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The map label for this gene is bioA

Identifier: 21672560

GI number: 21672560

Start: 320276

End: 321574

Strand: Direct

Name: bioA

Synonym: BUsg281

Alternate gene names: 21672560

Gene position: 320276-321574 (Clockwise)

Preceding gene: 21672558

Following gene: 21672562

Centisome position: 49.93

GC content: 27.33

Gene sequence:

>1299_bases
ATGAGTCAATCTGATATATTTTTTGATCATAAACATATTTGGCATCCATATTCTTCTATGGTCAATCCTCTTCCTTGTTA
TTCTGTAATATCAGCAAAAGGTGTTTATTTAAAATTAAAAAATGGAAAAAATATAATAGATGGTATGTCTTCATGGTGGT
CTACCATACACGGTTATAATCATCCTATATTAAATAAATCTTTAAAAAAACAAATAAGAAAAATGTCCCATGTAATGTTT
GGAGGGATTACTCATCCTTCTGCTATTCTACTTTGTAGAAAATTGCTAAAATTAACTCCAAAAAAATTAGATTGTGTTTT
TCTTTCTGATTCTGGTTCAATAGCTATTGAAGTTGCAATAAAAATGTTAATACAATATTGGGAAGCATTAGGACAAAAAA
GAACACAAATTCTAACAATTAAAAATGGATATCATGGAGATACTTTTTCAGCTATGTCCATTTCTGATCCCAATAATTCT
ATGCATAAAATATATAACAAATTTTTACCTAAAAATTTATTTGCAGAAACACCTACTTCTTCTTTTCATAAAGAATGGAA
TTCTATTGATATCCAATCTTTTAAAAAAATAATAGAAAAAAAATCAAAAAAAATAGCTGGTGTAATACTAGAACCTATTG
TACAAGGTGTAGGAGGAATGAATTTTTATCATCCTACATATCTAAAAGAAATAAAAAAATTATGTAAAGCTTATTCTATT
CCATTAGTATTTGATGAAATTGCAACAGGATTCGGCCGTACTGGAAAATTTTTTGCTTTTCAACACGCTAATGTTATACC
AGATATACTATGTTTAGGTAAAGCTATGACAGGTGGTACAATAACATTAGCTGCCACTTTAACTTCACGAAATATTGCAC
ATACAATTAGCAGCAGTAAGGTAAGTTGCTTTATGCATGGACCAACTTATATGGGTAATCCATTAGCATGTGCAGTGGCT
AATGCTAATATAAAAATATTAGAAAAAAATGAATGGAAAAAACAAGTTATTAACATTGAAAAACAACTTTGTCAAAGTTT
ATTACCGTTAATTCATCATCCAAGAGTAGTAGATGTTCGCGTATTAGGTGCAATTGGTGTAGTTGAATGTTTTCATTTTG
TAAACATGGCTCTCATACAAAAATTTTTTGTAAAAAATGGTGTTTGGATTCGACCTTTTAAAAAAATAATTTATATTGTA
CCACCTTATATTATAAGTATGAATTGTTTAAAAAAACTTATCAATGTTATTGAAAAATCTTTAGATAATGATACATTATT
TAATGTAGAAAATATTTAA

Upstream 100 bases:

>100_bases
AGGTTCCATTTTCGTTTCATATTAATCTCCAAAAAAAATATGATTTTGTTTAATTAAAAGTTTATAATGAATTATTTAAT
ATTTTTATATATAAATCATA

Downstream 100 bases:

>100_bases
TTTATAATATTTCTCTTTGAAAAATTTAAATTAAAAATGAAGTTATCCATAAAGGACCGTTACCTGTTTGATATTGATTT
ATTTTTTTTAATTCACCTGT

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSQSDIFFDHKHIWHPYSSMVNPLPCYSVISAKGVYLKLKNGKNIIDGMSSWWSTIHGYNHPILNKSLKKQIRKMSHVMF
GGITHPSAILLCRKLLKLTPKKLDCVFLSDSGSIAIEVAIKMLIQYWEALGQKRTQILTIKNGYHGDTFSAMSISDPNNS
MHKIYNKFLPKNLFAETPTSSFHKEWNSIDIQSFKKIIEKKSKKIAGVILEPIVQGVGGMNFYHPTYLKEIKKLCKAYSI
PLVFDEIATGFGRTGKFFAFQHANVIPDILCLGKAMTGGTITLAATLTSRNIAHTISSSKVSCFMHGPTYMGNPLACAVA
NANIKILEKNEWKKQVINIEKQLCQSLLPLIHHPRVVDVRVLGAIGVVECFHFVNMALIQKFFVKNGVWIRPFKKIIYIV
PPYIISMNCLKKLINVIEKSLDNDTLFNVENI

Sequences:

>Translated_432_residues
MSQSDIFFDHKHIWHPYSSMVNPLPCYSVISAKGVYLKLKNGKNIIDGMSSWWSTIHGYNHPILNKSLKKQIRKMSHVMF
GGITHPSAILLCRKLLKLTPKKLDCVFLSDSGSIAIEVAIKMLIQYWEALGQKRTQILTIKNGYHGDTFSAMSISDPNNS
MHKIYNKFLPKNLFAETPTSSFHKEWNSIDIQSFKKIIEKKSKKIAGVILEPIVQGVGGMNFYHPTYLKEIKKLCKAYSI
PLVFDEIATGFGRTGKFFAFQHANVIPDILCLGKAMTGGTITLAATLTSRNIAHTISSSKVSCFMHGPTYMGNPLACAVA
NANIKILEKNEWKKQVINIEKQLCQSLLPLIHHPRVVDVRVLGAIGVVECFHFVNMALIQKFFVKNGVWIRPFKKIIYIV
PPYIISMNCLKKLINVIEKSLDNDTLFNVENI
>Mature_431_residues
SQSDIFFDHKHIWHPYSSMVNPLPCYSVISAKGVYLKLKNGKNIIDGMSSWWSTIHGYNHPILNKSLKKQIRKMSHVMFG
GITHPSAILLCRKLLKLTPKKLDCVFLSDSGSIAIEVAIKMLIQYWEALGQKRTQILTIKNGYHGDTFSAMSISDPNNSM
HKIYNKFLPKNLFAETPTSSFHKEWNSIDIQSFKKIIEKKSKKIAGVILEPIVQGVGGMNFYHPTYLKEIKKLCKAYSIP
LVFDEIATGFGRTGKFFAFQHANVIPDILCLGKAMTGGTITLAATLTSRNIAHTISSSKVSCFMHGPTYMGNPLACAVAN
ANIKILEKNEWKKQVINIEKQLCQSLLPLIHHPRVVDVRVLGAIGVVECFHFVNMALIQKFFVKNGVWIRPFKKIIYIVP
PYIISMNCLKKLINVIEKSLDNDTLFNVENI

