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The map label for this gene is hisB

Identifier: 21672387

GI number: 21672387

Start: 107890

End: 108957

Strand: Direct

Name: hisB

Synonym: BUsg095

Alternate gene names: 21672387

Gene position: 107890-108957 (Clockwise)

Preceding gene: 21672386

Following gene: 21672388

Centisome position: 16.82

GC content: 27.15

Gene sequence:

>1068_bases
ATGAAACAAAAAATATTATTTATTGATCGAGATGGAACATTAATTCATGAACCATCTAATGATTGTCAAGTGGATGCAAT
TAATAAACTTGAATTTAAAAAATATATTATTTCTTCACTATGTCAATTAATGAATTTTGGTTATAAATTTGTTATGGTGA
CAAACCAAGATGGTCTTGGCAGTAAATCATTTCCTCGGGAAAATTTTAATATTCCACATTTTTTTATGTTAAACATTTTT
CGTTCAGAAGGAATAATATTTGAAGATGTTTTAATTTGTCCTCATTTTTTAGATGATAATTGTGATTGTCGTAAACCTCA
AACTAAACTGTTAAAACCTTGGTTGAAAAAAAATAAGATAGATAAACAACGCAGTTATGTAATTGGTGATCGAGAAACTG
ATATGGAATTAGCAAAAAATATAAATTTAACAGGTATACAATACAAGGAGAAAGAATTTAATTGGATAGATATTACAAAA
GAAATTATAAAAAGAAATAGATATAGAGAAGTGATTCGAGAAACAAAAGAAACTTATATACATATAAAGTTATGGTTGGA
TTTAGAACATCATAGTTGTATCCAAACTGGTATTAATTTTTTTGATCATATGTTAGAACAATTATCTATTCATAGCGGAA
TTTCAATGTATATTTTAGCAAAAGGAGATTTGCAAATTGATGACCATCATACTATAGAAGATACTGGAATTGTCTTAGGA
GAGGCATTATCTCAAGCATTAAACAATAAAAATGGTTTATCTAGATATGGTTTTGTTTTGCCTATGGATGAAAGTCAAGC
AAAATGCATTATAGATTTATCAAATCGTCCATATTTATCTTTTAATGCTCACTTTAAACATAAAATGGTTGGTGATATGA
ATACTGATATGGTTGAACATTTTTTTTATTCTCTTTGTTGTTCTATGAAAATCACCTTACATATAGATGTTAAAGGAAAA
AATGATCATCATTGTATTGAAAGTTTGTTTAAAGCATTTGGACGTGCACTCCGCAAGGCAGTAAAAATAGAAGGAAATAC
ACTGCCAACATCTAAAGGGATTTTATAA

Upstream 100 bases:

>100_bases
ATTGTTTAAGAATATCAATAGGATCCAAGTCAGAATGTATGCGTTTAGTTCAAGAGTTAAAAAATTTTATTTAAAAAATA
ATTTTTTCAATGAGGTATTG

Downstream 100 bases:

>100_bases
GTGGATATTGCAATATTAAATACTGGTTGTGCTAATTTAACTTCAATTCAAGTTGCAATTAAAAAATTAGGTTATGATTC
CATAGTAACTTCTGATCCTT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKQKILFIDRDGTLIHEPSNDCQVDAINKLEFKKYIISSLCQLMNFGYKFVMVTNQDGLGSKSFPRENFNIPHFFMLNIF
RSEGIIFEDVLICPHFLDDNCDCRKPQTKLLKPWLKKNKIDKQRSYVIGDRETDMELAKNINLTGIQYKEKEFNWIDITK
EIIKRNRYREVIRETKETYIHIKLWLDLEHHSCIQTGINFFDHMLEQLSIHSGISMYILAKGDLQIDDHHTIEDTGIVLG
EALSQALNNKNGLSRYGFVLPMDESQAKCIIDLSNRPYLSFNAHFKHKMVGDMNTDMVEHFFYSLCCSMKITLHIDVKGK
NDHHCIESLFKAFGRALRKAVKIEGNTLPTSKGIL

Sequences:

>Translated_355_residues
MKQKILFIDRDGTLIHEPSNDCQVDAINKLEFKKYIISSLCQLMNFGYKFVMVTNQDGLGSKSFPRENFNIPHFFMLNIF
RSEGIIFEDVLICPHFLDDNCDCRKPQTKLLKPWLKKNKIDKQRSYVIGDRETDMELAKNINLTGIQYKEKEFNWIDITK
EIIKRNRYREVIRETKETYIHIKLWLDLEHHSCIQTGINFFDHMLEQLSIHSGISMYILAKGDLQIDDHHTIEDTGIVLG
EALSQALNNKNGLSRYGFVLPMDESQAKCIIDLSNRPYLSFNAHFKHKMVGDMNTDMVEHFFYSLCCSMKITLHIDVKGK
NDHHCIESLFKAFGRALRKAVKIEGNTLPTSKGIL
>Mature_355_residues
MKQKILFIDRDGTLIHEPSNDCQVDAINKLEFKKYIISSLCQLMNFGYKFVMVTNQDGLGSKSFPRENFNIPHFFMLNIF
RSEGIIFEDVLICPHFLDDNCDCRKPQTKLLKPWLKKNKIDKQRSYVIGDRETDMELAKNINLTGIQYKEKEFNWIDITK
EIIKRNRYREVIRETKETYIHIKLWLDLEHHSCIQTGINFFDHMLEQLSIHSGISMYILAKGDLQIDDHHTIEDTGIVLG
EALSQALNNKNGLSRYGFVLPMDESQAKCIIDLSNRPYLSFNAHFKHKMVGDMNTDMVEHFFYSLCCSMKITLHIDVKGK
NDHHCIESLFKAFGRALRKAVKIEGNTLPTSKGIL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=55.4929577464789, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1786399, Length=151, Percent_Identity=28.476821192053, Blast_Score=68, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=45.4545454545455, Blast_Score=155, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_BUCAP (Q9ZHE4)

Other databases:

- EMBL:   AF067228
- EMBL:   AE013218
- RefSeq:   NP_660454.1
- ProteinModelPortal:   Q9ZHE4
- SMR:   Q9ZHE4
- EnsemblBacteria:   EBBUCT00000000054
- GeneID:   1005912
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg095
- GeneTree:   EBGT00050000008038
- HOGENOM:   HBG289010
- OMA:   QDGLGTP
- ProtClustDB:   PRK05446
- BioCyc:   BAPH198804:BUSG095-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01022
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01261
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P; SSF54211 Ribosomal_S5_D2-typ_fold; SSF56784 SSF56784

EC number: =3.1.3.15; =4.2.1.19

Molecular weight: Translated: 41303; Mature: 41303

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKILFIDRDGTLIHEPSNDCQVDAINKLEFKKYIISSLCQLMNFGYKFVMVTNQDGLG
CCCEEEEEECCCCEEECCCCCCEEECHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
SKSFPRENFNIPHFFMLNIFRSEGIIFEDVLICPHFLDDNCDCRKPQTKLLKPWLKKNKI
CCCCCCCCCCCCEEEEEEEHHCCCCEEEHHHHCCHHCCCCCCCCCCHHHHHHHHHHHCCC
DKQRSYVIGDRETDMELAKNINLTGIQYKEKEFNWIDITKEIIKRNRYREVIRETKETYI
CCHHCEEECCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEE
HIKLWLDLEHHSCIQTGINFFDHMLEQLSIHSGISMYILAKGDLQIDDHHTIEDTGIVLG
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCHHHHHHH
EALSQALNNKNGLSRYGFVLPMDESQAKCIIDLSNRPYLSFNAHFKHKMVGDMNTDMVEH
HHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEECCCCCHHHCCCCHHHHHH
FFYSLCCSMKITLHIDVKGKNDHHCIESLFKAFGRALRKAVKIEGNTLPTSKGIL
HHHHHHHCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure
MKQKILFIDRDGTLIHEPSNDCQVDAINKLEFKKYIISSLCQLMNFGYKFVMVTNQDGLG
CCCEEEEEECCCCEEECCCCCCEEECHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
SKSFPRENFNIPHFFMLNIFRSEGIIFEDVLICPHFLDDNCDCRKPQTKLLKPWLKKNKI
CCCCCCCCCCCCEEEEEEEHHCCCCEEEHHHHCCHHCCCCCCCCCCHHHHHHHHHHHCCC
DKQRSYVIGDRETDMELAKNINLTGIQYKEKEFNWIDITKEIIKRNRYREVIRETKETYI
CCHHCEEECCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCEE
HIKLWLDLEHHSCIQTGINFFDHMLEQLSIHSGISMYILAKGDLQIDDHHTIEDTGIVLG
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCHHHHHHH
EALSQALNNKNGLSRYGFVLPMDESQAKCIIDLSNRPYLSFNAHFKHKMVGDMNTDMVEH
HHHHHHHCCCCCCCCCCEEEECCCCCCEEEEEECCCCEEEEECCCCCHHHCCCCHHHHHH
FFYSLCCSMKITLHIDVKGKNDHHCIESLFKAFGRALRKAVKIEGNTLPTSKGIL
HHHHHHHCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767718; 12089438