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The map label for this gene is uppS

Identifier: 21672511

GI number: 21672511

Start: 260728

End: 261477

Strand: Direct

Name: uppS

Synonym: BUsg230

Alternate gene names: 21672511

Gene position: 260728-261477 (Clockwise)

Preceding gene: 21672510

Following gene: 21672512

Centisome position: 40.65

GC content: 25.47

Gene sequence:

>750_bases
ATGTTATATAAATCCTCGTTAAAAAATAAAAAAAGAATTCAAAAAGAAAATCTTCGTCATATAGCAATTATTATGGATGG
AAATGGAAGATGGGCTGAAAAAAGAGGAAAAATACGTACCTTAGGTCATAAAGAAGGTTTTAAAACAGCTAGAAAAATAA
TAAAGTATGCCGTTGAAAATAACATAAAAATATTAACATTATATGTTTTTAGTCGAGAAAATTGGAGACGTCCCAAGTTA
GAAATTACAGCGTTGATGAAATTATTTTTTTTTGCATTAAAAAGTGAAATAAAAAATTTAAATAAATATAATATTCGTTT
AAAAATAATTGGAGATACAAGTCCTTTTAATGAAAATTTAAAAAATTATATTCACAAAGTAGAAAAACAAACTTTTAATA
ATACTGGTTTAATTTTAAATATTGCTGCAAATTATAGTGGTAGATGGGATATTATACGAGGTATAAAGAAAATCATCAAA
GATGTTCAAAAAGATGTGTTAGATATTGATCAAATTCAAGAACGAAATTTCTCTCAATATTTATCTACAAGTGAATTACT
ACCAGTAGATTTAGTGATTAGAACAGGAGGAGAAAAAAGAATTAGTAATTTTTTGTTATGGCAAATAGCATATTCTGAAT
TATATTTTACTGATATTTTATGGCCTGATTTTAACTGGCGCGATTTTCAGCATGCAATTGATTATTTTTTTACTCGTGAA
CGTCGTTTTGGAGGAATTTCAATTAGTTAA

Upstream 100 bases:

>100_bases
AAAAAACAAGAATAAAATCTCAAAAAAAAATATCGTCTCTAATATTTTAATATTATTTTATATAATTTAAAAAATTTTTT
AAGAGAAATTTAGAGAAATT

Downstream 100 bases:

>100_bases
AAAACATTTTTTTAAACAGTATGGATCATATATAAAAAACGTTTTATTAAAAAAAATCAAATTTTTTATTAAAGTAATTT
TTACTCAAATCTTCTTTTTT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MLYKSSLKNKKRIQKENLRHIAIIMDGNGRWAEKRGKIRTLGHKEGFKTARKIIKYAVENNIKILTLYVFSRENWRRPKL
EITALMKLFFFALKSEIKNLNKYNIRLKIIGDTSPFNENLKNYIHKVEKQTFNNTGLILNIAANYSGRWDIIRGIKKIIK
DVQKDVLDIDQIQERNFSQYLSTSELLPVDLVIRTGGEKRISNFLLWQIAYSELYFTDILWPDFNWRDFQHAIDYFFTRE
RRFGGISIS

Sequences:

>Translated_249_residues
MLYKSSLKNKKRIQKENLRHIAIIMDGNGRWAEKRGKIRTLGHKEGFKTARKIIKYAVENNIKILTLYVFSRENWRRPKL
EITALMKLFFFALKSEIKNLNKYNIRLKIIGDTSPFNENLKNYIHKVEKQTFNNTGLILNIAANYSGRWDIIRGIKKIIK
DVQKDVLDIDQIQERNFSQYLSTSELLPVDLVIRTGGEKRISNFLLWQIAYSELYFTDILWPDFNWRDFQHAIDYFFTRE
RRFGGISIS
>Mature_249_residues
MLYKSSLKNKKRIQKENLRHIAIIMDGNGRWAEKRGKIRTLGHKEGFKTARKIIKYAVENNIKILTLYVFSRENWRRPKL
EITALMKLFFFALKSEIKNLNKYNIRLKIIGDTSPFNENLKNYIHKVEKQTFNNTGLILNIAANYSGRWDIIRGIKKIIK
DVQKDVLDIDQIQERNFSQYLSTSELLPVDLVIRTGGEKRISNFLLWQIAYSELYFTDILWPDFNWRDFQHAIDYFFTRE
RRFGGISIS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=33.4841628959276, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=33.4841628959276, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786371, Length=245, Percent_Identity=56.734693877551, Blast_Score=308, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71993029, Length=220, Percent_Identity=33.6363636363636, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=29.6296296296296, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18857969, Length=217, Percent_Identity=31.7972350230415, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_BUCAP (Q8K9S6)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660578.1
- ProteinModelPortal:   Q8K9S6
- SMR:   Q8K9S6
- EnsemblBacteria:   EBBUCT00000000373
- GeneID:   1005429
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg230
- GeneTree:   EBGT00050000008198
- HOGENOM:   HBG627837
- OMA:   ACMERGV
- ProtClustDB:   CLSK2516824
- BioCyc:   BAPH198804:BUSG230-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29602; Mature: 29602

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 26-26

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYKSSLKNKKRIQKENLRHIAIIMDGNGRWAEKRGKIRTLGHKEGFKTARKIIKYAVEN
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHC
NIKILTLYVFSRENWRRPKLEITALMKLFFFALKSEIKNLNKYNIRLKIIGDTSPFNENL
CCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHH
KNYIHKVEKQTFNNTGLILNIAANYSGRWDIIRGIKKIIKDVQKDVLDIDQIQERNFSQY
HHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHH
LSTSELLPVDLVIRTGGEKRISNFLLWQIAYSELYFTDILWPDFNWRDFQHAIDYFFTRE
HCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHH
RRFGGISIS
HCCCCCCCC
>Mature Secondary Structure
MLYKSSLKNKKRIQKENLRHIAIIMDGNGRWAEKRGKIRTLGHKEGFKTARKIIKYAVEN
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCEEECCCHHHHHHHHHHHHHHHHC
NIKILTLYVFSRENWRRPKLEITALMKLFFFALKSEIKNLNKYNIRLKIIGDTSPFNENL
CCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHH
KNYIHKVEKQTFNNTGLILNIAANYSGRWDIIRGIKKIIKDVQKDVLDIDQIQERNFSQY
HHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHH
LSTSELLPVDLVIRTGGEKRISNFLLWQIAYSELYFTDILWPDFNWRDFQHAIDYFFTRE
HCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHH
RRFGGISIS
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438