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The map label for this gene is pncB [H]

Identifier: 23097841

GI number: 23097841

Start: 409388

End: 410851

Strand: Direct

Name: pncB [H]

Synonym: OB0386

Alternate gene names: 23097841

Gene position: 409388-410851 (Clockwise)

Preceding gene: 23097840

Following gene: 23097842

Centisome position: 11.28

GC content: 36.41

Gene sequence:

>1464_bases
ATGAATTACATTGATGACAGCTTGGCATTACATACGGATTTATATCAAATTAATATGGCAGAAACATATTGGAATGACGA
TGTTCATAATAGGAAAGCAGTGTTTGATCTATATTTCCGCAGCCTTCCATTTGGAAACGGATATGGAGTGTATGCTGGTT
TAGAACGGATAATCGAGTATATGAATAATTTTCGATTTACAGATGCAGATCTAACTTATTTAAAAGAGATTGGTTATCAA
GATGACTTTATCGAATATTTAAAAAGTATACGCTTCACTGGTACGATTAAGTCAATGAAAGAAGGGGAAATCGTATTTGC
CAATGAGCCGATTCTTCGTGTAGAGGCTAGTCTTGCTGAGGCGCAATTATTAGAAACAGCTTTATTAAATATTGTTAATT
ACCAAACGCTTATTGCTACCAAAGCATCGCGTATTCGCCAGCTTGTAGGAGATCAGCTTGTAATGGAATTTGGAACGAGA
AGAGCGCAGGAAATGGATGCAGCAGTTTGGGGTACTCGCGCTGCATTTATTGGAGGCTTTAGTGCAACGAGTAATGTCCG
TGCAGGCAAATTATTTGGTATTCCTGTCTCAGGAACCCATGCGCACTCGATGATTCAGGCGTATCGAGATGAATATAAAG
CGTTTATGAAGTACGCCGAACGACACAAAGACTGTGTGTTTCTTGTTGATACATACGATACATTACGTTCAGGAGTTCCG
AACGCTATTAAAGCTGCAAAAGAGCTAGGGGATAGTATTAATTTCCAAGGAATACGATTAGACAGCGGAGATTTAGCTTA
TTTATCAAAAGAAGCAAGAAGAATGCTTGATGAAGCTGGTTTTCCAGATGCAAAAATTTATGCATCGAATGATTTAGATG
AATATACGATTGCAAGTCTTCTCGCACAGGGAGCGAAGATTGATGTGTGGGGAATTGGAACAAAGCTGATTACTGCGTAT
GATCAACCTGCACTAGGTGCAGTATATAAACTTGTGTCTATTGAAGATGAAAATGGGGATATGAAAGATACCATTAAATT
ATCAGGAAATCCAGAAAAAATGACAACACCTGCTATGAAAAAGGTTTACCGAATTATAAATAAGGAAAATCAACATAGTG
AAGGAGATTATCTCACGCTGGAAAATGAGTATCCAAATGAACAAGAAGAAGTGATGTTATTCCATCCGGTGCATACTTAC
TATAAAAAGTTTGTTTCTAATTTTGAAGCTGTAAATCTCCATCATGATATTTTCATTGATGGACAACTTGTTTATGAATG
TCCTGATTTGGCAGAGATTCAATTATTTACTGAAAATCAACTTAATTTATTCTGGGACGAGTATAAAAGAACAAACTATC
CGGCTGAGTATCCGGTCGATTTAAGTGAAGCATTATGGAATAATAAGATGAATCATATTGAACGAGTGAAACAAGCAGTA
AAAGATAAAATTAATAAACGATAA

Upstream 100 bases:

>100_bases
TTTACGAATCAAGTAATTGTACCATCTATCTGGGAATAAATTGATTTTGCGCTTATGAATCCATAGAAAGTAGCGCATTC
TATAATTTAGGAGGAAAACA

Downstream 100 bases:

>100_bases
ATTAAGGAGGAAAATGCATGAGTGATTTACAAAAAACGATCATTGAAGATTTGCATGTTGAACCTGAAATTGATCCGAAA
CAAGAAATTCGTACGCGAGT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MNYIDDSLALHTDLYQINMAETYWNDDVHNRKAVFDLYFRSLPFGNGYGVYAGLERIIEYMNNFRFTDADLTYLKEIGYQ
DDFIEYLKSIRFTGTIKSMKEGEIVFANEPILRVEASLAEAQLLETALLNIVNYQTLIATKASRIRQLVGDQLVMEFGTR
RAQEMDAAVWGTRAAFIGGFSATSNVRAGKLFGIPVSGTHAHSMIQAYRDEYKAFMKYAERHKDCVFLVDTYDTLRSGVP
NAIKAAKELGDSINFQGIRLDSGDLAYLSKEARRMLDEAGFPDAKIYASNDLDEYTIASLLAQGAKIDVWGIGTKLITAY
DQPALGAVYKLVSIEDENGDMKDTIKLSGNPEKMTTPAMKKVYRIINKENQHSEGDYLTLENEYPNEQEEVMLFHPVHTY
YKKFVSNFEAVNLHHDIFIDGQLVYECPDLAEIQLFTENQLNLFWDEYKRTNYPAEYPVDLSEALWNNKMNHIERVKQAV
KDKINKR

Sequences:

>Translated_487_residues
MNYIDDSLALHTDLYQINMAETYWNDDVHNRKAVFDLYFRSLPFGNGYGVYAGLERIIEYMNNFRFTDADLTYLKEIGYQ
DDFIEYLKSIRFTGTIKSMKEGEIVFANEPILRVEASLAEAQLLETALLNIVNYQTLIATKASRIRQLVGDQLVMEFGTR
RAQEMDAAVWGTRAAFIGGFSATSNVRAGKLFGIPVSGTHAHSMIQAYRDEYKAFMKYAERHKDCVFLVDTYDTLRSGVP
NAIKAAKELGDSINFQGIRLDSGDLAYLSKEARRMLDEAGFPDAKIYASNDLDEYTIASLLAQGAKIDVWGIGTKLITAY
DQPALGAVYKLVSIEDENGDMKDTIKLSGNPEKMTTPAMKKVYRIINKENQHSEGDYLTLENEYPNEQEEVMLFHPVHTY
YKKFVSNFEAVNLHHDIFIDGQLVYECPDLAEIQLFTENQLNLFWDEYKRTNYPAEYPVDLSEALWNNKMNHIERVKQAV
KDKINKR
>Mature_487_residues
MNYIDDSLALHTDLYQINMAETYWNDDVHNRKAVFDLYFRSLPFGNGYGVYAGLERIIEYMNNFRFTDADLTYLKEIGYQ
DDFIEYLKSIRFTGTIKSMKEGEIVFANEPILRVEASLAEAQLLETALLNIVNYQTLIATKASRIRQLVGDQLVMEFGTR
RAQEMDAAVWGTRAAFIGGFSATSNVRAGKLFGIPVSGTHAHSMIQAYRDEYKAFMKYAERHKDCVFLVDTYDTLRSGVP
NAIKAAKELGDSINFQGIRLDSGDLAYLSKEARRMLDEAGFPDAKIYASNDLDEYTIASLLAQGAKIDVWGIGTKLITAY
DQPALGAVYKLVSIEDENGDMKDTIKLSGNPEKMTTPAMKKVYRIINKENQHSEGDYLTLENEYPNEQEEVMLFHPVHTY
YKKFVSNFEAVNLHHDIFIDGQLVYECPDLAEIQLFTENQLNLFWDEYKRTNYPAEYPVDLSEALWNNKMNHIERVKQAV
KDKINKR

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=518, Percent_Identity=32.046332046332, Blast_Score=259, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI71997952, Length=528, Percent_Identity=36.5530303030303, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI71997947, Length=528, Percent_Identity=36.5530303030303, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI71997955, Length=213, Percent_Identity=44.6009389671362, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24581587, Length=518, Percent_Identity=36.6795366795367, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=43.6274509803922, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=43.6274509803922, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=43.6274509803922, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=43.6274509803922, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=43.6274509803922, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55737; Mature: 55737

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYIDDSLALHTDLYQINMAETYWNDDVHNRKAVFDLYFRSLPFGNGYGVYAGLERIIEY
CCCCCCHHHHHHHHEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MNNFRFTDADLTYLKEIGYQDDFIEYLKSIRFTGTIKSMKEGEIVFANEPILRVEASLAE
HHCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCEECCCCCCCCEEEECCCCEEEHHHHHH
AQLLETALLNIVNYQTLIATKASRIRQLVGDQLVMEFGTRRAQEMDAAVWGTRAAFIGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
SATSNVRAGKLFGIPVSGTHAHSMIQAYRDEYKAFMKYAERHKDCVFLVDTYDTLRSGVP
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCC
NAIKAAKELGDSINFQGIRLDSGDLAYLSKEARRMLDEAGFPDAKIYASNDLDEYTIASL
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
LAQGAKIDVWGIGTKLITAYDQPALGAVYKLVSIEDENGDMKDTIKLSGNPEKMTTPAMK
HHCCCEEEEEECCCEEEEECCCCHHHHHEEEEEEECCCCCCCEEEEECCCCCCCCCHHHH
KVYRIINKENQHSEGDYLTLENEYPNEQEEVMLFHPVHTYYKKFVSNFEAVNLHHDIFID
HHHHHHCCCCCCCCCCEEEECCCCCCCHHCEEEEEHHHHHHHHHHCCCEEEEEEEEEEEC
GQLVYECPDLAEIQLFTENQLNLFWDEYKRTNYPAEYPVDLSEALWNNKMNHIERVKQAV
CEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHH
KDKINKR
HHHHCCC
>Mature Secondary Structure
MNYIDDSLALHTDLYQINMAETYWNDDVHNRKAVFDLYFRSLPFGNGYGVYAGLERIIEY
CCCCCCHHHHHHHHEEEEEHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MNNFRFTDADLTYLKEIGYQDDFIEYLKSIRFTGTIKSMKEGEIVFANEPILRVEASLAE
HHCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCEECCCCCCCCEEEECCCCEEEHHHHHH
AQLLETALLNIVNYQTLIATKASRIRQLVGDQLVMEFGTRRAQEMDAAVWGTRAAFIGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
SATSNVRAGKLFGIPVSGTHAHSMIQAYRDEYKAFMKYAERHKDCVFLVDTYDTLRSGVP
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHCCCC
NAIKAAKELGDSINFQGIRLDSGDLAYLSKEARRMLDEAGFPDAKIYASNDLDEYTIASL
HHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
LAQGAKIDVWGIGTKLITAYDQPALGAVYKLVSIEDENGDMKDTIKLSGNPEKMTTPAMK
HHCCCEEEEEECCCEEEEECCCCHHHHHEEEEEEECCCCCCCEEEEECCCCCCCCCHHHH
KVYRIINKENQHSEGDYLTLENEYPNEQEEVMLFHPVHTYYKKFVSNFEAVNLHHDIFID
HHHHHHCCCCCCCCCCEEEECCCCCCCHHCEEEEEHHHHHHHHHHCCCEEEEEEEEEEEC
GQLVYECPDLAEIQLFTENQLNLFWDEYKRTNYPAEYPVDLSEALWNNKMNHIERVKQAV
CEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHH
KDKINKR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]