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The map label for this gene is gpmA

Identifier: 62185474

GI number: 62185474

Start: 1016074

End: 1016757

Strand: Direct

Name: gpmA

Synonym: CAB872

Alternate gene names: 62185474

Gene position: 1016074-1016757 (Clockwise)

Preceding gene: 62185471

Following gene: 62185475

Centisome position: 88.79

GC content: 40.5

Gene sequence:

>684_bases
ATGGCCTTTCTTATCTTATTACGACACGGGAAATCCGTCTGGAATGAAAAAAACCTTTTTACAGGATGGGTGGATATTCC
CCTAAGTCAAAAAGGTATTGACGAAGCAATGCTTGCAGGCGAAGCCATCAAAGACCTTCCCATAGATTGCATCTTTACCT
CCTCTCTTGTGCGAAGTTTAATGACGGCATTGCTTGCTATGACGCATCACAACTCTAAAAAAATCCCTTACATTGTTCAC
GATGATCCTGAACAAAAGCACATGAGTAAGATCTATAGTGATGAAGTCAACCACATGATCCCACTGTACCGTTCTAGCGC
ACTCAATGAAAGAATGTACGGGGAACTCCAAGGAAAAAATAAAAAAAAAACCGCTGAGCAATTTGGGGAGGAGCAAGTAA
AATTGTGGCGACGTAGTTATAAGACCGCCCCTCCTAATGGCGAAAGTCTTTATGATACTGGGCAACGCACCATCCCCTAT
TTTCAGGAAACTATTTTCCCTTTGTTGCAGAATTCAAAAAATGTATTTGTATCTGCACATGGAAATTCCTTACGTTCACT
CATTATGGATATAGAAAAATTAAGTGAAGAAGAGGTACACTCCTTGGAGTTACCTACAGGAAAACCCATAGTATATTTAT
GGACCGGTCACACATTCGAACGACATCCAGAGTTATTTGGTTAA

Upstream 100 bases:

>100_bases
TCTTTATTATAAAAAAATGTTGTCTGGGGAAAATCTTTCTTCTGGACAAAAGTTTTTTTGTTCCTATGCTAGTTTTCTTA
ATCTCATTACTCAAGAAGCC

Downstream 100 bases:

>100_bases
ACAACCAACAAGCGATTCCTCCTTCTGCTTCAGTGAGGGGGAGCTTTGAAACCTATGCCGATCCCTTTTCCTTGATACCC
TCTTCAGCAATCAAGCTCCT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MAFLILLRHGKSVWNEKNLFTGWVDIPLSQKGIDEAMLAGEAIKDLPIDCIFTSSLVRSLMTALLAMTHHNSKKIPYIVH
DDPEQKHMSKIYSDEVNHMIPLYRSSALNERMYGELQGKNKKKTAEQFGEEQVKLWRRSYKTAPPNGESLYDTGQRTIPY
FQETIFPLLQNSKNVFVSAHGNSLRSLIMDIEKLSEEEVHSLELPTGKPIVYLWTGHTFERHPELFG

Sequences:

>Translated_227_residues
MAFLILLRHGKSVWNEKNLFTGWVDIPLSQKGIDEAMLAGEAIKDLPIDCIFTSSLVRSLMTALLAMTHHNSKKIPYIVH
DDPEQKHMSKIYSDEVNHMIPLYRSSALNERMYGELQGKNKKKTAEQFGEEQVKLWRRSYKTAPPNGESLYDTGQRTIPY
FQETIFPLLQNSKNVFVSAHGNSLRSLIMDIEKLSEEEVHSLELPTGKPIVYLWTGHTFERHPELFG
>Mature_226_residues
AFLILLRHGKSVWNEKNLFTGWVDIPLSQKGIDEAMLAGEAIKDLPIDCIFTSSLVRSLMTALLAMTHHNSKKIPYIVHD
DPEQKHMSKIYSDEVNHMIPLYRSSALNERMYGELQGKNKKKTAEQFGEEQVKLWRRSYKTAPPNGESLYDTGQRTIPYF
QETIFPLLQNSKNVFVSAHGNSLRSLIMDIEKLSEEEVHSLELPTGKPIVYLWTGHTFERHPELFG

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=238, Percent_Identity=36.1344537815126, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI4505753, Length=239, Percent_Identity=36.8200836820084, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI4502445, Length=239, Percent_Identity=35.1464435146443, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI40353764, Length=239, Percent_Identity=35.1464435146443, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI71274132, Length=242, Percent_Identity=35.5371900826446, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI310129614, Length=140, Percent_Identity=37.8571428571429, Blast_Score=91, Evalue=8e-19,
Organism=Escherichia coli, GI1786970, Length=236, Percent_Identity=38.135593220339, Blast_Score=155, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322697, Length=239, Percent_Identity=37.2384937238494, Blast_Score=151, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320183, Length=262, Percent_Identity=26.7175572519084, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324516, Length=261, Percent_Identity=24.1379310344828, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646216, Length=239, Percent_Identity=38.0753138075314, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI85725270, Length=239, Percent_Identity=35.5648535564854, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI85725272, Length=239, Percent_Identity=35.5648535564854, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24650981, Length=239, Percent_Identity=35.5648535564854, Blast_Score=148, Evalue=2e-36,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_CHLAB (Q5L4Y3)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220259.1
- ProteinModelPortal:   Q5L4Y3
- SMR:   Q5L4Y3
- GeneID:   3338019
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB872
- HOGENOM:   HBG658938
- OMA:   IRTLWFV
- PhylomeDB:   Q5L4Y3
- ProtClustDB:   PRK01112
- BioCyc:   CABO218497:CAB872-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 26073; Mature: 25942

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFLILLRHGKSVWNEKNLFTGWVDIPLSQKGIDEAMLAGEAIKDLPIDCIFTSSLVRSL
CEEEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
MTALLAMTHHNSKKIPYIVHDDPEQKHMSKIYSDEVNHMIPLYRSSALNERMYGELQGKN
HHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KKKTAEQFGEEQVKLWRRSYKTAPPNGESLYDTGQRTIPYFQETIFPLLQNSKNVFVSAH
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEC
GNSLRSLIMDIEKLSEEEVHSLELPTGKPIVYLWTGHTFERHPELFG
CHHHHHHHHHHHHHCHHHHHEEECCCCCCEEEEEECCCHHCCCCCCC
>Mature Secondary Structure 
AFLILLRHGKSVWNEKNLFTGWVDIPLSQKGIDEAMLAGEAIKDLPIDCIFTSSLVRSL
EEEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
MTALLAMTHHNSKKIPYIVHDDPEQKHMSKIYSDEVNHMIPLYRSSALNERMYGELQGKN
HHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KKKTAEQFGEEQVKLWRRSYKTAPPNGESLYDTGQRTIPYFQETIFPLLQNSKNVFVSAH
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEC
GNSLRSLIMDIEKLSEEEVHSLELPTGKPIVYLWTGHTFERHPELFG
CHHHHHHHHHHHHHCHHHHHEEECCCCCCEEEEEECCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA