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The map label for this gene is uvrB

Identifier: 62185531

GI number: 62185531

Start: 1085938

End: 1087908

Strand: Direct

Name: uvrB

Synonym: CAB931

Alternate gene names: 62185531

Gene position: 1085938-1087908 (Clockwise)

Preceding gene: 62185530

Following gene: 62185532

Centisome position: 94.89

GC content: 42.21

Gene sequence:

>1971_bases
ATGACCTTTGAATTACGCGCTGCTTTTTCGCCTTGTGGAGATCAGCCCGAAGCTATTGCTAAACTCACGCAAGGCGTACG
TAATCGCACGCCATCTCAGGTGTTGTTAGGCACTACAGGATCAGGGAAAACATTTACCATTGCTAATGTTGTTGCTAATG
TCAATCGCCCTACGCTCGTATTAGCACATAATAAAACATTAGCTGCACAGTTGTATCAAGAATTCAAAGAATTCTTCCCT
AATAATGCTGTTGAATACTTTATCTCTTACTACGATTATTACCAACCTGAAGCCTATATTGCCCGTAATGATACCTACAT
AGAAAAAAGTCTCTTAATCAACAGTGAAATCGATAAACTGCGTTTATCCGCAACGCGATCTATTCTAGAGCGTAGAGATA
CTTTAATTGTTTCTTCTGTATCTTGTATTTATGGTATTGGCTCTCCCGAAAACTACACTTCCATGGCATTAGAACTCACA
GTGGGCACGGAATATCCCAGAGCACTACTAGCCTCTCAGCTTGTAAAAATGCATTATCAAGCTTCCTCAGTCCCCCAACG
CTCAACTTTTCGCGAACGCGGTAGTGTGATCGATATTTTCCCTGCGTATGAGAGCGAGCTCGCCATTCGTTTAGAATTTT
TCAATGACACATTAACTTCCATAGACTACAGCGATCCTCTCACTATGATGCCTAAGGAATCGGTCACCTCAGTGATTTTA
TATCCGGGATCCCACTATGTCACTCCTGAAGCTGTTCGCGAACAAGCGATACGCTCTATACGAGAAGAGCTAGAAGAACG
TTTAGCATTCTTCCAAGATCGTCCTATAGAACAAGATCGCTTATTCCATAGAACGACTCACGATATCGAAATGATCAAAG
AAACCGGATTTTGTAAAGGTATAGAAAACTATTCTCGCCACTTTACAAACACGCCTCCGGGAGCGCCTCCCACCTGCCTA
TTAGACTATTTCCCCGAGGACTTCTTACTGGTTATTGATGAATCACACCAAACATTACCGCAGATACGCGCTATGTACCG
CGGAGACTTTTCTAGGAAACAATCTTTAGTAGAATACGGCTTTCGTCTTCCCTCTGCTTATGACAACCGCCCTCTAACCT
ATGAAGAAGCTAGGAAATATTTCCATAATGTGATTTATGTATCTGCTACTCCTGGAGAGACAGAACTCAACGAAAGTCAA
GGTCATATTGTCGAACAGATTCTCCGCCCTACAGGAATTCCTGACCCTATTCCAGAAATCCGTCCGGCAACAGGGCAAGT
AGACGATCTCCTAGAAGAAATTCGCAAACGCTTATCTAAATCTCAGGAAAAGATTCTCGTCATCTCCATCACCAAAAAGC
TTGCCGAGGATATCGCAGCTTTCCTTTCAGAATTAGATATTGCTGCCGCCTACTTACATTCTGGCATAGAAACAGCAGAG
CGTACGCGTATTCTCTCTGACTTGCGTTTAGGGAATATTGACGTGCTCATAGGTGTCAACTTACTTCGTGAAGGCTTAGA
TCTCCCTGAAGTTTCTTTAGTTGCTATTCTTGATGCCGATAAGGAAGGTTTTCTACGTAGCACTTCGTCCTTAATACAGT
TTTGTGGAAGAGCTGCACGAAATGTGGATGGGAAAGTCATTTTTTATGCTGACCACAAAACTCTCTCTATAGAACAAACC
TTAAAAGAAACAGAGCGTCGTCGGCACATACAGTTGGAATACAATAAAGCAAATAACATTACACCAAAACCCATCATCAA
AGCGATCTTTGCCAATCCCATTCCGCAAGGGGGAAAAAAGGCAGTGCAAGACACTCCGCAAAAACCTTTATCTACGCAAG
AATTAGAAAAGCTTATAAAAAAATACGAAAATCTCATGCTGCAAGCGGCCAACGCGTTCAGATTTGATGAAGCTGCTCAA
TACCGTGATAAAATGAAAGCTGCTAAAGAACAACTTCTTTATCTCTCATAA

Upstream 100 bases:

>100_bases
GCGTGCTGTAGCCAAAGAAACCATGGAAGAAGTCCATGACACCTTAGGGTTAAGCCATAAATGGCGCTCTCGTTTACTAC
CTTAATTGCTATATGCTCCT

Downstream 100 bases:

>100_bases
CACATGAAAAACAACCGAAATGAAATCTGCTTGCTTTTTGTAAAATCAGAACCTAATATTGCCTTAATCTCCCCGCAACC
TCATGGTGATCATATGATCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MTFELRAAFSPCGDQPEAIAKLTQGVRNRTPSQVLLGTTGSGKTFTIANVVANVNRPTLVLAHNKTLAAQLYQEFKEFFP
NNAVEYFISYYDYYQPEAYIARNDTYIEKSLLINSEIDKLRLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALELT
VGTEYPRALLASQLVKMHYQASSVPQRSTFRERGSVIDIFPAYESELAIRLEFFNDTLTSIDYSDPLTMMPKESVTSVIL
YPGSHYVTPEAVREQAIRSIREELEERLAFFQDRPIEQDRLFHRTTHDIEMIKETGFCKGIENYSRHFTNTPPGAPPTCL
LDYFPEDFLLVIDESHQTLPQIRAMYRGDFSRKQSLVEYGFRLPSAYDNRPLTYEEARKYFHNVIYVSATPGETELNESQ
GHIVEQILRPTGIPDPIPEIRPATGQVDDLLEEIRKRLSKSQEKILVISITKKLAEDIAAFLSELDIAAAYLHSGIETAE
RTRILSDLRLGNIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAARNVDGKVIFYADHKTLSIEQT
LKETERRRHIQLEYNKANNITPKPIIKAIFANPIPQGGKKAVQDTPQKPLSTQELEKLIKKYENLMLQAANAFRFDEAAQ
YRDKMKAAKEQLLYLS

Sequences:

>Translated_656_residues
MTFELRAAFSPCGDQPEAIAKLTQGVRNRTPSQVLLGTTGSGKTFTIANVVANVNRPTLVLAHNKTLAAQLYQEFKEFFP
NNAVEYFISYYDYYQPEAYIARNDTYIEKSLLINSEIDKLRLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALELT
VGTEYPRALLASQLVKMHYQASSVPQRSTFRERGSVIDIFPAYESELAIRLEFFNDTLTSIDYSDPLTMMPKESVTSVIL
YPGSHYVTPEAVREQAIRSIREELEERLAFFQDRPIEQDRLFHRTTHDIEMIKETGFCKGIENYSRHFTNTPPGAPPTCL
LDYFPEDFLLVIDESHQTLPQIRAMYRGDFSRKQSLVEYGFRLPSAYDNRPLTYEEARKYFHNVIYVSATPGETELNESQ
GHIVEQILRPTGIPDPIPEIRPATGQVDDLLEEIRKRLSKSQEKILVISITKKLAEDIAAFLSELDIAAAYLHSGIETAE
RTRILSDLRLGNIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAARNVDGKVIFYADHKTLSIEQT
LKETERRRHIQLEYNKANNITPKPIIKAIFANPIPQGGKKAVQDTPQKPLSTQELEKLIKKYENLMLQAANAFRFDEAAQ
YRDKMKAAKEQLLYLS
>Mature_655_residues
TFELRAAFSPCGDQPEAIAKLTQGVRNRTPSQVLLGTTGSGKTFTIANVVANVNRPTLVLAHNKTLAAQLYQEFKEFFPN
NAVEYFISYYDYYQPEAYIARNDTYIEKSLLINSEIDKLRLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALELTV
GTEYPRALLASQLVKMHYQASSVPQRSTFRERGSVIDIFPAYESELAIRLEFFNDTLTSIDYSDPLTMMPKESVTSVILY
PGSHYVTPEAVREQAIRSIREELEERLAFFQDRPIEQDRLFHRTTHDIEMIKETGFCKGIENYSRHFTNTPPGAPPTCLL
DYFPEDFLLVIDESHQTLPQIRAMYRGDFSRKQSLVEYGFRLPSAYDNRPLTYEEARKYFHNVIYVSATPGETELNESQG
HIVEQILRPTGIPDPIPEIRPATGQVDDLLEEIRKRLSKSQEKILVISITKKLAEDIAAFLSELDIAAAYLHSGIETAER
TRILSDLRLGNIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAARNVDGKVIFYADHKTLSIEQTL
KETERRRHIQLEYNKANNITPKPIIKAIFANPIPQGGKKAVQDTPQKPLSTQELEKLIKKYENLMLQAANAFRFDEAAQY
RDKMKAAKEQLLYLS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=670, Percent_Identity=51.3432835820895, Blast_Score=658, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CHLAB (Q5L4S6)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220316.1
- ProteinModelPortal:   Q5L4S6
- GeneID:   3338239
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB931
- HOGENOM:   HBG703949
- OMA:   EKDLAIN
- ProtClustDB:   PRK05298
- BioCyc:   CABO218497:CAB931-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 74485; Mature: 74353

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFELRAAFSPCGDQPEAIAKLTQGVRNRTPSQVLLGTTGSGKTFTIANVVANVNRPTLV
CCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHCCCCCEEE
LAHNKTLAAQLYQEFKEFFPNNAVEYFISYYDYYQPEAYIARNDTYIEKSLLINSEIDKL
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCHHHH
RLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALELTVGTEYPRALLASQLVKMHYQ
HHHHHHHHHHHHHHHEEEEHHHHEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
ASSVPQRSTFRERGSVIDIFPAYESELAIRLEFFNDTLTSIDYSDPLTMMPKESVTSVIL
HCCCCCHHHHHHCCCEEEEECCCCCCEEEEEEECCCHHHCCCCCCCCCCCCCCCCCEEEE
YPGSHYVTPEAVREQAIRSIREELEERLAFFQDRPIEQDRLFHRTTHDIEMIKETGFCKG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
IENYSRHFTNTPPGAPPTCLLDYFPEDFLLVIDESHQTLPQIRAMYRGDFSRKQSLVEYG
HHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
FRLPSAYDNRPLTYEEARKYFHNVIYVSATPGETELNESQGHIVEQILRPTGIPDPIPEI
CCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
RPATGQVDDLLEEIRKRLSKSQEKILVISITKKLAEDIAAFLSELDIAAAYLHSGIETAE
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTRILSDLRLGNIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAAR
HHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHC
NVDGKVIFYADHKTLSIEQTLKETERRRHIQLEYNKANNITPKPIIKAIFANPIPQGGKK
CCCCEEEEEECCCEEEHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCH
AVQDTPQKPLSTQELEKLIKKYENLMLQAANAFRFDEAAQYRDKMKAAKEQLLYLS
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TFELRAAFSPCGDQPEAIAKLTQGVRNRTPSQVLLGTTGSGKTFTIANVVANVNRPTLV
CEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHCCCCCEEE
LAHNKTLAAQLYQEFKEFFPNNAVEYFISYYDYYQPEAYIARNDTYIEKSLLINSEIDKL
EECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCHHHH
RLSATRSILERRDTLIVSSVSCIYGIGSPENYTSMALELTVGTEYPRALLASQLVKMHYQ
HHHHHHHHHHHHHHHEEEEHHHHEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
ASSVPQRSTFRERGSVIDIFPAYESELAIRLEFFNDTLTSIDYSDPLTMMPKESVTSVIL
HCCCCCHHHHHHCCCEEEEECCCCCCEEEEEEECCCHHHCCCCCCCCCCCCCCCCCEEEE
YPGSHYVTPEAVREQAIRSIREELEERLAFFQDRPIEQDRLFHRTTHDIEMIKETGFCKG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCC
IENYSRHFTNTPPGAPPTCLLDYFPEDFLLVIDESHQTLPQIRAMYRGDFSRKQSLVEYG
HHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHH
FRLPSAYDNRPLTYEEARKYFHNVIYVSATPGETELNESQGHIVEQILRPTGIPDPIPEI
CCCCCCCCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
RPATGQVDDLLEEIRKRLSKSQEKILVISITKKLAEDIAAFLSELDIAAAYLHSGIETAE
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTRILSDLRLGNIDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSTSSLIQFCGRAAR
HHHHHHHHCCCCEEEEEEHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHC
NVDGKVIFYADHKTLSIEQTLKETERRRHIQLEYNKANNITPKPIIKAIFANPIPQGGKK
CCCCEEEEEECCCEEEHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCH
AVQDTPQKPLSTQELEKLIKKYENLMLQAANAFRFDEAAQYRDKMKAAKEQLLYLS
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA