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The map label for this gene is pyrH

Identifier: 57238146

GI number: 57238146

Start: 1327594

End: 1328313

Strand: Reverse

Name: pyrH

Synonym: CJE1410

Alternate gene names: 57238146

Gene position: 1328313-1327594 (Counterclockwise)

Preceding gene: 57238147

Following gene: 57238145

Centisome position: 74.72

GC content: 33.47

Gene sequence:

>720_bases
ATGCAAGAGAGAAAAAGAGTTTTAGTAAAATTTTCAGGAGAGGCTTTAGCAGGTGAAAATGGCTTTGGTATAGAAAATTC
TATTTTAAAATTCATAGCTTCAGAGATTAAAGAACTTATAAAAAATCAAATAGAAGTAGGCATAGTTATAGGCGGTGGTA
ATATTATTCGCGGAGTAAGTGCTGCTAAGGGCGGATTGATTAAAAGGACAAGTGGAGATCATATGGGAATGCTTGCTACA
GTTATCAATGCTATTGCTATACAAGAAGCTTTGGAAAGCTCTGGACTTGAAGTTAGGGTTCAAAGCGCCATTCAGATGGA
AGCATTTTGTGAAACTTATATTATGAGAAGAGCGCAAAGACACTTAGAAAAGGGTCGTGTTGTGGTTTTTGCTGCAGGTA
CTGGAAACCCTTATTTTACTACGGATACAACAGCTATTTTAAGAGCTGTGGAAATTGATGCAGATATGGTAATAAAAGCT
ACAAAAGTTAATGGAGTTTATGATAAAGATCCAAAACAATTTGATGATGCAGTATTTTTAAATACTTTAAGTTATGATGA
GGCTATGCAAGATAATATTAAAGTGATGGATGATACAGCTATAGCTTTAGCTAAAGATAACAAACTTCCTATTGTGGTTT
GTAATATGTTTGAAGAGGGTAATTTACTTAAAATCATACAAGGTGATACTAGCCTTTGTTCAATCGTTAAAAATAATTAA

Upstream 100 bases:

>100_bases
TCAAAAAAATTTTCATATCAATCCTTTGGAACTCATTAGCTTAAATTAGCTAAATTTAATGGAATTTAAAATATAATTTC
AAGTTAAATAAGGAGAAATA

Downstream 100 bases:

>100_bases
GGAGAAAATTATGGATAAAAGAATAGAAGAAGTAGCGGCAAAAGCTTTGGAAAAAATGGGTAATGATAGATATCGCCTTT
CTTTAGTGGTAGCAAAAAGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQERKRVLVKFSGEALAGENGFGIENSILKFIASEIKELIKNQIEVGIVIGGGNIIRGVSAAKGGLIKRTSGDHMGMLAT
VINAIAIQEALESSGLEVRVQSAIQMEAFCETYIMRRAQRHLEKGRVVVFAAGTGNPYFTTDTTAILRAVEIDADMVIKA
TKVNGVYDKDPKQFDDAVFLNTLSYDEAMQDNIKVMDDTAIALAKDNKLPIVVCNMFEEGNLLKIIQGDTSLCSIVKNN

Sequences:

>Translated_239_residues
MQERKRVLVKFSGEALAGENGFGIENSILKFIASEIKELIKNQIEVGIVIGGGNIIRGVSAAKGGLIKRTSGDHMGMLAT
VINAIAIQEALESSGLEVRVQSAIQMEAFCETYIMRRAQRHLEKGRVVVFAAGTGNPYFTTDTTAILRAVEIDADMVIKA
TKVNGVYDKDPKQFDDAVFLNTLSYDEAMQDNIKVMDDTAIALAKDNKLPIVVCNMFEEGNLLKIIQGDTSLCSIVKNN
>Mature_239_residues
MQERKRVLVKFSGEALAGENGFGIENSILKFIASEIKELIKNQIEVGIVIGGGNIIRGVSAAKGGLIKRTSGDHMGMLAT
VINAIAIQEALESSGLEVRVQSAIQMEAFCETYIMRRAQRHLEKGRVVVFAAGTGNPYFTTDTTAILRAVEIDADMVIKA
TKVNGVYDKDPKQFDDAVFLNTLSYDEAMQDNIKVMDDTAIALAKDNKLPIVVCNMFEEGNLLKIIQGDTSLCSIVKNN

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=225, Percent_Identity=49.7777777777778, Blast_Score=226, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CAMJ8 (A8FMY0)

Other databases:

- EMBL:   CP000814
- RefSeq:   YP_001482794.1
- ProteinModelPortal:   A8FMY0
- SMR:   A8FMY0
- STRING:   A8FMY0
- GeneID:   5617391
- GenomeReviews:   CP000814_GR
- KEGG:   cju:C8J_1218
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   CJEJ407148:C8J_1218-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26031; Mature: 26031

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 73-73 BINDING 161-161 BINDING 167-167 BINDING 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERKRVLVKFSGEALAGENGFGIENSILKFIASEIKELIKNQIEVGIVIGGGNIIRGVS
CCCHHEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHEECCH
AAKGGLIKRTSGDHMGMLATVINAIAIQEALESSGLEVRVQSAIQMEAFCETYIMRRAQR
HHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
HLEKGRVVVFAAGTGNPYFTTDTTAILRAVEIDADMVIKATKVNGVYDKDPKQFDDAVFL
HHHCCCEEEEEECCCCCEEECCHHHHHHHEECCCCEEEEEEEECCCCCCCCHHHCCEEEE
NTLSYDEAMQDNIKVMDDTAIALAKDNKLPIVVCNMFEEGNLLKIIQGDTSLCSIVKNN
EECCHHHHHHCCCEEECCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCHHHHEEECC
>Mature Secondary Structure
MQERKRVLVKFSGEALAGENGFGIENSILKFIASEIKELIKNQIEVGIVIGGGNIIRGVS
CCCHHEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHEECCH
AAKGGLIKRTSGDHMGMLATVINAIAIQEALESSGLEVRVQSAIQMEAFCETYIMRRAQR
HHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
HLEKGRVVVFAAGTGNPYFTTDTTAILRAVEIDADMVIKATKVNGVYDKDPKQFDDAVFL
HHHCCCEEEEEECCCCCEEECCHHHHHHHEECCCCEEEEEEEECCCCCCCCHHHCCEEEE
NTLSYDEAMQDNIKVMDDTAIALAKDNKLPIVVCNMFEEGNLLKIIQGDTSLCSIVKNN
EECCHHHHHHCCCEEECCCEEEEEECCCCCEEEEEECCCCCEEEEEECCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA