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The map label for this gene is mutL

Identifier: 21672810

GI number: 21672810

Start: 603477

End: 605225

Strand: Reverse

Name: mutL

Synonym: BUsg550

Alternate gene names: 21672810

Gene position: 605225-603477 (Counterclockwise)

Preceding gene: 21672811

Following gene: 21672809

Centisome position: 94.35

GC content: 21.21

Gene sequence:

>1749_bases
ATGCAACCTATTCGTATGTTATCATCTAGTTTATCCAGTCAAATTTCAGCTGGAGAAGTAATTGAAAGACCATCATCTGT
TATTAAAGAGCTTTTAGAAAACAGTATTGATGCGCAAGCAAAAAACATTGATATCAGTGTCGAAAGAAGTGGACTTAATT
CTATAACAGTAAAAGATGATGGTTTTGGCATTGAAAAAGACCAATTATTACTTGCGATTTCACGTCATGCCACTAGTAAA
ATTAATAGACTTTCAGATTTAGATAATATCAATACATTTGGTTTTAGAGGAGAAGCGTTAGCAAGTATTCGTGCTGTTTC
AAGGATGAAATTAATTTCATGTTCTCAAAATAGTAATATAGCATGGAGTATATATTCAGAAGGATTTTCTAATCATACTT
TATTGCAACCGATTGCTCATCCAATTGGAACGAGTATAATAGTAGATAATTTATTTTATAATATCCCTGTTCGTCTTAAA
TTTATAAAAAATGAAAGATCAGAATTTCTAAAAATTGATGAAACAATAAAAAAGATTGCTTTATCTAATTTTGGTATCAA
TATTTTTTTTAAAAAAGATAAAAAATTATTTGTATCATATAAAGCAATAACAAAAAATAACAATAAAATTCATCGATTAA
AAACAGTATTTAATCAAATCGACCTAAATTATGTTTTAGAAATTAAAGAAAAAATGCACAATATTACATTGTTTGGATGG
TTAATTTTTCCTTCATCTCTTTCAAGTACTTTTAAAAAAATACAATATTGCTATGTTAACAATCGATTTGTTTATAACAA
TCTTATAAAGAGTGCTGTTTTTAATTCATTTTATGAAATAATAGGGAATAAAAGAAGTACATCGTTTATTTTATATCTTA
CATTGCCTTCTAATGAAATAGATATTAATATTCATCCTACTAAAAATGAAATTAAATTTCATAAATCTAACATTATTTAT
TTTTTTGTATATCAATCTATTTTATCTAGTTTAAAAAAATGTAAAATTAAATATATTTCAAATAATTTTTTTTTAAAAAC
TCATTCTAATAAATGTAAAAATAATAATTCTGATTCTTTAAATACTAAGTTAGTATCTCAAATTCATTCTAAATACGAAA
AAAAAGATTTATATAAAGATGTAATATCAACTGATTTGTTTAAAATCAATTCTCAAAGATTTTTAAAAGAATACTTTTTT
TCTTTTGGAAAATTATTAATTGTTTTTCAAAAATATTATGGATTAATGTATTATTCAAATACCTTTTCATTGATTTCTTT
TCCCCTAGCAAAAAAGATAGTTGAACAATATAAATTACGAAGCGCTATTAAAAATAATATGATACCTGAAATTTTTTCAT
ATAATTTTTTGTATTTTATAACTTTTAAACAGAATAAAATATTATCTAATAATTTAAAATTATTATTAAAATTTGGTTTT
AATCTTATTTTGAAAGAAAAATATTTTTTTTTAAAAACTATTCCTATTTTTTTAAAAAATCAAAATCTTGATGTGTTGTT
ATCTAGTTTTTTTTCATTTATTTTTTTTAAAAAAAAAATATATATTAAAGATATAATTAAATGGTTTGATACTACTATAT
TAATAGAAAAAAATTCTTGGAATTATGAAGACGGAATTTCAATATTATTAGAAATAGAGTATTTTTGTCCTTCTATATTT
AAAAAACCTCCATTAAAACTATTGCAAAAAATAAATGTTGATGAAGTATTATGTATATTAAAAGTATAA

Upstream 100 bases:

>100_bases
GAAATTAGGATAATTATTTCAGAATATCATTCTATAATAAAAGATTTTTTATAAATTTATACTAAAAATCATTTCTTATA
ATTTTAGAGAATAAGGTCAA

Downstream 100 bases:

>100_bases
GTTCTGATAAAGAGAAAAAACCTATTATTTTTTTTTTAATGGGACCAACTGGATGCGGAAAAAGTAAATTCGCTATTTTT
CTGAGAAAATATTTACCAAT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 582

Protein sequence:

>582_residues
MQPIRMLSSSLSSQISAGEVIERPSSVIKELLENSIDAQAKNIDISVERSGLNSITVKDDGFGIEKDQLLLAISRHATSK
INRLSDLDNINTFGFRGEALASIRAVSRMKLISCSQNSNIAWSIYSEGFSNHTLLQPIAHPIGTSIIVDNLFYNIPVRLK
FIKNERSEFLKIDETIKKIALSNFGINIFFKKDKKLFVSYKAITKNNNKIHRLKTVFNQIDLNYVLEIKEKMHNITLFGW
LIFPSSLSSTFKKIQYCYVNNRFVYNNLIKSAVFNSFYEIIGNKRSTSFILYLTLPSNEIDINIHPTKNEIKFHKSNIIY
FFVYQSILSSLKKCKIKYISNNFFLKTHSNKCKNNNSDSLNTKLVSQIHSKYEKKDLYKDVISTDLFKINSQRFLKEYFF
SFGKLLIVFQKYYGLMYYSNTFSLISFPLAKKIVEQYKLRSAIKNNMIPEIFSYNFLYFITFKQNKILSNNLKLLLKFGF
NLILKEKYFFLKTIPIFLKNQNLDVLLSSFFSFIFFKKKIYIKDIIKWFDTTILIEKNSWNYEDGISILLEIEYFCPSIF
KKPPLKLLQKINVDEVLCILKV

Sequences:

>Translated_582_residues
MQPIRMLSSSLSSQISAGEVIERPSSVIKELLENSIDAQAKNIDISVERSGLNSITVKDDGFGIEKDQLLLAISRHATSK
INRLSDLDNINTFGFRGEALASIRAVSRMKLISCSQNSNIAWSIYSEGFSNHTLLQPIAHPIGTSIIVDNLFYNIPVRLK
FIKNERSEFLKIDETIKKIALSNFGINIFFKKDKKLFVSYKAITKNNNKIHRLKTVFNQIDLNYVLEIKEKMHNITLFGW
LIFPSSLSSTFKKIQYCYVNNRFVYNNLIKSAVFNSFYEIIGNKRSTSFILYLTLPSNEIDINIHPTKNEIKFHKSNIIY
FFVYQSILSSLKKCKIKYISNNFFLKTHSNKCKNNNSDSLNTKLVSQIHSKYEKKDLYKDVISTDLFKINSQRFLKEYFF
SFGKLLIVFQKYYGLMYYSNTFSLISFPLAKKIVEQYKLRSAIKNNMIPEIFSYNFLYFITFKQNKILSNNLKLLLKFGF
NLILKEKYFFLKTIPIFLKNQNLDVLLSSFFSFIFFKKKIYIKDIIKWFDTTILIEKNSWNYEDGISILLEIEYFCPSIF
KKPPLKLLQKINVDEVLCILKV
>Mature_582_residues
MQPIRMLSSSLSSQISAGEVIERPSSVIKELLENSIDAQAKNIDISVERSGLNSITVKDDGFGIEKDQLLLAISRHATSK
INRLSDLDNINTFGFRGEALASIRAVSRMKLISCSQNSNIAWSIYSEGFSNHTLLQPIAHPIGTSIIVDNLFYNIPVRLK
FIKNERSEFLKIDETIKKIALSNFGINIFFKKDKKLFVSYKAITKNNNKIHRLKTVFNQIDLNYVLEIKEKMHNITLFGW
LIFPSSLSSTFKKIQYCYVNNRFVYNNLIKSAVFNSFYEIIGNKRSTSFILYLTLPSNEIDINIHPTKNEIKFHKSNIIY
FFVYQSILSSLKKCKIKYISNNFFLKTHSNKCKNNNSDSLNTKLVSQIHSKYEKKDLYKDVISTDLFKINSQRFLKEYFF
SFGKLLIVFQKYYGLMYYSNTFSLISFPLAKKIVEQYKLRSAIKNNMIPEIFSYNFLYFITFKQNKILSNNLKLLLKFGF
NLILKEKYFFLKTIPIFLKNQNLDVLLSSFFSFIFFKKKIYIKDIIKWFDTTILIEKNSWNYEDGISILLEIEYFCPSIF
KKPPLKLLQKINVDEVLCILKV

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=335, Percent_Identity=32.8358208955224, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI4505913, Length=347, Percent_Identity=26.5129682997118, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI310128478, Length=347, Percent_Identity=26.2247838616715, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI4505911, Length=331, Percent_Identity=29.607250755287, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI189458898, Length=331, Percent_Identity=29.607250755287, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=29.4303797468354, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI91992160, Length=358, Percent_Identity=24.8603351955307, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=358, Percent_Identity=24.8603351955307, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310128480, Length=310, Percent_Identity=23.8709677419355, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=28.6307053941909, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790612, Length=613, Percent_Identity=31.1582381729201, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71991825, Length=328, Percent_Identity=27.7439024390244, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17562796, Length=358, Percent_Identity=29.0502793296089, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=328, Percent_Identity=34.1463414634146, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324247, Length=337, Percent_Identity=29.080118694362, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=289, Percent_Identity=28.0276816608997, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=347, Percent_Identity=24.7838616714697, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136968, Length=318, Percent_Identity=30.188679245283, Blast_Score=165, Evalue=8e-41,
Organism=Drosophila melanogaster, GI17136970, Length=187, Percent_Identity=32.620320855615, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_BUCAP (Q8K913)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660877.1
- ProteinModelPortal:   Q8K913
- EnsemblBacteria:   EBBUCT00000000405
- GeneID:   1005813
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg550
- GeneTree:   EBGT00050000007768
- HOGENOM:   HBG520262
- OMA:   KNEIKFH
- ProtClustDB:   CLSK316519
- BioCyc:   BAPH198804:BUSG550-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 67945; Mature: 67945

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPIRMLSSSLSSQISAGEVIERPSSVIKELLENSIDAQAKNIDISVERSGLNSITVKDD
CCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEECC
GFGIEKDQLLLAISRHATSKINRLSDLDNINTFGFRGEALASIRAVSRMKLISCSQNSNI
CCCCCHHHEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCE
AWSIYSEGFSNHTLLQPIAHPIGTSIIVDNLFYNIPVRLKFIKNERSEFLKIDETIKKIA
EEEEECCCCCCCCHHHHHHHHCCCHHEEHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
LSNFGINIFFKKDKKLFVSYKAITKNNNKIHRLKTVFNQIDLNYVLEIKEKMHNITLFGW
HHCCCEEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEE
LIFPSSLSSTFKKIQYCYVNNRFVYNNLIKSAVFNSFYEIIGNKRSTSFILYLTLPSNEI
EEECHHHHHHHHHEEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEE
DINIHPTKNEIKFHKSNIIYFFVYQSILSSLKKCKIKYISNNFFLKTHSNKCKNNNSDSL
EEEEECCCCCEEEEECCEEEEEHHHHHHHHHHHCEEEEECCEEEEEECCCCCCCCCCCHH
NTKLVSQIHSKYEKKDLYKDVISTDLFKINSQRFLKEYFFSFGKLLIVFQKYYGLMYYSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
TFSLISFPLAKKIVEQYKLRSAIKNNMIPEIFSYNFLYFITFKQNKILSNNLKLLLKFGF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEEECCCCHHHHHHHHHHHCC
NLILKEKYFFLKTIPIFLKNQNLDVLLSSFFSFIFFKKKIYIKDIIKWFDTTILIEKNSW
CEEEECCEEHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
NYEDGISILLEIEYFCPSIFKKPPLKLLQKINVDEVLCILKV
CCCCCCEEEEEEEHHCHHHCCCCCHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MQPIRMLSSSLSSQISAGEVIERPSSVIKELLENSIDAQAKNIDISVERSGLNSITVKDD
CCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEECC
GFGIEKDQLLLAISRHATSKINRLSDLDNINTFGFRGEALASIRAVSRMKLISCSQNSNI
CCCCCHHHEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCE
AWSIYSEGFSNHTLLQPIAHPIGTSIIVDNLFYNIPVRLKFIKNERSEFLKIDETIKKIA
EEEEECCCCCCCCHHHHHHHHCCCHHEEHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
LSNFGINIFFKKDKKLFVSYKAITKNNNKIHRLKTVFNQIDLNYVLEIKEKMHNITLFGW
HHCCCEEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEE
LIFPSSLSSTFKKIQYCYVNNRFVYNNLIKSAVFNSFYEIIGNKRSTSFILYLTLPSNEI
EEECHHHHHHHHHEEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEE
DINIHPTKNEIKFHKSNIIYFFVYQSILSSLKKCKIKYISNNFFLKTHSNKCKNNNSDSL
EEEEECCCCCEEEEECCEEEEEHHHHHHHHHHHCEEEEECCEEEEEECCCCCCCCCCCHH
NTKLVSQIHSKYEKKDLYKDVISTDLFKINSQRFLKEYFFSFGKLLIVFQKYYGLMYYSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEC
TFSLISFPLAKKIVEQYKLRSAIKNNMIPEIFSYNFLYFITFKQNKILSNNLKLLLKFGF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEEEECCCCHHHHHHHHHHHCC
NLILKEKYFFLKTIPIFLKNQNLDVLLSSFFSFIFFKKKIYIKDIIKWFDTTILIEKNSW
CEEEECCEEHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
NYEDGISILLEIEYFCPSIFKKPPLKLLQKINVDEVLCILKV
CCCCCCEEEEEEEHHCHHHCCCCCHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438