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The map label for this gene is accD [H]

Identifier: 21241038

GI number: 21241038

Start: 318083

End: 319693

Strand: Reverse

Name: accD [H]

Synonym: XAC0264

Alternate gene names: 21241038

Gene position: 319693-318083 (Counterclockwise)

Preceding gene: 21241039

Following gene: 21241037

Centisome position: 6.18

GC content: 64.93

Gene sequence:

>1611_bases
ATGAGCGTGATCGATAGCCAGCTGCAGGTCAGCGGCGAGACTTTTCAACACAACGCTGCCGCGATGCGCGCGGTGATCGA
CGACCTGCGCCGCACCCTCGCCCAGACCGCCCGTGGCGGCAGCGACGCCGCACGCGCCAAGCACACGGCACGCGGCAAGC
TGCTGGCGCGCGAGCGCATCGACGCACTTCTGGATCGGGGCAGCGCCCTGCTGGAAATCGCGCCCCTGGCCGCCCATGGC
ATGTACGAGGACCAGGTCCCGTGCGCAGGCGTGGTGGCCGGCATCGGCCGCGTGTCCGGCGTGGAATGCGTGATCGTCGC
CAACGATGCCACCGTCAAGGGCGGCACCTATTACCCGATGACGGTGAAGAAGCATTTGCGCGCGCAGGAGATCGCGCAGC
AAAACCGGCTGCCGTGCATCTATCTGGTCGATTCCGGCGGTGCATTCCTGCCGTTGCAGGACGAAGTGTTTCCGGACCGC
GATCACTTCGGGCGCATCTTCTACAACCAGGCCAATCTGTCCGCCCGAGGCATCCCGCAGATTGCATGTGTGATGGGATC
GTGCACCGCTGGCGGCGCCTATGTGCCGGCAATGAGCGATGAAACGGTGATCGTGCGCGAGCAAGGCACCATCTTCCTGG
GCGGCCCGCCGCTGGTGAAGGCCGCCACCGGCGAAGAAGTCAGTGCTGAAGACCTGGGCGGCGCCGATGTGCATACGCGC
ATCTCCGGTGTGGCCGATCATTTTGCCGACAACGACCTGCAGGCGCTGGCGCGCGTGCGCGCCATCATCGCGCAGCTCAA
CTGGCGCAAACCTGCCGCGTCGTTGGCGCTGCAGGCACCATTGCCGCCACGCTATGCCGCCGACGAACTGTACGGCGTGA
TTCCTGCCGACACGCGCAAACCGTTCGATGTACGCGAAGTGATTGCGCGCGTCGTCGACGATTCGCGCCTGGACGAATTC
AAACCGCGCTATGGCAGCACGCTGGTCACCGGGTTTGCGCACCTGCATGGCTACCCGGTCGGCATCATTGCCAACAACGG
CATCCTGTTTTCCGAGTCCGCGCTCAAGGGTGCGCATTTCATCGAGCTGTGCACGCAGCGCGGCATTCCGCTGGTGTTTC
TGCAGAACATCACCGGCTTCATGGTCGGGCGCAAATACGAACATGGCGGCATCGCCAAGGACGGCGCCAAGCTGGTGATG
GCGGTGGCCTGCGCCAAGGTGCCCAAGTTCACCGTGGTGATCGGCGGCTCGTTCGGTGCGGGCAACTACGGCATGTGCGG
GCGCGCGTATTCGCCGAACTTCTTGTGGATGTGGCCGAACGCGCGCATCGGCGTGATGGGCGGCGAACAGGCGGCCAGTG
TGTTGGCCACCGTGCGTCGCGATGGTATCGAAGCCAAGGGCGGTACGTGGTCGGGCGAAGACGAGGAGACGTTCAAGGCG
CCGATCCGCGCGCAATTCGAGCAGCAAGGCCATCCGTATTACGCCAGTGCTCGGCTCTGGGACGATGGCATCATCGACCC
GGCCGATACGCGCCGCGTGCTGGGCCTGGGATTGTCGGCGGCCTTGAACGCGCCGATCGAACCCACGCGCTTTGGTGTGT
TTCGCATGTGA

Upstream 100 bases:

>100_bases
CGCGATGCCAAGTTGTACGAGATTGGCGCGGGCACTTCGGAGATTCGCCGCATGCTGATCGGCCGCGAATTGTTCGAACG
CACCGCCTGACGGAGCCACC

Downstream 100 bases:

>100_bases
GGTCATTTGGCGCACTGCAGCCGCAATGCTGCGGTGCCCGTGCTGGTGTGCAGGCTGGAGTGAGGTTCTGTCGTATGCGT
GCCGGCAATCGTGGACGTTT

Product: acyl-CoA carboxyltransferase subunit beta

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSVIDSQLQVSGETFQHNAAAMRAVIDDLRRTLAQTARGGSDAARAKHTARGKLLARERIDALLDRGSALLEIAPLAAHG
MYEDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDR
DHFGRIFYNQANLSARGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRKPFDVREVIARVVDDSRLDEF
KPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVM
AVACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGTWSGEDEETFKA
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM

Sequences:

>Translated_536_residues
MSVIDSQLQVSGETFQHNAAAMRAVIDDLRRTLAQTARGGSDAARAKHTARGKLLARERIDALLDRGSALLEIAPLAAHG
MYEDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDR
DHFGRIFYNQANLSARGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRKPFDVREVIARVVDDSRLDEF
KPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVM
AVACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGTWSGEDEETFKA
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM
>Mature_535_residues
SVIDSQLQVSGETFQHNAAAMRAVIDDLRRTLAQTARGGSDAARAKHTARGKLLARERIDALLDRGSALLEIAPLAAHGM
YEDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRD
HFGRIFYNQANLSARGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTRI
SGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRKPFDVREVIARVVDDSRLDEFK
PRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMA
VACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGTWSGEDEETFKAP
IRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=537, Percent_Identity=64.2458100558659, Blast_Score=708, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=531, Percent_Identity=33.5216572504708, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI295821216, Length=551, Percent_Identity=32.486388384755, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI310133460, Length=143, Percent_Identity=53.8461538461538, Blast_Score=146, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17552936, Length=534, Percent_Identity=60.4868913857678, Blast_Score=683, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=485, Percent_Identity=36.2886597938144, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI25147362, Length=485, Percent_Identity=36.2886597938144, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=62.9764065335753, Blast_Score=717, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57517; Mature: 57386

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIDSQLQVSGETFQHNAAAMRAVIDDLRRTLAQTARGGSDAARAKHTARGKLLARERI
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DALLDRGSALLEIAPLAAHGMYEDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPM
HHHHHCCCEEEEEECHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRDHFGRIFYNQANLSARGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCC
IACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
EEHEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRK
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCHHHEEECCCCCCC
PFDVREVIARVVDDSRLDEFKPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHF
CCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEECHHHCCHHH
IELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMAVACAKVPKFTVVIGGSFGA
HHHHHHCCCCEEEECCCHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
GNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGTWSGEDEETFKA
CCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHC
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVIDSQLQVSGETFQHNAAAMRAVIDDLRRTLAQTARGGSDAARAKHTARGKLLARERI
CCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
DALLDRGSALLEIAPLAAHGMYEDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPM
HHHHHCCCEEEEEECHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRDHFGRIFYNQANLSARGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCC
IACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEDLGGADVHTR
EEHEEECCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHFADNDLQALARVRAIIAQLNWRKPAASLALQAPLPPRYAADELYGVIPADTRK
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCHHHEEECCCCCCC
PFDVREVIARVVDDSRLDEFKPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHF
CCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEECHHHCCHHH
IELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMAVACAKVPKFTVVIGGSFGA
HHHHHHCCCCEEEECCCHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
GNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGTWSGEDEETFKA
CCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHC
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIEPTRFGVFRM
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]