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The map label for this gene is hisC

Identifier: 28199152

GI number: 28199152

Start: 1474945

End: 1476042

Strand: Reverse

Name: hisC

Synonym: PD1266

Alternate gene names: 28199152

Gene position: 1476042-1474945 (Counterclockwise)

Preceding gene: 28199153

Following gene: 28199151

Centisome position: 58.58

GC content: 62.02

Gene sequence:

>1098_bases
ATGAACGCACAGACCCATACGGTCCTTGACCTGGTACGTCAAGAACTACGCAGCTTTGCTGGCTACTCCTCCGCGCGCAG
TGTCGCTTTGACCGGTGACCTCTGGCTCAATGCCAACGAATCGGCCTGGCCCAATCCCGCTGACTCCCACGCCACCATGC
GACGTTATCCAGAACCGCAACCGCCCAAGTTGCGCCAGATGCTGGCGGCACTCTACGGCTGTCTTCCCGAGCAAGTATTG
ATTGGTCGTGGCAGTGATGAAGGGATCGACTTACTGGTACGCGCCGTGTGCGAACCGAGACGTGATCCCGTCCTGGTCAC
CCCCCCGGTGTTCGGCATGTATGCCGTTTCCGCACAGTTGCAGAACGCCCCATTGATCCAAGTCCCTTTAGTTGATGACG
CCGCGGGCTTCCATGCCGACGTGCCTGCGATCATCACTGCCGCACAGACCTCCCGCGCCAAACTCGTGTTCTTGTGCTCA
CCCTCCAATCCGGTCGGTGCCGCGATCCCGCTACAGCAGATTGAGACCATCTTGCAGACACTTGCCGGCACTGCTCTCGT
CGTGGTGGATGAAGCTTACGGAGAATTCTCCGATGTCCCTTCCGTGGTGCCCCTGCTGGCCCGCTACCCACATCTTGTCG
TGCTGCGTACCTTGTCCAAAGCCCATGCCCTGGCTGCTGTGCGTATCGGCAGCGTGATCGCCGATGCCCATTTAGTCGCG
GTATTACGTCGCTGCCAAGCACCGTATCCCTTGCCCACCCCCTGCGTGAGCTTGGCTGAGCAGGGGCTGTCAGCCGCCGC
GTTACACGTTACCGCACAGCGTGTGGCCGAGATCCGTGCTGAGCGTGAGCGCCTGCGTGCCGCCCTGGCCTGTCTGTCTG
GCGTGCGCCGCGTCTATCCCTCCCAAGGGAACTTCCTCCTGGTGCGCTTTGATGATGCCGAGGCCGCGTTTCAGGCGCTG
TACGCCGCTGGCGTCGTCGTGCGCGACCAGCGTGCCGCACCGCAGTTGCATGATGCCTTGCGGCTGACCGTGGGAACCCC
CGAACAAAACACACGTCTCCTGGCCGTGTTGCGTGACATCCAGGCGGTGCCCGCATGA

Upstream 100 bases:

>100_bases
GCGGTATTGCTGAAATTGGCGGCTGTGCATTGACCTTGGCGCGTGCCGAAGGATTGGATGCACACGCCAATGCTGTCGCC
TTACGGATGGGATCAGCCCC

Downstream 100 bases:

>100_bases
CCCCCATCGTGTTTATTGACCGTGACGGCACGCTCATTGAAGAGCCGCCTGATTTTCAGATTGATGCCTACGAAAAACTG
CGCCTTGTCAACGGCGTGAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNAQTHTVLDLVRQELRSFAGYSSARSVALTGDLWLNANESAWPNPADSHATMRRYPEPQPPKLRQMLAALYGCLPEQVL
IGRGSDEGIDLLVRAVCEPRRDPVLVTPPVFGMYAVSAQLQNAPLIQVPLVDDAAGFHADVPAIITAAQTSRAKLVFLCS
PSNPVGAAIPLQQIETILQTLAGTALVVVDEAYGEFSDVPSVVPLLARYPHLVVLRTLSKAHALAAVRIGSVIADAHLVA
VLRRCQAPYPLPTPCVSLAEQGLSAAALHVTAQRVAEIRAERERLRAALACLSGVRRVYPSQGNFLLVRFDDAEAAFQAL
YAAGVVVRDQRAAPQLHDALRLTVGTPEQNTRLLAVLRDIQAVPA

Sequences:

>Translated_365_residues
MNAQTHTVLDLVRQELRSFAGYSSARSVALTGDLWLNANESAWPNPADSHATMRRYPEPQPPKLRQMLAALYGCLPEQVL
IGRGSDEGIDLLVRAVCEPRRDPVLVTPPVFGMYAVSAQLQNAPLIQVPLVDDAAGFHADVPAIITAAQTSRAKLVFLCS
PSNPVGAAIPLQQIETILQTLAGTALVVVDEAYGEFSDVPSVVPLLARYPHLVVLRTLSKAHALAAVRIGSVIADAHLVA
VLRRCQAPYPLPTPCVSLAEQGLSAAALHVTAQRVAEIRAERERLRAALACLSGVRRVYPSQGNFLLVRFDDAEAAFQAL
YAAGVVVRDQRAAPQLHDALRLTVGTPEQNTRLLAVLRDIQAVPA
>Mature_365_residues
MNAQTHTVLDLVRQELRSFAGYSSARSVALTGDLWLNANESAWPNPADSHATMRRYPEPQPPKLRQMLAALYGCLPEQVL
IGRGSDEGIDLLVRAVCEPRRDPVLVTPPVFGMYAVSAQLQNAPLIQVPLVDDAAGFHADVPAIITAAQTSRAKLVFLCS
PSNPVGAAIPLQQIETILQTLAGTALVVVDEAYGEFSDVPSVVPLLARYPHLVVLRTLSKAHALAAVRIGSVIADAHLVA
VLRRCQAPYPLPTPCVSLAEQGLSAAALHVTAQRVAEIRAERERLRAALACLSGVRRVYPSQGNFLLVRFDDAEAAFQAL
YAAGVVVRDQRAAPQLHDALRLTVGTPEQNTRLLAVLRDIQAVPA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=42.8571428571429, Blast_Score=286, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6322075, Length=373, Percent_Identity=33.5120643431635, Blast_Score=189, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_XYLF2 (B2I5Y0)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830043.1
- ProteinModelPortal:   B2I5Y0
- SMR:   B2I5Y0
- GeneID:   6202228
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1351
- HOGENOM:   HBG646350
- OMA:   IMRVIAP
- ProtClustDB:   PRK04781
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39244; Mature: 39244

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQTHTVLDLVRQELRSFAGYSSARSVALTGDLWLNANESAWPNPADSHATMRRYPEPQ
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCCCC
PPKLRQMLAALYGCLPEQVLIGRGSDEGIDLLVRAVCEPRRDPVLVTPPVFGMYAVSAQL
CHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
QNAPLIQVPLVDDAAGFHADVPAIITAAQTSRAKLVFLCSPSNPVGAAIPLQQIETILQT
CCCCEEEEECCCCCCCCCCCCCHHEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
LAGTALVVVDEAYGEFSDVPSVVPLLARYPHLVVLRTLSKAHALAAVRIGSVIADAHLVA
HCCCEEEEEECHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRRCQAPYPLPTPCVSLAEQGLSAAALHVTAQRVAEIRAERERLRAALACLSGVRRVYP
HHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQGNFLLVRFDDAEAAFQALYAAGVVVRDQRAAPQLHDALRLTVGTPEQNTRLLAVLRDI
CCCCEEEEEECCHHHHHHHHHHHCEEEECCCCCHHHHHHEEEEECCCCCCHHHHHHHHHH
QAVPA
HHCCC
>Mature Secondary Structure
MNAQTHTVLDLVRQELRSFAGYSSARSVALTGDLWLNANESAWPNPADSHATMRRYPEPQ
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCCCC
PPKLRQMLAALYGCLPEQVLIGRGSDEGIDLLVRAVCEPRRDPVLVTPPVFGMYAVSAQL
CHHHHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
QNAPLIQVPLVDDAAGFHADVPAIITAAQTSRAKLVFLCSPSNPVGAAIPLQQIETILQT
CCCCEEEEECCCCCCCCCCCCCHHEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHH
LAGTALVVVDEAYGEFSDVPSVVPLLARYPHLVVLRTLSKAHALAAVRIGSVIADAHLVA
HCCCEEEEEECHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRRCQAPYPLPTPCVSLAEQGLSAAALHVTAQRVAEIRAERERLRAALACLSGVRRVYP
HHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQGNFLLVRFDDAEAAFQALYAAGVVVRDQRAAPQLHDALRLTVGTPEQNTRLLAVLRDI
CCCCEEEEEECCHHHHHHHHHHHCEEEECCCCCHHHHHHEEEEECCCCCCHHHHHHHHHH
QAVPA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA