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The map label for this gene is lsrK [H]

Identifier: 22127635

GI number: 22127635

Start: 4186325

End: 4187956

Strand: Reverse

Name: lsrK [H]

Synonym: y3764

Alternate gene names: 22127635

Gene position: 4187956-4186325 (Counterclockwise)

Preceding gene: 22127636

Following gene: 22127634

Centisome position: 91.03

GC content: 54.35

Gene sequence:

>1632_bases
GTGACGCCAAATAAGCAGGGTATTCAAGAGGAGCGCGCAATGAGTCAACTCGATACGACTACCCCATCAGGTGATTACTT
GATGGCGCTGGATGCCGGTACCGGCAGTGTCCGGGCGGTGATATTTGATCTTAATGGTAATCAGATTGCCGCCGGGCAGG
CGGAGTGGCTGCATCTGCCGGTACCCGATGTTCCGGGGTCGATGGAGTTTGATTTAACCACCAATTGGCAACTCACGTGC
CAGTGTATCCGCCAGGCACTGCATTTGGCTAAGTTACCGGCCAGTGCTATCCGTGCTGTCGCTGCCTGTTCAATGCGTGA
AGGGATCGTACTCTATGATCGCAGTGGAACCCCGATCTGGGCCTGTGCCAATGTGGATGCTCGCGCCAGCCGTGAAGTCA
GCGAATTAAAAGAGCTGCACAATAATGGATTTGAGTTAGAAGTCTATCAATGCTCCGGCCAGACGCTGGCACTGAGTGCC
ATGCCCCGGTTGTTGTGGTTGGCGCACTATCGGCCCGATATTTATCGTCAGGCAGGAACACTGACCATGATCAGTGACTG
GCTGGCCAATATGCTCAGTGGGGAGCTGGCGGTCGATCCCTCCAACGCGGGGACCACGGGTATGCTGGATCTCGTCACCC
GTAACTGGCAACCGAACTTGCTGGAAATGGCCGGGTTACGTGCGGATATTCTCTCGCCAGTGAAAGAGACAGGCACCTTG
CTGGGCCATGTCACGGCGAAGGCCGCGCAAGAATGTGGTTTGCTGGCCGGAACGCCGGTGGTGATGGGCGGTGGCGATGT
ACAACTGGGTTGTTTGGGGTTGGGAGTGGTGCACGCAGGCCAGACGGCGGTATTGGGCGGTACTTTCTGGCAGCAGGTGG
TTAATTTACCGCAGCCGATTATTGATCCCAATATGAATACCCGAATAAACCCTCATGTTATCCCCGGTATGGTTCAGGCG
GAGTCCATCAGCTTCTTTACTGGTCTGACAATGCGCTGGTTCCGTGATGCGTTTTGCGCCGAAGAAAAATTACTGGCGCA
GCGATTGGGGATTGATACCTACAGTTTATTGGAGGATATGGCCGCCAGGGTTCCCGCCGGTGCTTATGGGGTTATGCCTA
TCTTCTCTGATGTGATGCGGTTTAAATCTTGGTATCACGCTGCGCCTTCATTTATTAACCTCTCACTCGATCCTGAAAAA
TGTAATAAAGCCACGTTATTCCGTGCGCTGGAAGAGAATGCGGCCATCGTCTCGGCCTGTAATTTAGCGCAAATTGCTGA
ATTCTCTGGCGTGAAAGCCTCGTCGGTGGTTTTTGCTGGCGGTGGCGCGAAAGGCAAACTGTGGAGCCAGATTCTGGCTG
ATGTCACCGGTGTTCCGGTGAAGGTGCCGGTGGTCAAAGAAGCAACCGCATTAGGCTGCGCGATTGCCGCCGGTGTTGGT
GTCGGCCTATATGAAGCATTGGATAAAACCGGCGAGCGGCTCGTGCGCTGGGAGCGGGAATACATCCCGAATACTGAGCA
TAAAGCGCTCTATCAAGCGGCAAAAACTAACTGGCAAGCGGTGTATACCGATCAACTGGGGCTGGTGGATTGTGGGTTGA
CGACGTCTCTTTGGAAGGCTCCTTGCCTCTAA

Upstream 100 bases:

>100_bases
GAGATTGGGCAGTGCTCGTGACCGTCACAGACTGTGTGTAGGCTCCGATCTCTGCGCGCGGTCCCACAGGCAACTTGAAA
TATGACGGGTAAACACTGCG

Downstream 100 bases:

>100_bases
AATGGATTATCTTCATTAATTGACTATCTTCATTCATTAACTATTTTGATTAATTAACTAGCTTGATTAATTAATAGCGA
AAAGCGGCCAGCTTGCGCTT

Product: autoinducer-2 (AI-2) kinase

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MTPNKQGIQEERAMSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLTTNWQLTC
QCIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSA
MPRLLWLAHYRPDIYRQAGTLTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTL
LGHVTAKAAQECGLLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHVIPGMVQA
ESISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEK
CNKATLFRALEENAAIVSACNLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVG
VGLYEALDKTGERLVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPCL

Sequences:

>Translated_543_residues
MTPNKQGIQEERAMSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLTTNWQLTC
QCIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSA
MPRLLWLAHYRPDIYRQAGTLTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTL
LGHVTAKAAQECGLLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHVIPGMVQA
ESISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEK
CNKATLFRALEENAAIVSACNLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVG
VGLYEALDKTGERLVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPCL
>Mature_542_residues
TPNKQGIQEERAMSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLPVPDVPGSMEFDLTTNWQLTCQ
CIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIWACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSAM
PRLLWLAHYRPDIYRQAGTLTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTLL
GHVTAKAAQECGLLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPIIDPNMNTRINPHVIPGMVQAE
SISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDMAARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEKC
NKATLFRALEENAAIVSACNLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVGV
GLYEALDKTGERLVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKAPCL

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2 [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=477, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787789, Length=530, Percent_Identity=78.3018867924528, Blast_Score=869, Evalue=0.0,
Organism=Escherichia coli, GI1790005, Length=501, Percent_Identity=25.1497005988024, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790361, Length=496, Percent_Identity=25.8064516129032, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789168, Length=493, Percent_Identity=23.1237322515213, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1789138, Length=525, Percent_Identity=23.4285714285714, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789987, Length=522, Percent_Identity=24.5210727969349, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535599, Length=462, Percent_Identity=25.5411255411255, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 58525; Mature: 58394

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPNKQGIQEERAMSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLP
CCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCCEEEEC
VPDVPGSMEFDLTTNWQLTCQCIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIW
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCEE
ACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPDIYRQAGT
EECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHCCCHHHHHCCC
LTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTL
HHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHH
LGHVTAKAAQECGLLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPI
HHHHHHHHHHHCCCEECCCEEECCCCEEEEEEEEEHEECCCEEEECHHHHHHHHCCCCCC
IDPNMNTRINPHVIPGMVQAESISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDM
CCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEENAAIVSAC
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHHHHHHCCHHHHHC
NLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVG
CHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCC
VGLYEALDKTGERLVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHCC
PCL
CCC
>Mature Secondary Structure 
TPNKQGIQEERAMSQLDTTTPSGDYLMALDAGTGSVRAVIFDLNGNQIAAGQAEWLHLP
CCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCCEEEEC
VPDVPGSMEFDLTTNWQLTCQCIRQALHLAKLPASAIRAVAACSMREGIVLYDRSGTPIW
CCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCEE
ACANVDARASREVSELKELHNNGFELEVYQCSGQTLALSAMPRLLWLAHYRPDIYRQAGT
EECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEHHHHHHHHHHHHCCCHHHHHCCC
LTMISDWLANMLSGELAVDPSNAGTTGMLDLVTRNWQPNLLEMAGLRADILSPVKETGTL
HHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHH
LGHVTAKAAQECGLLAGTPVVMGGGDVQLGCLGLGVVHAGQTAVLGGTFWQQVVNLPQPI
HHHHHHHHHHHCCCEECCCEEECCCCEEEEEEEEEHEECCCEEEECHHHHHHHHCCCCCC
IDPNMNTRINPHVIPGMVQAESISFFTGLTMRWFRDAFCAEEKLLAQRLGIDTYSLLEDM
CCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AARVPAGAYGVMPIFSDVMRFKSWYHAAPSFINLSLDPEKCNKATLFRALEENAAIVSAC
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHHHHHHCCHHHHHC
NLAQIAEFSGVKASSVVFAGGGAKGKLWSQILADVTGVPVKVPVVKEATALGCAIAAGVG
CHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCC
VGLYEALDKTGERLVRWEREYIPNTEHKALYQAAKTNWQAVYTDQLGLVDCGLTTSLWKA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCHHHHCC
PCL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA