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The map label for this gene is pepA [H]

Identifier: 57237757

GI number: 57237757

Start: 940399

End: 941850

Strand: Direct

Name: pepA [H]

Synonym: CJE1007

Alternate gene names: 57237757

Gene position: 940399-941850 (Clockwise)

Preceding gene: 57237756

Following gene: 57237758

Centisome position: 52.9

GC content: 31.96

Gene sequence:

>1452_bases
ATGAAATTTGAATTAAACGATAAAAAACTAGATGCTATAAAAGCAGACTTTGAACTTGTTTTTATACAGGATAAAAATTT
AAAAATTTTTAACAAAGAAAAAGATTTTTTTAAACTTAATAATTACAAAGGCGAAGGTGCATTATTAGACTTAAACAATA
AAAAGCTTTATTTAGAGCTTAAAAGTCTTGCTTATGAGGATATAAGATTAAGTCTTTGCACAGCATATAAAACTCTTGAG
AAACTTAATATTAAAAGCGTAAAACTTCCTAGCATAATAGGAGATTGTGTAGTTAGAAGTTTTGCATCTTTAGTTGAAGG
CGTACTTTTTGGAGCTTATAAATTTGACAAATATAAAAGCGAGAAAAAAACAAGTACTTTGGAAAAATTTATTATTTCAA
ACGAAGAATTAAATGGTAAGAAATTTAATAAAGATGAAGCTAAGATAGGTTTAGAGCGTGGAGAAATTTTAGCCAATGCT
ACAAATTTTACTAAAAATATAGTCAATGAAATTCCTGAAATTTACACCCCTTTAAAAATGGCAGAAGATGCGCAAAATTT
AGCTAAAGAAAATAAAAACATTATTTGTAAAATTTATGATGAAAAATTTTTAGCCAAAGAAAAAATGAATGCCTTTTTAG
CGGTAAATCATGCCTCGGTACACCCACCACGCCTCATTCATCTAAGCTATAAAGCCAAAAATGCAAAAAAACGTGTTGTA
TTTGTTGGAAAAGGCTTAACTTACGATAGCGGTGGATTAAGCTTAAAACCAGCTGATTTTATGCTTACAATGAAAGCTGA
TAAAAGCGGTGCAGCAGCAGCAATGGGAATCATAAAAGCCGTAGCTGAACTTGCTTTAGATTTAGAAGTGCATTGCATTT
TGGGCGCAACTGAAAATATGATAGGCGGCAATGCTTATAAGCCTGATGATGTGTTAATCAGTCGTGAAGGTGTAAGCATA
GAGGTAAGAAATACAGATGCAGAAGGACGCTTGGTTTTAGCTGATTGTCTTTCTTTTGCACAGGATTTAAAACCTGATTT
ACTTATCGATATGGCAACTCTTACTGGAGCTTGTGTTGTAGGACTTGGAGAATTTACAAGCGCTATTATGGGAAATAATG
AGGAATTGCAAAATGATTTTTATCTAAGCTCTAAAAAAAGCGGAGAATATACCACAATCTTACATTTCAACCCTCACTTA
AAAGAACTTATAAAATCAAATATTGCCGATGTTAGTAATACTGCCTCTAGTCGCTACGGAGGTGCAATTACCGCAGGGTT
ATTTTTAGATAAATTTATTCGTAAAGAATATAAAGATAAATGGCTACATCTTGATATAGCAGGACCTGCTTATACAGAAA
AATCTTGGGGATATTCTAGTTTTGGCGCAGGTGGAGCTGGAGTTAGAATGTGTGTTAATTATTTAATTCAAATTTTAAGG
AAAGCTAAATGA

Upstream 100 bases:

>100_bases
GGTATTATGCAGCCATTATTATTATAGCTTTTTTATCCCTTTTATTATTTGGTTTTAAACAAATGGAAAAAGCTATACTT
AAAGATAAAAGGAAAAAATC

Downstream 100 bases:

>100_bases
GTTTAAGCGTAGGTATAGTAGGACTTCCAAATGTTGGCAAATCAACAACTTTTAATGCTTTAACTAAAGCACAAAATGCC
CAAAGTGCAAACTATCCTTT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKFELNDKKLDAIKADFELVFIQDKNLKIFNKEKDFFKLNNYKGEGALLDLNNKKLYLELKSLAYEDIRLSLCTAYKTLE
KLNIKSVKLPSIIGDCVVRSFASLVEGVLFGAYKFDKYKSEKKTSTLEKFIISNEELNGKKFNKDEAKIGLERGEILANA
TNFTKNIVNEIPEIYTPLKMAEDAQNLAKENKNIICKIYDEKFLAKEKMNAFLAVNHASVHPPRLIHLSYKAKNAKKRVV
FVGKGLTYDSGGLSLKPADFMLTMKADKSGAAAAMGIIKAVAELALDLEVHCILGATENMIGGNAYKPDDVLISREGVSI
EVRNTDAEGRLVLADCLSFAQDLKPDLLIDMATLTGACVVGLGEFTSAIMGNNEELQNDFYLSSKKSGEYTTILHFNPHL
KELIKSNIADVSNTASSRYGGAITAGLFLDKFIRKEYKDKWLHLDIAGPAYTEKSWGYSSFGAGGAGVRMCVNYLIQILR
KAK

Sequences:

>Translated_483_residues
MKFELNDKKLDAIKADFELVFIQDKNLKIFNKEKDFFKLNNYKGEGALLDLNNKKLYLELKSLAYEDIRLSLCTAYKTLE
KLNIKSVKLPSIIGDCVVRSFASLVEGVLFGAYKFDKYKSEKKTSTLEKFIISNEELNGKKFNKDEAKIGLERGEILANA
TNFTKNIVNEIPEIYTPLKMAEDAQNLAKENKNIICKIYDEKFLAKEKMNAFLAVNHASVHPPRLIHLSYKAKNAKKRVV
FVGKGLTYDSGGLSLKPADFMLTMKADKSGAAAAMGIIKAVAELALDLEVHCILGATENMIGGNAYKPDDVLISREGVSI
EVRNTDAEGRLVLADCLSFAQDLKPDLLIDMATLTGACVVGLGEFTSAIMGNNEELQNDFYLSSKKSGEYTTILHFNPHL
KELIKSNIADVSNTASSRYGGAITAGLFLDKFIRKEYKDKWLHLDIAGPAYTEKSWGYSSFGAGGAGVRMCVNYLIQILR
KAK
>Mature_483_residues
MKFELNDKKLDAIKADFELVFIQDKNLKIFNKEKDFFKLNNYKGEGALLDLNNKKLYLELKSLAYEDIRLSLCTAYKTLE
KLNIKSVKLPSIIGDCVVRSFASLVEGVLFGAYKFDKYKSEKKTSTLEKFIISNEELNGKKFNKDEAKIGLERGEILANA
TNFTKNIVNEIPEIYTPLKMAEDAQNLAKENKNIICKIYDEKFLAKEKMNAFLAVNHASVHPPRLIHLSYKAKNAKKRVV
FVGKGLTYDSGGLSLKPADFMLTMKADKSGAAAAMGIIKAVAELALDLEVHCILGATENMIGGNAYKPDDVLISREGVSI
EVRNTDAEGRLVLADCLSFAQDLKPDLLIDMATLTGACVVGLGEFTSAIMGNNEELQNDFYLSSKKSGEYTTILHFNPHL
KELIKSNIADVSNTASSRYGGAITAGLFLDKFIRKEYKDKWLHLDIAGPAYTEKSWGYSSFGAGGAGVRMCVNYLIQILR
KAK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=416, Percent_Identity=31.4903846153846, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI47155554, Length=363, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1790710, Length=369, Percent_Identity=37.6693766937669, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=34.375, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17556903, Length=307, Percent_Identity=33.5504885993485, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=211, Percent_Identity=36.4928909952607, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357381, Length=270, Percent_Identity=36.6666666666667, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI221379063, Length=270, Percent_Identity=36.6666666666667, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI221379062, Length=270, Percent_Identity=36.6666666666667, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI21355725, Length=424, Percent_Identity=29.0094339622642, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24661038, Length=424, Percent_Identity=29.0094339622642, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24662227, Length=395, Percent_Identity=25.0632911392405, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI20129969, Length=404, Percent_Identity=25.990099009901, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI161077148, Length=303, Percent_Identity=27.3927392739274, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130057, Length=303, Percent_Identity=27.3927392739274, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646701, Length=310, Percent_Identity=32.5806451612903, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646703, Length=310, Percent_Identity=32.5806451612903, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21358201, Length=310, Percent_Identity=32.5806451612903, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129963, Length=297, Percent_Identity=28.2828282828283, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21355645, Length=428, Percent_Identity=22.4299065420561, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24662223, Length=428, Percent_Identity=22.4299065420561, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI19922386, Length=346, Percent_Identity=25.1445086705202, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53667; Mature: 53667

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFELNDKKLDAIKADFELVFIQDKNLKIFNKEKDFFKLNNYKGEGALLDLNNKKLYLEL
CCCCCCCCHHHHEECCEEEEEEECCCEEEEECCCCEEEECCCCCCEEEEEECCCEEEEEE
KSLAYEDIRLSLCTAYKTLEKLNIKSVKLPSIIGDCVVRSFASLVEGVLFGAYKFDKYKS
HHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKKTSTLEKFIISNEELNGKKFNKDEAKIGLERGEILANATNFTKNIVNEIPEIYTPLKM
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHH
AEDAQNLAKENKNIICKIYDEKFLAKEKMNAFLAVNHASVHPPRLIHLSYKAKNAKKRVV
HHHHHHHHHCCCCEEEEECCHHHHHHHHCCEEEEEECCCCCCCEEEEEEEECCCCCEEEE
FVGKGLTYDSGGLSLKPADFMLTMKADKSGAAAAMGIIKAVAELALDLEVHCILGATENM
EEECCCEECCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCCC
IGGNAYKPDDVLISREGVSIEVRNTDAEGRLVLADCLSFAQDLKPDLLIDMATLTGACVV
CCCCCCCCCCEEEECCCCEEEEECCCCCCCEEHHHHHHHHHHCCCHHEEEHHHHHHHHHE
GLGEFTSAIMGNNEELQNDFYLSSKKSGEYTTILHFNPHLKELIKSNIADVSNTASSRYG
EHHHHHHHHHCCCHHHCCCEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCCC
GAITAGLFLDKFIRKEYKDKWLHLDIAGPAYTEKSWGYSSFGAGGAGVRMCVNYLIQILR
CHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KAK
HCC
>Mature Secondary Structure
MKFELNDKKLDAIKADFELVFIQDKNLKIFNKEKDFFKLNNYKGEGALLDLNNKKLYLEL
CCCCCCCCHHHHEECCEEEEEEECCCEEEEECCCCEEEECCCCCCEEEEEECCCEEEEEE
KSLAYEDIRLSLCTAYKTLEKLNIKSVKLPSIIGDCVVRSFASLVEGVLFGAYKFDKYKS
HHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKKTSTLEKFIISNEELNGKKFNKDEAKIGLERGEILANATNFTKNIVNEIPEIYTPLKM
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHCCHHH
AEDAQNLAKENKNIICKIYDEKFLAKEKMNAFLAVNHASVHPPRLIHLSYKAKNAKKRVV
HHHHHHHHHCCCCEEEEECCHHHHHHHHCCEEEEEECCCCCCCEEEEEEEECCCCCEEEE
FVGKGLTYDSGGLSLKPADFMLTMKADKSGAAAAMGIIKAVAELALDLEVHCILGATENM
EEECCCEECCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCCC
IGGNAYKPDDVLISREGVSIEVRNTDAEGRLVLADCLSFAQDLKPDLLIDMATLTGACVV
CCCCCCCCCCEEEECCCCEEEEECCCCCCCEEHHHHHHHHHHCCCHHEEEHHHHHHHHHE
GLGEFTSAIMGNNEELQNDFYLSSKKSGEYTTILHFNPHLKELIKSNIADVSNTASSRYG
EHHHHHHHHHCCCHHHCCCEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCCCC
GAITAGLFLDKFIRKEYKDKWLHLDIAGPAYTEKSWGYSSFGAGGAGVRMCVNYLIQILR
CHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KAK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]