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The map label for this gene is hisD

Identifier: 21672385

GI number: 21672385

Start: 105492

End: 106799

Strand: Direct

Name: hisD

Synonym: BUsg093

Alternate gene names: 21672385

Gene position: 105492-106799 (Clockwise)

Preceding gene: 21672384

Following gene: 21672386

Centisome position: 16.45

GC content: 27.45

Gene sequence:

>1308_bases
ATGAAATATTTTAATACAATTGTTAATTGGAATATGTTAAATTCTAATGAACAAAAAAATATTCTATTAAGACCCGTTAT
AAAAAACAATAATTCTATCAAAAAAAAAGTAAAAAAAATAATAGAAAATATTCAAGTTTTAGGAGAAAAAGCATTAAGAG
AATATACAATTTTATTTGAAAAATGTCATATTAATAAATTTGAAGTTTCTAAAGAAAAAATGTTATCTTCTTCTTTATAC
GTCAACCAATCACTAAAAGATGCAATTTCAACTGCTAAAAAAAATATTACATCTTTTCATACAGCTCAAATTTTATCTCC
AATAGACATTGAAACTCAAGTTGGAGTACGATGTCAACAGATTTATTTACCATTAAATTCTGTTGGAATTTATATTCCAA
GTGGAATTGCTCCTTTGTTTTCTACTGTTTTAATGCTTGCTATACCTGCTAAAATTGCTGGTTGTAAACAAATTATTCTT
TGTTCTCCACCTCCTATTGATAATACAATACTTTATGCGGCAAATATTTGTGGTGTCGATAAAATATTTCAAATGGGAGG
TGCTCAAGCTATAGCAGCATTAGCTTTTGGTACTAAAAACATTCCTAAAGTAGATAAAATTTTTGGTCCAGGAAATGCTT
ATGTTACAGAAGCAAAATTACAAGTTAGTTCTATTTTTAATGGACCTCAAATAGATATGTTGGCTGGACCTTCAGAATTA
CTAATCATTGCTGATGAAGCGTCTAATGCTGATTTTATTGCTGCTGATTTATTGTCACAAGCTGAACATAGTATATCTTC
TCAAGTCATATTGTTGACACCATCTCTTCAATTAGCTAAAAAAGTTATTATATCTATTAACAATCAGTTAAAAAATCTCT
CTAAATCAGATGATATATCAACTGCATTAGATAATAGTGTTATTATTTTAACAAAAGACTTATTTGAATGCATTAAAATA
TCAAATATCTATGCTCCTGAACATCTAATTATTCAAACAAAAGAACCAAGATTAATACTTAAAGAAATATTAAATGCTAG
TTCAATCTTTTTAGGACCATGGTCTCCTGAATCAGCAGGTGATTATGCATCTGGCACTAATCATGTTTTACCTACTTATG
GAAAATCTGTTTCAAGTTCTGCTTTGGGTTTATGTGATTTTAAAAAACGTGTATTAATTCAAGAATTGACATCTCAAGGT
TTTATAAATTTATCTAATACGCTTAAAATTCTATCTGAAGCGGAAAAACTTGAAGCACATAAAAATGCTGTAAAAATAAG
AGTAGATTTTTTAAAGGAAAAAATATGA

Upstream 100 bases:

>100_bases
AGTGAAACATTATTTTGGGAAACGATGGAGAAATTAAAATCTTTAGGTGCTAGTTCAATTTTAGTTTTACCAATTGAAAA
AATGATGGAGTAAAAATTTA

Downstream 100 bases:

>100_bases
CAGCTAATATAAATAAGTTAGCTCGAAAAAATATACAGAAATTAAACCCTTATCAATCAGCTAGACGAATTGGTGGAAAA
GGTGATACATGGTTAAATGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKYFNTIVNWNMLNSNEQKNILLRPVIKNNNSIKKKVKKIIENIQVLGEKALREYTILFEKCHINKFEVSKEKMLSSSLY
VNQSLKDAISTAKKNITSFHTAQILSPIDIETQVGVRCQQIYLPLNSVGIYIPSGIAPLFSTVLMLAIPAKIAGCKQIIL
CSPPPIDNTILYAANICGVDKIFQMGGAQAIAALAFGTKNIPKVDKIFGPGNAYVTEAKLQVSSIFNGPQIDMLAGPSEL
LIIADEASNADFIAADLLSQAEHSISSQVILLTPSLQLAKKVIISINNQLKNLSKSDDISTALDNSVIILTKDLFECIKI
SNIYAPEHLIIQTKEPRLILKEILNASSIFLGPWSPESAGDYASGTNHVLPTYGKSVSSSALGLCDFKKRVLIQELTSQG
FINLSNTLKILSEAEKLEAHKNAVKIRVDFLKEKI

Sequences:

>Translated_435_residues
MKYFNTIVNWNMLNSNEQKNILLRPVIKNNNSIKKKVKKIIENIQVLGEKALREYTILFEKCHINKFEVSKEKMLSSSLY
VNQSLKDAISTAKKNITSFHTAQILSPIDIETQVGVRCQQIYLPLNSVGIYIPSGIAPLFSTVLMLAIPAKIAGCKQIIL
CSPPPIDNTILYAANICGVDKIFQMGGAQAIAALAFGTKNIPKVDKIFGPGNAYVTEAKLQVSSIFNGPQIDMLAGPSEL
LIIADEASNADFIAADLLSQAEHSISSQVILLTPSLQLAKKVIISINNQLKNLSKSDDISTALDNSVIILTKDLFECIKI
SNIYAPEHLIIQTKEPRLILKEILNASSIFLGPWSPESAGDYASGTNHVLPTYGKSVSSSALGLCDFKKRVLIQELTSQG
FINLSNTLKILSEAEKLEAHKNAVKIRVDFLKEKI
>Mature_435_residues
MKYFNTIVNWNMLNSNEQKNILLRPVIKNNNSIKKKVKKIIENIQVLGEKALREYTILFEKCHINKFEVSKEKMLSSSLY
VNQSLKDAISTAKKNITSFHTAQILSPIDIETQVGVRCQQIYLPLNSVGIYIPSGIAPLFSTVLMLAIPAKIAGCKQIIL
CSPPPIDNTILYAANICGVDKIFQMGGAQAIAALAFGTKNIPKVDKIFGPGNAYVTEAKLQVSSIFNGPQIDMLAGPSEL
LIIADEASNADFIAADLLSQAEHSISSQVILLTPSLQLAKKVIISINNQLKNLSKSDDISTALDNSVIILTKDLFECIKI
SNIYAPEHLIIQTKEPRLILKEILNASSIFLGPWSPESAGDYASGTNHVLPTYGKSVSSSALGLCDFKKRVLIQELTSQG
FINLSNTLKILSEAEKLEAHKNAVKIRVDFLKEKI

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=431, Percent_Identity=56.3805104408353, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319819, Length=421, Percent_Identity=41.3301662707838, Blast_Score=313, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_BUCAP (Q9ZHE6)

Other databases:

- EMBL:   AF067228
- EMBL:   AE013218
- RefSeq:   NP_660452.1
- ProteinModelPortal:   Q9ZHE6
- SMR:   Q9ZHE6
- EnsemblBacteria:   EBBUCT00000000199
- GeneID:   1005910
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg093
- GeneTree:   EBGT00050000008005
- HOGENOM:   HBG329596
- OMA:   MIRIARV
- ProtClustDB:   PRK00877
- BioCyc:   BAPH198804:BUSG093-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47738; Mature: 47738

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00611 HISOL_DEHYDROGENASE; PS00599 AA_TRANSFER_CLASS_2

Important sites: ACT_SITE 327-327 ACT_SITE 328-328 BINDING 131-131 BINDING 189-189 BINDING 212-212 BINDING 238-238 BINDING 260-260 BINDING 263-263 BINDING 328-328 BINDING 361-361 BINDING 415-415 BINDING 420-420

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYFNTIVNWNMLNSNEQKNILLRPVIKNNNSIKKKVKKIIENIQVLGEKALREYTILFE
CCHHHHEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCHINKFEVSKEKMLSSSLYVNQSLKDAISTAKKNITSFHTAQILSPIDIETQVGVRCQQ
HHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
IYLPLNSVGIYIPSGIAPLFSTVLMLAIPAKIAGCKQIILCSPPPIDNTILYAANICGVD
EEEEHHHCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHH
KIFQMGGAQAIAALAFGTKNIPKVDKIFGPGNAYVTEAKLQVSSIFNGPQIDMLAGPSEL
HHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEEEEEEEHHCCCCCEEEEECCCEE
LIIADEASNADFIAADLLSQAEHSISSQVILLTPSLQLAKKVIISINNQLKNLSKSDDIS
EEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHH
TALDNSVIILTKDLFECIKISNIYAPEHLIIQTKEPRLILKEILNASSIFLGPWSPESAG
HHHCCCEEEEEHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCCEEECCCCCCCCC
DYASGTNHVLPTYGKSVSSSALGLCDFKKRVLIQELTSQGFINLSNTLKILSEAEKLEAH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHH
KNAVKIRVDFLKEKI
HCCEEEEEHHHHHCC
>Mature Secondary Structure
MKYFNTIVNWNMLNSNEQKNILLRPVIKNNNSIKKKVKKIIENIQVLGEKALREYTILFE
CCHHHHEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCHINKFEVSKEKMLSSSLYVNQSLKDAISTAKKNITSFHTAQILSPIDIETQVGVRCQQ
HHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
IYLPLNSVGIYIPSGIAPLFSTVLMLAIPAKIAGCKQIILCSPPPIDNTILYAANICGVD
EEEEHHHCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHH
KIFQMGGAQAIAALAFGTKNIPKVDKIFGPGNAYVTEAKLQVSSIFNGPQIDMLAGPSEL
HHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEEEEEEEHHCCCCCEEEEECCCEE
LIIADEASNADFIAADLLSQAEHSISSQVILLTPSLQLAKKVIISINNQLKNLSKSDDIS
EEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHH
TALDNSVIILTKDLFECIKISNIYAPEHLIIQTKEPRLILKEILNASSIFLGPWSPESAG
HHHCCCEEEEEHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHCCCCCEEECCCCCCCCC
DYASGTNHVLPTYGKSVSSSALGLCDFKKRVLIQELTSQGFINLSNTLKILSEAEKLEAH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHH
KNAVKIRVDFLKEKI
HCCEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767718; 12089438