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The map label for this gene is dcp [H]

Identifier: 21241023

GI number: 21241023

Start: 296221

End: 298299

Strand: Direct

Name: dcp [H]

Synonym: XAC0249

Alternate gene names: 21241023

Gene position: 296221-298299 (Clockwise)

Preceding gene: 21241022

Following gene: 21241025

Centisome position: 5.72

GC content: 63.2

Gene sequence:

>2079_bases
GTGCCCGAGAAAACCGCCCCGGCTCCGGCCGCGGATGCTGCATCCAACCCCTTGCTGACCGCCAGCACGCTGCCGTTCCA
GGCGCCGCCGTTCGACAAGATCCAGGACGCCGATTATCTGCCGGCGTTCGAAGAAGGCATGCGCCAGCATCTGGCCGACA
TCCGCAAGATCGCCGATAACCCAGAAGCGCCGACCTTCGACAACACCATCGAAGCGATGGAGCGCGGCGGCGAAACGCTC
ACGCGCGTGTCGCGCATCTTCTTCGGGCTGGTGCAGGCCGATACCAGCGACGCACGCCAGAAAATCCAGGAAGAGATCGC
GCCCAAGCTGGCCGCGCATCAGGACGAGATCAATCTCGACCCCAAACTCTTCGCCCGCGTCAAGACCATCTACGACCAGC
GCGACACGCTGAATCTGGATCCGGAGCAGAAGCGTCTGGTCGAGCGCGACTACGAAGAGCTGGTACGCGCCGGCGCGCAG
TTGTCCGATGCCGACAAGGACAGCCTGCGCAAGCTCAACGTGGAAGAAACCACCCTCTCCACGCAGTTCCATACCCGCCT
GGTCGCCGCCTCGGCTGCCGGCGCGGTGGTGGTGGACGACAAGGCCAAGCTCGATGGCCTGAGCGAAGGCGATATCGCCG
CCGCGGCCGATGCCGCCAAGGCCCGCAAGCTCGATGGCAAGTATCTGCTCACTCTGCAGAACACCACCCAGCAGCCGGTG
CTGGCGTCGCTGAAAAATCGCGAGCTGCGTGCCGAGGTATTGAAGGCCTCTGAGACGCGCGCGGAAAAGGGCGATGCCAA
CGACACCCGCCAGACCATCCAGCGGCTGGCGCAGCTGCGCGCGCAGAAGGCCAAGTTGCTCGGCTTCGACAACTACGCCG
CCTACAGCCTGGGCGACCAGATGGCCAAGACGCCGGATGCCGCGCTCAAGCTGCTGACCGACACCGTGCCGGCTGCCACT
GCCAAGGCACGCCGCGAAGCGGCCGAGATGCAGAAGGTCATCGACGCGCAGAAAGGCGGCTTCAAACTCGCCGCCTCCGA
TTGGGACGTCTACGCCGAGCAGGTGCGCAAGGCCAAGTACGACCTGGACGAATCCCAGATCAAGCCGTACTTCGAACTGG
ACAACGTGCTCAACAACGGCGTGTTCTACGCCGCCACGCAGCTGTACGGCATCACGTTCAAGCAGCGCACCGACATCCCG
ACCTATCACGCGGATATGAAGGTGTATGAGGTGTTCGATGCCGACGGCACCTCGATGGCGTTGTTCTACACCGACTACTT
CAAGCGCGACAGCAAGTCCGGTGGCGCGTGGATGGACGTGTTCGTCGAGCAAGACGGCCTGACCGGTGCCAAGCCGGTGG
TCTACAACGTGTGCAACTTCACCAAGCCGGCCGCCGGCCAGCCGGCGCTGCTCAGCTTCGACGACGTCACCACCTTGTTC
CATGAGTTCGGCCATGCGCTGCATGGCATGTTCTCCAAGGTGAAGTACCCCTCGATTGCCGGCACCAGCACCTCGCGCGA
CTTCGTGGAATTCCCCTCGCAGTTCAACGAGCACTGGGCGTCCGATCCGAAGGTCTTCGCCAACTACGCCAAGCACTACC
AGACCGGCGCAGCGATGCCGGCCGAGCTGGTGGAAAAGATCAAGAAGGCCAAGACCTTCAACAGCGGCTACGCCACCACC
GAATACCTGTCGGCGGCGCTGCTGGATCTGGCCTGGCATACCCAGCCGGCCGATGCGCCGCTGCAGGACGTGAGCAAGTT
CGAAGCCGATGCCTTGAAGCGCTTCAAGGTGGATCTGGCCGAAGTGCCGCCGCGCTACCGCAGCAGTTATTTCGATCACA
TCTGGGGCGGCGGGTATTCGGCCGGGTACTACGCGTACTTCTGGTCGGAAGTGCTCGACGACGATGCGTTCGAATGGTTC
AAGGAAAACGGTGGCCTGACCCGCAAGAACGGCGATACCTTCCGCGCCAAGATCCTCTCGCGCGGCAATACTGTCGATCT
GGCCACGTTGTACCGCGATTTCCGCGGCAAGGACCCCAGCGTCAAGGCGCTGCTGGAAAACCGCGGGTTGACCGAGTGA

Upstream 100 bases:

>100_bases
ATCACACGCCATGTCGCGTACCGTCGTTCTGGCCGCTGCCATCACCCTGGCACTGGCTGCTTGTTCTGGAAAAGAGTCGT
CTGGCCAGGAGTCCACCACC

Downstream 100 bases:

>100_bases
GCGATGTGCGTGCGTAGGCATGCATGCCTCGCCAGTGCGATTGGCAAACAAAGACGGGATGGCCATGGCCATCCCGTCTT
TGTTCGTGCGCATGTGACGC

Product: peptidyl-dipeptidase

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MPEKTAPAPAADAASNPLLTASTLPFQAPPFDKIQDADYLPAFEEGMRQHLADIRKIADNPEAPTFDNTIEAMERGGETL
TRVSRIFFGLVQADTSDARQKIQEEIAPKLAAHQDEINLDPKLFARVKTIYDQRDTLNLDPEQKRLVERDYEELVRAGAQ
LSDADKDSLRKLNVEETTLSTQFHTRLVAASAAGAVVVDDKAKLDGLSEGDIAAAADAAKARKLDGKYLLTLQNTTQQPV
LASLKNRELRAEVLKASETRAEKGDANDTRQTIQRLAQLRAQKAKLLGFDNYAAYSLGDQMAKTPDAALKLLTDTVPAAT
AKARREAAEMQKVIDAQKGGFKLAASDWDVYAEQVRKAKYDLDESQIKPYFELDNVLNNGVFYAATQLYGITFKQRTDIP
TYHADMKVYEVFDADGTSMALFYTDYFKRDSKSGGAWMDVFVEQDGLTGAKPVVYNVCNFTKPAAGQPALLSFDDVTTLF
HEFGHALHGMFSKVKYPSIAGTSTSRDFVEFPSQFNEHWASDPKVFANYAKHYQTGAAMPAELVEKIKKAKTFNSGYATT
EYLSAALLDLAWHTQPADAPLQDVSKFEADALKRFKVDLAEVPPRYRSSYFDHIWGGGYSAGYYAYFWSEVLDDDAFEWF
KENGGLTRKNGDTFRAKILSRGNTVDLATLYRDFRGKDPSVKALLENRGLTE

Sequences:

>Translated_692_residues
MPEKTAPAPAADAASNPLLTASTLPFQAPPFDKIQDADYLPAFEEGMRQHLADIRKIADNPEAPTFDNTIEAMERGGETL
TRVSRIFFGLVQADTSDARQKIQEEIAPKLAAHQDEINLDPKLFARVKTIYDQRDTLNLDPEQKRLVERDYEELVRAGAQ
LSDADKDSLRKLNVEETTLSTQFHTRLVAASAAGAVVVDDKAKLDGLSEGDIAAAADAAKARKLDGKYLLTLQNTTQQPV
LASLKNRELRAEVLKASETRAEKGDANDTRQTIQRLAQLRAQKAKLLGFDNYAAYSLGDQMAKTPDAALKLLTDTVPAAT
AKARREAAEMQKVIDAQKGGFKLAASDWDVYAEQVRKAKYDLDESQIKPYFELDNVLNNGVFYAATQLYGITFKQRTDIP
TYHADMKVYEVFDADGTSMALFYTDYFKRDSKSGGAWMDVFVEQDGLTGAKPVVYNVCNFTKPAAGQPALLSFDDVTTLF
HEFGHALHGMFSKVKYPSIAGTSTSRDFVEFPSQFNEHWASDPKVFANYAKHYQTGAAMPAELVEKIKKAKTFNSGYATT
EYLSAALLDLAWHTQPADAPLQDVSKFEADALKRFKVDLAEVPPRYRSSYFDHIWGGGYSAGYYAYFWSEVLDDDAFEWF
KENGGLTRKNGDTFRAKILSRGNTVDLATLYRDFRGKDPSVKALLENRGLTE
>Mature_691_residues
PEKTAPAPAADAASNPLLTASTLPFQAPPFDKIQDADYLPAFEEGMRQHLADIRKIADNPEAPTFDNTIEAMERGGETLT
RVSRIFFGLVQADTSDARQKIQEEIAPKLAAHQDEINLDPKLFARVKTIYDQRDTLNLDPEQKRLVERDYEELVRAGAQL
SDADKDSLRKLNVEETTLSTQFHTRLVAASAAGAVVVDDKAKLDGLSEGDIAAAADAAKARKLDGKYLLTLQNTTQQPVL
ASLKNRELRAEVLKASETRAEKGDANDTRQTIQRLAQLRAQKAKLLGFDNYAAYSLGDQMAKTPDAALKLLTDTVPAATA
KARREAAEMQKVIDAQKGGFKLAASDWDVYAEQVRKAKYDLDESQIKPYFELDNVLNNGVFYAATQLYGITFKQRTDIPT
YHADMKVYEVFDADGTSMALFYTDYFKRDSKSGGAWMDVFVEQDGLTGAKPVVYNVCNFTKPAAGQPALLSFDDVTTLFH
EFGHALHGMFSKVKYPSIAGTSTSRDFVEFPSQFNEHWASDPKVFANYAKHYQTGAAMPAELVEKIKKAKTFNSGYATTE
YLSAALLDLAWHTQPADAPLQDVSKFEADALKRFKVDLAEVPPRYRSSYFDHIWGGGYSAGYYAYFWSEVLDDDAFEWFK
ENGGLTRKNGDTFRAKILSRGNTVDLATLYRDFRGKDPSVKALLENRGLTE

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=595, Percent_Identity=29.5798319327731, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI14149738, Length=643, Percent_Identity=27.8382581648523, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI156105687, Length=658, Percent_Identity=22.3404255319149, Blast_Score=135, Evalue=2e-31,
Organism=Escherichia coli, GI1787819, Length=676, Percent_Identity=55.7692307692308, Blast_Score=777, Evalue=0.0,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=32.5072886297376, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI32565901, Length=455, Percent_Identity=23.0769230769231, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319793, Length=659, Percent_Identity=26.2518968133536, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6322715, Length=474, Percent_Identity=25.1054852320675, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356111, Length=571, Percent_Identity=25.2189141856392, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI20129717, Length=420, Percent_Identity=26.9047619047619, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 76957; Mature: 76826

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKTAPAPAADAASNPLLTASTLPFQAPPFDKIQDADYLPAFEEGMRQHLADIRKIADN
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
PEAPTFDNTIEAMERGGETLTRVSRIFFGLVQADTSDARQKIQEEIAPKLAAHQDEINLD
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PKLFARVKTIYDQRDTLNLDPEQKRLVERDYEELVRAGAQLSDADKDSLRKLNVEETTLS
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHH
TQFHTRLVAASAAGAVVVDDKAKLDGLSEGDIAAAADAAKARKLDGKYLLTLQNTTQQPV
HHHHHHHHHHCCCCEEEECCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LASLKNRELRAEVLKASETRAEKGDANDTRQTIQRLAQLRAQKAKLLGFDNYAAYSLGDQ
HHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MAKTPDAALKLLTDTVPAATAKARREAAEMQKVIDAQKGGFKLAASDWDVYAEQVRKAKY
HHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHC
DLDESQIKPYFELDNVLNNGVFYAATQLYGITFKQRTDIPTYHADMKVYEVFDADGTSMA
CCCHHHCCCHHHHHHHHHCCCEEEEHHHHEEEECCCCCCCCEECCCEEEEEECCCCCEEE
LFYTDYFKRDSKSGGAWMDVFVEQDGLTGAKPVVYNVCNFTKPAAGQPALLSFDDVTTLF
EEEEHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCEECHHHHHHHH
HEFGHALHGMFSKVKYPSIAGTSTSRDFVEFPSQFNEHWASDPKVFANYAKHYQTGAAMP
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
AELVEKIKKAKTFNSGYATTEYLSAALLDLAWHTQPADAPLQDVSKFEADALKRFKVDLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EVPPRYRSSYFDHIWGGGYSAGYYAYFWSEVLDDDAFEWFKENGGLTRKNGDTFRAKILS
HCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHH
RGNTVDLATLYRDFRGKDPSVKALLENRGLTE
CCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
PEKTAPAPAADAASNPLLTASTLPFQAPPFDKIQDADYLPAFEEGMRQHLADIRKIADN
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
PEAPTFDNTIEAMERGGETLTRVSRIFFGLVQADTSDARQKIQEEIAPKLAAHQDEINLD
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PKLFARVKTIYDQRDTLNLDPEQKRLVERDYEELVRAGAQLSDADKDSLRKLNVEETTLS
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHH
TQFHTRLVAASAAGAVVVDDKAKLDGLSEGDIAAAADAAKARKLDGKYLLTLQNTTQQPV
HHHHHHHHHHCCCCEEEECCCHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LASLKNRELRAEVLKASETRAEKGDANDTRQTIQRLAQLRAQKAKLLGFDNYAAYSLGDQ
HHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
MAKTPDAALKLLTDTVPAATAKARREAAEMQKVIDAQKGGFKLAASDWDVYAEQVRKAKY
HHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHC
DLDESQIKPYFELDNVLNNGVFYAATQLYGITFKQRTDIPTYHADMKVYEVFDADGTSMA
CCCHHHCCCHHHHHHHHHCCCEEEEHHHHEEEECCCCCCCCEECCCEEEEEECCCCCEEE
LFYTDYFKRDSKSGGAWMDVFVEQDGLTGAKPVVYNVCNFTKPAAGQPALLSFDDVTTLF
EEEEHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCEECHHHHHHHH
HEFGHALHGMFSKVKYPSIAGTSTSRDFVEFPSQFNEHWASDPKVFANYAKHYQTGAAMP
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
AELVEKIKKAKTFNSGYATTEYLSAALLDLAWHTQPADAPLQDVSKFEADALKRFKVDLA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EVPPRYRSSYFDHIWGGGYSAGYYAYFWSEVLDDDAFEWFKENGGLTRKNGDTFRAKILS
HCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHHHHHH
RGNTVDLATLYRDFRGKDPSVKALLENRGLTE
CCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226676; 9097039; 9278503 [H]