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The map label for this gene is dxr

Identifier: 21672510

GI number: 21672510

Start: 259481

End: 260677

Strand: Direct

Name: dxr

Synonym: BUsg229

Alternate gene names: 21672510

Gene position: 259481-260677 (Clockwise)

Preceding gene: 21672509

Following gene: 21672511

Centisome position: 40.45

GC content: 26.9

Gene sequence:

>1197_bases
ATGAAAAAAATAACTGTTTTAGGATCTACTGGTTCTATCGGCATTAGTACTCTGTCTATTGTTAAAAATAATCCTTCTTT
ATTTAAAGTTATTGTTTTAGTAGCTAATAAAAATTCTTCTATGATGTTAGAACAATGTGAATATTTTTCTCCTGATTGGG
CTATCATGAAGAATAAAAAATCAGCTCATATTTTAAAAAAAAGATTAAAAGATAAAAAAATAAAAACACAAGTTTTATCT
GGTAATAAAGCTATTTGTCAACTAGCTGCTTTAAAAGAATCCGATTTAGTTATATCTGCCATTGTAGGAATGGCAGGTTT
ATTACCTACTTTATCTGCAATAAATGCTGGGAAAACAATTTTATTAGCTAATAAAGAATCTCTAATTGTCTGTGGTATTA
TTTTTATGAAAGCTTTATCTTCTAATAAAGCTAAAATTTTTCCTATTGATAGTGAACATAACGCTATTTTTCAAGTTTTG
CCTAAGTTTGTTCAAAAAAATTTAGGTAAAGTTAATTTAAAAAAAAATGGTGTTAAATCTATTATTTTAACTGCTTCTGG
AGGTCCATTTTATAATTTTAAAAGAGAAAACTTATCTTTTGTTACTCCTTTAGAAGCATGTTCTCACCCAAATTGGTCAA
TGGGAAGAAAAATATCAATAGATTCAGCAACTATGATAAATAAAGGTTTTGAATATGCTGAAGCAAGATTGCTATTTAAT
GCCTCATCTTCAGAAATTGATATTTTAATTCATCCTCAATCAATTATTCATTCTATGGTTGAGTATATTGATGGAACAAT
ATTAGCACAACTTTCAGTTCCTGATATGAAGGTTGCAATTTCTTATGCAATGTCTTGGCCTAATCGTATATCTTCTGGAG
CGAAATTTTTAAATTTTAATAAATTAAGCAATTTGAGTTTTTTTAAACCAGATTTTATTCAGTTTCCATGCTTAAAATTA
GCTATTGATGCTTTTTCTCAAGGTCAAGCGGCAATGACAGTTTTAAATGCTGTTAATGAAGTTACTGTTTCAGCTTTTTT
AGATTCAAAAATTAGTTTTAATAAAATTTCGGAAATCAATACTGATATTTTAATGTCTTCTTCTTTTTCAGAACCTGTTT
CCGTTGAAGAGGTTTTAGAAATTGACAAAAAAACAAGAATAAAATCTCAAAAAAAAATATCGTCTCTAATATTTTAA

Upstream 100 bases:

>100_bases
ACATAGAATATTTTGTAAATCATTTTCTATATTTTATCGTATTATTTTTGTACAGTCATTTTAGCAATTCAATATTATTT
ATTAATATTAAAAATTTTTT

Downstream 100 bases:

>100_bases
TATTATTTTATATAATTTAAAAAATTTTTTAAGAGAAATTTAGAGAAATTATGTTATATAAATCCTCGTTAAAAAATAAA
AAAAGAATTCAAAAAGAAAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKKITVLGSTGSIGISTLSIVKNNPSLFKVIVLVANKNSSMMLEQCEYFSPDWAIMKNKKSAHILKKRLKDKKIKTQVLS
GNKAICQLAALKESDLVISAIVGMAGLLPTLSAINAGKTILLANKESLIVCGIIFMKALSSNKAKIFPIDSEHNAIFQVL
PKFVQKNLGKVNLKKNGVKSIILTASGGPFYNFKRENLSFVTPLEACSHPNWSMGRKISIDSATMINKGFEYAEARLLFN
ASSSEIDILIHPQSIIHSMVEYIDGTILAQLSVPDMKVAISYAMSWPNRISSGAKFLNFNKLSNLSFFKPDFIQFPCLKL
AIDAFSQGQAAMTVLNAVNEVTVSAFLDSKISFNKISEINTDILMSSSFSEPVSVEEVLEIDKKTRIKSQKKISSLIF

Sequences:

>Translated_398_residues
MKKITVLGSTGSIGISTLSIVKNNPSLFKVIVLVANKNSSMMLEQCEYFSPDWAIMKNKKSAHILKKRLKDKKIKTQVLS
GNKAICQLAALKESDLVISAIVGMAGLLPTLSAINAGKTILLANKESLIVCGIIFMKALSSNKAKIFPIDSEHNAIFQVL
PKFVQKNLGKVNLKKNGVKSIILTASGGPFYNFKRENLSFVTPLEACSHPNWSMGRKISIDSATMINKGFEYAEARLLFN
ASSSEIDILIHPQSIIHSMVEYIDGTILAQLSVPDMKVAISYAMSWPNRISSGAKFLNFNKLSNLSFFKPDFIQFPCLKL
AIDAFSQGQAAMTVLNAVNEVTVSAFLDSKISFNKISEINTDILMSSSFSEPVSVEEVLEIDKKTRIKSQKKISSLIF
>Mature_398_residues
MKKITVLGSTGSIGISTLSIVKNNPSLFKVIVLVANKNSSMMLEQCEYFSPDWAIMKNKKSAHILKKRLKDKKIKTQVLS
GNKAICQLAALKESDLVISAIVGMAGLLPTLSAINAGKTILLANKESLIVCGIIFMKALSSNKAKIFPIDSEHNAIFQVL
PKFVQKNLGKVNLKKNGVKSIILTASGGPFYNFKRENLSFVTPLEACSHPNWSMGRKISIDSATMINKGFEYAEARLLFN
ASSSEIDILIHPQSIIHSMVEYIDGTILAQLSVPDMKVAISYAMSWPNRISSGAKFLNFNKLSNLSFFKPDFIQFPCLKL
AIDAFSQGQAAMTVLNAVNEVTVSAFLDSKISFNKISEINTDILMSSSFSEPVSVEEVLEIDKKTRIKSQKKISSLIF

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=56.5656565656566, Blast_Score=479, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_BUCAP (Q8K9S7)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660577.1
- ProteinModelPortal:   Q8K9S7
- SMR:   Q8K9S7
- EnsemblBacteria:   EBBUCT00000000496
- GeneID:   1005428
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg229
- GeneTree:   EBGT00050000007831
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   BAPH198804:BUSG229-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43728; Mature: 43728

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITVLGSTGSIGISTLSIVKNNPSLFKVIVLVANKNSSMMLEQCEYFSPDWAIMKNKK
CCEEEEEECCCCCCEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHCCCCCHHEEECCC
SAHILKKRLKDKKIKTQVLSGNKAICQLAALKESDLVISAIVGMAGLLPTLSAINAGKTI
HHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
LLANKESLIVCGIIFMKALSSNKAKIFPIDSEHNAIFQVLPKFVQKNLGKVNLKKNGVKS
EEECCCCEEEHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEE
IILTASGGPFYNFKRENLSFVTPLEACSHPNWSMGRKISIDSATMINKGFEYAEARLLFN
EEEEECCCCCCCEECCCCCEECCHHHHCCCCCCCCCEEECCCHHHHHCCCHHEEEEEEEE
ASSSEIDILIHPQSIIHSMVEYIDGTILAQLSVPDMKVAISYAMSWPNRISSGAKFLNFN
CCCCCEEEEECCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCHHHCCCCEEEECC
KLSNLSFFKPDFIQFPCLKLAIDAFSQGQAAMTVLNAVNEVTVSAFLDSKISFNKISEIN
CCCCCCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
TDILMSSSFSEPVSVEEVLEIDKKTRIKSQKKISSLIF
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKITVLGSTGSIGISTLSIVKNNPSLFKVIVLVANKNSSMMLEQCEYFSPDWAIMKNKK
CCEEEEEECCCCCCEEEEEEEECCCCEEEEEEEEECCCCCHHHHHHHCCCCCHHEEECCC
SAHILKKRLKDKKIKTQVLSGNKAICQLAALKESDLVISAIVGMAGLLPTLSAINAGKTI
HHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
LLANKESLIVCGIIFMKALSSNKAKIFPIDSEHNAIFQVLPKFVQKNLGKVNLKKNGVKS
EEECCCCEEEHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEE
IILTASGGPFYNFKRENLSFVTPLEACSHPNWSMGRKISIDSATMINKGFEYAEARLLFN
EEEEECCCCCCCEECCCCCEECCHHHHCCCCCCCCCEEECCCHHHHHCCCHHEEEEEEEE
ASSSEIDILIHPQSIIHSMVEYIDGTILAQLSVPDMKVAISYAMSWPNRISSGAKFLNFN
CCCCCEEEEECCHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHCCCHHHCCCCEEEECC
KLSNLSFFKPDFIQFPCLKLAIDAFSQGQAAMTVLNAVNEVTVSAFLDSKISFNKISEIN
CCCCCCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
TDILMSSSFSEPVSVEEVLEIDKKTRIKSQKKISSLIF
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438