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The map label for this gene is haaO

Identifier: 21242353

GI number: 21242353

Start: 1852539

End: 1853069

Strand: Reverse

Name: haaO

Synonym: XAC1603

Alternate gene names: NA

Gene position: 1853069-1852539 (Counterclockwise)

Preceding gene: 21242354

Following gene: 21242352

Centisome position: 35.8

GC content: 62.15

Gene sequence:

>531_bases
ATGCTGACCCCGCCAATCAACCTGCACGCCTGGATCGAGGAACACCGCCACCTGCTCAAACCGCCGGTGGGCAACAAGTG
CATCCAGCAGGATGGCTTCATCATCATGGTTGTCGGGGGACCGAACGCGCGCACCGACTATCACTACGACGAAGGCCCGG
AGTGGTTCTTCCAGCTCGAGGGCGAAATGGTGTTGAAGGTGCAGGACGAGGGCGTGGCGCGCGACATCCCGATCCGTGCC
GGCGAAGTCTTTCTGCTGCCACCCAAGGTACCGCATTCGCCGCAACGCGCGGACGGCTCGATCGGCCTGGTGATCGAACG
CGAGCGCCTGCCCACCGAGCAGGACGGCCTGCAATGGTATTGCCCGCAGTGCAATCACAAGTTGTATGAAGCGATGTTTC
CGCTAAAAAACATCGAAACCGACTTCCCGCCGGTGTTCGATCGCTTCTACCGCTCGCCCGCACTGCGCACCTGTTCGCAG
TGCGGGCACCTGCATCCTGCGCCTGAGCGCTATGCCACGGTCGAGGGTTGA

Upstream 100 bases:

>100_bases
CAAACCGAGCGCTGAGCCGTACGCACACGTGGCCGGCCGCAGCGTCCATCGCACATCGGCGGCCGACTGAACCGGATATC
TTCTTTGCCGAGAAACGTCG

Downstream 100 bases:

>100_bases
CAACCTAACCGCACGCGATCGCGCGCAGCAGGTCTGGCGCTCGCATGCTCCGAAACCGGCACCATGCTGCGCGCACTGAT
CGACCTCAAACCACGCGATG

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MLTPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQDEGVARDIPIRA
GEVFLLPPKVPHSPQRADGSIGLVIERERLPTEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSPALRTCSQ
CGHLHPAPERYATVEG

Sequences:

>Translated_176_residues
MLTPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQDEGVARDIPIRA
GEVFLLPPKVPHSPQRADGSIGLVIERERLPTEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSPALRTCSQ
CGHLHPAPERYATVEG
>Mature_176_residues
MLTPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQDEGVARDIPIRA
GEVFLLPPKVPHSPQRADGSIGLVIERERLPTEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSPALRTCSQ
CGHLHPAPERYATVEG

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family

Homologues:

Organism=Homo sapiens, GI188497625, Length=152, Percent_Identity=47.3684210526316, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17562218, Length=152, Percent_Identity=45.3947368421053, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322485, Length=169, Percent_Identity=42.0118343195266, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 3HAO_XANAC (Q8PM31)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641935.1
- ProteinModelPortal:   Q8PM31
- SMR:   Q8PM31
- GeneID:   1155674
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1603
- NMPDR:   fig|190486.1.peg.1579
- HOGENOM:   HBG341987
- OMA:   LKPPVNN
- ProtClustDB:   PRK13264
- BioCyc:   XAXO190486:XAC1603-MONOMER
- BRENDA:   1.13.11.6
- HAMAP:   MF_00825
- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- TIGRFAMs:   TIGR03037

Pfam domain/function: PF06052 3-HAO; SSF51182 RmlC_like_cupin

EC number: =1.13.11.6

Molecular weight: Translated: 20155; Mature: 20155

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: BINDING 44-44 BINDING 54-54 BINDING 96-96 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLE
CCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEC
GEMVLKVQDEGVARDIPIRAGEVFLLPPKVPHSPQRADGSIGLVIERERLPTEQDGLQWY
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEE
CPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSPALRTCSQCGHLHPAPERYATVEG
CCCCCHHHHHHHCCHHCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCEEECCC
>Mature Secondary Structure
MLTPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMVVGGPNARTDYHYDEGPEWFFQLE
CCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEC
GEMVLKVQDEGVARDIPIRAGEVFLLPPKVPHSPQRADGSIGLVIERERLPTEQDGLQWY
CEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEE
CPQCNHKLYEAMFPLKNIETDFPPVFDRFYRSPALRTCSQCGHLHPAPERYATVEG
CCCCCHHHHHHHCCHHCCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217