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The map label for this gene is iscS [H]

Identifier: 62185475

GI number: 62185475

Start: 1016712

End: 1017869

Strand: Direct

Name: iscS [H]

Synonym: CAB873

Alternate gene names: 62185475

Gene position: 1016712-1017869 (Clockwise)

Preceding gene: 62185474

Following gene: 62185476

Centisome position: 88.84

GC content: 44.04

Gene sequence:

>1158_bases
ATGGACCGGTCACACATTCGAACGACATCCAGAGTTATTTGGTTAAACAACCAACAAGCGATTCCTCCTTCTGCTTCAGT
GAGGGGGAGCTTTGAAACCTATGCCGATCCCTTTTCCTTGATACCCTCTTCAGCAATCAAGCTCCTGAATGAAACTGAAG
AGGCTGTCCGTAAGCTGGTCGGTTGTTCTAAAGAAACGCACACGTTTCATTTTCTTCCACATTTCCCTCATGCTGTTATG
ATTATTGTAGCGGCATTATTAGAGAATCTGACTTTTTTCCAGGGGAGGAATCACCTTCTGATTTCTTCTCATGAACAGCA
ATATCATATCGACGCGATTTGCCGCCGCCAAGGTTTGGGAACTACTTATGATTGGGTAACGATCAACTCGTCGGGAAGAC
TCTCTCCGGAACAACTTACAGAAGCATTAACACCACGCACTTTATTATTTTCATTATCTGCAGCTAACGGCATGACGGGG
CTGATCGAACCTATAGAGACATTACAGCCCTTATGTCAGGATCGGGGGGTTATCTTGCACTTAGATCTCTCTGATATTTT
AGGACGTGCCACGGTAACTCCAGAAATGCTGCATGCCGATATCCTAACGTTTTCTTCTCTAGCTTTAGGAGGCATTGGGA
ACATCGGAGGAATGTTCATTAAAAAATCCCTGAGTAAGTTTTTCGATTTATGGTTACCTTCTAACTCTCCAGGAACATTG
TGTTTAGGTTCTGTAGCCGCGATGAAAACGGCTTGTCAAGAACGCGCATCTTCTTTGTCCTCACTCATCTTACAATCGAT
AAATCTAAGAAGCAAACTGACGAAAGAACTCCAAGCAGCGTGTCCTGACGTGCAATTTCTTTTCCCTGAGTTAGAAAATA
AACTTCCCAATGTCATGCTCGCCGCTATAGAGGATACCCCTGCAGAGAGCTTAGCTTTCTTCCTGCATCAACAAGGCATC
TATCCCGGGCTGGGTTACGAACGCTTCCAACCTATATCTCAAATCTTACAAAATTGTGGTGTATCGCCTTTTCTCTGTCA
TAGTACCCTACACTTTTCCTTTACAGAGAGAACGAAAGATGAACAGTTTACTACCTTAGGGCATGTTATCCAAGAGGGTA
TTGCCCACCTAAAATCTGCAATTGCGAGCTCCGTATGA

Upstream 100 bases:

>100_bases
ATGGAAATTCCTTACGTTCACTCATTATGGATATAGAAAAATTAAGTGAAGAAGAGGTACACTCCTTGGAGTTACCTACA
GGAAAACCCATAGTATATTT

Downstream 100 bases:

>100_bases
CAATTCCATTTCAACCTGTCGCCTCTTGGGCAAACGTATCTCCAAAAGTGATGAAGAAGTTTCACAAGTTTTACTGTGGG
GGAACATTTTCCGCTGAAGA

Product: putative cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDRSHIRTTSRVIWLNNQQAIPPSASVRGSFETYADPFSLIPSSAIKLLNETEEAVRKLVGCSKETHTFHFLPHFPHAVM
IIVAALLENLTFFQGRNHLLISSHEQQYHIDAICRRQGLGTTYDWVTINSSGRLSPEQLTEALTPRTLLFSLSAANGMTG
LIEPIETLQPLCQDRGVILHLDLSDILGRATVTPEMLHADILTFSSLALGGIGNIGGMFIKKSLSKFFDLWLPSNSPGTL
CLGSVAAMKTACQERASSLSSLILQSINLRSKLTKELQAACPDVQFLFPELENKLPNVMLAAIEDTPAESLAFFLHQQGI
YPGLGYERFQPISQILQNCGVSPFLCHSTLHFSFTERTKDEQFTTLGHVIQEGIAHLKSAIASSV

Sequences:

>Translated_385_residues
MDRSHIRTTSRVIWLNNQQAIPPSASVRGSFETYADPFSLIPSSAIKLLNETEEAVRKLVGCSKETHTFHFLPHFPHAVM
IIVAALLENLTFFQGRNHLLISSHEQQYHIDAICRRQGLGTTYDWVTINSSGRLSPEQLTEALTPRTLLFSLSAANGMTG
LIEPIETLQPLCQDRGVILHLDLSDILGRATVTPEMLHADILTFSSLALGGIGNIGGMFIKKSLSKFFDLWLPSNSPGTL
CLGSVAAMKTACQERASSLSSLILQSINLRSKLTKELQAACPDVQFLFPELENKLPNVMLAAIEDTPAESLAFFLHQQGI
YPGLGYERFQPISQILQNCGVSPFLCHSTLHFSFTERTKDEQFTTLGHVIQEGIAHLKSAIASSV
>Mature_385_residues
MDRSHIRTTSRVIWLNNQQAIPPSASVRGSFETYADPFSLIPSSAIKLLNETEEAVRKLVGCSKETHTFHFLPHFPHAVM
IIVAALLENLTFFQGRNHLLISSHEQQYHIDAICRRQGLGTTYDWVTINSSGRLSPEQLTEALTPRTLLFSLSAANGMTG
LIEPIETLQPLCQDRGVILHLDLSDILGRATVTPEMLHADILTFSSLALGGIGNIGGMFIKKSLSKFFDLWLPSNSPGTL
CLGSVAAMKTACQERASSLSSLILQSINLRSKLTKELQAACPDVQFLFPELENKLPNVMLAAIEDTPAESLAFFLHQQGI
YPGLGYERFQPISQILQNCGVSPFLCHSTLHFSFTERTKDEQFTTLGHVIQEGIAHLKSAIASSV

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=308, Percent_Identity=22.0779220779221, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI48994898, Length=302, Percent_Identity=21.523178807947, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=294, Percent_Identity=22.7891156462585, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319831, Length=298, Percent_Identity=20.8053691275168, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017773
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42412; Mature: 42412

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSHIRTTSRVIWLNNQQAIPPSASVRGSFETYADPFSLIPSSAIKLLNETEEAVRKLV
CCCCHHCCCCEEEEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GCSKETHTFHFLPHFPHAVMIIVAALLENLTFFQGRNHLLISSHEQQYHIDAICRRQGLG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCC
TTYDWVTINSSGRLSPEQLTEALTPRTLLFSLSAANGMTGLIEPIETLQPLCQDRGVILH
CEEEEEEECCCCCCCHHHHHHHHCCHHHEEEEHHCCCCHHHHHHHHHHHHHHHCCCEEEE
LDLSDILGRATVTPEMLHADILTFSSLALGGIGNIGGMFIKKSLSKFFDLWLPSNSPGTL
EEHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
CLGSVAAMKTACQERASSLSSLILQSINLRSKLTKELQAACPDVQFLFPELENKLPNVML
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEE
AAIEDTPAESLAFFLHQQGIYPGLGYERFQPISQILQNCGVSPFLCHSTLHFSFTERTKD
EEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHEEEEHHHCCH
EQFTTLGHVIQEGIAHLKSAIASSV
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRSHIRTTSRVIWLNNQQAIPPSASVRGSFETYADPFSLIPSSAIKLLNETEEAVRKLV
CCCCHHCCCCEEEEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
GCSKETHTFHFLPHFPHAVMIIVAALLENLTFFQGRNHLLISSHEQQYHIDAICRRQGLG
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCC
TTYDWVTINSSGRLSPEQLTEALTPRTLLFSLSAANGMTGLIEPIETLQPLCQDRGVILH
CEEEEEEECCCCCCCHHHHHHHHCCHHHEEEEHHCCCCHHHHHHHHHHHHHHHCCCEEEE
LDLSDILGRATVTPEMLHADILTFSSLALGGIGNIGGMFIKKSLSKFFDLWLPSNSPGTL
EEHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCE
CLGSVAAMKTACQERASSLSSLILQSINLRSKLTKELQAACPDVQFLFPELENKLPNVML
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEE
AAIEDTPAESLAFFLHQQGIYPGLGYERFQPISQILQNCGVSPFLCHSTLHFSFTERTKD
EEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHEEEEHHHCCH
EQFTTLGHVIQEGIAHLKSAIASSV
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA