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The map label for this gene is gpsA

Identifier: 28377615

GI number: 28377615

Start: 690727

End: 691743

Strand: Direct

Name: gpsA

Synonym: lp_0756

Alternate gene names: 28377615

Gene position: 690727-691743 (Clockwise)

Preceding gene: 28377614

Following gene: 28377616

Centisome position: 20.88

GC content: 48.38

Gene sequence:

>1017_bases
ATGATGAAAAAAATTGCCGTTTTAGGTGCTGGCTCATGGGGTAGCATTTTGGCAAATCTGTTGGATGAAAATGGCCACTC
AGTGCGGCTCTGGTCGTACTCACCGGCCCAAGTCACAGAATTAAATGAGAAACACACGAATGAGCGATACGTTCCTGATT
TTAAATATTCAGAAACGTTGACTGCTTATTCTAATCTAACACAGGCGATTGATGGTGCGGATGTAATCTTGTTTGTCGTA
CCAACCAAAGCGATTCGCGAAGTGGCCCAACAAGTGACTGCCGTGCTTGCCAAGACCCATCAGCGGCCGATTATTGTGCA
TGCTAGCAAGGGACTCGAACAAGAGACACACAAGCGGCTGTCGCAAGTTTTGGCAGAAGAAATTCCCACCGAATTACGAC
AAGCGATCGTTGTCTTATCGGGCCCTAGTCATGCTGAAGAAGTGGCCCGCCACGATATTACGTTGATTACGGCGGCTAGC
GCCGATGAATCTGCAGCCGAATTAGTACAGCAACTCTTCATGAATGACTATTTCCGCATTTACACGAATACCGACGTGGT
TGGTGTTGAACTAGGTGCGGCGCTCAAAAATATCATTGCCCTGGGTGCTGGTGCGCTACACGGCCTGGGCTATGGTGATG
ACGCCAAGGCAGCCTTAATGACTCGTGGTTTAGCTGAAATCAGTCGGCTCGGAGTGGCGTTGGGCGCAGAGCCGTTGACA
TTTATCGGTTTATCCGGTGTAGGCGATTTAATTGTTACGGCAACTAGTGTCCATTCGCGTAACTGGCGTGCTGGTAATGA
GTTAGGTGCTGGTCAGGACCTCAAGACGGTGATTGATACCATGGGCATGGTTATTGAAGGTATCCCGTCAACTAAAGCCG
CTTACGAGCTTGCACAGCAACAAAATATCGAAATGCCCATCACTGAAGCGATTTATGATGTATTATATAAGAGTGCCGAC
ATTAAGGAAGTCATTCCACAATTGATGCGGCGCGAGGGGAAACCTGAGATTCAGTAG

Upstream 100 bases:

>100_bases
TGATCTGGCGCCGGCATCACAATCCGAATAATCGTTGGTATTTAGCGGGTTCTGGTCAAAAGGTTGTCGCAGAAAATAAG
TAGATTAGAGGGTTATTTGA

Downstream 100 bases:

>100_bases
GAATTTCCAAACTAATTTCACTATTTTTAGGAGGATTTATCACATGTCAAAAGTTAGAAAAGCCGTTATCCCAGCGGCCG
GATTAGGAACACGGTTTTTG

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MMKKIAVLGAGSWGSILANLLDENGHSVRLWSYSPAQVTELNEKHTNERYVPDFKYSETLTAYSNLTQAIDGADVILFVV
PTKAIREVAQQVTAVLAKTHQRPIIVHASKGLEQETHKRLSQVLAEEIPTELRQAIVVLSGPSHAEEVARHDITLITAAS
ADESAAELVQQLFMNDYFRIYTNTDVVGVELGAALKNIIALGAGALHGLGYGDDAKAALMTRGLAEISRLGVALGAEPLT
FIGLSGVGDLIVTATSVHSRNWRAGNELGAGQDLKTVIDTMGMVIEGIPSTKAAYELAQQQNIEMPITEAIYDVLYKSAD
IKEVIPQLMRREGKPEIQ

Sequences:

>Translated_338_residues
MMKKIAVLGAGSWGSILANLLDENGHSVRLWSYSPAQVTELNEKHTNERYVPDFKYSETLTAYSNLTQAIDGADVILFVV
PTKAIREVAQQVTAVLAKTHQRPIIVHASKGLEQETHKRLSQVLAEEIPTELRQAIVVLSGPSHAEEVARHDITLITAAS
ADESAAELVQQLFMNDYFRIYTNTDVVGVELGAALKNIIALGAGALHGLGYGDDAKAALMTRGLAEISRLGVALGAEPLT
FIGLSGVGDLIVTATSVHSRNWRAGNELGAGQDLKTVIDTMGMVIEGIPSTKAAYELAQQQNIEMPITEAIYDVLYKSAD
IKEVIPQLMRREGKPEIQ
>Mature_338_residues
MMKKIAVLGAGSWGSILANLLDENGHSVRLWSYSPAQVTELNEKHTNERYVPDFKYSETLTAYSNLTQAIDGADVILFVV
PTKAIREVAQQVTAVLAKTHQRPIIVHASKGLEQETHKRLSQVLAEEIPTELRQAIVVLSGPSHAEEVARHDITLITAAS
ADESAAELVQQLFMNDYFRIYTNTDVVGVELGAALKNIIALGAGALHGLGYGDDAKAALMTRGLAEISRLGVALGAEPLT
FIGLSGVGDLIVTATSVHSRNWRAGNELGAGQDLKTVIDTMGMVIEGIPSTKAAYELAQQQNIEMPITEAIYDVLYKSAD
IKEVIPQLMRREGKPEIQ

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI24307999, Length=347, Percent_Identity=28.8184438040346, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI33695088, Length=345, Percent_Identity=27.8260869565217, Blast_Score=134, Evalue=9e-32,
Organism=Escherichia coli, GI1790037, Length=339, Percent_Identity=42.7728613569322, Blast_Score=260, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI32564399, Length=275, Percent_Identity=31.2727272727273, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI193210136, Length=280, Percent_Identity=29.2857142857143, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32564403, Length=280, Percent_Identity=29.2857142857143, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17507425, Length=338, Percent_Identity=26.9230769230769, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193210134, Length=275, Percent_Identity=28, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324513, Length=358, Percent_Identity=28.2122905027933, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320181, Length=356, Percent_Identity=27.5280898876405, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136204, Length=330, Percent_Identity=27.8787878787879, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17136202, Length=330, Percent_Identity=27.8787878787879, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17136200, Length=330, Percent_Identity=27.8787878787879, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI22026922, Length=274, Percent_Identity=22.992700729927, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281362270, Length=265, Percent_Identity=26.4150943396226, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551945, Length=265, Percent_Identity=26.4150943396226, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648969, Length=217, Percent_Identity=26.2672811059908, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_LACPL (Q88YK1)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784507.1
- ProteinModelPortal:   Q88YK1
- SMR:   Q88YK1
- GeneID:   1063667
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0756
- NMPDR:   fig|220668.1.peg.641
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   LPLA220668:LP_0756-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36579; Mature: 36579

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 196-196 BINDING 110-110 BINDING 110-110 BINDING 145-145 BINDING 260-260 BINDING 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKIAVLGAGSWGSILANLLDENGHSVRLWSYSPAQVTELNEKHTNERYVPDFKYSETL
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHH
TAYSNLTQAIDGADVILFVVPTKAIREVAQQVTAVLAKTHQRPIIVHASKGLEQETHKRL
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHH
SQVLAEEIPTELRQAIVVLSGPSHAEEVARHDITLITAASADESAAELVQQLFMNDYFRI
HHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCEEE
YTNTDVVGVELGAALKNIIALGAGALHGLGYGDDAKAALMTRGLAEISRLGVALGAEPLT
EECCCEEEHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCE
FIGLSGVGDLIVTATSVHSRNWRAGNELGAGQDLKTVIDTMGMVIEGIPSTKAAYELAQQ
EEECCCCCHHHEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QNIEMPITEAIYDVLYKSADIKEVIPQLMRREGKPEIQ
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMKKIAVLGAGSWGSILANLLDENGHSVRLWSYSPAQVTELNEKHTNERYVPDFKYSETL
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHH
TAYSNLTQAIDGADVILFVVPTKAIREVAQQVTAVLAKTHQRPIIVHASKGLEQETHKRL
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHH
SQVLAEEIPTELRQAIVVLSGPSHAEEVARHDITLITAASADESAAELVQQLFMNDYFRI
HHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCEEE
YTNTDVVGVELGAALKNIIALGAGALHGLGYGDDAKAALMTRGLAEISRLGVALGAEPLT
EECCCEEEHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCE
FIGLSGVGDLIVTATSVHSRNWRAGNELGAGQDLKTVIDTMGMVIEGIPSTKAAYELAQQ
EEECCCCCHHHEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QNIEMPITEAIYDVLYKSADIKEVIPQLMRREGKPEIQ
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566