Click here to switch to the map view.

The map label for this gene is hisC

Identifier: 21672386

GI number: 21672386

Start: 106796

End: 107863

Strand: Direct

Name: hisC

Synonym: BUsg094

Alternate gene names: 21672386

Gene position: 106796-107863 (Clockwise)

Preceding gene: 21672385

Following gene: 21672387

Centisome position: 16.65

GC content: 26.03

Gene sequence:

>1068_bases
ATGACAGCTAATATAAATAAGTTAGCTCGAAAAAATATACAGAAATTAAACCCTTATCAATCAGCTAGACGAATTGGTGG
AAAAGGTGATACATGGTTAAATGCAAATGAATCACCTATATCTGTTCCGTTTAAAGGAAAAGTAAAAGTATTTAATCGTT
ATCCAGAATGTCAACCTAATAATTTACTTTCTTCTTATGCGAATTACGTTGGTTTATTAAATAATCAAATTTTAGTTACT
AGAGGAGCAGATGAAGGTATTGAACTTTTGATTAAAGCTTTTTGTGAACCCGGTAAAGATGCAATAATTTACTGTCCTCC
AACCTATGATATGTATGCCATAAATGCCAAAATTGCAAATGTTGAAATAAAAGAAATTCCTACTTTTAAAAATACTTGGA
AAATAGATTTATTGAATATTCGATCCAATCTTAATAAAGTTAAATTAATATATATTTGTAATCCTAACAATCCTACTGGA
AACATTGTTTCTCAAGAAGATTTAAAAAGTTTATTAAAAGTTACATTAGGACAATCTCTTGTAATAATAGATGAAGCTTA
TATCGAATTTTCCCCAAAAAACAGTATGGTAAATTATTTAAAAACATTTCCCAATTTAATCATTTTAAGAACTTTATCCA
AAGCATTTGCATTAGCAGGAATAAGATGTGGTTTTACATTGGCACAAAAAGAGGTGATTGATATTTTACATAAAGTGATT
AGTCCTTATCCAATATCTACATTAATTGCTGACATAGCAGTACAATCTTTAGAAAAGAAAGCAATTGACGATATGAAAAA
TAGAGTCTTAAAATTAAATATGAATCGTATTTGGTTAATTGATGAATTAAAAAAAATTTCTTGTGTAAAAAAAGTTTTTG
ATAGTCATGCTAATTATATTTTAGTAGAATTTTACATGTTTAAAAAAATATTTCAGAGTTTGTGGCAAAAAGGTATAATT
TTAAGAAATCAAAATCATAAAAACAATTTGAAAAATTGTTTAAGAATATCAATAGGATCCAAGTCAGAATGTATGCGTTT
AGTTCAAGAGTTAAAAAATTTTATTTAA

Upstream 100 bases:

>100_bases
TAAATTTATCTAATACGCTTAAAATTCTATCTGAAGCGGAAAAACTTGAAGCACATAAAAATGCTGTAAAAATAAGAGTA
GATTTTTTAAAGGAAAAAAT

Downstream 100 bases:

>100_bases
AAAATAATTTTTTCAATGAGGTATTGATGAAACAAAAAATATTATTTATTGATCGAGATGGAACATTAATTCATGAACCA
TCTAATGATTGTCAAGTGGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTANINKLARKNIQKLNPYQSARRIGGKGDTWLNANESPISVPFKGKVKVFNRYPECQPNNLLSSYANYVGLLNNQILVT
RGADEGIELLIKAFCEPGKDAIIYCPPTYDMYAINAKIANVEIKEIPTFKNTWKIDLLNIRSNLNKVKLIYICNPNNPTG
NIVSQEDLKSLLKVTLGQSLVIIDEAYIEFSPKNSMVNYLKTFPNLIILRTLSKAFALAGIRCGFTLAQKEVIDILHKVI
SPYPISTLIADIAVQSLEKKAIDDMKNRVLKLNMNRIWLIDELKKISCVKKVFDSHANYILVEFYMFKKIFQSLWQKGII
LRNQNHKNNLKNCLRISIGSKSECMRLVQELKNFI

Sequences:

>Translated_355_residues
MTANINKLARKNIQKLNPYQSARRIGGKGDTWLNANESPISVPFKGKVKVFNRYPECQPNNLLSSYANYVGLLNNQILVT
RGADEGIELLIKAFCEPGKDAIIYCPPTYDMYAINAKIANVEIKEIPTFKNTWKIDLLNIRSNLNKVKLIYICNPNNPTG
NIVSQEDLKSLLKVTLGQSLVIIDEAYIEFSPKNSMVNYLKTFPNLIILRTLSKAFALAGIRCGFTLAQKEVIDILHKVI
SPYPISTLIADIAVQSLEKKAIDDMKNRVLKLNMNRIWLIDELKKISCVKKVFDSHANYILVEFYMFKKIFQSLWQKGII
LRNQNHKNNLKNCLRISIGSKSECMRLVQELKNFI
>Mature_354_residues
TANINKLARKNIQKLNPYQSARRIGGKGDTWLNANESPISVPFKGKVKVFNRYPECQPNNLLSSYANYVGLLNNQILVTR
GADEGIELLIKAFCEPGKDAIIYCPPTYDMYAINAKIANVEIKEIPTFKNTWKIDLLNIRSNLNKVKLIYICNPNNPTGN
IVSQEDLKSLLKVTLGQSLVIIDEAYIEFSPKNSMVNYLKTFPNLIILRTLSKAFALAGIRCGFTLAQKEVIDILHKVIS
PYPISTLIADIAVQSLEKKAIDDMKNRVLKLNMNRIWLIDELKKISCVKKVFDSHANYILVEFYMFKKIFQSLWQKGIIL
RNQNHKNNLKNCLRISIGSKSECMRLVQELKNFI

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=53.8461538461538, Blast_Score=429, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71994472, Length=179, Percent_Identity=27.3743016759777, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=179, Percent_Identity=27.3743016759777, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=30.3430079155673, Blast_Score=169, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BUCAP (Q9ZHE5)

Other databases:

- EMBL:   AF067228
- EMBL:   AE013218
- RefSeq:   NP_660453.1
- ProteinModelPortal:   Q9ZHE5
- SMR:   Q9ZHE5
- EnsemblBacteria:   EBBUCT00000000472
- GeneID:   1005911
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg094
- GeneTree:   EBGT00050000007997
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- ProtClustDB:   PRK01688
- BioCyc:   BAPH198804:BUSG094-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40474; Mature: 40343

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANINKLARKNIQKLNPYQSARRIGGKGDTWLNANESPISVPFKGKVKVFNRYPECQPN
CCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCH
NLLSSYANYVGLLNNQILVTRGADEGIELLIKAFCEPGKDAIIYCPPTYDMYAINAKIAN
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEE
VEIKEIPTFKNTWKIDLLNIRSNLNKVKLIYICNPNNPTGNIVSQEDLKSLLKVTLGQSL
EEHHHCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEE
VIIDEAYIEFSPKNSMVNYLKTFPNLIILRTLSKAFALAGIRCGFTLAQKEVIDILHKVI
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SPYPISTLIADIAVQSLEKKAIDDMKNRVLKLNMNRIWLIDELKKISCVKKVFDSHANYI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEHHHHHHHHHHHHHHHCCCCEE
LVEFYMFKKIFQSLWQKGIILRNQNHKNNLKNCLRISIGSKSECMRLVQELKNFI
EHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TANINKLARKNIQKLNPYQSARRIGGKGDTWLNANESPISVPFKGKVKVFNRYPECQPN
CCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCH
NLLSSYANYVGLLNNQILVTRGADEGIELLIKAFCEPGKDAIIYCPPTYDMYAINAKIAN
HHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEE
VEIKEIPTFKNTWKIDLLNIRSNLNKVKLIYICNPNNPTGNIVSQEDLKSLLKVTLGQSL
EEHHHCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEE
VIIDEAYIEFSPKNSMVNYLKTFPNLIILRTLSKAFALAGIRCGFTLAQKEVIDILHKVI
EEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
SPYPISTLIADIAVQSLEKKAIDDMKNRVLKLNMNRIWLIDELKKISCVKKVFDSHANYI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEHHHHHHHHHHHHHHHCCCCEE
LVEFYMFKKIFQSLWQKGIILRNQNHKNNLKNCLRISIGSKSECMRLVQELKNFI
EHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767718; 12089438