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The map label for this gene is hisD [H]

Identifier: 28199153

GI number: 28199153

Start: 1476039

End: 1477334

Strand: Reverse

Name: hisD [H]

Synonym: PD1267

Alternate gene names: 28199153

Gene position: 1477334-1476039 (Counterclockwise)

Preceding gene: 28199154

Following gene: 28199152

Centisome position: 58.63

GC content: 60.57

Gene sequence:

>1296_bases
ATGAAAATCATTGATTGGAACCAACTTGATACTGCGGCCCAGGCCAAGACACTGACCCGTCCCGCGCAGACCATCGCCAC
ACAAACCCGTGAGGCCGTTACCGCCTTAATTGAACAAGTGCGTCGCGGCGGTGATACTGCCTTGCGTGACATCACCGCCC
GCTTTGATGGTGTTGACCTGGCCACGTTTGAGGTTACTGCGGCCGAGCTGGCCGCTGCGGCCACGGCCGTTGCCCCAGAA
CTACAGCACGCCATGCAGACAGCCGCAGCCCGGATCGAAGCCTTCCACCGTGCCGGAATGACTAACGACTATCGTGTGGA
AACGGCGCCCGGTGTGGTGTGTGAACGGCTAGTACGTCCGATCGCCCGCGTGGGCTTGTACGTCCCTGCCGGCAGCGCCC
CGTTATTTTCAACGGCCTTAATGCTGGGTGTCCCCGCACGGCTGGCCGGCTGCCGTGAAGTCGTCTTGTGTACCCCACCC
TCTAAAGATGGCCGTGCCAATCCGGCGGTCCTGCTGGCCGCACGTCTTACCGGAGTCACACGCGTCTTCACACTGGGCGG
CGCCCAGGCCATTGCGGCGATGGCTTACGGTACCGCAAGCGTTCCCACCTGTGACAAAGTGTTTGGCCCTGGAAATAGCT
TTGTCACCGAAGCCAAACAACAGCTTGCACAAGCCGGCGTCGTCGCAATCGACATGCCGGCAGGCCCCTCGGAGGTCCTG
GTGATCGCTGATGCCGCCGCCAATCCTGCGTTTATCGCTGCTGATCTCCTCTCCCAAGCAGAACACGGCCCGGATTCCCA
AGTCCTCCTGTTATCTGACAGTGATGCACTGATGACAGCGGTACAGAATGCCCTTGCTCTCCAATTGCAGCAGCTATCCC
GTGCCGAGATAGCGCGTCAGGCCTTAGCGCACTCCAGGTTCATTAAAGTGGCCACCCTGGAGACTGCCTTTGACATCAGC
AACCGCTATGCGCCCGAACATTTGATTTTGGCATTGCGCCAACCGCGTGCCTGGCTGCATCGCGTCGCAGCCGCCGGTTC
CGTCTTCCTTGGCGACTACACCCCCGAAGCCCTGGGTGACTATTGCAGCGGTACTAACCACGTCTTGCCCACCGGCGGTG
CAGCCCGCGCCTATAGCGGCGTGAGCGTCTCCAGCTTCCAAAACATGATCAGCGTCCAAGCGGCCAGCCGCAGCGGTATT
GCTGAAATTGGCGGCTGTGCATTGACCTTGGCGCGTGCCGAAGGATTGGATGCACACGCCAATGCTGTCGCCTTACGGAT
GGGATCAGCCCCATGA

Upstream 100 bases:

>100_bases
AGACTATGTGTCATGGCACCATCACCTGGCAGCGTTTGGAAGAACTGGAACGTGCTGGTGCTCAGGGCTTGATGGTATTG
ACAGTAGAGCGATCCCTCGC

Downstream 100 bases:

>100_bases
ACGCACAGACCCATACGGTCCTTGACCTGGTACGTCAAGAACTACGCAGCTTTGCTGGCTACTCCTCCGCGCGCAGTGTC
GCTTTGACCGGTGACCTCTG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDLATFEVTAAELAAAATAVAPE
LQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRPIARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPP
SKDGRANPAVLLAARLTGVTRVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLAQAGVVAIDMPAGPSEVL
VIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIARQALAHSRFIKVATLETAFDIS
NRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGDYCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGI
AEIGGCALTLARAEGLDAHANAVALRMGSAP

Sequences:

>Translated_431_residues
MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDLATFEVTAAELAAAATAVAPE
LQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRPIARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPP
SKDGRANPAVLLAARLTGVTRVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLAQAGVVAIDMPAGPSEVL
VIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIARQALAHSRFIKVATLETAFDIS
NRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGDYCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGI
AEIGGCALTLARAEGLDAHANAVALRMGSAP
>Mature_431_residues
MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDLATFEVTAAELAAAATAVAPE
LQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRPIARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPP
SKDGRANPAVLLAARLTGVTRVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLAQAGVVAIDMPAGPSEVL
VIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIARQALAHSRFIKVATLETAFDIS
NRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGDYCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGI
AEIGGCALTLARAEGLDAHANAVALRMGSAP

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=428, Percent_Identity=50.7009345794392, Blast_Score=418, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319819, Length=425, Percent_Identity=46.5882352941176, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44840; Mature: 44840

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEE
ATFEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRP
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
IARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVT
HHHHCEECCCCCCHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCCCCCCEEEHHHHHHHH
RVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLAQAGVVAIDMPAGPSEVL
HHEECCCHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCEE
VIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIARQ
EEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAHSRFIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGD
HHHHHHEEEEEEHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCCHHHHHH
YCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGGCALTLARAEGLDAHA
HHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHEEEEHHCCCCCCC
NAVALRMGSAP
CEEEEEECCCC
>Mature Secondary Structure
MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEE
ATFEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRP
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
IARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVT
HHHHCEECCCCCCHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCCCCCCEEEHHHHHHHH
RVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLAQAGVVAIDMPAGPSEVL
HHEECCCHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCEE
VIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIARQ
EEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAHSRFIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGD
HHHHHHEEEEEEHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHCCCEEECCCCHHHHHH
YCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGGCALTLARAEGLDAHA
HHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHEEEEHHCCCCCCC
NAVALRMGSAP
CEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]