRRAILILVFSEFLVCLGISLVIPVMPFIKNELHLTATDMGIMNALFALAQFVASPIIGRVSDKVGRKPVLTVGLV
LYMVSEVLFALTNQLWVFNISRIVGGLSAAMVVPTAMALASDITTKRQRAKVIGWLSAAFSGGLILGPGIGGVLAGISYK
TPFWVAGALGLLSAIVLVILLPADRQIDPDREAITATTTTTNHPMTRAFWTVPIIILFTMILVSSFGLQGFESIYSIYVN
EVFHFSLSNIALVLTLNGLISLFLQVALFDTFVQRWGERRVIRVCFAAAALCTIWITQAHSKVAVMVATLVIFSAFDLLR
PAITTLLTKASEANQGLINGLNMSLTSVGNIVGPIMSGMLLDMNYHYPYLVVAGFLIVSYLMAFMLRLPNQVHSHQQV
>Mature_398_residues
MDRQTRRAILILVFSEFLVCLGISLVIPVMPFIKNELHLTATDMGIMNALFALAQFVASPIIGRVSDKVGRKPVLTVGLV
LYMVSEVLFALTNQLWVFNISRIVGGLSAAMVVPTAMALASDITTKRQRAKVIGWLSAAFSGGLILGPGIGGVLAGISYK
TPFWVAGALGLLSAIVLVILLPADRQIDPDREAITATTTTTNHPMTRAFWTVPIIILFTMILVSSFGLQGFESIYSIYVN
EVFHFSLSNIALVLTLNGLISLFLQVALFDTFVQRWGERRVIRVCFAAAALCTIWITQAHSKVAVMVATLVIFSAFDLLR
PAITTLLTKASEANQGLINGLNMSLTSVGNIVGPIMSGMLLDMNYHYPYLVVAGFLIVSYLMAFMLRLPNQVHSHQQV

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI94721311, Length=330, Percent_Identity=22.4242424242424, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI39753965, Length=324, Percent_Identity=21.2962962962963, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787291, Length=386, Percent_Identity=25.6476683937824, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17551570, Length=343, Percent_Identity=23.9067055393586, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17738085, Length=338, Percent_Identity=23.6686390532544, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357569, Length=344, Percent_Identity=23.2558139534884, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI161080926, Length=351, Percent_Identity=22.7920227920228, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161080924, Length=351, Percent_Identity=22.7920227920228, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24656463, Length=351, Percent_Identity=22.7920227920228, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24656468, Length=351, Percent_Identity=22.7920227920228, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43350; Mature: 43350

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRQTRRAILILVFSEFLVCLGISLVIPVMPFIKNELHLTATDMGIMNALFALAQFVASP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHH
IIGRVSDKVGRKPVLTVGLVLYMVSEVLFALTNQLWVFNISRIVGGLSAAMVVPTAMALA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHH
SDITTKRQRAKVIGWLSAAFSGGLILGPGIGGVLAGISYKTPFWVAGALGLLSAIVLVIL
HHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LPADRQIDPDREAITATTTTTNHPMTRAFWTVPIIILFTMILVSSFGLQGFESIYSIYVN
CCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EVFHFSLSNIALVLTLNGLISLFLQVALFDTFVQRWGERRVIRVCFAAAALCTIWITQAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SKVAVMVATLVIFSAFDLLRPAITTLLTKASEANQGLINGLNMSLTSVGNIVGPIMSGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHCEE
LDMNYHYPYLVVAGFLIVSYLMAFMLRLPNQVHSHQQV
EECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure
MDRQTRRAILILVFSEFLVCLGISLVIPVMPFIKNELHLTATDMGIMNALFALAQFVASP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHH
IIGRVSDKVGRKPVLTVGLVLYMVSEVLFALTNQLWVFNISRIVGGLSAAMVVPTAMALA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHH
SDITTKRQRAKVIGWLSAAFSGGLILGPGIGGVLAGISYKTPFWVAGALGLLSAIVLVIL
HHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LPADRQIDPDREAITATTTTTNHPMTRAFWTVPIIILFTMILVSSFGLQGFESIYSIYVN
CCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EVFHFSLSNIALVLTLNGLISLFLQVALFDTFVQRWGERRVIRVCFAAAALCTIWITQAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SKVAVMVATLVIFSAFDLLRPAITTLLTKASEANQGLINGLNMSLTSVGNIVGPIMSGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHCEE
LDMNYHYPYLVVAGFLIVSYLMAFMLRLPNQVHSHQQV
EECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA