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The map label for this gene is mraY

Identifier: 21241547

GI number: 21241547

Start: 921412

End: 922497

Strand: Direct

Name: mraY

Synonym: XAC0777

Alternate gene names: 21241547

Gene position: 921412-922497 (Clockwise)

Preceding gene: 21241546

Following gene: 21241548

Centisome position: 17.8

GC content: 62.15

Gene sequence:

>1086_bases
ATGCTGCTTGAGTTGGCCCGTTGGCTGCAGCAACTGGAGAGCCTGTTCGGGCTGTTCAACTATCTGACCTTCCGCGGCAT
CTTGGCTGCGCTGACGGCGCTGTTCCTGTCGTTGTGGATGGGCCCTGCGGTGATCCGCAAGCTCGCCCAGTTCAAGGGCG
GCCAGCCGATCCGCCAGGACGGCCCGCAAACGCATTTTTCCAAGGCCGGCACGCCGACCATGGGCGGTTCGCTGATCCTG
CTCACCGTCACCTTGTCGGTGCTGCTGTGGGGCGACCTGCGCAACCGCTACGTGTGGTTGGTGCTGGCGGTGATGATCTG
CTTCGGTGCGATCGGCTGGTACGACGACTGGATCAAGATCGTCAAACGCGATCCCAATGGTTTGAAGTCGCGCTGGAAGT
ATCTGCTGCAGTCGATCTTCGGACTGGCCGCTGGCTTGTTCCTGTACTACACCGCCGACGTGCCGGCGGCGATCACGTTC
TACATCCCGATGTTCAAGTCGATCGCGCTGCCGCTGGCCGGCGTGAGCTTCGTGGTGATCGCCTACTTCTGGATCGTGGG
CTTCTCCAACGCGGTGAACCTCACCGATGGCCTGGATGGCTTGGCCATCATGCCGACCGTGCTGGTGGCCTGCGCGCTGG
GCGTGTTCGCGTATGCGTCCGGCAACGTGGTGTTCGCCGAATACCTGAAAATTCCGCTGATTCCCGGTGCCGGCGAGCTG
ATCATCATCTGCTCGGCGATTGCGGGGGCAGGCTTGGGCTTCCTGTGGTTCAACACCTACCCGGCAATGGTGTTCATGGG
CGACATCGGCGCGTTGTCGCTGGGCGCAGTGCTCGGCACCATCGCGGTGATCGTGCGTCAGGAGATGGTGCTGGTGATCA
TGGGCGGCGTGTTCGTGATCGAAACGCTGTCGGTGATGATCCAGGTGGCCAGCTTCAAGCTGACCGGCAAGCGCGTATTC
CGCATGGCGCCGATCCACCACCATTTCGAGCTCAAGGGTTGGCCGGAGCCGCGCGTGATCGTGCGCTTCTGGATCATTTC
GGTGGTGCTGGTGCTGATCGGCCTTGCCACGTTGAAGGTGCGCTGA

Upstream 100 bases:

>100_bases
TCGGGTGCCGCCTCCATCACGATCCTGGTGAAGGGCTCGCGCGGTAGCGCGATGGACCGCGTCGTCACCGCGCTGCTCGC
ATCGGCGGAGGGCGCATCCC

Downstream 100 bases:

>100_bases
TGAACGACATGTCCCGCCAGGCAACACGACTGGACGCCATCGGCGGCCGCTACGACCCGTGGCTGCTCGGGGCCGCAGTC
ACGCTCGCGTCGCTGGGTGT

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLLELARWLQQLESLFGLFNYLTFRGILAALTALFLSLWMGPAVIRKLAQFKGGQPIRQDGPQTHFSKAGTPTMGGSLIL
LTVTLSVLLWGDLRNRYVWLVLAVMICFGAIGWYDDWIKIVKRDPNGLKSRWKYLLQSIFGLAAGLFLYYTADVPAAITF
YIPMFKSIALPLAGVSFVVIAYFWIVGFSNAVNLTDGLDGLAIMPTVLVACALGVFAYASGNVVFAEYLKIPLIPGAGEL
IIICSAIAGAGLGFLWFNTYPAMVFMGDIGALSLGAVLGTIAVIVRQEMVLVIMGGVFVIETLSVMIQVASFKLTGKRVF
RMAPIHHHFELKGWPEPRVIVRFWIISVVLVLIGLATLKVR

Sequences:

>Translated_361_residues
MLLELARWLQQLESLFGLFNYLTFRGILAALTALFLSLWMGPAVIRKLAQFKGGQPIRQDGPQTHFSKAGTPTMGGSLIL
LTVTLSVLLWGDLRNRYVWLVLAVMICFGAIGWYDDWIKIVKRDPNGLKSRWKYLLQSIFGLAAGLFLYYTADVPAAITF
YIPMFKSIALPLAGVSFVVIAYFWIVGFSNAVNLTDGLDGLAIMPTVLVACALGVFAYASGNVVFAEYLKIPLIPGAGEL
IIICSAIAGAGLGFLWFNTYPAMVFMGDIGALSLGAVLGTIAVIVRQEMVLVIMGGVFVIETLSVMIQVASFKLTGKRVF
RMAPIHHHFELKGWPEPRVIVRFWIISVVLVLIGLATLKVR
>Mature_361_residues
MLLELARWLQQLESLFGLFNYLTFRGILAALTALFLSLWMGPAVIRKLAQFKGGQPIRQDGPQTHFSKAGTPTMGGSLIL
LTVTLSVLLWGDLRNRYVWLVLAVMICFGAIGWYDDWIKIVKRDPNGLKSRWKYLLQSIFGLAAGLFLYYTADVPAAITF
YIPMFKSIALPLAGVSFVVIAYFWIVGFSNAVNLTDGLDGLAIMPTVLVACALGVFAYASGNVVFAEYLKIPLIPGAGEL
IIICSAIAGAGLGFLWFNTYPAMVFMGDIGALSLGAVLGTIAVIVRQEMVLVIMGGVFVIETLSVMIQVASFKLTGKRVF
RMAPIHHHFELKGWPEPRVIVRFWIISVVLVLIGLATLKVR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=361, Percent_Identity=60.387811634349, Blast_Score=424, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_XANAC (Q8PPB0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641129.1
- GeneID:   1154848
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0777
- NMPDR:   fig|190486.1.peg.773
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- ProtClustDB:   PRK00108
- BioCyc:   XAXO190486:XAC0777-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 39627; Mature: 39627

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb07390c)-; HASH(0xdb5ce6c)-; HASH(0xdc12f18)-; HASH(0xdb5d0a0)-; HASH(0xdcb307c)-; HASH(0xdc15f68)-; HASH(0xdc97ebc)-; HASH(0xdc12f9c)-; HASH(0xda9af68)-; HASH(0xd098620)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLELARWLQQLESLFGLFNYLTFRGILAALTALFLSLWMGPAVIRKLAQFKGGQPIRQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCC
GPQTHFSKAGTPTMGGSLILLTVTLSVLLWGDLRNRYVWLVLAVMICFGAIGWYDDWIKI
CCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VKRDPNGLKSRWKYLLQSIFGLAAGLFLYYTADVPAAITFYIPMFKSIALPLAGVSFVVI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYFWIVGFSNAVNLTDGLDGLAIMPTVLVACALGVFAYASGNVVFAEYLKIPLIPGAGEL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCC
IIICSAIAGAGLGFLWFNTYPAMVFMGDIGALSLGAVLGTIAVIVRQEMVLVIMGGVFVI
EEHHHHHHHCCHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLSVMIQVASFKLTGKRVFRMAPIHHHFELKGWPEPRVIVRFWIISVVLVLIGLATLKV
HHHHHHHHHHHHHCCHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
R
H
>Mature Secondary Structure
MLLELARWLQQLESLFGLFNYLTFRGILAALTALFLSLWMGPAVIRKLAQFKGGQPIRQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCC
GPQTHFSKAGTPTMGGSLILLTVTLSVLLWGDLRNRYVWLVLAVMICFGAIGWYDDWIKI
CCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VKRDPNGLKSRWKYLLQSIFGLAAGLFLYYTADVPAAITFYIPMFKSIALPLAGVSFVVI
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYFWIVGFSNAVNLTDGLDGLAIMPTVLVACALGVFAYASGNVVFAEYLKIPLIPGAGEL
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCC
IIICSAIAGAGLGFLWFNTYPAMVFMGDIGALSLGAVLGTIAVIVRQEMVLVIMGGVFVI
EEHHHHHHHCCHHHHHHHHCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLSVMIQVASFKLTGKRVFRMAPIHHHFELKGWPEPRVIVRFWIISVVLVLIGLATLKV
HHHHHHHHHHHHHCCHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
R
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217