Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 21241039

GI number: 21241039

Start: 319704

End: 320867

Strand: Reverse

Name: acdA [H]

Synonym: XAC0265

Alternate gene names: 21241039

Gene position: 320867-319704 (Counterclockwise)

Preceding gene: 21241043

Following gene: 21241038

Centisome position: 6.2

GC content: 65.72

Gene sequence:

>1164_bases
ATGCATGTGCCGTCCTTGAACTTCGAGCTTGGCGAAGAGATCGACCTGCTGCGCGAAAGCGTGGCCGCGTTCGCCAGCCA
CCATATCGCTCCGCTGGCCGCGGCAGCCGACCACGATAACGTGTTCCCCGCCCAGCTATGGCGCCTGCTCGGCGAACAAG
GCCTGCTCGGCCTGACCGTAGAAGACGCGTACGGCGGCAGCGGCATGGGCTATCTGGCGCATGTGGTGGCGATGGAAGAG
ATTTCGCGTGCTGGCGGTGCGATCGGGTTGTCGTATGGCGCGCACTCCAATCTGTGCCTGAACCAGCTGCGCAAGAACGC
CAGCCACGCGCAGAAGCAGCGCTACCTGCCCAAGCTATGCAGCGGCGAGCATGTGGGCGCGCTGGCGATGAGCGAGGCCG
GCTCCGGCTCGGATGTGGTGTCGATGAAGCTGCGCGCCGATGCGCGCGGCGACCGCTTTGTGCTCAACGGCAGCAAGATG
TGGATCACCAACGGCCCGGATGCCGATGTGCTGGTGGTGTACGCCAAGACCGACCCGGACGCCGGCGCGCGCGGCATCAC
CGCCTTCATCGTCGAAAAGGGCATGCCGGGCTTTTCCACCGCGCAGAAGCTCGACAAGCTGGGCATGCGCGGCTCCAACA
CCTGCGAGCTGGTGTTCACCGATTGCGAAGTACCGGCCGAAAACGTGCTCGGCACGCTCAACGGCGGCGCACGCGTATTG
ATGTCCGGGCTGGATTTCGAACGCGTGGTGCTGGCCGGCGGCCCGCTCGGGCTGATGGCCGCAGCGATGGATGTGGTGCT
GCCGTATGTGCACGAGCGCAAGCAGTTCGGCGAGCCGATCGGCACCTTCCAGTTGATGCAGGCCAAGCTGGCCGACATGT
ATGTGGGGCTCAATGCCTGCCGCGCGTATGTGTATGCGGTGGCGCGCGCCTGCGATGCCGGGCGCACCACCCGCCAGGAC
GCAGCCGGCGCCATTCTTTACGCCGCCGAGAAGGCAACCTGGCTGACCGGCCAGGCCATCCAGGTGCTGGGCGGCAACGG
CTACATCAACGACTACCCCACCGGACGCCTGTGGCGCGATGCCAAGTTGTACGAGATTGGCGCGGGCACTTCGGAGATTC
GCCGCATGCTGATCGGCCGCGAATTGTTCGAACGCACCGCCTGA

Upstream 100 bases:

>100_bases
TTTGGTTCACTTTTTTGTTGCGGGCCGCTAGTCTGGCCGTATTCGCCGCGCGGTCCGCCCGCTCCCACCCGGCACACCCC
GATCCCTGTGGAGTTGTTGC

Downstream 100 bases:

>100_bases
CGGAGCCACCATGAGCGTGATCGATAGCCAGCTGCAGGTCAGCGGCGAGACTTTTCAACACAACGCTGCCGCGATGCGCG
CGGTGATCGACGACCTGCGC

Product: acyl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLLGEQGLLGLTVEDAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASHAQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGARVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Sequences:

>Translated_387_residues
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLLGEQGLLGLTVEDAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASHAQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGARVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA
>Mature_387_residues
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLLGEQGLLGLTVEDAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNASHAQKQRYLPKLCSGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPDAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGARVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=64.8, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=64.054054054054, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=39.1644908616188, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=36.3874345549738, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=34.8051948051948, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=34.8051948051948, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=36.9014084507042, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4501857, Length=372, Percent_Identity=32.258064516129, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=32.4675324675325, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI4557235, Length=388, Percent_Identity=35.5670103092784, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=35.5670103092784, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=31.6326530612245, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=32.5966850828729, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=25.1748251748252, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=25.1748251748252, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=28.6089238845144, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=28.7958115183246, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=29.7297297297297, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081702, Length=272, Percent_Identity=24.2647058823529, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=62.8647214854111, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=33.7730870712401, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=32.6259946949602, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=34.5549738219895, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=34.025974025974, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=33.1619537275064, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=38.2142857142857, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=31.2169312169312, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=32.6760563380282, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.4014598540146, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=34.1991341991342, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=368, Percent_Identity=30.9782608695652, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=28.9817232375979, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=29.3010752688172, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=32.6315789473684, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.9623430962343, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=27.4021352313167, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=27.0462633451957, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=63.254593175853, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=39.4179894179894, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=38.2113821138211, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=35.5437665782493, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=35.4330708661417, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=33.1444759206799, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=29.7927461139896, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41356; Mature: 41356

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLLGEQGLLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCCCEEEEE
EDAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNASHAQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
SGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKMWITNGPDADVLVVYAKTDPD
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGARVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCEECCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNAC
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGRTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHVPSLNFELGEEIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLLGEQGLLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCCCEEEEE
EDAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNASHAQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
SGEHVGALAMSEAGSGSDVVSMKLRADARGDRFVLNGSKMWITNGPDADVLVVYAKTDPD
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGARVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCEECCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNAC
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGRTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINDYPTGRLWRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]