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=435, Percent_Identity=28.0459770114943, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=29.2834890965732, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI13994255, Length=326, Percent_Identity=27.9141104294479, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI37574042, Length=430, Percent_Identity=24.1860465116279, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=23.953488372093, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI226442709, Length=401, Percent_Identity=24.6882793017456, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI24119277, Length=350, Percent_Identity=25.7142857142857, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI188536080, Length=290, Percent_Identity=25.8620689655172, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38679950, Length=290, Percent_Identity=25.8620689655172, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI38679946, Length=290, Percent_Identity=25.8620689655172, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=58.3138173302108, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI145693181, Length=389, Percent_Identity=28.0205655526992, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789759, Length=347, Percent_Identity=30.5475504322767, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1788044, Length=301, Percent_Identity=32.5581395348837, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=23.6180904522613, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1787560, Length=353, Percent_Identity=27.1954674220963, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786349, Length=393, Percent_Identity=25.4452926208651, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=315, Percent_Identity=28.8888888888889, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=202, Percent_Identity=33.6633663366337, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=362, Percent_Identity=27.0718232044199, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=406, Percent_Identity=23.6453201970443, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=452, Percent_Identity=46.6814159292035, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6323470, Length=451, Percent_Identity=26.8292682926829, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=26.1306532663317, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321456, Length=268, Percent_Identity=23.5074626865672, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357415, Length=434, Percent_Identity=27.1889400921659, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21356575, Length=365, Percent_Identity=24.6575342465753, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161085790, Length=360, Percent_Identity=26.3888888888889, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574759, Length=360, Percent_Identity=26.3888888888889, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281366494, Length=284, Percent_Identity=27.112676056338, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24667139, Length=284, Percent_Identity=27.112676056338, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24667143, Length=284, Percent_Identity=27.112676056338, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOA_BUCAP (Q8K9P0)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660627.1
- ProteinModelPortal:   Q8K9P0
- SMR:   Q8K9P0
- EnsemblBacteria:   EBBUCT00000000146
- GeneID:   1005485
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg281
- GeneTree:   EBGT00050000007756
- HOGENOM:   HBG725944
- OMA:   THEPALE
- ProtClustDB:   CLSK315863
- BioCyc:   BAPH198804:BUSG281-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF8
- TIGRFAMs:   TIGR00508

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.62

Molecular weight: Translated: 48742; Mature: 48611

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 17-17 BINDING 245-245 BINDING 274-274 BINDING 307-307 BINDING 309-309 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSDIFFDHKHIWHPYSSMVNPLPCYSVISAKGVYLKLKNGKNIIDGMSSWWSTIHGYN
CCCCCEEECCHHHCCCHHHHCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCC
HPILNKSLKKQIRKMSHVMFGGITHPSAILLCRKLLKLTPKKLDCVFLSDSGSIAIEVAI
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
KMLIQYWEALGQKRTQILTIKNGYHGDTFSAMSISDPNNSMHKIYNKFLPKNLFAETPTS
HHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCH
SFHKEWNSIDIQSFKKIIEKKSKKIAGVILEPIVQGVGGMNFYHPTYLKEIKKLCKAYSI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
PLVFDEIATGFGRTGKFFAFQHANVIPDILCLGKAMTGGTITLAATLTSRNIAHTISSSK
CCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHCCCC
VSCFMHGPTYMGNPLACAVANANIKILEKNEWKKQVINIEKQLCQSLLPLIHHPRVVDVR
EEEEEECCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VLGAIGVVECFHFVNMALIQKFFVKNGVWIRPFKKIIYIVPPYIISMNCLKKLINVIEKS
EHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHEEEECCHHHHHHHHHHHHHHHHHHH
LDNDTLFNVENI
CCCCCCEEECCC
>Mature Secondary Structure 
SQSDIFFDHKHIWHPYSSMVNPLPCYSVISAKGVYLKLKNGKNIIDGMSSWWSTIHGYN
CCCCEEECCHHHCCCHHHHCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCC
HPILNKSLKKQIRKMSHVMFGGITHPSAILLCRKLLKLTPKKLDCVFLSDSGSIAIEVAI
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
KMLIQYWEALGQKRTQILTIKNGYHGDTFSAMSISDPNNSMHKIYNKFLPKNLFAETPTS
HHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCH
SFHKEWNSIDIQSFKKIIEKKSKKIAGVILEPIVQGVGGMNFYHPTYLKEIKKLCKAYSI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
PLVFDEIATGFGRTGKFFAFQHANVIPDILCLGKAMTGGTITLAATLTSRNIAHTISSSK
CCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHCCCC
VSCFMHGPTYMGNPLACAVANANIKILEKNEWKKQVINIEKQLCQSLLPLIHHPRVVDVR
EEEEEECCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
VLGAIGVVECFHFVNMALIQKFFVKNGVWIRPFKKIIYIVPPYIISMNCLKKLINVIEKS
EHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHEEEECCHHHHHHHHHHHHHHHHHHH
LDNDTLFNVENI
CCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438