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The map label for this gene is hisG

Identifier: 28199154

GI number: 28199154

Start: 1477331

End: 1478245

Strand: Reverse

Name: hisG

Synonym: PD1268

Alternate gene names: 28199154

Gene position: 1478245-1477331 (Counterclockwise)

Preceding gene: 28199155

Following gene: 28199153

Centisome position: 58.67

GC content: 58.58

Gene sequence:

>915_bases
ATGAGTGCGTCCACCGCATTACCGGTACGCGATCGACTGCGTATTGCGATTCAAAAAAGTGGGCGTTTGACAGAACCGGC
CCGCCGCCTCCTGACGGCTTGCGGACTGAGCTGGCGTCAGAGCCGCGACAAACTGTTTTGCTACGGTGAATCGCTGCCGG
TGGATCTATTGTTGGTGCGCGATGACGACATCCCCGGCTTGATTGCCCAGGGCGTGTGCGACCTTGGCATCGTGGGTCGT
AATGAACTGGATGAACAGGCAGCCTCACGGCGCCGCAACGGCCTCCCCGTTCCTTACCAAACCCTACGTGGACTGCACTT
TGGCCAATGCCGACTCATGCTTGCGGTGCCTGAAGAATGGGAGTGGCAAGACATATCGCAATTGACAGGCAAGCGCATCG
CCACCAGCTACCCCGCAATCTTGGCCGACTGGCTACAGACACATCACATTGCTGCACAGATCGTCGAACTCTCCGGCTCG
GTCGAAATCGCCCCACGCCTGGGTACCGCTGACCTCATCTGTGATTTAGTGTCCTCCGGCGCCACATTGGCTGCTCACCA
ACTCAAACCCGTCATCCAGATCATGGAGAGCCAAGCCGTGCTTGCCGGCATGATCTGCCAACCTGCCGATGCCCGTGCCG
GACTCTTGGCCATGCTGCTGCGGCGCATTGATGGCATGGTCAACCTGCGTGACAGCAACTTACTGATGTTCCGTGCCTTC
CAAGAACACCTGGACGCCTTGACCCGCTTACTGCCCGATGCCGACCCATTGGTACAGCTACCCGATGACGGCAGCGGCAC
CCTACGCGTGCAGACTATGTGTCATGGCACCATCACCTGGCAGCGTTTGGAAGAACTGGAACGTGCTGGTGCTCAGGGCT
TGATGGTATTGACAGTAGAGCGATCCCTCGCATGA

Upstream 100 bases:

>100_bases
TCGGCCGTGTCGCGCGTTGCCTTGAACACGGTACCGGCGGCTATGCAGCGGTATTGCAGGCCCAGGCCATGCCTCCTGCC
AGCTCCATTGAGAAACCACA

Downstream 100 bases:

>100_bases
AAATCATTGATTGGAACCAACTTGATACTGCGGCCCAGGCCAAGACACTGACCCGTCCCGCGCAGACCATCGCCACACAA
ACCCGTGAGGCCGTTACCGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSASTALPVRDRLRIAIQKSGRLTEPARRLLTACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIAQGVCDLGIVGR
NELDEQAASRRRNGLPVPYQTLRGLHFGQCRLMLAVPEEWEWQDISQLTGKRIATSYPAILADWLQTHHIAAQIVELSGS
VEIAPRLGTADLICDLVSSGATLAAHQLKPVIQIMESQAVLAGMICQPADARAGLLAMLLRRIDGMVNLRDSNLLMFRAF
QEHLDALTRLLPDADPLVQLPDDGSGTLRVQTMCHGTITWQRLEELERAGAQGLMVLTVERSLA

Sequences:

>Translated_304_residues
MSASTALPVRDRLRIAIQKSGRLTEPARRLLTACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIAQGVCDLGIVGR
NELDEQAASRRRNGLPVPYQTLRGLHFGQCRLMLAVPEEWEWQDISQLTGKRIATSYPAILADWLQTHHIAAQIVELSGS
VEIAPRLGTADLICDLVSSGATLAAHQLKPVIQIMESQAVLAGMICQPADARAGLLAMLLRRIDGMVNLRDSNLLMFRAF
QEHLDALTRLLPDADPLVQLPDDGSGTLRVQTMCHGTITWQRLEELERAGAQGLMVLTVERSLA
>Mature_303_residues
SASTALPVRDRLRIAIQKSGRLTEPARRLLTACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIAQGVCDLGIVGRN
ELDEQAASRRRNGLPVPYQTLRGLHFGQCRLMLAVPEEWEWQDISQLTGKRIATSYPAILADWLQTHHIAAQIVELSGSV
EIAPRLGTADLICDLVSSGATLAAHQLKPVIQIMESQAVLAGMICQPADARAGLLAMLLRRIDGMVNLRDSNLLMFRAFQ
EHLDALTRLLPDADPLVQLPDDGSGTLRVQTMCHGTITWQRLEELERAGAQGLMVLTVERSLA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=43.3447098976109, Blast_Score=223, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6320896, Length=298, Percent_Identity=28.8590604026846, Blast_Score=115, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_XYLF2 (B2I5Y2)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830045.1
- ProteinModelPortal:   B2I5Y2
- SMR:   B2I5Y2
- GeneID:   6202759
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1353
- HOGENOM:   HBG391868
- OMA:   LLMFRAE
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 33468; Mature: 33337

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASTALPVRDRLRIAIQKSGRLTEPARRLLTACGLSWRQSRDKLFCYGESLPVDLLLVR
CCCCCCCCHHHHHEEEEECCCCCCHHHHHHHHHHCCHHHCCCCCEEEECCCCCEEEEEEE
DDDIPGLIAQGVCDLGIVGRNELDEQAASRRRNGLPVPYQTLRGLHFGQCRLMLAVPEEW
CCCCCCHHHHCCHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCC
EWQDISQLTGKRIATSYPAILADWLQTHHIAAQIVELSGSVEIAPRLGTADLICDLVSSG
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCC
ATLAAHQLKPVIQIMESQAVLAGMICQPADARAGLLAMLLRRIDGMVNLRDSNLLMFRAF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHH
QEHLDALTRLLPDADPLVQLPDDGSGTLRVQTMCHGTITWQRLEELERAGAQGLMVLTVE
HHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEC
RSLA
CCCC
>Mature Secondary Structure 
SASTALPVRDRLRIAIQKSGRLTEPARRLLTACGLSWRQSRDKLFCYGESLPVDLLLVR
CCCCCCCHHHHHEEEEECCCCCCHHHHHHHHHHCCHHHCCCCCEEEECCCCCEEEEEEE
DDDIPGLIAQGVCDLGIVGRNELDEQAASRRRNGLPVPYQTLRGLHFGQCRLMLAVPEEW
CCCCCCHHHHCCHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEECCCCC
EWQDISQLTGKRIATSYPAILADWLQTHHIAAQIVELSGSVEIAPRLGTADLICDLVSSG
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCC
ATLAAHQLKPVIQIMESQAVLAGMICQPADARAGLLAMLLRRIDGMVNLRDSNLLMFRAF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHH
QEHLDALTRLLPDADPLVQLPDDGSGTLRVQTMCHGTITWQRLEELERAGAQGLMVLTVE
HHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEC
RSLA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA