Click here to switch to the map view.

The map label for this gene is hrmI

Identifier: 21244968

GI number: 21244968

Start: 5017767

End: 5019185

Strand: Reverse

Name: hrmI

Synonym: XAC4251

Alternate gene names: 21244968

Gene position: 5019185-5017767 (Counterclockwise)

Preceding gene: 21244969

Following gene: 77748769

Centisome position: 96.98

GC content: 65.96

Gene sequence:

>1419_bases
ATGCGTTCTTCCGTGTTGTCCTTGCATCCCGATCGTTTGCTGCCGGCCGATCCCGGCACGCGCGCGATCGCCCGCCGCCT
GTACGCGCAGGTCGCAACGCTGCCCATCATCAGCCCACATGGCCACACCGACCCGGCCTGGTTCGCCACCAATGCGCCGT
TCGCCAACGCCACCGAACTGTTGTTGGTGCCGGACCACTATGTGTTCCGCATGTTGTACAGCCAGGGCATCGACCTCGAT
GCCCTGGGCATCCCACGCGCAGATGGAACCCGCGCAACAGTCGACCCGCGTGCGGCGTGGCGCGTGTTTGCCGAGCACTA
CACGTTGTTGCGCGGCACGCCGTCGGCGCTGTGGCTCAATCATGTGTTCCATGACGTTTTCGATCTACGTATTCGTCTCG
ACGCCGGTACCGCCGATCACTATTACGACCACATCACCGCCGCGCTGCAAACGCCAGCATTCCTGCCGCGCGCGTTGTTC
GAGCGCTTCAATATCGAGGTGATCGCCACCACCGAATCGCCGCTGGATCGGCTGCAGCACCATGCGGCCATTGCCGCCAG
CGGCTGGCAGGGACGGGTGGTGACGGCGTATCGCCCCGACCCGGTCGTGGACCCGGAGCACGAGCAGTTCGCCGGCGCGC
TGCAGCAGTTCGGCGCGCTCACCGGTGAGGACGTGCTGACCTGGGATGGCTACTTGCGCGCGCATCGGCAACGGCGTGCG
TTCTTTGCCGCGCACGGCGCCACCTCGACCGATCACGGGCACCCCAGCGCCGCGACCGCCGATCTGTCGCCGGCCGAAGC
GCAGCGCCTGTTCGATACGGTGGTGCGCGGTGCGGCCACGCCGGAGCAGGCCGAACTGTTTCGCGCGCAGGTGCTGACCG
AAATGGCGGCGATGAGCCTGGACGACGGCCTGGTGATGCAGCTGCATCCGGGCTGCTTCCGCAATCACAATCGGCAGCTG
TTCGAGCAGTACGGACGCGACAAGGGCGCCGATATTCCGATGCGCACCGACTACGTGCATGCGTTGAAGCCGTTGCTGGA
TCGGCATGGCAACGACCCGCGCCTGCGCCTGATCGTGTTCACCCTGGACGAGACCAGCTACAGCCGCGAGCTGGCGCCAT
TGGCCGGGCATTACCCCTCCCTGCTGCTCGGCCCGGCGTGGTGGTTCCATGATGCGCCGGAAGGCATGTGGCGCTTTCGC
GAGCAGACCCTGGCCAGCGCCGGCTTCTACAACACCGTGGGCTTCAACGACGATACCCGCGCATTCCTGTCCATTCCGGC
GCGACACGATGTGGCGCGGCGCGTGGATAGCGCCTTCCTGGCCAAACTCGTTGCCGAGCACCGGTTAGAAGAGGACGAGG
CCACCGAGGTGGCGATCGACCTGGCCTACCGCCTACCCAAGCAAGCGTACAAGCTGTGA

Upstream 100 bases:

>100_bases
GACGGCAGCGAACGCCCGGCATTGACCTGGCTACGCAGCTACGTCGCCAGCAAGCCCTGACCAGGGTTCCCATTTATTGT
CCATAGGGCTGATATCGATC

Downstream 100 bases:

>100_bases
GGTGGCGCAAACGGAGGGCGGTGGTGCCGACGCGTCCGCACGCGTCGTCGCTGCATCCTGCGCAGCGGAAGGGTCGGTGA
ACTGATGCGTACACACGCCA

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATELLLVPDHYVFRMLYSQGIDLD
ALGIPRADGTRATVDPRAAWRVFAEHYTLLRGTPSALWLNHVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALF
ERFNIEVIATTESPLDRLQHHAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLTWDGYLRAHRQRRA
FFAAHGATSTDHGHPSAATADLSPAEAQRLFDTVVRGAATPEQAELFRAQVLTEMAAMSLDDGLVMQLHPGCFRNHNRQL
FEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVFTLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFR
EQTLASAGFYNTVGFNDDTRAFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYKL

Sequences:

>Translated_472_residues
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATELLLVPDHYVFRMLYSQGIDLD
ALGIPRADGTRATVDPRAAWRVFAEHYTLLRGTPSALWLNHVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALF
ERFNIEVIATTESPLDRLQHHAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLTWDGYLRAHRQRRA
FFAAHGATSTDHGHPSAATADLSPAEAQRLFDTVVRGAATPEQAELFRAQVLTEMAAMSLDDGLVMQLHPGCFRNHNRQL
FEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVFTLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFR
EQTLASAGFYNTVGFNDDTRAFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYKL
>Mature_472_residues
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATELLLVPDHYVFRMLYSQGIDLD
ALGIPRADGTRATVDPRAAWRVFAEHYTLLRGTPSALWLNHVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALF
ERFNIEVIATTESPLDRLQHHAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLTWDGYLRAHRQRRA
FFAAHGATSTDHGHPSAATADLSPAEAQRLFDTVVRGAATPEQAELFRAQVLTEMAAMSLDDGLVMQLHPGCFRNHNRQL
FEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVFTLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFR
EQTLASAGFYNTVGFNDDTRAFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYKL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=435, Percent_Identity=27.816091954023, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_XANAC (Q8PET9)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644550.1
- ProteinModelPortal:   Q8PET9
- SMR:   Q8PET9
- GeneID:   1158322
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC4251
- NMPDR:   fig|190486.1.peg.4194
- HOGENOM:   HBG293306
- OMA:   AWAKTVP
- ProtClustDB:   PRK02925
- BioCyc:   XAXO190486:XAC4251-MONOMER
- BRENDA:   5.3.1.12
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 52896; Mature: 52896

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATEL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCCCCCEE
LLVPDHYVFRMLYSQGIDLDALGIPRADGTRATVDPRAAWRVFAEHYTLLRGTPSALWLN
EECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
HVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALFERFNIEVIATTESPLDRLQH
HHHHHHHEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEEECCHHHHHHHH
HAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLTWDGYLRAHRQRRA
HHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
FFAAHGATSTDHGHPSAATADLSPAEAQRLFDTVVRGAATPEQAELFRAQVLTEMAAMSL
HEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DDGLVMQLHPGCFRNHNRQLFEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVF
CCCEEEEECCCHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
TLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFREQTLASAGFYNTVGFNDDTR
EECCCCCHHHHHHHHCCCCHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
AFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYKL
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MRSSVLSLHPDRLLPADPGTRAIARRLYAQVATLPIISPHGHTDPAWFATNAPFANATEL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCCCCCEE
LLVPDHYVFRMLYSQGIDLDALGIPRADGTRATVDPRAAWRVFAEHYTLLRGTPSALWLN
EECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
HVFHDVFDLRIRLDAGTADHYYDHITAALQTPAFLPRALFERFNIEVIATTESPLDRLQH
HHHHHHHEEEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCEEEEEECCHHHHHHHH
HAAIAASGWQGRVVTAYRPDPVVDPEHEQFAGALQQFGALTGEDVLTWDGYLRAHRQRRA
HHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
FFAAHGATSTDHGHPSAATADLSPAEAQRLFDTVVRGAATPEQAELFRAQVLTEMAAMSL
HEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
DDGLVMQLHPGCFRNHNRQLFEQYGRDKGADIPMRTDYVHALKPLLDRHGNDPRLRLIVF
CCCEEEEECCCHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEE
TLDETSYSRELAPLAGHYPSLLLGPAWWFHDAPEGMWRFREQTLASAGFYNTVGFNDDTR
EECCCCCHHHHHHHHCCCCHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
AFLSIPARHDVARRVDSAFLAKLVAEHRLEEDEATEVAIDLAYRLPKQAYKL
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217