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The map label for this gene is hisG

Identifier: 21672384

GI number: 21672384

Start: 104585

End: 105484

Strand: Direct

Name: hisG

Synonym: BUsg092

Alternate gene names: 21672384

Gene position: 104585-105484 (Clockwise)

Preceding gene: 21672383

Following gene: 21672385

Centisome position: 16.3

GC content: 29.67

Gene sequence:

>900_bases
ATGTTTAATACTAATCGTGTACGTATAGCGATGCAGAAAACTGGTCGTTTAAGTAGTGAATCTATAAAATTACTTACATG
TTGTGGAATTAAAATTAATTTAAAGCAGCAAAAATTAATAGCTTTTGCTGAAAATATGCCTATTGATGTTATGCTAGTAC
GTGATGATGATATTCCAGGATTAGTTATGGATGGTGTAGTAGACTTAGGTATAGTAGGAGAAAATGTTCTTCAAGAAGAA
TTATTACATCGAATATCACAAAATCTAGAAAATTCTTATATTACATTAAGACGACTTGATTTTGGCATTTGTCGTTTATC
TTTAGCTATTCCTATTAATACTCCATATGTTGATATAACATCTTTAAAAAATTTTAGGATTGCTACCTCTTATCCTCATT
TATTAAAAAAATATTTAGATAGTAAAAACATTGTTTTCAAGTCTTGTATGTTAAATGGTTCTGTAGAAGTTGCACCTAGA
GCTGGTTTAGCAGATGCTATTTGTGATTTAGTTTCAACTGGTGCAACATTAGAAGCAAACGGTTTACGTGAAGTACAAGT
GGTTTTTCGTTCTCATGCTTGTTTAATTTGTAAAACTGGTAATATTAATTTTGCAAAAAAAGAAGTAATTAATAAGTTAA
TGACTCGTATCAAAGGTGTAATTAAAGCACGTGAATCTAAATATATTATGCTTCATGCTCCTGTTAATAAACTTGAAGAA
GTAATATCTTTATTACATGGAGCAGAAAAACCGACTATTTTAAAATTAGCCGGAGATGATCATCGTGTAGCTATGCATAT
GGTCAGTAGTGAAACATTATTTTGGGAAACGATGGAGAAATTAAAATCTTTAGGTGCTAGTTCAATTTTAGTTTTACCAA
TTGAAAAAATGATGGAGTAA

Upstream 100 bases:

>100_bases
ATATAATTTTTAAAAAACCCTGATTTTGGGTTTTTTTATTTTAAAAGATATTAAATTGCAAGTTTGTTTTTAAATATAAA
AAAATTAAAGGATTTTCAAG

Downstream 100 bases:

>100_bases
AAATTTAATGAAATATTTTAATACAATTGTTAATTGGAATATGTTAAATTCTAATGAACAAAAAAATATTCTATTAAGAC
CCGTTATAAAAAACAATAAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MFNTNRVRIAMQKTGRLSSESIKLLTCCGIKINLKQQKLIAFAENMPIDVMLVRDDDIPGLVMDGVVDLGIVGENVLQEE
LLHRISQNLENSYITLRRLDFGICRLSLAIPINTPYVDITSLKNFRIATSYPHLLKKYLDSKNIVFKSCMLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVQVVFRSHACLICKTGNINFAKKEVINKLMTRIKGVIKARESKYIMLHAPVNKLEE
VISLLHGAEKPTILKLAGDDHRVAMHMVSSETLFWETMEKLKSLGASSILVLPIEKMME

Sequences:

>Translated_299_residues
MFNTNRVRIAMQKTGRLSSESIKLLTCCGIKINLKQQKLIAFAENMPIDVMLVRDDDIPGLVMDGVVDLGIVGENVLQEE
LLHRISQNLENSYITLRRLDFGICRLSLAIPINTPYVDITSLKNFRIATSYPHLLKKYLDSKNIVFKSCMLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVQVVFRSHACLICKTGNINFAKKEVINKLMTRIKGVIKARESKYIMLHAPVNKLEE
VISLLHGAEKPTILKLAGDDHRVAMHMVSSETLFWETMEKLKSLGASSILVLPIEKMME
>Mature_299_residues
MFNTNRVRIAMQKTGRLSSESIKLLTCCGIKINLKQQKLIAFAENMPIDVMLVRDDDIPGLVMDGVVDLGIVGENVLQEE
LLHRISQNLENSYITLRRLDFGICRLSLAIPINTPYVDITSLKNFRIATSYPHLLKKYLDSKNIVFKSCMLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVQVVFRSHACLICKTGNINFAKKEVINKLMTRIKGVIKARESKYIMLHAPVNKLEE
VISLLHGAEKPTILKLAGDDHRVAMHMVSSETLFWETMEKLKSLGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=299, Percent_Identity=73.2441471571906, Blast_Score=454, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6320896, Length=298, Percent_Identity=31.2080536912752, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_BUCAP (Q9ZHE7)

Other databases:

- EMBL:   AF067228
- EMBL:   AE013218
- RefSeq:   NP_660451.1
- ProteinModelPortal:   Q9ZHE7
- SMR:   Q9ZHE7
- EnsemblBacteria:   EBBUCT00000000380
- GeneID:   1005909
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg092
- GeneTree:   EBGT00050000007976
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- BioCyc:   BAPH198804:BUSG092-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 33350; Mature: 33350

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNTNRVRIAMQKTGRLSSESIKLLTCCGIKINLKQQKLIAFAENMPIDVMLVRDDDIPG
CCCCCEEEEEEECCCCCCCCCEEEEEEECCEEECCHHHHHHHHCCCCEEEEEEECCCCCC
LVMDGVVDLGIVGENVLQEELLHRISQNLENSYITLRRLDFGICRLSLAIPINTPYVDIT
HHHHCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEE
SLKNFRIATSYPHLLKKYLDSKNIVFKSCMLNGSVEVAPRAGLADAICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREVQVVFRSHACLICKTGNINFAKKEVINKLMTRIKGVIKARESKYIMLHAPVNKLEE
CCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
VISLLHGAEKPTILKLAGDDHRVAMHMVSSETLFWETMEKLKSLGASSILVLPIEKMME
HHHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEHHHHCC
>Mature Secondary Structure
MFNTNRVRIAMQKTGRLSSESIKLLTCCGIKINLKQQKLIAFAENMPIDVMLVRDDDIPG
CCCCCEEEEEEECCCCCCCCCEEEEEEECCEEECCHHHHHHHHCCCCEEEEEEECCCCCC
LVMDGVVDLGIVGENVLQEELLHRISQNLENSYITLRRLDFGICRLSLAIPINTPYVDIT
HHHHCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEEECCCCEEEEE
SLKNFRIATSYPHLLKKYLDSKNIVFKSCMLNGSVEVAPRAGLADAICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREVQVVFRSHACLICKTGNINFAKKEVINKLMTRIKGVIKARESKYIMLHAPVNKLEE
CCHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
VISLLHGAEKPTILKLAGDDHRVAMHMVSSETLFWETMEKLKSLGASSILVLPIEKMME
HHHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9767718; 12089438