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The map label for this gene is pyrH

Identifier: 21672508

GI number: 21672508

Start: 258047

End: 258769

Strand: Direct

Name: pyrH

Synonym: BUsg227

Alternate gene names: 21672508

Gene position: 258047-258769 (Clockwise)

Preceding gene: 21672507

Following gene: 21672509

Centisome position: 40.23

GC content: 28.49

Gene sequence:

>723_bases
ATGTCTACCAATACAAAATTTATATACCACCGCATCTTACTTAAAATAAGCGGTGAAGTCTTGCAAGGAGTCAATAAATT
TGGTATTGATATAAATTCTTTAAAAAGAATAGTAAAAGAAATTAAATTAGTATTGCAATTTGGTATTCAAGTAGGTTTAG
TTATTGGTAGTGGTAATTTATTTCGTGGTGCTACTTTATCTCAGTTAGGAGTAAATAGAATAGTATCAGATCATATAGGT
ATATTATCAACAATAATCAATAGCTTAGCTATGAAAGATATTATGAATTCTTATTCTATTCCTAGCTACGTTATGTCGTC
TATACCAGTTGATGGTATATGCGAAACATATAATTACGAAAGAGCGATAGATTTGTTATCTAATAATTTTGTCGTGATTT
TTGCTGCCGGTACAGGTAATCCTTTATTTACAACTGACTCTGCAGCGTGTCTACGTGGCATTGAAATTAAATCAGATATA
ATTTTAAAGGGTACAAAAGTTGATGGAGTTTATTCAAAAGATCCAAAAAAATATTCTCAAGCAGTTTTTTATAAAAGATT
AACATATAAAGATGTTATTCAAAAAGAATTAAAAGTGATGGATTTATCGGCTTTTTCTTTAGCTAGAGATCATAATTTAC
CCATTCGAGTATTTAATATCAATAAACCTAAATCTTTATACCGTATTGTTAAAGGTTATGATGAAGGTACTCTGATTAAA
TAA

Upstream 100 bases:

>100_bases
TGATTTTAAAAGACTATTTTAAAAAACAAAATATATATTGATCAATTTACAAAAAGTAAAAAATATTTTTAATAAAAAAT
TTATTTAGGTTAAAAACAAT

Downstream 100 bases:

>100_bases
ATTATTAACAAATATTGTAAATTAAAGAATATATTGTATAGGTACTCATGTGATTAATGATATTTATATTAAAAGTAATG
AAAAAATGAAAGTATGTATT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSTNTKFIYHRILLKISGEVLQGVNKFGIDINSLKRIVKEIKLVLQFGIQVGLVIGSGNLFRGATLSQLGVNRIVSDHIG
ILSTIINSLAMKDIMNSYSIPSYVMSSIPVDGICETYNYERAIDLLSNNFVVIFAAGTGNPLFTTDSAACLRGIEIKSDI
ILKGTKVDGVYSKDPKKYSQAVFYKRLTYKDVIQKELKVMDLSAFSLARDHNLPIRVFNINKPKSLYRIVKGYDEGTLIK

Sequences:

>Translated_240_residues
MSTNTKFIYHRILLKISGEVLQGVNKFGIDINSLKRIVKEIKLVLQFGIQVGLVIGSGNLFRGATLSQLGVNRIVSDHIG
ILSTIINSLAMKDIMNSYSIPSYVMSSIPVDGICETYNYERAIDLLSNNFVVIFAAGTGNPLFTTDSAACLRGIEIKSDI
ILKGTKVDGVYSKDPKKYSQAVFYKRLTYKDVIQKELKVMDLSAFSLARDHNLPIRVFNINKPKSLYRIVKGYDEGTLIK
>Mature_239_residues
STNTKFIYHRILLKISGEVLQGVNKFGIDINSLKRIVKEIKLVLQFGIQVGLVIGSGNLFRGATLSQLGVNRIVSDHIGI
LSTIINSLAMKDIMNSYSIPSYVMSSIPVDGICETYNYERAIDLLSNNFVVIFAAGTGNPLFTTDSAACLRGIEIKSDII
LKGTKVDGVYSKDPKKYSQAVFYKRLTYKDVIQKELKVMDLSAFSLARDHNLPIRVFNINKPKSLYRIVKGYDEGTLIK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=239, Percent_Identity=59.8326359832636, Blast_Score=319, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_BUCAP (P59002)

Other databases:

- EMBL:   AE013218
- RefSeq:   NP_660575.1
- ProteinModelPortal:   P59002
- SMR:   P59002
- EnsemblBacteria:   EBBUCT00000000329
- GeneID:   1005426
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg227
- GeneTree:   EBGT00050000007735
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   BAPH198804:BUSG227-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26721; Mature: 26589

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: BINDING 58-58 BINDING 62-62 BINDING 77-77 BINDING 165-165 BINDING 171-171 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNTKFIYHRILLKISGEVLQGVNKFGIDINSLKRIVKEIKLVLQFGIQVGLVIGSGNL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCE
FRGATLSQLGVNRIVSDHIGILSTIINSLAMKDIMNSYSIPSYVMSSIPVDGICETYNYE
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCHH
RAIDLLSNNFVVIFAAGTGNPLFTTDSAACLRGIEIKSDIILKGTKVDGVYSKDPKKYSQ
HHHHHHCCCEEEEEEECCCCCEEECCHHHHHHCCEECCCEEEECCEECCCCCCCHHHHHH
AVFYKRLTYKDVIQKELKVMDLSAFSLARDHNLPIRVFNINKPKSLYRIVKGYDEGTLIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STNTKFIYHRILLKISGEVLQGVNKFGIDINSLKRIVKEIKLVLQFGIQVGLVIGSGNL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCE
FRGATLSQLGVNRIVSDHIGILSTIINSLAMKDIMNSYSIPSYVMSSIPVDGICETYNYE
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCHH
RAIDLLSNNFVVIFAAGTGNPLFTTDSAACLRGIEIKSDIILKGTKVDGVYSKDPKKYSQ
HHHHHHCCCEEEEEEECCCCCEEECCHHHHHHCCEECCCEEEECCEECCCCCCCHHHHHH
AVFYKRLTYKDVIQKELKVMDLSAFSLARDHNLPIRVFNINKPKSLYRIVKGYDEGTLIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438